ANNUAL REPORT
2008-2009
DEPARTMENT OF MOLECULAR BIOMEDICAL SCIENCES
COLLEGE OF VETERINARY MEDICINE
NORTH CAROLINA STATE UNIVERSITY
M. Christine McGahan, Professor and Department Head
Prepared May 2009
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Table of Contents
Page
Departmental Report
3
I.
Changes in Environment
3
II.
Compact Plan
3
III.
Diversity
3
IV.
Instructional Program
9
V.
Faculty
17
VI.
Students
18
VII.
Research
19
VIII.
Administration and Staff
19
IX.
Recommendations and concerns for the future
20
X.
The University’s Five Focus Areas
23
Appendix I
List of Faculty/EPA Employees Including Graduate Students
27
Appendix II
List of Administrative and Staff Personnel
28
Appendix III
Courses Offered by Departmental Faculty Including DVM courses
Presented by Departmental Faculty and Graduate Courses Offered by and Participated in
by Departmental Faculty
31
Appendix IV
Clinical Service Offered by Departmental Faculty
33
Appendix V
Publications, Presentations, Intellectual Property by Departmental Faculty
61
Appendix VI
Professional Activities by Departmental Faculty (Includes Memberships on Research Grant
and Study Reviews, Memberships on Editorial Boards, and Ad hoc Manuscript Reviews,
Committee Memberships within MBS, CVM, NCSU, and National Committees
73
Appendix VII
Research Grants Awarded to Departmental Faculty
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I.
Change in Environment
Faculty retirement: N/A
Faculty resignations:
Linda Martin; Assistant Professor of Cell Biology; July 1, 2008
Anthony Pease; Assistant Professor of Radiology; September 2, 2008
Doodipala Reddy; Assistant Professor of Neuroscience and Pharmacology; July 2, 2008
Faculty hires:
Gabriela Seiler; Associate Professor of Radiology; appointment begins July 1, 2009.
We currently have one faculty position open for identified needs in Pharmacology. We are unsure about whether
we will be allowed to recruit for this position because of the current budget situation. We have already lost the
Stem Cell position that we had begun recruitment for last year.
We are anticipating serious budget cuts at the State level which will negatively impact the department. At this
point in time we do not know how much of our budget is in jeopardy. This will be a major challenge for the
Department and College moving forward.
II.
Compact Plan: For 2008-2010 the Compact Plan was developed at the College level.
III.
Diversity
Kenneth Adler has been awarded a supplement to his NIH grant for “underrepresented minorities” for Ms.
Teresa Green, a graduate student in his laboratory.
Prema Arasu, within context of diversity strategies as defined by NCSU Office of Diversity,
(http://www.ncsu.edu/odi/initiatives/Diversity_Advisory.pdf), has: helped coordinate outreach seminars focused
on livestock production/biofuels/health with NCSU faculty and students and external stakeholders (through
USDA funded award; teamed with CVM Faculty Maria Correa and Isabel Gimeno and CALS faculty Vivek
Fellner and Ratna Sharma); served as advisor for newly formed “Minority Association for Pre-Medical Students”
Fall 2008; in the process, Dr. Arasu consulted with Dr. Anita Flick and we agreed that this group of students was
better served by coming under the umbrella of the NCSU Pre-Health Club. From this experience, Dr. Arasu was
also able to help College of Humanities and Social Sciences via Dean Jeff Braden to link with the Pre-Health
Club and establish a new chapter for students interested in careers related to mental health (Dr. Arasu served
only in facilitating role); served as advisor and coordinator for two undergraduate students interested in
international health experiences - one worked with Public Health Foundation of India in New Delhi, India over the
summer 2008; contributed to article on CVM women in science and health for regional news magazine,
Women’s Edge; completed term (07/08) as advisor to university Graduate Student Association; served as NCSU
representative to Research Triangle Global Coordinating Council (organized by RTRP Doug Aitkin/Ted
Abernathy); serving on NCSU College of Management Biosciences Management/Industry (external) Advisory
Board; connected NCSU CVM as a partner with the national Alliance for Oral Contraception of Cats and Dogs,
and with the Global Alliance for Rabies Control.
Jill Barnes has contributed to improving diversity: Member, Ad-Hoc Diversity Committee (NCSU CVM); Attended
“Advising students of color” workshop April 19; USDA, Veterinary Career Pathways Program, May 2008,
mentored six minority students in the program in veterinary anatomy “short course”, consisted of 5 weeks of 7
hrs of instruction/week on the limbs/ thoracic cavity /head /abdominal cavity; SAVE program, NC A&T students,
heart dissection lab; won the NCSU Faculty Diversity Award, 2009.
Gregg Dean participated in DVM admissions, molecular biology training program, DVM/PhD training program,
and GAANN program. Recruited and hired undergraduate minority student, objective is to provide mentorship
prior to application to DVM program and participated in ‘Advising students of color’’ workshop April 2008.
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Troy Ghashghaei has hired and advised students, postdocs, and technicians from multiple ethnic backgrounds:
Raul Salinas-Mordagon (Technician; Hispanic), Benjamin Jacquet (Ph.D. Student; Belgian), Jihey Lim (Postdoc;
Korean), Atif Sheikh (undergraduate; Pakistani background), and Huixuan Liang (Ph.D student; Chinese). He
also has an equal distribution of male-to-female ratio in the laboratory.
Jorge Piedrahita is a Co-PI in an NIH training grant to bring minority undergraduate and graduates into sciences
(PI - Trudy McKay). Program is Initiative for Maximizing Student Diversity (IMSD;
http://www.ncsu.edu/grad/imsd/index.php). He is a member of the steering committee and of the admission
committee for this program. Dr. Piedrahita participated as a panel member for the BFF (Building Future Faculty)
program.
Barbara Sherry serves on the Executive Committee for Expanding Your Horizons Workshops, Spring 2009.
NCSU invites 400 seventh grade girls, with an emphasis on those from under-represented groups, to participate
in a single-day conference to encourage their pursuit of scientific careers. Dr. Sherry organized participation of
60 -100 of the girls at the College of Veterinary Medicine, for workshops developed by colleagues. We
scheduled a record 9 workshops at the College of Veterinary Medicine for March 3rd 2009, but unfortunately the
conference was cancelled the day before due to snow!
IV.
Instructional Program Initiatives including curriculum development and program review
Curriculum Development
MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by
faculty to develop and introduce teaching innovations to enhance student problem-solving and communication
abilities. This is particularly evident in the selective courses taught at the end of each semester, which provide a
variety of offerings, which expand flexibility in the curriculum and new and varied experiences for students.
We are continuing to work on changes within existing courses to incorporate molecular medicine into the
curriculum. We are continuing to work on the Physiology course (VMA 913 and 923) to include genomics and
molecular medicine concepts, as well as to better align the subject matter in order to match more closely with
Anatomy.
Prema Arasu participated in CVM sub-committee (FCCCE, Subgroup Core led by Dr. Jennifer Neel) on CVM
core curriculum reform/assessment. She formed working group to develop a public heatlh focus/courses/track
at the undergraduate level at NCSU; applied for sponsorship and was awarded paid slot to attend the July 2008
AACU “The Educated Citizen and Public health” workshop in Crystal City, Virgina/DC (helped obtain matching
support from Provost's office and attended workshop together with Dr. Maria Correa, CVM; Gerry Luginbuhl,
CALS; Maxine Thompson, CHASS). Our efforts have culminated in the development of the first course, GPH
201, Global Public health, which will be offered by the Dept of Biology, CALS, as an inquiry course in Fall 2009.
The second course proposed is a basic course in epidemiology/biostatistics. She formed working group across
6 colleges to develop a Master’s in Development Practice (similar to International Development); co-wrote and
submitted pre-proposal to MacArthur Foundation for funds to establish the program with Dr. Heidi Hobbs. We
were invited to submit a full proposal but decided to partner with TERI India and other global partners for a
stronger application; pending decision on support (Lead at NCSU will be Dr. Heidi Hobbs, Director of the Master
in International Studies, CHASS); proposal pending. Dr. Arasu is also working with Heidi Hobbs to develop a
professional science master's focused on international development (bridging life sciences, natural sciences,
social sciences and management). New course at Ohio State University based on 1 week selective
"International Veterinary Medicine" at NC State University CVM. Dr. Arasu delivered a guest lecture on Dec 15,
2008, by videoconference to veterinary students at Ohio State University (course coordinator Dr. Wondwossen
Gebreyes).
Jill Barnes is developing a summer workshop “Canine Anatomy” designed to aid in transition of incoming
freshman students into the professional program.
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Matthew Breen is serving his third year on the FCCCE, which has begun a complete reevaluation of the DVM
curriculum at NC State. The activities of this committee required a considerable effort as we moved toward a
faculty driven outline for change.
Gregg Dean has developed comparative medicine and translational research training program for specialty
trained post-DVM PhD candidates.
