REGISTER OF LICENSES FOR ANIMALS USED FOR SCIENTIFIC PURPOSES 1. 2. 3. 4. № and date of the license Name of the holder of the license 56000258/ 20.07.05 “BalkanpharmaTroyan” JSC, Troyan Address/main office of the license holder Troyan town, № 1 “Krayrechna” str. Purpose/name of the scientific project(s) concerned First, second and family name of the person responsible for Animal Welfare Date of the official position of Ethics Commission Stefka Nikolaeva Dichevska Zornica Kuteva Radoevska 12.07.2005 Type and location of the relevant cite Number and species Vivarium; Troyan town, №1 “Krayrechna” str. 200 rabbits 100 mice Quality control of materials used for production of infusion solutions and finalpeptides 430 rats 300 mice 80 rabbits 20 guineapigs 1000 frogs 270 rats Academic and scientific purposes Prof. Grigor Angelov Gorchev Dr. Ivo Dimitrov Monevski 19.01.2007 Assoc. Prof.. Hristo Naydenski Dr. Petia Stoianova 19.01.2007 Assoc. Prof. Ilia Jordanov Bankov Marin Aleksandrov Vitanov 19.01.2007 58000183/ 19.01.07 Medical University – Pleven Pleven town, № 1 “Kliment Ohridski” str. Vivarium; Pleven town, №1 “Kliment Ohridski”str. 11130005/ 19.01.07 Institute of Microbiolog y –Bulgarian Academy of Sciences, Sofia Sofia city, № 26 “Akad. G. Bonchev” str. Vivarium; Sofia city, №26 “Akad. G. Bonchev” str. 210 mice Protective efficacy of various chemical substances synthesized on experimentally infected mice with Yersinia pseudotuberculosis 11130007/ 19.01.07 Institute of Experimenta l Pathology and Parasitology - Bulgarian Academy of Sciences, Sofia Vivarium; Sofia city, №25 “Akad. G. Bonchev” str. 740 rats 955 mice 5 rabbits 30 sirian hamsters 255 hamsters 50 lambs 60 chickens 20 guinia fowls For research and experimental purposes on themes developed at the Institute of Experimental Pathology and Parasitology. The project will be developed within the 6th Framework Program of the European Union - №- FoodCT-2005-CT-023025 Deliver Sofia city, №25 “Akad. G. Bonchev”str. First, second and family name of the person responsible for the scientific project 5. 6. 7. 72000096/ 04.06.07 11130011/ 05.06.07 15040001/ 15.08.07 1. 50 mice – Analysis of toxicity; “BOIVET JSC – branch Razgrad”, Razgrad Razgrad town, № 1 “Aprilsko vustanie”str. Institute of Genetics Bulgarian Academy of Sciences, Sofia Sofia city, 13 km “ Tcarigradsko shose”str. “Bul-bio – National Center of Infectious and Parasitic Diseases” Ltd, Sofia Razgrad town, № 1 “Aprilsko vustanie” str. 50 mice, 360 rabbits 10 cats Eng. Veneta Velikova Koleva Dr. Nina Velikova Koleva 13.04.2007 Assoc. Prof. Elena Dimitrova Georgieva Dr. Leonid Ivanov Pankov 11.04.2007 Assoc. Prof. Plamen Nenkov Dr. Metodi Vladimirov Ivanov 20.07.2007 Research carried out in the Center for Research on Radiation and Chemical Protection Assoc. Prof. Plamen Stefanov Petrunov Dr. Ivan Todorov Penkov 15.11.2007 For the department of experimental surgery Assoc. Prof. Krasimir Stefanov Vasilev Dr. Ivan Todorov Penkov 22.11.2007 2. 360 rabbits – Analysis of pyrogenic ability; 3. 10 cats – Analysis of depressor substances Sofia city, №26 “Janko Sakuzov” str. Sofia city, 13 km, “Tcarigradsko shose” str. Sofia city, №26 “Janko Sakuzov”str. 500 mice 50 rats 1200 mice 600 guineapigs 100 rabbits Molecular genetic studies of the regulation of the expression of genes in the development of the mammals 1. Determination of abnormal activity and toxicity of tetanus toxoid, tetanus-diphtheria in a imunovenin intact, immunoglobulin, histaglobin, albumin, stabilized protein purified solution, mammalian, anti snake serum, allergens, vaccine for Crimean haemorrhagic fever (CHFvaccine). 2. Determination of the activity of absorbed vaccines containing bacterial toxoides – tetatox, tetadif, deftet, deftetkok 8. 16180001/ 15.11.07 Military Medical Academy, Sofia Sofia city, № 3 “Georgi Sofiiski” str. Sofia city, Ovcha Kupel, №1. “Institutska”str . 170 mice 120 rats 20 rabbits 30 guineapigs 9. 14310001/ 22.11.07 Military Medical Academy, Sofia Sofia city, № 3 “Georgi Sofiiski”str. Sofia city, № 3 “Georgi Sofiiski” str. 50 pigs 10 dogs 50 mice 10. 11. 12. . 13. 