CURRICULUM VITAE
Full Name
ANTONIO FERNANDEZ SANTIDRIAN
Birth Date
4-March-1978
Organization
THE SCRIPPS RESEARCH INSTITUTE
DEPARTMENT CHEMICAL PHYSIOLOGY.
Phone
+1 858-784-8612
Fax
+1 858-784-2174
e-mail
afsant@scripps.edu
Professional Status
Research associate Sr.
START DATE
March 2008
VISA STATUS:
H1-B (From March 1st 2013) Before I was on J1
A. Personal Statement.
I have a strong background in the analysis of molecular mechanisms that control tumor cell
apoptosis, and in the evaluation of new therapeutic targets and signaling pathways to disrupt
cancer cell survival. I have also experience in the detection of genomic alterations in tumor cells. I
have developed a strong background in breast cancer and cellular and mitochondrial metabolism,
NAD+ metabolism, survival pathways, as well as autophagy and its alterations during tumor
progression. I have a strong background in xenograft and spontaneous breast cancer animal
models and metabolic stress response that relate to tumor progression.
The main objective of my research is to understand the role of cellular and mitochondrial
metabolism on regulating tumor transformation and progression focusing on finding new
therapeutic approaches that can prevent breast cancer progression.
Recently, the Journal of Clinical Investigation has accepted for publication our work:
Mitochondrial Complex I activity and NAD+/NADH balance regulate breast cancer progression
which I am the first author.
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1. ACADEMIC BACKGROUND AND PROFESSIONAL EXPERIENCE
BATCHELOR DEGREE / PHARMACY (University of Barcelona)
DATE Sept-1996 / Sept-2001
DOCTORATE BIOMEDICINE (Dept. CIENCIES FISIOLOGIQUES II, UNIVERSITY OF
BARCELONA)
DATE Sept-2001 / Feb-2007
RESEARCH ASSOCIATE Dept. CIENCIES FISIOLOGIQUES II, UNIVERSITY OF
BARCELONA
DATE March-2007 / Feb-2008
RESEARCH ASSOCIATE AT THE SCRIPPS RESEARCH INSTITUTE (Dr. Felding group)
DATE March-2008 / Feb 2013
SENIOR RESEARCH ASSOCIATE AT THE SCRIPPS RESEARCH INSTITUTE (Dr. Felding
group) March-2013 / present
LANGUAGES:
- Spanish: high level in written and spoken Spanish.
- Catalan: high level in written and spoken Catalan.
- English: good level in written and spoken English.
2. PARTICIPATION IN FINANCED RESEARCH PROJECTS
PROJECT TITLE Molecular basis of apoptosis regulation in B cell chronic lymphocytic
leukemia (B-CLL)
FINANCING ENTITY Science and technology ministery
DURATION. FROM 2001 TO 2004
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
PROJECT TITLE New therapeutic targets and signaling pathways in apoptosis regulation
in B cell chronic lymphocytic leukemia (B-CLL)
FINANCING ENTITY Education and Science ministery
DURATION. FROM 2004 TO 2007
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
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PROJECT TITLE Aicar (Acadesine), new proapoptotic agent in B-cells lymphoproliferative
disorders.
FINANCING ENTITY Advanced in Vitro cell Technologies, S.L. (ADVANCELL)
DURATION. FROM 2004 TO 2006
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
PROJECT TITLE Aicar (Acadesine), new proapoptotic agent in B-cells lymphoproliferative
disorders. In vivo assay on balb/c mouse.
FINANCING ENTITY Advanced in Vitro cell Technologies, S.L. (ADVANCELL)
DURATION. FROM august 2006 TO December 2006
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
PROJECT TITLE Aicar (Acadesine), new proapoptotic agent in B-cells lymphoproliferative
disorders. Assay on dog lymphocytes.
FINANCING ENTITY Advanced in Vitro cell Technologies, S.L. (ADVANCELL)
DURATION. January 2007 TO august 2007
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
PROJECT TITLE Aicar (Acadesine), new proapoptotic agent in B-cells lymphoproliferative
disorders. Death-associated protein kinase 1 (DAPK1). Analysis in acadesine-treated CLL
cells.