Lloyd Fleisher is an ex officio member of the CVM Curriculum Committee, he has been actively involved in a
major revision of the Veterinary teaching curriculum. Dr. Fleisher also serves on a subcommittee charged with
devising novel testing paradigms for the new curriculum.
John Gadsby wrote 2 new lectures “Introduction to Endocrine Pharmacology” and “Drugs affecting
Reproduction”, and presented them in VMB933 Veterinary Pharmacology as a guest lecturer, Fall 2008.
Troy Ghashghaei initiated the development of a new format of teaching the Neurophysiology portion of the
Physiology course in the first year DVM curriculum.
Jon Horowitz developed and was the course coordinator of a new four credit graduate course “CBS771: Cancer
Biology” that was completed by thirteen students in the Fall of 2008. This course was taught by six professors,
two from MBS and four from the Dept. of Environmental and Molecular Toxicology, and received very strong
evaluations from participating students. Dr. Horowitz wrote and presented 40% of the lectures in this course.
Lola Hudson - development/initiation of a new on line course in conjunction with Drs. Klesath (Zoology), Hardie,
and our medical illustrator. This course is intended to ascertain that incoming students have a certain level of
anatomical knowledge and medical terminology before they enter the rigorous professional curriculum. This
course was offered in summer of 2008 and Dr. Klesath has received grade information from Dr. Hudson on the
veterinary classes being compared for statistical analysis.
Chris McGahan continues to redesign curriculum in Veterinary Physiology.
Mark Papich serves on the College Curriculum Committee (FCCCE) (term started in the fall of 2007) as the
department representative. This committee has been charged with reviewing, reorganizing, and proposing
changes in the DVM curriculum to better prepare our future veterinarians. This committee meets every two
weeks and the focus on curriculum evaluation will continue into next year.
In 2009, Dr. Papich published a new edition of a long-standing textbook for teaching veterinary pharmacology.
He was one of the editors for the book, Veterinary Pharmacology and Therapeutics, 9th Edition, Wiley-Blackwell
Publishing, Ames, Iowa, USA, 1524 pages; 2009. This book is now in its 9th edition and is a standard textbook
for teaching veterinary pharmacology to students.
In 2009, Dr. Papich was one of the consulting editors for the book, Kirk’s Current Veterinary Therapy XIV, edited
by Bonagura JD & Twedt DC, Saunders-Elsevier. This book is a widely-cited clinical textbook used by students,
now in its 14th edition.
Lysa Posner serves on the subcommittee for PBL (Problem Based Learning), 2008-2009.
Ian Roberston’s ongoing improvement of VMB 976 course, for which he is the supervisor, involved generating
extensive online quiz material via Blackboard Vista and generating other self directed learning resources.
Korinn Saker participated in meetings and discussion groups here at NCSU-CVM pertaining to development of
the Wellness Training Program for DVM students. Dr. Saker also participated in the Deans Forum – Innovations
in Education (November 2008) to discuss important issues that impact the veterinary curriculum.
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Cliff Swanson was an invited participant and facilitator, AAVMC Educational Symposium, Washington DC, March
13-15, 2008.
Jeff Yoder, as course director for CBS565 Fundamentals of Biomedical Sciences, over the past 4 years, has
gained an appreciation for the different educational backgrounds that the incoming CBS graduate students bring
with them. It became clear that many students lacked an understanding of multiple standard cellular and
molecular methods used in biomedical research. As co-course directors, Dr. Matthew Breen and Dr. Jeff Yoder
have developed a new 1-credit graduate course to be offered every fall starting in 2009 (currently waiting
approval from the Administrative Board of the Graduate School). This course, CBS570, Methods in Biomedical
Sciences, will provide a 1 hr lecture each week on a variety of standard methods. Dr. Yoder will be providing
lectures on DNA/RNA/protein analyses, PCR, cloning cDNAs, expression constructs, transgenesis, gene “knockout” models and flow cytometry.
Dr. Yoder, as course director for CBS565 Fundamentals of Biomedical Sciences, over the past 4 years, has
concluded that the overall course topics and lecture schedule in CBS565 needed to be rethought and
reorganized. At a meeting of the teaching faculty for this course, it was agreed that more focus and continuity
was needed for the lecture topics and a task force committee was appointed. When this committee met, it was
agreed that each of the 5 Concentration Areas within CBS (Cell Biology, Pathology, Pharmacology, Infectious
Disease and Population Medicine) should have equal representation in this course. Thus each Concentration
Area Leader will be responsible for deciding the 4-5 lecture topics to be included in CBS565 and will identify the
appropriate faculty members to present the lectures in this course. We will be implementing these modifications
in the fall of 2009.
Clinician Scientist Focus Area (CSFA) has been a departmental initiative which continues to develop and grow.
Prema Arasu - served as Chair, Steering Committee, One Health Intellectual Exchange Group - committee
convened in September 2008; inaugural seminar in January 2009 with subsequent, one seminar a month held at
NC Biotechnology Center, targeting students in veterinary and human medicine ( as well as graduate students,
public health) from NCSU, Duke, UNC. Dr. Arasu was responsible for selecting topics and speakers.
Matthew Breen is the leader of the Clinician Scientist Focus area and as such has continued to identify research
oriented DVM students that could be encouraged to become involved in research activities at NCSU. Dr. Breen
meet with the enrolled CSFA students one:one on a regular basis to gauge their feel for the program and to
monitor their progress in the research aspects of their DVM program.
Gregg Dean provided a research experience as a selective for Austin Duncan a freshman DVM student.
John Gadsby, coordinator (and presenter) of “Research in Reproduction” research day within the one week
“Introduction to Research at CVM” selective (VMB 990D) – Fall 2008.
Korinn Saker developed a feline mammary gland organ culture system to evaluate chemotherapeutic and
selected nutrients. Dr. Saker also developed and procured funding for two educational programs in Clinical
Nutrition. i) IAMS Rotating Nutrition Internship – a 1-year internship training in small animal disciplines as well
as small animal clinical nutrition. Initial funding is for 2 years. ii) Nestle Purina Clinical Nutrition Residency – a
2-year clinical training program here at NCSU-CVM.
Introduction to Research at the CVM
“Introduction to Research at the CVM” (VMB 991D) is offered in the fall semester as a one-week selective and
will be required for all students interested in the CSFA. Students are expected to take this selective in the fall of
the 1st yr of the DVM curriculum. This selective will be open to any student interested in exploring the possibility
of choosing the CSFA. All three departments participate in this Focus Area.
In this selective, mentors in the different areas of clinical and basic research experience will present a summary
of ongoing projects in their laboratories. This selective will be divided into identifiable areas of research based
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on the group of participating mentors (i.e. oncology, neurology, therio, etc., ideally combining both basic and
clinical aspects of research), with each group responsible for presenting their area of interest to the students.
Students will be required to interview briefly with three potential mentors during the time of the selective.
Students will also be required to prepare a personal statement indicating their personal and academic goals,
their reasons for choosing the CSFA, and their reasons for pursuing a particular mentor opportunity.
Other
Selectives will be chosen based upon the career goals and research interests of the individual student, in
consultation with their primary mentor and committee. Students are encouraged, although not required, to take
additional research-related selectives (i.e. Molecular Medicine Initiative selectives such as Trangenics,
Developmental Toxicology and Teratology and VMB 992E Biomedical Research Experience).
Students choosing the Clinician Scientist Focus Area (CSFA) will also declare a clinical interest (equine, small
animal, pathology, food animal, mixed animal, epidemiology and public health, laboratory animal) that will give
them priority in clinical rotation scheduling equal to that of students declaring a specific clinical focus area. The
clinical interest must be declared by the end of the second year. Alternatively, CSFA students may, in
consultation with their guidance committee, create a required list of clinical senior rotations. CSFA students will
then be given top priority for these rotations. This list much also be completed and approved by the guidance
committee by the end of the second year.
The following MBS Faculty members are available as mentors in this program:
Arasu, Prema Degrees/expertise: PhD, DVM
We use dog hookworm parasite as our model to study host-pathogen interactions and developmental aspects of
the hookworm nematode. Research in the lab spans the breadth of clinical, animal-based questions to basic
research approaches using genomics, molecular biology, immunology, cell biology and the mouse model. For
example, one project in the lab is focused on the pregnancy-induced reactivation and transmammary
transmission of hookworm infection to nursing puppies. What is the signaling mechanism between the
underlying molecular mechanisms and identify strategies of preventing this route of pathogen transmission?
Barnes, Jill Degrees/expertise: DVM, PhD
My laboratory investigates the role of stress protein expression and it's impact on the development and
treatment of breast cancer. Students would be exposed to a number of cellular and molecular techniques such
as cell culture, transfections, DNA, RNA and protein isolation, real-time PCR, Western analysis, reporter assays
and flow cytometry/cell cycle analysis.