17000002/ 07.12.07 University of Forestry, Sofia 11910024/ 10.01.08 National Diagnostic and Research Veterinary Institute “Prof. dr. G. Pavlov”, Sofia 21310219/ 30.01.08 “КUSSMalina Ltd”, village Gorna Malina 90000088/ 30.01.08 14. 90000088/ 30.01.08 15. 90000088/ 30.01.08 Medical University “Prof.Dr. P Stoyanov”, Varna Medical University “Prof. Dr. P. Stoyanov”, Varna Medical University “Prof. Dr. P. Sofia city, №10 “Kliment Ohridski”str. Sofia city, №10 “Kliment Ohridski” str. Sofia city, №15 “Pencho Slaveiikov” str. Vivarium; Pancharevo , Kokaliane village Gorna Malina village, №97 ,21 str. Vivarium; Gorna Malina village, №97, 21 str. Varna tawn, №55 “Prof. Marin Drinov” str. Varna town, №55 “Prof. Marin Drinov”str. Varna town, №55 “Prof. Marin Drinov”str. Vivarium; Varna town ,№55, “Prof. Marin Drinov” str. Vivarium; Varna town, №55 “Prof. Marin Drinov”str. Vivarium; Varna town, №55 “Prof. 2526 frogs 59 mice 136 rats 18 rabbits 6 chickens 17 hens 3 sheep 3 dogs 46 guineapigs 26 pigs 35 sheep 10 lambs 30 kids; 300 hens 170 guineapigs 200 rabbits 150 rats 550 mice 1 dog Training of students from the Faculty for Veterinary Medicine Assoc. Prof. Andon Atanasov Filchev Assoc. Prof.. Andon Atanasov Filchev 20.11.2007 For the tasks of the Scientific Research Plan at the National Diagnostic and Research Veterinary Institute, diagnostic research, PHDstudent training Assoc. Prof. Ivanka Dimitrova Bruchkova Dr. Anna Grigorieva Ignatova 20.11.2007 Comparative experiment “in vivo”, including implantation of bioactive impregnate materials (PDLLA) and highly porous materials of natural origin in sheep ribs Dr. Vencislav Heruvimov Stoev Dr. Vencislav Heruvimov Stoev 30.01.2008 Training studies for students Assoc. Prof. Negrin Nesterov Negriev Dr. Krasimir Atanasov Kuzmanov 30.01.2008 450 frogs 78 mice 52 guineapigs 92 rabbits Training studies for students Assoc. Prof. Ganka Jordanova Bekiarova Dr. Krasimir Atanasov Kuzmanov 30.01.2008 100 rats 1. Research carried on markers of the endothelial dysfunction in stress Assoc. Prof. Ganka Jordanova Dr. Krasimir Atanasov Kuzmanov 30.01.2008 50 sheep 710 frogs 127 rats 40 mice Stoyanov”, Varna Marin Drinov” str. Bekiarova 2. Research carried on the role of the endothelial dysfunction on changes of haemostasis and rheological properties of blood in cold- immobilized stress 3. Research carried on the oxidative damage in some organs (stomach, liver, lung) in cold-immobilized stress; 16. 90000088/ 30.01.08 17. 13310010/ 20.05.08 18. 11130005/ 26.06.08 19. 21310219/ 17.12.08 Medical University “Prof. Dr. P. Stoyanov”, Varna Institute for Control of Veterinary Medicinal Products, Sofia Institute of Microbiolog y –Bulgarian Academy of Sciences, Sofia “KUSS Malina Ltd”, Varna town, №55 “Prof. Marin Drinov”str. Vivarium; Varna town, №55 “Prof. Marin Drinov” str. 24 rats Sofia city, №7 “Shose Bankya”str. Vivarium; Sofia city, №7 “Shose Bankya” str. 80 guineapigs 80 mice Sofia city, bl. 26 “Akad. G. Bonchev”str. Vivarium; Sofia city, bl. 26 “Akad. G. Bonchev”str. Gorna Malina village, №97 ”21” Gorna Malina village, №97 4. Research on the protective effect of the Melatonin and Nacetil-cystein on endothelial dysfunction, the rheological properties of blood, haemostasis and oxidative damage in several organs in cold -immobilized stress Experimental research carried on “Influence of fruit juice from Aronia Melanocarpa on gastrointestinal passage in rats” Assoc. Prof. Stefka Vasileva Vulcheva Kuzmanova Dr. Krasimir Atanasov Kuzmanov 30.01.2008 Testing of veterinary medicinal products Dr. Tereza Gulabinova Vladimirova Dr. Stefania Toncheva Haralampiev a 23.05.2008 80 mice For scientific research on “Suppression of allergenspecific B-cells in humanized SCID-mice by antigen chimeras” Prof. Andrei Ivanov Chorbanov Prof. Andrei Ivanov Chorbanov 26.06.2008 50 sheep Comparative experiment “in vivo”, including implantation Dr. Vencislav Heruvimov Dr. Vencislav 17.12.2008 village Dolna Malina 20. 21. 