FINANCING ENTITY Advanced in Vitro cell Technologies, S.L. (ADVANCELL)
DURATION. FROM agust 2007 to December
PRINCIPAL RESEARCHER Dr JOAN GIL SANTANO
PROJECT TITLE Targeting Hyaluronidase-1 for Treatment of Cancer Progression
FINANCING ENTITY Scripps Translational Science Institute (STSI) (from NIH)
DURATION. FROM Octuber 2008
to March 2009
PRINCIPAL RESEARCHER: Dr Brunhilde Felding-Habermann
PROJECT TITLE Normalizing Breast Cancer Metabolism to Prevent Progression and
Recurrence
FINANCING ENTITY: NIH/NCI
DURATION. FROM August 2012
to July 2016
PRINCIPAL RESEARCHER: Dr Brunhilde Felding-Habermann
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PROJECT TITLE Role of mitochondrial complex I and cellular NAD+/NADH redox balance
in breast cancer progression.
FINANCING ENTITY: SUSAN G. KOMEN FOR THE CURE
DURATION. FROM September 2010
to September 2013
PRINCIPAL RESEARCHER: Dr Brunhilde Felding-Habermann
3. PUBLICATIONS
1-TITLE: 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but
the AMP-activated protein kinase is not involved.
AUTHORS Lopez JM, Santidrian AF, Campas C, Gil J.
JOURNAL: Biochem J; 15(Pt3), 1027-1032, (2003)
2-TITLE: Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic
leukemia cells but not in T lymphocytes.
AUTHORS:Campas C, Lopez JM, Santidrian AF, Barragan M, Bellosillo B, Colomer D, Gil J
JOURNAL: Blood. 101(9), 3674-80, (2003)
3-TITLE: Dopamine induces autophagic cell death and alpha-synuclein increase in human
neuroblastoma SH-SY5Y cells.
AUTHORS: Gomez-Santos C, Ferrer I, Santidrian AF, Barrachina M, Gil J, Ambrosio S
JOURNAL: J Neurosci Res 73(3): 341-50. (2003)
4-TITLE: Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic
marginal zone lymphoma.
AUTHORS:Campas C, Santidrian AF, Domingo A, Gil J.
JOURNAL: Leukemia. 19(2):292-4 (2005)
5-TITLE: Re: Prognostic significance of a short sequence insertion in the MCL-1 promoter
in chronic lymphocytic leukemia
AUTHORS:Iglesias-Serret D, Coll-Mulet L, Santidrian AF, Navarro-Sabate A, Domingo A, Pons
G, Gil J.
JOURNAL: J Natl Cancer Inst Jul 20;97(14):1090-1; author reply 1093-5. 2005
6-TITLE: MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell
chronic lymphocytic leukemia cells
AUTHORS: Coll-Mulet L, Iglesias-Serret D, Santidrian AF, Cosialls AM, de Frias M, Castano E,
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Campas C, Barragan M, Fernandez de Sevilla A, Domingo A, Vassilev LT, Pons G, Gil J.
JOURNAL: Blood. 2006 May 15;107(10):4109-14.
7-TITLE: Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase
C{beta}.
AUTHORS: Barragan M, de Frias M, Iglesias-Serret D, Campas C, Castano E, Santidrian AF,
Coll-Mulet L, Cosialls AM, Domingo A, Pons G, Gil J.
JOURNAL: J Leukoc Biol. 2006 Dec;80(6):1473-9.
8-TITLE: Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
AUTHORS: Campas C, Cosialls AM, Barragan M, Iglesias-Serret D, Santidrian AF, Coll-Mulet L,
de Frias M, Domingo A, Pons G, Gil J.
JOURNAL: Exp Hematol. 2006 Dec;34(12):1663-9.
9-TITLE: Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival
signals and proteasome in chronic lymphocytic leukemia cells.
AUTHORS: Iglesias-Serret D, de Frias M, Santidrian AF, Coll-Mulet L, Cosialls AM, Barragan
M, Domingo A, Gil J, Pons G.
JOURNAL: Leukemia. 2007 Feb;21(2):281-7. Epub 2006 Dec 7.
10-TITLE: The potential anticancer agent pk11195 induces apoptosis irrespective of p53
and ATM status in chronic lymphocytic leukemia cells.
AUTHORS: Santidrian AF Cosialls AM, Coll-Mulet L, Iglesias-Serret D, de Frias M, GonzálezGironès DM, Campas C, Domingo A, Pons G, Gil J.
JOURNAL: Haematologica 2007 Dec;92(12):1631-8.
11-TITLE: Multiplex ligation-dependent probe amplification for detection of genomic
alterations in chronic lymphocytic leukemia.
AUTHORS: Coll-Mulet L, Santidrián AF, Cosialls AM, Iglesias-Serret D, de Frias M, Grau J,
Menoyo A, González-Barca E, Pons G, Domingo A, Gil J.
JOURNAL: Br J Haematol. 2008 Sep;142(5):793-801. Epub 2008 Jun 17.
12. TITLE: Effects of dopamine on LC3-II activation as a marker of autophagy in a
neuroblastoma cell model.