Breen, Matthew Degrees/expertise: PhD, C Biol, MI Biol
Chromosome aberrations are hallmarks of the instability of the tumor genome. Our research program is focused
on the cytogenetics of canine cancers. In particular we have developed molecular cytogenetic tools and reagents
that allow us to interrogate canine tumors (individual tumor cells and tumor cell populations) to reveal recurrent
chromosome aberrations. We work closely with clinicians and pathologists so that we are able to correlate
cytogenetic findings with clinical features such as tumor subtype, tumor progression, response to therapy etc. In
this way we have begun to identify chromosome changes in canine cancers that have both diagnostic and
prognostic significance. As a consequence we are a) working towards offering the clinician a means by which to
improve the sophistication of clinical management of dogs with cancer and b) developing a better understanding
of the genes involved in cancer initiation and progression, which may ultimately lead to improved therapies.
Dean, Gregg Degrees/expertise: DVM, PhD, DACVP
Students will be exposed to in vitro and in vivo work. Mice and cats are used to evaluate immunological
responses to novel vaccine strategies and cats are used in the study of feline immunodeficiency virus. Students
may be involved in collecting and processing samples, immunological and virologic assays, and numerous
molecular techniques. Specific assays may include flow cytometry, ELISA, ELISpot, western blot, cloning, PCR,
bacterial culture, cell culture, and bioassays.
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Gadsby, John Degrees/expertise: PhD
Students could be exposed to animal surgeries (ovariectomies and ovarian infusions), tissue dissociation, cell
isolation/separation and cell culture, steroid and peptide hormone analysis (RIA or ELISA), enzyme activity
(protein kinase C) assays, mRNA extraction and analysis by RT-PCR, protein extraction and analysis by
Western blotting, microarray analysis and possibly RNA interference (in the near future). Specifically he could
partner with Theriogenology (he already collaborates with Carlos Pinto) or Swine (he also collaborates with Glen
Almond) faculty.
McGahan, Chris Degrees/expertise: PhD
The focus of my laboratory is the study of the metabolism of iron in ocular tissues. We are investigating iron
uptake and storage in lens and retinal pigmented epithelial cells. These investigations include measurements of
a labile pool of iron within the cytoplasm that is thought to be available for participation in generation of free
radicals and subsequent cellular damage. It is therefore essential to understand the regulation of the size of this
pool, which at this point is almost completely unknown. We are also determining how alterations in the subunit
composition of the iron storage protein, ferritin, affect iron storage and the size of the labile iron pool. Tied in with
these basic studies of iron movement within cells are investigations into iron’s roles in regulating basic metabolic
pathways, including the production of the excitatory neurotransmitter, glutamate. The clinical importance of
understanding iron metabolism in the eye is underscored by the fact that dysregulation of iron metabolism and
resulting free radical damage have been implicated in cataract formation and in retinal degeneration.
Piedrahita, Jorge Degrees/expertise: PhD
Dr. Piedrahita's laboratory is primarily interested in understanding the role of imprinted genes in embryo
development and in disease, and in the development of transgenic animals for use in human and veterinary
medicine, and in agriculture. Towards this end, his laboratory combines techniques in functional genomics, cell
biology, embryo manipulation, and molecular biology. Specifically, students would be introduced to a range of
recombinant DNA, and genomic technologies as they relate to a clinically-relevant phenotype.
Contributions to Selectives:
Prema Arasu, Course coordinator for International Veterinary Medicine, 1 week selective, Fall 2008; Course
coordinator for “Animal Acupuncture: China”, two week course at Zhejiang University, Hangzhou, May 2008.
Makoto Asakawa supervised first, second and third year students in anesthesia selective.
Matthew Breen re-offered the full week selective, “Introduction to Research at the CVM” (VMB991D), providing a
group of 15 DVM students with a ‘taster’ of the range of research activities ongoing at the CVM. The course is
team-taught and covers a variety of research exposures. Dr. Breen met with the class each day and spent time
reviewing the course, which allows the development of a good rapport with the students. At the end of the week
we have a frank discussion about the good and bad aspects of the course and this session also serves to identify
those students who have developed a real thirst for research. Dr. Breen arranged to meet with these students in
the following weeks and then seek to match them with a faculty mentor who will help them gain more experience
with their developing research interest.
Nigel Campbell, VMC 992Z Active Learning in the VTH (students become an active member of the Clinical
Anesthesia Service for 2 weeks).
John Gadsby, coordinator (and presenter) of “Research in Reproduction” research day within the one week
“Introduction to Research at CVM” selective (VMB 990D) – Fall 2008.
Jon Horowitz presented a single hour-long lecture in an ongoing selective (VMB 991E Section 004:
Transgenics).
Nanette Nascone-Yoder, VMB 992 - Developmental Toxicology and Teratology.
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Jorge Piedrahita, VMB991E Transgenics, participating faculty; Reproductive Selective, participating faculty.
Lysa Posner, VMC 991 Primate Medicine, Anesthetic concerns for Primates, 1 hr, April 2008
Korinn Saker, developed the syllabus and course program for: Advanced Small Animal Clinical Nutrition –
offered in Fall 2008 and Spring 2009, and Equine Nutrition – offered Spring 2009.
Ed Smallwood continues to offer and teach VMB 991G, Avian Anatomy.
Jeff Yoder, VMB991E Transgenics, course director; VMC991Q Fish Medicine, participating faculty.
A listing of courses presented by MBS faculty in the professional curriculum and graduate courses presented by
MBS faculty can be found in Appendix III (p. 28).
MBS Selectives taught by MBS faculty
Faculty
Breen
Khosla
Arasu
Arasu
Hudson
Nordone
Smallwood
Yoder
Semester
Fall
Fall
Fall//Spring
Fall/Spring
Spring
Spring
Spring
Spring
Title
Introduction to Research at the CVM (VMB991D)
Histologic Techniques in Health (VMB991B)
International Veterinary Medicine (VMP991Y)
International Veterinary Medicine Experience (VMB991S)
Veterinary Medicine and Farriery (VMB991I)
Immunodiagnostics (VMB991B)
Avian Anatomy & Physiology (VMB991G)
Transgenics (VMB991E)
Program Reviews
MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by
faculty to develop and introduce teaching innovations to enhance student problem-solving and
communication abilities. This is particularly evident in the selective courses taught at the end of each
semester, which provide a variety of offerings, which expand flexibility in the curriculum and new and varied
experiences for students.
V.
Faculty
Honors
Accomplishments of MBS faculty have been recognized at national, international, state and campus levels.
Documentation of several faculty invitations and recognition’s of scholarly activity, not included below, can be
found in Appendix VI (p. 61) that includes memberships on editorial boards, ad hoc manuscript reviews, and
membership on research grant and study reviews.
Kenneth Adler
Prema Arasu
Jill Barnes
NIH NHLBI MERIT Award (5 R37 HL-36982): 2004 – 2014
Invited to serve on review panel for USDA International Science and Education
Program. Reviewed 15 proposals and spent two days in Washington D.C. for the final
selection process (March 17-18, 2009).
Nominated for the Alumni Distinguished Undergraduate Professorship Award for the
CVM
Winner NCSU Faculty Diversity Award
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John Gadsby
Chris McGahan
Shila Nordone
Mark Papich
Jorge Piedrahita
Philip Sannes
Barbara Sherry
Chair of the Triangle Consortium for Reproductive Biology (TCRB) for 2009-2010.
Major role is the organization of the 2010 annual meeting to be held at NIEHS, RTP,
February 2010
Member, National Advisory Eye Council
ARVO Fellow, Silver level, inducted April 2009
Fort Dodge Research Scholar 2007- September 2008
Huffman Leadership Award, in recognition of outstanding contributions to NC State
University College of Veterinary Medicine, 2008.
Pfizer Award for Research Excellence, for outstanding achievement and dedication in
the field of Veterinary Medicine, 2008.
NIH Study Section, DEV-1 NICHHD, Regular member, October 2006-2010
College recipient of the Board of Governors’ Award for Excellence in Teaching
Outstanding Teacher Award.
Received the Alumni Distinguished Graduate Professor award in May 2008 for
leadership efforts in helping to develop and lead the university-wide Genomic Sciences
graduate program. There are only two of these awards presented each year across the
entire university.
Accomplishments related to research efforts: (Does not include grants and publications which are listed in Appendix VII
(p. 73) and Appendix V (p. 33).
Kenneth Adler - A start-up company (BioMarck) that has been licensed through the NCSU technology transfer office has
developed a drug based on technology from his laboratory. The drug has been approved by the FDA and is to be tested
in human patients suffering from chronic bronchitis starting at the end of April 2008. Phase 2a studies have been started
and the first cohort of patients has been finished…data from this cohort will be available in four weeks (end of May).