22. str. ”21” str. 11130007/ 19.01.07 Institute of Experimenta l Pathology and Parasitology - Bulgarian Academy of Sciences, Sofia Sofia city, №25 “Akad. G. Bonchev”str. Sofia city, № 25 “Akad. G. Bonchev” str. 1/ 29.05.09 National Centre of Radiobiolog y and Radiation Protection, Sofia Sofia city, №132 ”Kliment Ohridski”str. Vivarium; Sofia city, № 15 ”Akad. Ivan Geshov”str. 2/ 29.05.09 Faculty of veterinary medicine, Trakiya University, Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Hospital Clinic of Small Animals, Faculty of Veterinary Medicine, Trakiya University Sofia city, №15 ”Akad. Ivan Geshov”str. Sofia city, №15 ”Akad. Ivan 23. 3/ 25.03.09 24. 4/ 25.03.09 National Center of Public Health Protection, Sofia National Center of of bioactive impregnate materials (PDLLA) and highly porous materials of natural origin in the globular outgrowth of the femur of sheep 740 rats 955 mice 5 rabbits 30 sirian hamsters 255 hamsters 50 lambs 60 chickens 20 guinea fowls; Stoev Heruvimov Stoev For experimental purposes Assoc. Prof. Ilia Jordanov Bankov Marian Aleksandrov Vitanov 19.01.2007 100 mice Research carried out on the effects of the radiation whips modified response agents Assoc. Prof. Sevdalina Tcankova Topalova Eng. Jonko Angelov Semerdjiev 29.05.2009 9 dogs Research performed on plasma concentration of certain proteins as biomarkers of the inflammation in the dogs with non infectious cause Assoc. Prof. Teodora Mircheva Georgieva Assoc. Prof. Teodora Mircheva Georgieva 29.05.2009 Sofia city, № 15 ”Akad. Ivan Geshov” str. 6 rabbits Development of immunological methods about control of chemicals under restrictions Assoc. Prof. Nelia Dimitrova Dimitrova Eng. Jonko Angelov Semerdjiev 26.03.2009 Sofia city, № 15 ”Akad. 80 mice Diagnostic of Botulism – demonstration of botulinum Assoc. Prof. Rosica Eng. Jonko Angelov 26.03.2009 25. 26 27 28 5/ 25.03.09 Public Health Protection, Sofia National Center of Public Health Protection, Sofia Geshov” str. Sofia city, № 15 ”Akad. Ivan Geshov”str. Ivan Geshov” str. toxin in food Sofia city, № 15 ”Akad. Ivan Geshov”str. Research on miozmin cytotoxic, genotoxic and anthropogenic influence and it dependence on oxidative stress in cells 120 mice 6/ 30.07.09 Medical University “Prof. Dr. P. Stoyanov”, Varna Varna city, №55 ”Prof. Marin Drinov” str. Varna town, №55 ”Prof. Marin Drinov”str. 7/ 30.07.09 Medical University “Prof. Dr. P. Stoyanov”, Varna Varna town, №55 ”Prof. Marin Drinov” str. Varna city, №55 ”Prof. Marin Drinov” str. Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Stara Zagora town, Region of Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Stara Zagora town, Region of Stara Zagora 34 pigs Kostinbrod town, Pochivka bus stop Kostinbrod town, Pochivka bus 200 chickens 8/ 25.03.09 29 9/ 25.03.09 30. 30/ 14.01.10 Faculty of veterinary medicine, Trakiya University, Stara Zagora Faculty of veterinary medicine, Trakiya University, Stara Zagora Institute of animal science, 100 rats 160 rats 5 cows Enikiva Semerdjiev Assoc. Prof. Galina Leksieva Gorneva Eng. Jonko Angelov Semerdjiev 26.03.2009 Assoc. Prof. Yanka Bekiarova Dr. Krasimir Atanasov Kuzmanov 30.07.2009 Assoc. Prof. Stefka VulchevaKuzmanova Dr. Krasimir Atanasov Kuzmanov 30.07.2009 Training studies for students Prof. Dinko Nedev Dinev Assoc. prof. Dimitrina Ivanova Gundasheva 26.03.2009 Training studies for students Prof. Dinko Nedev Dinev Assoc. prof. Dimitrina Ivanova Gundasheva 26.03.2009 Prof. Dimitar Ivanov Gudev Mariana Ivanova Veleva 14.01.2010 Research carried on the protective effect of plant extracts with high contents of polyphenols on biochemical markers of adipose dystrophy, endothelial disfunction and oxidative damage in the experimental model of metabolic dystrophy Research on standardized fruit juice from Aronia Melanocarpa; protective effect in experimental models of radiation and drug toxicity in rats Stress in industrial poultry farming. Ways to asses the intensity of stress and its 31. 31/ 14.01.10 32. 32/ 14.01.10 33. 33/ 14.01.10 34. 10/ 26.04.10 35. 36. 