AUTHORS: Giménez-Xavier P, Francisco R, Santidrián AF, Gil J, Ambrosio S.
JOURNAL: Neurotoxicology. 2009 Jul;30(4):658-65.
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13.
TITLE:
Fructose
1,6-bisphosphate
reduced
TNF-alpha-induced
apoptosis
in
galactosamine sensitized rat hepatocytes through activation of nitric oxide and cGMP
AUTHORS: Calafell R, Boada J, Santidrian AF, Gil J, Roig T, Perales JC, Bermudez J.
JOURNAL: Eur J Pharmacol. 2009 May 21;610(1-3):128-33.
14. TITLE: Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
AUTHORS: de Frias M, Iglesias-Serret D, Cosialls AM, Coll-Mulet L, Santidrián AF, GonzálezGironès DM, de la Banda E, Pons G, Gil J
JOURNAL: Haematologica. 2009 Dec;94(12):1698-707.
15. TITLE: Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB
and MAPKs through alteration of the Mcl-1/Noxa balance
AUTHORS: Iglesias-Serret D, Piqué M, Barragán M, Cosialls AM, Santidrián AF, GonzálezGironès DM, Coll-Mulet L, de Frias M, Pons G, Gil J
JOURNAL: Apoptosis. 2010 Feb;15(2):219-29.
16. TITLE: Study of the in vivo phosphorylation of E2F1 on Ser403
AUTHORS: Real S, Espada L, Espinet C, Santidrián AF, Tauler A.
JOURNAL: Biochim Biophys Acta. 2010 Aug;1803(8):912-8.
17. TITLE: AICAR induces apoptosis independently of AMPK and p53 through upregulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
AUTHORS: Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM,
de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G,
Villunger A, Gil J.
JOURNAL: Biochim Biophys Acta. Blood. 2010 Oct 21;116(16):3023-32.
18. TITLE: Synthesis of site-specific antibody-drug conjugates using unnatural amino
acids.
AUTHORS: Axup JY, Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, Halder R,
Forsyth JS, Santidrian AF, Stafin K, Lu Y, Tran H, Seller AJ, Biroc SL, Szydlik A, Pinkstaff JK,
Tian F, Sinha SC, Felding-Habermann B, Smider VV, Schultz PG.
JOURNAL: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16101-6
19. TITLE: Epigenetic profile in chronic lymphocytic leukemia using methylation-specific
multiplex ligation-dependent probe amplification
AUTHORS: Cosialls AM, Santidrián AF, Coll-Mulet L, Iglesias-Serret D, González-Gironès DM,
Pérez-Perarnau A, Rubio-Patiño C, González-Barca E, Alonso E, Pons G, Gil J.
JOURNAL: Epigenomics. 2012 Oct;4(5):491-501.
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20. TITLE: Mitochondrial Complex I activity and NAD+/NADH balance regulate breast
cancer progression
AUTHORS: Santidrián AF, Matsuno-Yagi A, Ritland M, Seo BB, LeBoeuf SE, Gay L, Yagi T,
Felding-Habermann B
JOURNAL: Journal of Clinical Investigation. 2013 Mar 1;123(3)
4. GRANTS AND FELLOWSHIPS RECEIVED
fellowship
Institution
Date
Agust Pi i Sunyer
Agust Pi i Sunyer foundation
01/2002-5/2002
FPI
Ministery of Science and Education (Spain)
06/2002-5/2006
FPI mobility
Ministery of Science and Education (Spain)
9/2004–12/2004
Final year of pHD student
Universitat de Barcelona
5/2006–12/2006
Postdoctoral fellowship
Susan G Komen for the Cure foundation
09/2010-present
5. STAYS IN FOREIGN CENTRES
CENTRE Center for Biomedical Sciences, Royal Holloway University of London (Dr. George
Dickson)
LOCATION: EGHAM. COUNTRY: UNITED KINGDOM
YEAR 2004
DURATION 3 months
TOPIC Viral transfection in B cell Chronic Lymphocytic Leukemia;
6. ATTENDANCES TO CONGRESSES AND CONFERENCES
AUTORS: Santidrián AF, Piqué M, López JM, Iglesias D, Pons G, Gil J ,
TITTLE: Inhibición de la actividad pro-apotótica de Bax por mutación de la treonina 169
PRESENTATION: Conferencia
CONGRESS: V Aporreunión Española
PLACE: Tordesillas (Valladolid)
DATE: 08/06/2002
AUTORS: Santidrián AF, Campàs C, López JM, Barragán M, Domingo A, Gil J.