Prema Arasu - Efforts are focused on building multidisciplinary teams (across NCSU colleges and building on life science
strengths of CALS and CVM) in area of food safety and security, and zoonotic/emerging diseases.
Matthew Breen - During the current reporting period, continued to grow the lab and to explore means to engage other
CVM faculty in a broader programmatic effort. As part of this initiative, was nominated and subsequently elected a full
member of the UNC-CH Lineberger Comprehensive Cancer Center. This status allowed application for funds through the
UCRF mechanism which resulting is a collaborative grant being awarded to Dr. Kristy Richards (UNC), Dr. Steven Suter
(DOCS), Dr. Alison Motsinger-Reif (Statistics) and Dr. Breen. This brought valuable UCRF dollars to the CVM and we
anticipate that this funding will continue over the coming years. In addition to a number of ongoing funded projects in the
lab, Dr. Breen has been awarded $530,000 in new extramural grant income during this annual reporting period.
Research activity in this past year has led to 14 peer-reviewed publications in quality journals. On 11 of these Dr. Breen is
the senior, co-senior or first author. During the reporting year work has been featured several time on the CVM and NCSU
website and also picked up by the local and national media. Editorials/commentaries about recent published findings that
human and dogs share evolutionarily conserved genomic changes in comparable cancers appeared in Nature Medicine
and the Journal of the National Cancer Institute.
Gregg Dean - Determined dendritic cell function is compromised by FIV function. Identified strains of lactobacillus that
can be used to induce tolerance and others that can be used as vaccine vectors. Cloned two autoantigens associated
with canine blistering skin disease. Determined effect or regulatory T cells on FIV disease pathogenesis.
John Gadsby - Major progress made in a study designed to determine the temporal and spatial patterns of expression of
Endothelin (ET)-1, Endothelin Converting Enzyme (ECE)-1 and ET-receptors (A & B) within the porcine CL throughout the
estrous cycle. Major progress made in a study desigend to examine the role of protein kinase C (PKC) in the mechanism
by which porcine CLs become sensitized to the luteolytic actions of PGF-2 in vivo and in vitro. Major progress was made
in the study designed to determine the temporal and spatial patterns of expression of TGFin peri-ovulatory porcine follicles. These data suggest that LH and TGFto promote luteinization of porcine
follicles. Major progress was made in the study to determine the temporal and spatial patterns of expression of
apoptosis-associated genes in the porcine CL throughout the estrous cycle. Major progress made in studies to examine
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the effects of uterine infectious disease on ovarian function in cattle: This NEW project initiated during Dr. Gadsby’s
sabbatical leave in the lab.
Jon Horowitz - Co-coordinate a new high school, undergraduate, and graduate training program in cancer research
(Jimmy V-NC State Cancer Therapeutics Training Program). This program has recruited four graduate students, four
undergraduates, and four high school students, and these students are being trained in various aspects of cancer
research. This novel training program has been featured on the NCSU home page, in the NCSU alumni magazine, in the
NCSU graduate school's Results magazine, and the CVM magazine.
Lola Hudson - Continuation of NIH subcontract, submission of an R21 as PI, and submission (in preparation) of an
administrative supplement subcontract, one manuscript published, and one submitted (first author). The latter was
rejected and is being rewritten with reviewers’ comments and suggested additional experiments as a guide.
Chris McGahan - Received supplement to NIH grant #04900-27, to support the purchase of an hypoxia chamber which
will allow for the development of preliminary data for the R01 competitive renewal in 2010.
Three papers were presented at meetings this past year. Dr. Goralska presented a paper at the International Society for
Eye Research meeting in Beijing and another paper at the Cell Biology meeting in New Orleans. Dr. McGahan presented
a paper at the annual Association for Research in Vision and Ophthalmology in Ft. Lauderdale.
Nanette Nascone-Yoder - Invited presentation at Southeast Regional Society for Developmental Biology meeting, April
2008, “Basolumenal endoderm intercalation: A geometrically unique execution of convergent extension during gut tube
elongation”. Invited presentation at University of Miami, Biology Department Seminar Series, 2008, “Mechanisms of
endoderm morphogenesis: a gut reaction”, Miami, FL.
Mark Papich - Fourteen new research manuscripts published in refereed journals. Five research abstracts were
presented at National meetings and conferences and one was presented at the NCSU Annual Research Forum. In
addition, four new research projects have been funded and two others submitted and are pending.
Jorge Piedrahita - One active R10, one active R21 as PI, one active R21 as co-PI, an active USDA and a pending R01.
Published four articles and two review papers this year. In addition, have two manuscript presently being reviewed
(already submitted) and two in preparation. Given four invited presentations this year and have three additional
invitations for the remaining of 2009. Two of those are international conferences.
Lysa Posner - Developed a model to study analgesic efficacy in teleost fish.
Philip Sannes - Recipient of NIH Director’s Bridge Award (R56).
Barbara Sherry - Invited to deliver a State-Of-The-Art platform presentation on Innate Immunity at the 27th annual
American Society for Virology meeting, July 12-16, 2008, Cornell University, Ithaca NY.
Rachael Thomas - Received Morris Animal Foundation Established Investigator Funding Award in feline genomics –
proposal ranked in 1st quartile. Successfully completed two-year Morris Animal Foundation First Award in feline
genomics. Profiled as one of “Tomorrow’s PI’s” by Genome Technology Online. Elected as a full member of the Center
for Comparative Medicine and Translational Research. Published five peer-reviewed papers, three as first author, two as
second author. Two further first author papers in preparation (for imminent submission). Contributing author on five
abstracts accepted for presentation at international canine genomics conference (one as first author, invited for an oral
presentation). Exceeded self-assigned goal of analyzing 30 feline sarcoma cases by microarray-based technology
(currently 42 cases). Identified potential new diagnostic factors for feline sarcoma. Developed novel feline injection-site
sarcoma cell-line. Exceeded designated goal of analyzing 100 canine lymphoma cases by microarray-based technology
(currently 124 cases). Developed and implemented revised protocols for genomic microarray analysis, resulting in
significant cost and time saving and improved data quality and consistency. Published first insight into karyotypic
conservation between canine and human brain tumors. Successfully guided undergraduate research assistant through
laboratory component of honors research program. Continued training and supervision of graduate research assistant.
Continued informal day-to-day responsibility for guiding and overseeing graduate research student. Continued role as
11
informal technical advisor to laboratory personnel. Continued role as co-ordinator of clinical samples and data for canine
lymphoma and brain tumor studies. Ad-hoc manuscript reviewer for Journal of Heredity and Veterinary Pathology.
Invited reviewer of America Kennel Club Canine Health Foundation funding awards
Jeff Yoder - Trainer for NCSU/NIH “Biotechnology Training” Grant. Trainer for proposed CVM/NIH “Interdisciplinary
Biomedical Research Training Program for Veterinary Students” training grant.
Research Achievements and Honors of Trainees:
Kenneth Adler - Program Manager for cooperative agreement between NCSU and the U.S. EPA that provides support for
numerous graduate students and postdoctoral trainees to work on collaborative projects between the 2 institutions.
Prema Arasu - Advisor to Rushil Patel, Undergraduate Honors Project - worked with her to review literature and write a
paper on Zoonotics Diseases in the state of Gujarat as representative of the profile of zoonotic diseases in India. Dr.
Arasu also provided Rushil Patel with the linkage for an externship at the Gujarat State Department of Health and
participation in the Zoonotic Diseases workshop held in Delhi in June 2008.
Matthew Breen - Dr. Stephanie Montgomery (DVM Class of 2011) was awarded a Morris Animal Foundation Scholarship
to allow her to work in the lab during the Summer of 2008. Dr. Montgomery will present her work at the MAF Annual
Meeting in Denver, June 2009. Dr. Benoit Hedan (PostDoc in my lab) was selected as the 2009 Recipient of the Bob
Kelley Young Investigator Award for his presentation at the international meeting Genes, Dogs, Cancer, Florida, 2009.
Gregg Dean - Rochelle Mikkelsen: Awarded Keystone Symposium Travel Scholarship and a platform presentation to the
HIV Pathogenesis meeting, April 2008.
John Gadsby - Leah Zorrilla (fomer graduate student) has had one paper published, two papers submitted as first author
and has one paper in press as co-author. Raja Sriperumbudur (former graduate student) has one paper in press as first
author, and one submitted as co-author.
Jon Horowitz - An undergraduate trainee, Bridgid Hast, was accepted into graduate school at UNC-Chapel Hill and has
already contributed to a manuscript published in Nature Medicine. A graduate trainee, Tae-Hyung Kim, has generated a
series of transgenic mouse lines and is in the process of characterizing their phenotypes. A poster describing some of
this work won second prize at the 2009 CVM Research Symposium. Mr. Kim was nominated as a trainee in the Jimmy
V/NCSU Cancer Therapeutics Training Program and was accepted. A graduate trainee, Haifeng Yin, generated a
conditional "knockout" mouse line and has characterized several extremely interesting phenotypes resulting from
inactivation of the gene of interest. Mr. Yin will graduate with a PhD in 2009. A graduate trainee, Jianzhen Xie,
characterized the expression of a gene of interest in early development and documented the differential expression of this
gene in adult tissues. An undergraduate trainee, Tojan Rahhal, joined the laboratory, was nominated as a trainee in the
Jimmy V/NCSU Cancer Therapeutics Training Program and was accepted.