37. Kostinbrod Institute of animal science, Kostinbrod Institute of animal science, Kostinbrod Institute of animal science, Kostinbrod Medical University “Prof. Dr. P. Stoyanov”, Varna Kostinbrod town, Pochivka bus stop Kostinbrod town, Pochivka bus stop Kostinbrod town, Pochivka bus stop Varna city, №55 ”Prof. Marin Drinov” str. 11/ 26.04.10 Special Hospital for Active Treatment in Oncology 36/ 09.06.10 Faculty of veterinary medicine, Trakiya University, Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University 37/ 09.06.10 Faculty of veterinary medicine, Trakiya University, Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Sofia , №6 Plovdivsko shoese str stop Kostinbrod town, Pochivka bus stop Kostinbrod town, Pochivka bus stop Kostinbrod town, Pochivka bus stop Varna city, №55 ”Prof. Marin Drinov” str. Sofia , №6 Plovdivsko shoese str Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya reduction. 300 sheep Manage the selection and reproduction of specialized breeds of sheep Prof. Emilia Toskova Raicheva Mariana Ivanova Veleva 14.01.2010 22 lambs 60 rabbits 120 pigs Raising livestock health and quality of their products Prof. Mariana Alexandrova Petkova Mariana Ivanova Veleva 14.01.2010 840 chickens 180 rabbits Biologically active herbal supplements, productivity incentive birds to pigs and rabbits Prof. Georgi Evtimov Vulchev Mariana Ivanova Veleva 14.01.2010 Prevention of septic shock by intravenous application of modified immunoglobulin preparations Assoc. prof Dimitar Kovachev Dr. Krasimir Atanasov Kuzmanov 26.04.2010 450 mice Chrome experience for modulating carcinogenic nature of tobacco smoke on mice with chemical agents with view of developing approaches of pathogenic prophylactic on humane Prof. Rumen Balanski Dr. Diana Gaideva 26.04.2010 12 dogs Study on the effect of ultrasound therapy on bone fractures Assoc. prof Mihail Paskalev Assoc. Prof. Galina Simeonova 09.06.2010 12 dogs Pasturela aeroginosa infection in dogs – potentional to improve diagnosis and therapy Assoc. Prof. Maria Andonova Assoc. Prof. Dimitrina Gundasheva 09.06.1010 90 ICR mice 38. 39. 40. 41. 12/ 01.10.10 Institute of animal science, Kostinbrod 13/ 05.11.10 Medical University “Prof. Dr. P. Stoyanov”, Varna 14/ 05.11.10 Medical Faculty, Medical University Sofia 15/ 05.11.10 42. 16/ 05.11.10 43. 19/ Faculty of Agriculture, Trakiya University – Stara Zagora Institute of Microbiolog y –Bulgarian Academy of Sciences, Sofia Medical Kostinbrod town, Pochivka bus stop Varna town, №55 ”Prof. Marin Drinov” str. Sofia town, №1 Georgi Sofiiski blv. University Kostinbrod town, Pochivka bus stop Medical University “Prof. Dr. P. Stoyanov”, Varna Vivarium Sofia town, №15 Akad. Ivan Geshov blv. 6 rams Health improving of the animals and their products through nutrition Prof. dr. Mariana Petkova Mariana Veleva 01.10.2010 500 rats Examination of standardized extract of Cotinus coggygria for acute and chronic toxicity of protective effect in experimental models in organ damage and behavioral effects in rats Assoc. Prof. dr. Stafka Vulcheva – Kuzmanova Dr. Kraismir Kuzmanov 28.10.2010 25 mice The role of stress proteins in reproduction Assoc. Prof. dr. Nedka Trifonova Yonko Semerdjiev 28.10.2010 Training studies for students Assoc. Prof. dr. Mihail Panayotov dr. Todor Slavov 28.10.2010 Assoc. Prof.. Hristo Naydenski dr. Petia Stoianova 28.10.2010 Stara Zagora town, Student campus, Faculty of Agriculture, Trakiya University – Stara Zagora Stara Zagora town, Student campus, Faculty of Agriculture, Trakiya University – Stara Zagora 96 cows 2 calves 101 sheep 14 rams 3 pigs 20 piglets 10 horses 33 rabbits 3 cocks 50 fish 270 frogs 25 families bees 10 000 silkworms Sofia city, bl. 26 “Akad. G. Bonchev”str. Vivarium; Sofia city, bl. 26 “Akad. G. Bonchev”str. 369 rabbits 677 guinea pigs 829 mice Varna town, №55 Vivarium 304 rats Testing the protective effectiveness of a vaccine against trachomata on experimentally infected with Chlamydia trachomatis experimental animals Study the influence of 08.04.2011 30.03.11 44. 45. University “Prof. Dr. P. Stoyanov”, Varna 19/ 30.03.11 Medical University “Prof. Dr. P. Stoyanov”, Varna 20/ 30.06.11 Faculty of veterinary medicine, Trakiya University, Stara Zagora 46. 47/ 30.06.11 Medical University Plovdiv town 47. 48/ 30.06.11 Medical University Plovdiv town 48. 49/ 30.06.11 49. 