TITTLE: Involvement of ampk in acadesine (aicar) -induced apoptosis in b-cell chronic
lymphocytic leukemia cells.
CONGRESS: Ampk2004
PRESENTATION: Poster
PLACE: Lorne Victoria , Australia
DATE: 2004
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AUTORS: AF Santidrián, C Campàs, L Coll-Mulet, D Iglesias-Serret, AM Cosialls, M De Frias, A
Domingo, A Fernandez De Sevilla, G Pons and J Gil.
TITTLE: Mechanism of acadesine-induced apoptosis in B-cell neoplasms.
PRESENTATION: poster
CONGRESS: The American Society of Hematology, 47th Annual Meeting and Exposition
Place: Atlanta (USA)
Date: 10/12/05-13/12/05
Autors: Af Santidrián, C Campàs, L Coll-Mulet, D Iglesias-Serret, Am Cosialls, M De Frias, A
Domingo, A Fernandez De Sevilla, G Pons And J Gil
Tittle: Mechanism of aicar (acadesine)-induced apoptosis in B-cell neoplasms.
Presentation: poster
Congress: From Bioenergetics to Apoptosis. Snowbird Resort, Snowbird, Utah
Place: Utah (USA)
Date: 02/04/06-07/04/06
Autors: Antonio F. Santidrián, Ana M Cosialls, Llorenç Coll-Mulet, Daniel Iglesias-Serret Mercè de
Frias, Gabriel Pons, and Joan Gil.
Tittle: 2-Methoxyestradiol, a superoxide dismutase inhibitor, induces vdac-dependent apoptosis in
chronic lymphocytic leukemia cells.
Presentation: poster
Congress: CNIO Cancer Conference: Inflamation and Cancer.
Place: Madrid (Spain)
Date: 22/05/06-24/05/06
Autors: Af Santidrián, C Campàs, L Coll-Mulet, D Iglesias-Serret, Am Cosialls, M De Frias, A
Domingo, A Fernandez De Sevilla, G Pons1 And J Gil
Tittle: Mechanism of aicar (acadesine)-induced apoptosis in B-cell neoplasms.
Presentation: poster
Congress: Metabolism and apoptosis
Place: : Big Sky Resort ,Montana (USA)
Date: 10/09/06-15/10/06
Autors: Af Santidrián, C Campàs, L Coll-Mulet, D Iglesias-Serret, Am Cosialls, M De Frias, A
Domingo, A Fernandez De Sevilla, G Pons1 And J Gil
Tittle: Mechanism of aicar (acadesine)-induced apoptosis in B-cell neoplasms.
Presentation: poster
Congress: Metabolism and apoptosis
Place: : Big Sky Resort ,Montana (USA)
Date: 10/09/06-15/10/06
Autors Santidrian AF, Staflin KB, Chen EI, Krueger JS, Lorger M, Yates JR, Kroener J, FeldingHabermann B
Tittle: Mechanisms of brain metastasis
Presentation: poster
Congress: Era of Hope Meeting Department of Defense Breast Cancer Research Program
2008 Mechanisms of brain metastasis. Era of Hope Meeting Department of Defense Breast
Cancer Research Program,
Lugar celebración: Baltimore, USA.
Fecha: July 2008
Autors Santidrian AF, Seo BB, Matsuno-Yagi A, Yagi T, Felding-Habermann B
Tittle: Mitochondrial complex I modulation of cellular NAD/NADH regulates tumorigenicity in
breast cancer
Presentation: poster
Congress: Metabolism and cancer
Place: La Jolla, USA.
Date: sept 2009
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Autors Santidrian AF, Seo BB, Matsuno-Yagi A, Yagi T, Felding-Habermann B
Tittle: Mitochondrial complex I modulation of cellular NAD+/NADH regulates autophagy and
breast cancer progression.
Presentation: poster
Congress: Cancer and metabolism
Place: Barcelona, Spain
Date: Nov 2010
Autors Santidrian AF, Seo BB, LeBoeuf S, Ritland M, Matsuno-Yagi A, Yagi T, FeldingHabermann B
Tittle: Mitochondrial complex I modulation of cellular NAD+/NADH regulates mTOR, autophagy
and breast cancer progression.
Presentation: poster
Congress: Cancer and Metabolism, (Keystone).
Place: Banff, Alberta Canada.
Date: Feb 2012
7. SCIENTIFIC MEMBERSHIPS
American Association for Cancer Research (AACR). Since 2008
Spanish Society of Biochemistry and Molecular Biology. Since 2002 (SEBBM)
8. AWARDS
Catalan Biology Society April 2003 for the work:
“Inhibition of proapoptotic activity of BAX by threonine 169 mutation.”
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