Nanette Nascone-Yoder - Two undergraduate research students (Mandy Womble, Meredith Parr) presented posters at
the NCSU Undergrad Research Symposium in April 2008. Mandy Womble won best poster award in the Molecular
Biology, Biochemistry, Genetics, and Cell Biology category. Both of these undergraduate students also presented their
posters at a National Society for Developmental Biology meeting at the University of Pennsylvania (Philadelphia) in July
2008. Meredith Parr won the award for Best Undergraduate poster at this national meeting. Graduate student Stephanie
Bloom presented a poster at the National Society for Developmental Biology meeting at the University of Pennsylvania
(Philadelphia) in July 2008. Stephanie was selected to give an oral presentation at the annual CVM Research
Symposium, and a platform (oral) presentation on her work at the Southeast Regional Society for Developmental Biology
conference, University of Alabama (Birmingham, AL), March 2009. Graduate student Allison Morckel presented a poster
on her work at the Southeast Regional Society for Developmental Biology conference, University of Alabama
(Birmingham, AL), March 2009.
Mark Papich - Katherine Tolbert, Resident in Small Animal Internal Medicine, NCSU-CVM. Winner of the 2009
CGS/Waltham Research Grant competition. Awarded for the study “Efficacy of oral omeprazole formulations for the
12
control of intragastric pH in dogs. Co-investigators (mentors), include Drs. S. Bissett, J, Gookin, and MG Papich. First
place award at the ACVIM Forum, 2008 in Neurology to: Sarah Moore (Internal Medicine Resident) for her presentation:
“The pharmacokinetics of levetiracetam in healthy dogs following single and multiple oral doses. [Abstract #83] 2008
ACVIM Forum, San Antonio, Texas. First place award at the ACVIM Forum, 2008 in Neurology to Dr. Dana Levine,
Clinical Resident for her presentation, “Ronidazole pharmacokinetics in cats after IV administration and oral
administration of an immediate release capsule and a colon-targeted delayed release tablet.” [Abstract #148] 2008
ACVIM Forum, San Antonio, Texas. Journal of Veterinary Internal Medicine 22: 745, 2008. First place award also
awarded by the AAVPT and ACVCP to Dr. Dana Levine for presentation listed above.
Lysa Posner - PI for project where Kristen Messenger (anesthesia resident) was awarded 2nd place in the CVM Research
Forum (Pharmacokinetics of Transmucosal Buprenorphine in Horses).
Korinn Saker - Summer Fellowship student Adrianna Wilson’s abstract was accepted for oral presentation at the 2008
Nutrition Forum in St. Louis, MO. Expanded abstract is published in peer reviewed journal. Nutrition Intern, Julianne
Davis’s abstract was accepted for oral presentation at the AAVN Clinical Nutrition & Research Symposium (in conjunction
with ACVIM) in Montreal, CANADA.
Barbara Sherry - Jennifer Zurney’s (graduate student) publication in the March 2009 issue of Journal of Virology was
selected as one of that issue's "Spotlights", which are "Articles of Significant Interest Selected from This Issue by the
Editors" (http://jvi.asm.org/current.dtl) for the second time (a previous publication of hers was also selected for this honor).
Rachael Thomas - Katie Saylor (CALS, undergraduate research assistant 2007-2008) successfully completed
undergraduate honors research project and has graduated cum laude, receiving a BS (Honors) in Biological Sciences
with a minor in Genetics. Recruited to a highly regarded pharmaceuticals company with an offer of permanent
employment.
Research Activities (Description of current/new research directions, development of new tools/reagents and new
collaborations):
Kenneth Adler - Collaborative endeavors have been set up between my laboratory and numerous other labs throughout
the country, including Duke, UNC-CH, NIEHS, EPA, UCLA, University of Pittsburgh, Dartmouth, etc.
Prema Arasu - Focus is on zoonotic diseases, food safety and the intersection of health with other disciplines (including
agriculture, engineering, environment, communications, community development, etc.). P.I., USDA International Science
and Education award, 2008-2012. Total $100,000. "Livestock production practices, biofuels, and environmental and
public health: lessons with India". Collaboration with Drs. Vivek Fellner, Ratna Sharma (CALS) and Isabel Gimeno,
Maria Correa (PHP). Co P.I., NSF Partners in International Research and Education, 'A Global FoodSafe Initiative', in
partnership with Dr. Noel Greis, UNC School of Management/Kenan Institute, to develop a cyber-platform for food safety
research, policy, course work. Pre-proposal submitted in January pending score and invitation to submit full proposal in
June. Wrote joint proposal with Dr. Lisa Roberts, Head of Microbiology, University of Surrey, U.K. to conduct a joint
NCSU/Surrey workshop on zoonotic diseases (funding by University of Surrey). As a result, three NCSU faculty will
participate May 21-22, 2009 at Surrey (Gregg Dean, Gerry Luginbuhl/CALS and Prema Arasu). Served as NCSU
reviewer for internal review and selection of 3 finalist NCSU pre-proposals for NSF PIRE grants (Partners in International
Research and Education). P.I., USAID Higher Education Development proposal " Malawi: Promoting food and
environmental security through integrated approaches and innovations in higher education": Co-PIs Daniel Robison,
CNR and Rick Brandenburg, CALS. Proposal not funded. P.I. Indo-U.S. Science and Technology Forum proposal
"Environment, Society and Development: Approaches to the practice of sustainable development". Co-P.I. Dr. Arabinda
Mishra, TERI India. Proposal pending.
Jill Barnes - Collaboration with Dr. Paul Orndorff on NIH R21 grant.
Matthew Breen - The main focus of the lab is on the molecular cytogenetic evaluation of canine cancers, using the unique
demographics of purebred dog populations to identify cancer-associated genes that remain ‘hidden’ in human
populations. Have retained an ongoing interest in chromosome evolution, especially as it relates to chromosome changes
13
occurring during speciation that may be associated also with cancer development. This work is ongoing, is funded by
several extramural grants and forms the basis of his lab’s research efforts. To embrace new technologies and maintain
pace with the rapid developments in these fields, established new collaborations with a variety of leading investigators
major US institutions including Duke, MIT, Harvard, John’s Hopkins, Fred Hutchinson Cancer Research Center,
University of Minnesota Masonic Cancer Center (and others) to bring new opportunities to the graduate students/post
docs etc in the lab and also to provide new avenues for future collaborative funding.
Jamie Brown - “Development of Computed Tomography Abdominal Scanning Protocols in the Sedated Canine Patient
and Comparison to Abdominal Ultrasound” research grant funded and currently in progress. Submitted grant for ACVR
Resident Research Grant “Development of a 3-Dimensional computer-based anatomical atlas of the equine head”.
Assisting in Ovarian Tumor model in Chickens (PI: John Barnes). Involvement includes ultrasonographic evaluation of
chickens suspected of having ovarian neoplasia as screening tool for MR analysis. Assisting in Hepatic Carcinoma
Tumorogenesis model in Woodchucks (PI: John Cullen). Involvement includes ultrasonographic evaluation of
woodchucks for tumor screening.
Gregg Dean - Continuing to determine the effects of FIV on innate immune function. Developing lactobacillus as a
vaccine vector. Developing an IL10-expressing lactobacillus to treat inflammatory bowel disease in cats. Studying the
role toll-like receptors on regulatory T cells during HIV infection. Expressing recombinant IL15 to treat FIV infected cats.
Depleting regulatory T cells in vivo as an adjunct approach to therapeutic vaccination. Testing a novel mycobacterium
tuberculosis vaccine to assess safety for use in captive and wild lions. Collaborating to express feline gamma interferon
in a plant system for use to treat feline infectious peritonitis. Collaborating to determine whether environmental
modification can reduce stress in shelter cats. Cloning and expressing NC16 to develop a diagnostic test for canine
bullous pemphigous. Cloning and expressing NC1 to develop a diagnostic test for canine. Collaborating to develop red
clover mosaic virus as a delivery system for chemotherapeutic agents. Collaborating to develop a novel synthetic
chlorophyll derivative as an in vivo fluorescence dye. Collaborating to develop a surgical technique for collection of
intestinal lymphatic fluid.