50/ 30.06.11 Medical University Plovdiv town Medical University Plovdiv ”Prof. Marin Drinov” str Varna town, №55 ”Prof. Marin Drinov” str Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Varna town, №55 ”Prof. Marin Drinov” str izoteolin on biochemical and behavioral manifestations of an experimental model of alcohol dependence. dr. Maria Delcheva JeliazkovaSavova Vivarium Varna town, №55 ”Prof. Marin Drinov” str 300 rats Role of vitamin K and vitamin K dependent proteins in the pathogenesis of diabetes and vascular calcification dr. Maria Delcheva JeliazkovaSavova 27 cats Clinical testing of parasite efficiency and safety of spoton formulation in a single treatment of cats with naturally invade intestinal nematodes and/or cestodes Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Plovdiv town, 15a„Vasil Aprilov”blvd Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil 380 rats 60 rats 405 rats 310 rats Changes in bioelectrogenesis and retracting activity of smooth musle of the gastrointestinal tract of experimentally induced abdominal hypertension and the influence on the motility tract in rats. Study the effect of Rhodiola rosea L. extract on learning and memory, antiinflammatory and analgetic activity in rats Comparative study of the effects of _holinesterase inhibitors on models of impaired memory functions. Neuropharmacological characteristic of Lacosamide (VIMPAT) on experimental dr. Zvezdelina Todorova Kirkova Assoc. Prof. Dr. Atanas Dimitrov Krastev dr.Krasimir Atanasov Kuzmanov dr.Krasimir Atanasov Kuzmanov assoc. prof. Dimitrina Ivanova Gundacheva dr. Radka Dimitrova AbrashevaTodorova Prof. dr. Damianka Peteva Getova dr. Radka Dimitrova AbrashevaTodorova Prof. dr. Damianka Peteva Getova dr. Radka Dimitrova AbrachevaTodorova dr. Radka Dimitrova Abrasheva- Assoc. Prof. dr. Ludmil 08.04.2011 30.06.2011 30.06.2011 30.06.2011 30.06.2011 30.06.2011 Aprilov”blvd town Peichev Peichev Assoc. Prof. Dr. Ivanka Ilieva Kostadinova 51/ 30.06.11 Medical University Plovdiv town Plovdiv town, 15a„Vasil Aprilov”blvd 52/ 19.03.12 Faculty of veterinary medicine, Trakiya University, Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University 53/ 19.03.12 Faculty of veterinary medicine, Trakiya University, Stara Zagora Stara Zagora town, Student campus, Faculty of Veterinary Medicine, Trakiya University 53. 54/ 19.03.12 Medical University Plovdiv town Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 155 rats 100 mice 30 rabbits 1070 frogs To educate students 54. 55/ 19.03.12 Medical University Plovdiv town Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 130 male white rats breed WISTER Experimental study of andropause Dr. Ivanka Ilieva Kostadinova 55. 56/ 19.03.12 Medical University Plovdiv town Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 962 male white rats breed WISTER Experimental study mechanisms of analgesic action of antidepressants Dr. Ivanka Ilieva Kostadinova 50. 51. 52. Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd animals. Trakiya University Faculty of Veterinary Medicine Student campus Trakiya University Faculty of Veterinary Medicine Student campus Todorova dr. Radka Dimitrova AbrashevaTodorova 30.06.2011 276 rats Experimental study of the pleiotropic effects of statins. 40 dogs To study the efficacy of single oral treatment with antiparasitic flavored tablets in dogs naturally infected with fleas and/or ticks Chief Assistant Dr. Zvezdelina Todorova Kirkova Associate Professor Dr. Dimitrina Ivanova Gundasheva 19.03.12 40 dogs To study the efficacy of single oral treatment with antiparasitic flavored tablets in dogs naturally invade with gastrointestinal nematodes Chief Assistant Dr. Zvezdelina Todorova Kirkova Associate Professor Dr. Dimitrina Ivanova Gundasheva 19.03.12 Professor. Trifon Atanasov Mihailov Dr. Radka Dimitrova AbrashevaTodorova Dr. Radka Dimitrova AbrashevaTodorova Dr. Radka Dimitrova AbrashevaTodorova 19.03.12 19.03.12 19.03.12 56. 57. 58. 57/ 19.03.12 Medical University Plovdiv town 58/ 19.03.12 Medical University Plovdiv town 59/ 19.03.12 Medical University Plovdiv town 40 male white rats breed WISTER Role of estrogens in some adaptations in endurance exercise Associate Professor Dr. Katerina Nikolova Georgieva Dr. Radka Dimitrova AbrashevaTodorova 19.03.12 Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 90 male white rats breed WISTER Changes in metabolism in various stages of induction of metabolic syndrome in rats and the effects of nonpharmacologic influence state Associate Professor Dr. Nikolai Petrov Boyadjiev Dr. Radka Dimitrova AbrashevaTodorova 19.03.12 Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 20 adolescents and 100 adult rats breed WISTER Development of formulated products for enteral nutrition in sepsis Associate Professor Dr. Nikolai Petrov Boyadjiev Dr. Radka Dimitrova AbrashevaTodorova 19.03.12 Dr. Radka Dimitrova AbrashevaTodorova 19.03.12 Associate Professor Dr. Iveta Atanasova Koeva and Associate Professor Dr. Stefan Todorov Sivkov Plovdiv town, 15a„Vasil Aprilov”blvd 30 rats breed WISTER Investigation of molecular markers for prenatal disontogeneza in schizophrenia-experimental and clinical study NDNIVI – Sofia Sofia blvd "Kliment Ohridski" № 10 Forestry - Faculty of Veterinary Medicine Sofia blvd "Kliment Ohridski" № 10 - Forestry Faculty of Veterinary Medicine 250 two-dayold chicks and 100 twenty old broiler chickens Comparative toxicological and pharmacological studies of Bulgarian methionyl zinc and zinc sulphate in broiler chickens Dr. Metodi Petrichev and Dr. Sofia Ivanova Associate Professor Dr. Andon Filchev 19.03.12 Medical University Plovdiv town Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd 60 rats and 100 guinea pig Tracking changes in the spontaneous activity of retracting smooth-muscle preparations from rat and Assosiate Professor Dr. Plamen Zagorchev Dr. Radka Dimitrova Abrasheva- 19.03.12 60. 61/ 19.03.12 61. 62/ 19.03.12 60/ 19.03.12 Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Medical University Plovdiv town 59. Plovdiv town, 15a„Vasil Aprilov”blvd 62. 63/ 19.03.12 Medical University Plovdiv town 64/ 02.10.12 “BUL-BIO NCIPD” Ltd Sofia town 65/ 02.10.12 66/ 02.10.12 67/ 02.10.12 Georgi Markov Savov Plovdiv town Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences "Biovet" Razgrad branch Plovdiv town, 15a„Vasil Aprilov” blvd Sofia town, 26 “Janko Sakazov” blvd Plovdiv town 30 “Han Persian” str. 1113 Sofia town “Akad. G. Bonchev” str. 7200 Razgrad town 68A “Aprilsko vastanie” blvd. Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Sofia town, 40 rats guinea pig caused by the response to adrenergic and dopaminergic receptor structures of peat extract, rosemary and ginkgo biloba Experimentally induced obesity. Role of adipose tissue, liver and muscles (CRP and SAA), involved in chronic inflammatory processes and used as biomarkers 3000 white mice, 8000 guinea pigs, 1200 rabbits Study of biological medicines and vaccines for human use Pigs farm Belozem/Rako vski/Plovdiv 60 sows 40 weaners Field testing protocol № 041/12 for determining the effectiveness of using Ivermektin form solution for irrigation Vivarium 450 mice 40 laboratory rat Molecular genetic studies of the regulation of gene expression during the development of mammals 26 “Janko Sakazov” blvd Vivarium for laboratory "Pharmacologi cal control " Department of "Quality Control" 7200 Razgrad town 68A “Aprilsko vastanie” blvd 360 New Zealand / Californian rabbits 50 white mice 10 cat To conduct pharmacopoeial analyzes the production of activists substances Todorova Assosiate Professor Dr. Vasil Kamenov dr. Radka Dimitrova AbrashevaTodorova 19.03.12 dr. Yuliana Savova Cenkova dr. Metodi Vladimirov Ivanov 02.10.12 dr. Nadja Alexandrova Bozakova 02.10.12 Associate Professor Leonid Ivanov Penkov 02.10.12 d-r Nina Georgieva Coneva 02.10.12 dr. Zvezdelina Todorova Kirkova Prof. d-r Lubomir Manolov Stoilov dr. Ivanka Dimitrova Miteva engineer Violet Miteva Decheva 68/ 02.10.12 Medical University, Varna town Varna town 55 “Prof. Marin Drinov” blvd. 688 rats Study of biologically active substances of plant origin (Ursolic acid, anethole and eugenol), behavioral effects and protective effects in experimental models of inflammatory bowel disease in rats 252 rats Examination of standardized fruit Aronia melanocarpa of a protective