John Gadsby - Collaboration with Dr. Alan Tonelli in the College of Textiles to synthesize a slow release cyclodextrin
complex with prostaglandin (cloprostenol) for use in estrous cycle regulation in swine. Initiated and maintained
collaboration with Dr. Martin Sheldon, Royal Veterinary College, London, U.K. to study the ovarian effects of infectious
uterine disease and on TLR function in bovine corpus luteum. This resulted from the sabbatical leave in his lab for 6
months (Jan-July 2008), supported by the presitigious Underwood Fellowship to Dr. Gadsby, from the British Biomedical
and Biological Research Council (BBSRC), U.K. Initiated collaboration on the effects of uterine infection on bovine
embryo function and viability with Dr. Peter Farin, PHP Dept., NCSU College of Veterinary Medicine. Also, through as
series of Invited Seminar Presentations, Dr. Gadsby had productive discussions of mutual areas of scientific interest with
Dr. Claire Wathes and Dr. Robert Abeysekara at RVC Hawkshead, Dr. Morag Hunter and her research group at
University of Nottingham-Sutton Bonington, and with Dr. Rob. Gilbert (Cornell Univ. Vet. College) at the LINK meeting at
Swansea University. These discussions at the very least generated a two-way exchange of research ideas and will likely
lead to future research interactions and collaborations. A major goal of the Underwood Fellowship was for the Visiting
Scientist to plan visits to, and present seminars at, other Universities and Scientific Institutions in the UK (see #3 below)
with a view to furthering scientific exchange and developing future research interactions/collaborations. Thus this goal
was accomplished with a high degree of success.
Troy Ghashghaei - Internal collaborations ongoing: Jon Horowitz and Ken Adler. External Collborations: Kenny
Campbell (Cincinnati), Steven Brody (Wash U.), Sally Temple (Albany), Magdalena Gotz (Germany); Roy Sillitoe (Albert
Einstein); Glenn Matsushima (UNC)
Jon Horowitz - Characterized a conditional "knockout" mouse line and a bevy of transgenic mouse and zebrafish lines
that have offered insights into the functions of several gene of interest. Continued a collaboration with Dr. Troy
Ghashghaei (MBS Dept.) that utilizes one of our mouse lines to understand the differentiation of neuronal stem cells.
Continued a collaboration with Drs. Adam Hawkridge and David Muddiman (NCSU Dept. of Chemistry) to identify early
biomarkers of ovarian cancer. Initiated a collaboration with Dr. Carol Trempus (NIH, NIEHS) to help us study skin
phenotypes in our transgenic mice. Initiated a collaboration with Dr. David Muddiman (NCSU Dept. of Chemistry) to
identify cancer gene-specific markers in vivo via mass spectrometry.
14
Kristina Howard - At present, pursuing two research directions. First, the study of acute mucosal pathogenesis in FIV
infection using a new technique (cannulation of the lymphatics) that allows me to assess lymphocytes trafficking from the
intestinal mucosa. These studies will better elucidate early events in the mucosa, permit serial sampling and correlation of
early responses with the eventual outcome of infection, and may provide new correlates of protection. Second, is the
study of AIDS-related lymphoma using the FIV model. Collaborating with Steve Suter (DOCS) and Rachael Thomas
(MBS) to identify cellular and molecular markers of progression to lymphoma, in addition to determining what immune
populations may provide immunity to lymphomas.
Lola Hudson - Continuing testing various cognitive-motor/behavioral tasks with Drs. Sherman and Gruen to determine
measureable, significant alterations in FIV-infected cats within a year of infection. Open field testing including habituation
and vocalization, and T-maze latencies with weaves and hoops have shown promising initial results. Have also started
collaboration with Dr. Ed Breitschwerdt to determine if Bartonella sp can infect cells of CNS origin as his studies have
suggested a neurologic component to human patients.
Nanette Nascone-Yoder - Current research directions: The role of retinoic acid in digestive organ morphogenesis and
evolution; Frog embryo-based chemical genetic screening to identify mechanisms of gut morphogenesis. New Research
directions: The role of Wnt/PCP pathway signaling in gut morphogenesis; The role of Pitx2 in left-right asymmetric gut
looping and rotation. New tools/reagents: In collaboration with Alex Dieters (NCSU Chemistry), developing
photoactivatable reagents (small molecules, morpholinos) for spatial control of gene expression and protein activity within
target tissues of living embryos.
Shila Nordone - New Collaborations: NCSU-CVM Dr. Jeff Yoder, TMEM150 gene discovery research; NYU Dr. David
Levy, HIV Treg latency model development; UNC Dr. David Margolis, Treg Immunopathogenesis in HIV+ patients.
Mark Papich - The research laboratory (Clinical Pharmacology Laboratory) has continued to develop new assays and
capabilities in 2008-2009. Developed drug assays for several new drugs, in addition to many more that have already
been validated. These efforts have led to research projects, successful funding, and several publications (see publication
list). One student participated in the summer internship training program (Elizabeth Cranston) and presented her abstract
at the annual CVM-Research Forum, 2009.
Jorge Piedrahita - Development of transgenic swine that can house human tissues. Identification of PEG3 as a gene
affecting human intrauterine growth restriction. Development of the first ever lacZ pig, and the first ever Nk cell deficient
pig. Completion of the most comprehensive survey of imprinted genes in swine to date. Manuscript has been submitted
for publication. Development of, to his knowledge, the first ever porcine induced pluripotential stem cells (iPS).
Korinn Saker - Current project focus: nutritional interventions for breast cancer utilizing the cat as both an animal model
for human breast tumors and utilizing and for the species itself as specific breeds of domestic felines have an increased
risk for mammary tumor development; cell culture studies with pomegranate fruit extract; development of mammary gland
organ culture system to evaluate pomegranate as well as a variety of other potential chemo preventive agents;
evaluation of intestinal tight junction proteins in relation to understanding disease mechanisms of IBD and identifying
efficacious nutritional intervention protocols for management of the IBD patient . This is a collaborative research effort
with pathologists and GI researchers in the CVM. It is a new research area for Dr. Saker; obesity in relation to both
oxidative stress and chronic inflammation. This is a collaborative research focus with Dr. Pratt in Animal Science
(NCSU). Small animal (mainly feline) obesity research continues with Dr.Terry Swecker (VMRCVM).
Philip Sannes - Submitted RO1A2 (renewal) of HL-44497 (priority score: 133; 4.5 percentile). Shift in research direction
away from control of epithelial proliferation in the adult lung alveolus toward differentiation. Submitted RO3 in response to
RFA on Interstitial Pulmonary Fibrosis (priority score: 146 (no percentiles in RFAs). This is a translational application
relating to the involvement of alveolar epithelial differentiation in the development of fibrosis. Continued studies on
defining signaling and genetic mechanisms that control the differentiation of epithelial cells in the pulmonary alveolus.
Initiated new studies on determining the role of alveolar epithelial differentiation and repair in pulmonary fibrosis.
15
Barbara Sherry - Continued collaboration with ImmunoBiosciences Inc., using their technology to develop a novel vaccine
against influenza infection in a mouse model. Continued proteomics efforts in our on-going collaboration with Research
Triangle Institute, in our effort to identify novel cardiac responses to viral infection.
Cliff Swanson - Initiation of a study using thrompboelastography in examining the mechanism of purported inhibitory
affects of acepromazine upon blood clotting. This is a resident research project for Dr. Bobbi Conner, Critical Care
Resident.
Rachael Thomas - Completion of cytogenetic study of feline sarcomas, identifying potential novel diagnostic biomarkers;
development and molecular characterization of a feline injection-site sarcoma cell line; awarded first funding proposal as
an established investigator in feline genomics and the application of cytogenetic profiling for molecular classification of
feline lymphoma; expansion of departmental, interdepartmental and international collaborations on feline abdominal
lymphoma, initiated new collaboration with UC Davis Veterinary School; currently initiating outreach communications with
feline rescue centers for education and recruitment of clinical specimens; expansion of laboratory-based studies on
canine lymphoma cytogenetics as a model for human lymphoma; continued/published a series of other collaborative
canine cancer/genomics studies.
Don Thrall - Preparing for the competing renewal of the Hyperthermia Program of Project Grants. In the new submission
we will be expanding the studies of canine tumors to include functional imaging of tumor hypoxia and perfusion, and also
to noninvasive measurement of tumor temperature. This will necessitate performing imaging and hyperthermia studies at
Duke University Medical Center as opposed to here in the CVM. This has been a bureaucratic challenge but progress is
being made and we expect to begin this activity over the next few months. This will be critical to remaining completive for
funding.