effect in experimental models of depressive-like states in rats Vivarium Varna town 55 “Prof. Marin Drinov” blvd Vivarium dr. Krasimir Atanasov Kuzmanov 02.10.12 dr. Krasimir Atanasov Kuzmanov 02.10.12 Yonko Angelov Semerdjiev 02.10.12 Yonko Angelov Semerdjiev 02.10.12 dr. Vencislav Heruvimov Stoev dr. Vencislav Heruvimov Stoev 03.12.12 Pharmacological analysis of the inhibition of glutamateergichnata mediation of neurotropic funds Prof. dr Damianka Peteva Getova, MD dr. Radka Dimitrova AbrashevaTodorova 03.12.12 Training students in pharmacology and toxicology Prof. N. Danchev, dr. Ventsislav 03.12.12 69/ 02.10.12 Medical University, Varna town Varna town 55 “Prof. Marin Drinov” blvd. 70/ 02.10.12 Technical University, Varna town 9010 Varna town 1 “Studentska” str. Pigs farm Topoli/Varna 6 pigs aged 5-6 months from one litter Create and explore a gradient micro-and nano-structured layers on titanium dental implants 71/ 02.10.12 Medical University, Sofia town Sofia city 1 “St. Georgi Sofiiski” blvd. Vivarium 2 “Zdrave” str. Sofia town 2500 frogs 661 rats 1435 mice 10 rabbits Academic work with students and research 120 sheep (Ovis aries) Comparative in vivo experiments involving implantation bioaktivnonaiteni kostnovazstanovi-tions and visokoporyozni bioactive materials from natural and synthetic origin in the bonebearing unit of sheep 72/ 03.12.12 “КUSSMalina Ltd”, village Gorna Malina 73/ 03.12.12 Medical University Plovdiv town 74/ 03.12.12 Faculty of Pharmacy of Gorna Malina village, №97 ,21 str Plovdiv town, 15a„Vasil Aprilov” blvd Sofia city, №2 “Dunav” str Varna town 55 “Prof. Marin Drinov” blvd Holding Gorna Malina village, №97 ,21 str Vivarium Plovdiv town, 15a„Vasil Aprilov”blvd Vivarium Sofia town, №2 “Dunav” str 276 male white rats breed WISTER 84 white mice 100 mice 350 rats Associate Professor Stefka Vassileva ValchevaKuzmanova, MD Associate Professor Stefka Vassileva ValchevaKuzmanova, MD Associate Professor d-r Metodi Zahariev Abadjiev Teachers, researchers from MU Sofia the Medical University Sofia 75/ 03.12.12 76/ 06.02.13 Faculty of Medicine Medical University, Sofia Prof. dr. Stoyan Dimitrov Tonev Professor Mitev, Prof. I. Nikolova, dots.Konstanti nov, Ch. Prof. R. Vitanska Sofia city, №1 Georgi Sofiiski blv. Sofia city, №3 Georgi Sofiiski blv Vivarium Sofia town, №2 “Zdrave” str Vivarium Sofia city, №3 Georgi Sofiiski blv 77/ 06.02.13 Prof. dr. Stoyan Dimitrov Tonev Sofia city, №3 Georgi Sofiiski blv Vivarium Sofia city, №3 Georgi Sofiiski blv Prof. d-r Stefan Kostyanev, Medical Plovdiv city, 15A 78/ 06.02.13 Vivarium, Plovdiv city, „Vasil Aprilov” blvd 15A „Vasil Aprilov” blvd 382 rats 52 pigs, 10 rabbits, 10 guinea pigs Research projects and training of students Courses in minimal invasive surgery and military medical experiments 150 white mices “Balb”, 20 rabbits, 20 guinea pigs, 150 white rats Wistar Experiments related to the protection of the population of different types of agents – biological, chemical and radiological 120 white new Zealand rabbits Behavior to the parietal pleura with spontaneous pneumothorax in experimental animals art. homer. Prof. Dr. Milka Vlaskovska Associate Professor Krasimir Vasilev, prof. Nikola Vladov, Associate Professor Borimir Vasilev Associate Professor Plamen Petrunov, Associate Professor Aleksej Manev, Associate Professor. Bozhin Kamarinchev, Associate Professor Ivan Samnaliev Dr. Tanio Stefanov Dimitrov Atanasov Yonko Angelov Semerdjiev Dr. Svetlin Nikolov Nikolov, Dr. Ivan Todorov Penkov Associate Professor Ivan Mihajlov Samnaliev, dr. Ivan Todorov Penkov Dr. Radka Abrasheva 06.02.13 06.02.13 06.02.13 79/ 06.02.13 80/ 06.02.113 81/ 06.02.13 University, Plovdiv Prof. d-r Stefan Kostyanev, Medical University, Plovdiv Professor d-r Veselin Brezin , University of Forestry, Sofia Prof. d-r Krasimir Ivanov, Medical University, Varna Plovdiv city, 15A „Vasil Aprilov” blvd Sofia city, 10 “Kliment Ochridski” blvd Varna city, 55 “ Prof. Marin Drinov” str. Vivarium, Plovdiv city, 15A „Vasil Aprilov” blvd Vivarium, Sofia city, 10 “Kliment Ochridski” blvd Vivarium, 55 “ Prof. Marin Drinov” str. Provoke of closed chest trauma