Jeff Yoder - New NIH R21: “Whole organism transcriptional profiling of innate immune response” PI: Yoder. June 15,
2008 – May 31, 2010. New Morris Animal Foundation: “Evaluation of TREM-1 as a Specific Biological Marker for Sepsis
in Dogs” PI: Nordone (NCSU MBS); co-PI Yoder. Sept., 1, 2008 – Aug. 31, 2011. New CVM grant: “Determining the
Barrier Function of the Chorion in the Fish Embryo Test” PI: Law (NCSU-PHP); co-PI: Yoder. July 1, 2008 – June 30,
2009. NIH R01: “Switchable systems for Spatio-Temporal Control of Gene Expression in Zebrafish” PI: Deiters (NCSU
Chemistry); co-I: Yoder. Aug 1, 2007- July 31, 2012. New Equipment Supplement to NIH R01: “Switchable systems for
Spatio-Temporal Control of Gene Expression in Zebrafish” PI: Deiters (NCSU Chemistry); co-I: Yoder. Summer, 2008.
For purchase of MicroPoint(C)® Laser System from Photonic Instruments, Inc. NIH R01: “Novel innate immune receptors
in zebrafish” PI: Litman (Univ. South Florida); Sr-I: Yoder. Dec 1, 2006- Nov 30, 2009. CVM grant: “Immune-related,
lectin-like receptor 3 (Illr3) and hematopoietic lineages in zebrafish” PI: Yoder. July 1, 2007 – June 30, 2008. CCMTR
Pilot Grant: “Defining novel immune response genes as candidate biomarkers for infection” PI: Yoder; co-I Birkenheuer
(DoCS); co-I Correa (PHP). July 1, 2007 – June 30, 2008. CCMTR Service Core Grant: “Assessing immune response
genes as biomarkers for infection” PI: Yoder. July 1, 2007 – June 30, 2008. CCMTR Innovations Grant: “Upgrade of
Compound Microscope Leica DM5000B and PC workstation” PI: Yoder. Awarded Spring 2008. NIH Shared
Instrumentation Grant "Nikon AZ100 Macro/Micro Zoom Microscope” PI: Horowitz; co-PIs: Yoder, McGahan, NasconeYoder, Sherry, Piedrahita, Rodriguez-Puebla.
Publications and Other Professional Activities
Please refer to Appendix V (p. 33) for details. MBS faculty contributed the following scholarly works during the past year:
52
2
5
1
27
80
87
Original works in peer-reviewed journals
Case reports in peer-reviewed journals
Review articles in peer-reviewed journals
Books
Book chapters, peer-reviewed
Abstracts from scientific and professional veterinary conferences
52 citable and 29 not citable
Invited presentations (including CE) where the primary audience was professionals
16
2
Works prepared for presentation and distribution through electronic media, including CD-ROMS, audio
and video disks and tapes, computer generated presentations, broadcast videos, etc
Continuing education presentations/papers/proceedings where the primary audience was not
professionals
3
Professional activities by MBS faculty (Editorial Boards, Ad hoc Manuscript Reviews, Memberships on Research Grant
and Study Reviews, Committee Memberships). Please refer to Appendix VI (p. 61) for specific details.
14
11
24
15
17
13
20
Faculty appointed or elected to research study sections
Faculty serves as members of editorial boards of journals
Faculty served as ad hoc reviewers for journals
Faculty served on MBS committees
Faculty served on CVM committees
Faculty served on NCSU committees
Faculty served on other committees
Minority Representation and Recruitment Efforts
The 33 departmental faculty positions (tenure and non-tenure track) include 9 White females, 19 White males, 1 American
Indian female, 2 Hispanic males, 1 Asian female, and 1 Asian male.
VI.
Students
Honors and other measures of quality
Professional Degree Program
Most activities involving veterinary students will be considered in detail in the annual report from the Office of the
Associate Dean of Academic Affairs. A complete list of courses presented and participated in by departmental
faculty is given in Appendix III (p. 28).
Graduate degree and Residency Programs
Departmental faculty actively participate in the NCSU Physiology, Immunology, Toxicology, Biotechnology,
Genomic Sciences, Animal Science, and UNC-CH School of Pharmacy graduate degree programs in addition to
the CVM’s Comparative Biomedical Sciences (CBS) program.
13 faculty served as major advisors to 37 PhD students and 1 MS student.
18 faculty served on the graduate committees of 59 PhD students and 3 MS students.
Minority Representation and Recruitment Efforts
Diversity among the graduate students majoring with departmental faculty is shown in the following table:
Male
Female
Totals
White
6
13
19
African-American
1
2
3
Hispanic
0
1
1
Asian
6
8
14
American Indian
0
1
1
Totals
13
25
38
17
VII.
Research
Volume of Activity
Extramural and intramural research grants awarded to each departmental faculty member are in listed in
Appendix VII (p. 73).
Extramural Grant Activity
The total for current year awards for MBS PIs on 48 extramural grants in effect this past year was $7,210,828.
The following table summarizes the distribution among extramural funding agencies:
Agency Source
Number Grants
US Government
Industry
Foundations
Trust
Other
34
3
9
0
2
Total for Current
Year Awards
6,409,567
118,300
538,394
0
144,567
Direct for Current
Year Awards
4,517,931
81,500
499,364
0
144,567
The following table summarizes distribution of the $7,210,828 into departmental research programs.
Program
Cell biology/respiratory
Cell biology/ocular
Gastrointestinal
Oncology/cancer
Genomics
Infectious Disease
Immunology
Other
Number Grants
13
2
1
11
7
9
4
1
Total for Current
Year Awards
2,093,088
293,129
111,632
1,660,234
1,003,446
1,507,795
433,860
107,644
NIH accounted for 30 of the 34 US government research awards. Of the remaining governmental grants, USDA
funded 2, EPA funded 1, and NSF funded 1. Included in these summaries is 1 training grants which total
$232,540 in total cost for the current year.
The total for current year awards for MBS Co-Is on 20 extramural grants and 3 NCSU grants this past year was
$3,111,650.
Intramural (CVM) Grant Activity
The total dollar amount awarded on 4 intramural grants to MBS faculty serving as PI this past year was $43,668.
Specific Achievements of Significance
Extramural grant submissions during 2008-2009: MBS PI faculty submitted 36 proposals for extramural grant
support in the amount of $32,128,254 (total grant period).
18
The following table summarizes distribution of the grant submissions into departmental research programs.
Program
Cell biology/respiratory
Gastrointestinal
Oncology/cancer
Pharmacology
Genomics
Infectious Disease
Immunology
Neurology
Nutrition
Other
VIII.
Extramural
Number Grants
Total for Total
Grant Period
3,812,500
3
2,170,219
3
4,033,626
2
31,596
2
1,540,317
2
12,981,635
15
3,318,688
4
3,700,000
2
22,181
1
517,492
2
Administration and Staff
Personnel
Department Head, Associate Dean of Research and Director of Research and Graduate Programs, Associate
Vice Provost for the Office of International Affairs, Director for the Comparative Medicine and Translational
Research Center. A complete list of Administrative and Staff Personnel appears in Appendix II (p. 27).
New Faculty Appointments
Gabriela Seiler; Associate Professor of Radiology; appointment begins July 1, 2009.
Staff:
A total of 26 SPA employees and 38 non-faculty EPA employees worked in the department this past year. The
overall performance of this staff in supporting the teaching, research and professional service activities of this
department is excellent. The staff complement currently stands at 19 with 2 new appointments, 6 resignations
and 1 transfer to the Graduate Program. The non-faculty EPA currently stands at 27 with 8 new appointments,
and 11 resignations.
IX.
Recommendations and concerns for the future
The Department will continue to pursue updating the curriculum with an emphasis on molecular medicine and in
enhancing the Clinician Scientist Focus area with the development of new Selectives. In addition, the
Department will continue to encourage efforts in Translational Research, specifically with an increase in
emphasis and support (time and resources) of meaningful Scholarly Activity of faculty who have a significant
clinical effort. Many MBS faculty members of the department are members of the Center for Comparative
Medicine and Translational Research and make contributions to the Center.
Our ability to continue to grow extramural research funding continues to be challenging. This is especially with
the anticipated loss of two open faculty positions, and SPA staff positions due to cuts in the State budget.
However, with the new Administration and the Stimulus package we have an opportunity to obtain significant
Federal resources for our faculty. NIH has been given an unprecedented $10.4B from the ARRA funds. Awards
will generally be made directly from the NIH institutes. These grants mechanisms include infrastructure
upgrades, a multimillion dollar core equipment proposal, individual administrative supplements and bridge
19
grants. Many MBS faculty members are applying for this funding, the full extent of which will not be known until
the fall. Fortunately, hospital revenue has not decreased significantly so far this year and is thus a positive factor
in the departmental budget and is due to the hard work and dedication of the Clinical faculty.
However, despite our past successes, the impact on the Department of continued pressure on both the state and
national budget is of grave concern for the future. The effect of these economic pressures may eventually result
in less flexibility in supporting research programs, difficulty in raising funds for faculty start-up packages, an
inability to provide assistance to faculty for the purchase of equipment, and less available funds to provide
technical and teaching support in the Department. It is important that the MBS department continue to maintain a
financial “war chest” of at least $250K in order to off-set the negative impact of reductions in the state budget.