in experimental animals of Wistar albino species Associate professor d-r Ivan Novakov Dr. Radka Abrasheva 06.02.13 182 frogs, 44 mices, 94 rats, 9 rabbits, 6 chickens, 20 hens, 3 dogs, 3 sheep Training of students for five years Associate professor d-r K. Genova, Associate professor d-r T. Todorov, Associate professor d-r V.Manov, Associate professor d-r K. Lilov, Associate professor d-r A.Filchev, assistant V. Alexandrova, assistant R. Bankova, assistant B. Ivanov Professor d-r Yanislav Iliev 06.02.13 160 rats Wistar Experimental researches, related to study markers of endothelial dysfunction and oxidative damage in several organs in different forms of oxidative stress and electrophysiological study parameters - resistance, capacitance, inductance of biologically active zones in oxidative stress Associate professor d-r Ganka Bekyarova Dr. Krasimir Kuzmanov 06.02.13 22 white rats Wistar albino 82/ 06.02.13 83/ 06.02.13 84-A/ 04.10.13 Prof. d-r Krasimir Ivanov, Medical University, Varna Prof. d-r Krasimir Ivanov, Medical University, Varna Prof. d-r Dimitrina Kacheva – Okoliiska, Institute of Biology and Immunology of Reproductio n “ Acad. Kiril Bratanov”, Bulgarian Academy of Experimental researches related to study markers of metabolic disorders, liver dysfunction and oxidative damage in Non-alcoholic fatty liver disease in an experimental model of metabolic syndrome and study of the protective effect of drugs with antioxidant activity on biochemical markers of adipocyte dysfunction, endothelial dysfunction and oxidative damage in different organs liver, pancreas, muscles, heart, lungs or kidneys in an experimental model of metabolic syndrome Associate professor d-r Ganka Bekyarova Dr. Krasimir Kuzmanov 06.02.13 Dr. Krasimir Kuzmanov 06.02.13 Dr. Stefan Manchev 04.10.13 Varna city, 55 “ Prof. Marin Drinov” str. Vivarium, 55 “ Prof. Marin Drinov” str. 160 rats Wistar Varna city, 55 “ Prof. Marin Drinov” str. Vivarium, 55 “ Prof. Marin Drinov” str. 5850 frogs, 1000 rats, 600 mices, 500 rabbits, 260 guinea pigs Training of students Associate professor d-r Zlatislav Dimitrov Sofia city, 73 “ Tsarigradsko shose” blvd. Vivarium, 73 “ Tsarigradsko shose” blvd. 75 rabbits, 1000 mices, 150 rabbits, 30 hamsters Basic and enclosed researches in the field of reproduction in humans and animals Prof. d-r Dimitrina Kacheva – Okoliiska 85/ 09.01.14 86/ 09.01.14 87/ 09.01.14 88/ 09.01.14 89/ 09.01.14 Science Associate professor d-r Mihni Luyckanov, Trakia University, Stara Zagora Prof. d-r Stefan Kostyanev, Medical University, Plovdiv Prof. d-r Stefan Kostyanev, Medical University, Plovdiv Prof. d-r Stefan Kostyanev, Medical University, Plovdiv Prof. Mariela Odzhakova, Faculty of Biology, Sofia University “ St. Kliment Ohridski” Stara Zagora city, Student city, Faculty of veterinary medicine Plovdiv city, 15A „Vasil Aprilov” blvd Plovdiv city, 15A „Vasil Aprilov” blvd Plovdiv city, 15A „Vasil Aprilov” blvd Sofia city, 8 “Dragan Tsankov” blvd Note: This register is updated to: 11.02.2014 Vivarium, Plovdiv city, 9 “ Knyaz Boris I” str. Vivarium, Plovdiv city, 15A „Vasil Aprilov” blvd Vivarium, Plovdiv city, 15A „Vasil Aprilov” blvd Vivarium, Sofia city, 8 “Dragan Tsankov” blvd 30 dogs Clinical testing the effectiveness of a single oral treatment with anti-flavored tablets in dogs naturally infected with fleas and / or ticks Associate professor d-r Dimitrina Gundasheva Chief assistant Zvezdelina Kirkova 09.01.14 340 male white rats Wistar Study on the possibilities of pharmacological release of adult stem cells in the peripheral blood of experimental animals Associate professor d-r Lyudmil Peychev Dr. Radka Abrasheva 09.01.14 954 male white rats Wistar Comparative study of Etifoxine hydrochloride and Pregabalin in scientific animals Associate professor d-r Lyudmil Peychev Dr. Radka Abrasheva 09.01.14 520 male white rats Wistar Experimental neuropharmacological characterization of Retigabine in scientific animals Associate professor d-r Lyudmil Peychev Dr. Radka Abrasheva 09.01.14 Training of students Prof. Hristo Gagov Chief assistant Mariela Chichova 09.01.14 800 rats, 3050 frogs, 250 mices