However this is only a temporary solution, deep cuts in our budget from the state of North Carolina can only be
offset for one-two years, then our cash reserves could be used up, and we will have to make alternative
budgetary plans in order to bridge productive programs and help them survive through future tough times.
X.
University’s Five Focus Areas
1. Producing leaders for the state, nation, and world
Adler - Numerous leadership positions held by Dr. Adler: chair of numerous study sections, invited speaker at
numerous meetings and at different academic, industrial and government institutions. Training of students and
postdoctoral fellows to do environmental research via the EPS/NCSU cooperative agreement managed by Dr.
Adler. Dr. Adler has received supplements from NIH for minority students working on his R37 grant from HNLBI.
Arasu - Working with Park Scholars (Class of 2011) - together with class committee, a learning lab was
organized that focused on the “National Debt” with meetings and discussions in Washington D.C. (October
2008).
Breen – Dr. Breen’s leading role in the fields of canine and comparative genomics provide members of his lab
(permanent and temporary) with good opportunities to become involved in cutting edge research that plays a key
role in major international collaborations.
Brody - After two years in Dr. Brody’s laboratory, Dr. Keith Salazar accepted a highly competitive position as a
staff scientist with the US Environmental Protection Agency. We are very proud that Keith qualified for this
research position and moved on to national service.
Ghashghaei - Initiated collaborations with a well known group in Germany.
Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program.
Nascone-Yoder - Dr. Nascone-Yoder has provided both undergraduate and graduate students with opportunities
to perform research in her lab, attend professional conferences, make scientific presentations and network with
top scientists.
Posner – Dr. Posner is part of the team that trains students, interns and residents as Veterinarians.
Veterinarians serve throughout the word; not just healing companion animals but protect our food sources,
monitor biosafety as well as contribute to scientific advancement. Furthermore, the training of Veterinary
Anesthesia Specialists helps create the next generation of Veterinary Leaders.
Sherry – Received the Alumni Distinguished Graduate Professor award for her leadership efforts in helping to
develop and lead the university-wide Genomic Sciences graduate program. Continued training 3 graduate
students pursuing PhD: Zurney (Microbiology PhD), first-authored publication featured as “Article of Significant
Interest”, awarded PhD in December 2008, currently employed as Study Director at Burleson Research
Technologies in Morrisville, NC; Li (Functional Genomics PhD), presented research at national meeting
20
(American Society for Virology); Irvin (CBS PhD), served on “Expanding Your Horizons” workshop executive
committee (brings 400 seventh-grade girls to NCSU for hands-on science workshops).
Yoder - By educating and training Immunology, Comparative Biomedical Sciences and Functional Genomics
graduate students (in classes and in his laboratory) Dr. Yoder is contributing to the development of future
scientific leaders.
2. Creating educational innovation
Arasu - In addition to study abroad experiences, Dr. Arasu has been working on building academic linkages with
partners abroad for NCSU community service learning projects. She is also contributing to the development of
a new degree program, Master’s in Development Practice. She was also instrumental in the development of an
undergraduate offering in public health.
Dean - (This program addresses #1 and #2) The Comparative Medicine and Translation Research Training
Program is a newly created program that targets individuals trained as veterinarians (have already earned a
doctorate in veterinary medicine, DVM) and that have specialty training. This means they have completed a
residency in specialty area such as pathology, internal medicine, dermatology, ophthalmology, etc. In this
program, individuals will earn a PhD and will focus on the use of animals in research for the purpose of
generating knowledge, drugs, therapies or diagnostic techniques that will direct application to veterinary and
possibly human patients. The unique combination of training will equip graduates to become leaders in
biomedical research. This program is the first of its kind and as such represents an innovative approach to meet
the national need for veterinary scientists.
Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program.
3. Improving health and well being
Adler - A drug developed from Dr. Adler's research and licensed through the university to a start-up
biotechnology company (BioMarck, Raleigh, NC) is now in phase 2a human clinical trials and could become a
new treatment for chronic bronchitis in the U.S. and worldwide.
Arasu - We will continue efforts initiated in 2008 to provide a public health track and courses to undergraduate
students towards a national movement focused on 'The Educated Citizen and Public Health'. We are also
beginning a new initiative to create a ‘Health and Wellbeing’ portal for NCSU. The Triangle Global Health
Consortium has been formed and is focused on recruiting a Director for fund raising and coordination of
institutional efforts.
Breen - Research in Dr. Breen’s lab is identifying regions of the canine genome that are associated with
response to therapy in cancer patients. Simultaneously, we are translating these canine changes to the human
genome and further testing corresponding region of the human genome for their association to prognosis.
Dean - The Center for Comparative Medicine and Translational Research (CCMTR) was conceived and
implemented by faculty that recognized strong multidisciplinary collaborative teams are necessary to accelerate
translational research. Translational research is process of moving laboratory observations into the clinical
setting through the creation of new therapeutics, vaccines, diagnostics, and biomedical devises. The Center
concept was proposed in 2003, given permission to organize in 2005 and was formally recognized as an official
UNC Center by the Board of Trustees in February 2006. The CCMTR has at present over 100 tenure-track
faculty representing 16 departments from 5 colleges, with approximately 50% of the participants residing on the
Centennial Biomedical Campus. In addition to the traditional biological disciplines found in the Colleges of
Veterinary Medicine and Agriculture and Life Sciences, truly multidisciplinary collaborations come through the
addition of faculty with expertise in biomedical engineering, biomedical textiles, mathematical modeling, nontraditional statistics, chemical engineering, molecular modeling and more. This brings together faculty that
speak different scientific languages but share the desire to bring medical solutions to the clinic. In the short time
21
since it’s inception, the CCMTR has accomplished the following: provided incentives and support to encourage
truly multidisciplinary collaborations and accelerate the translation of laboratory research to improved patient
care, engaged external academic and corporate advisors to identify research goals and strategies, provided
access to sophisticated research equipment. offered facilities and technical assistance to perform clinical trials,
awarded seed grant money to launch new ideas and collaborations, hosted workshops and symposia to help
faculty remain innovative and knowledgeable, provided educational opportunities for undergraduate and
graduate students (including veterinarians) in translational research, developed ties with biomedical researchers
at other UNC institutions, created a powerful research enterprise to attract corporate partners to the Centennial
Biomedical Campus.
Nascone-Yoder – Dr. Nascone-Yoder’s lab conducts federally funded research aimed at understanding the
etiology of birth defects.
Posner - Veterinarians are major contributors to maintaining the world’s heath through food surveillance and
biosafety (bacterial, viral and toxilogical). The training of the next generation of protectors is vital.
Sannes - Continues work directed toward understanding the role of alveolar epithelial differentiation in pulmonary
fibrosis.
Sherry - Continued collaboration with ImmunoBiosciences, Inc. Conducted investigations of
ImmunoBiosciences’ vaccine technology for efficacy against influenza infection in a mouse model. Expanded
our proteomics efforts in our on-going collaboration with Research Triangle Institute, in our effort to identify novel
cardiac responses to viral infection. Received continuation of NIH funding for this research
Thrall - We are assessing the biologic effects of tumor hyperthermia in terms of alteration of tumor physiology
that may be beneficial, and the optimum manner in which to prescribe hyperthermia. Results of these studies
have the potential to refine the use of hyperthermia as a cancer treatment modality in animals and humans.
Yoder - The research in Dr. Yoder’s laboratory includes basic functional studies of evolutionarily conserved novel
immune response genes. These functional studies will likely form the basis for clinical based studies
investigating the roles of these genes in human disease. Ultimately, an understanding of how all genes
contribute to the response to and recovery from infection will promote better drug designs for improving human
health.
4. Fueling economic development
Arasu - Linked with the above mentioned ‘health and wellbeing’ portal for the university, Dr. Arasu will be
working with other colleagues/units on campus to improve extension, outreach and economic development
related to the health sector at NCSU.
Sherry – Dr. Sherry’s graduate student (Jennifer Zurney) was hired by a NC company (Burleson Research
Technologies, Inc.), which performs fee-for-service assays.
5. Driving innovation in energy and the environment
Arasu - Our USDA International Science and Education award for 2008-2012 bridges sustainable livestock
production practices with biofuels and environmental and public health. This is a joint effort between faculty in
CVM and CALS; Dr. Arasu is the PI on this award that will also link NCSU with regional stakeholders and our
partners in India.
22
Appendix I
List of Faculty/EPA Employees Including Graduate Students
FACULTY
Kenneth Adler, PhD
Prema Arasu, DVM
Makoto Asakawa, BVSc
Jill Barnes, PhD
Matthew Breen, PhD
Arnold Brody, PhD
James Brown, DVM
Nigel Campbell, PhD
Gregg Dean, DVM
David C. Dorman, DVM, PhD
James Douglass, DVM
Lloyd Fleisher, PhD
John Gadsby, PhD
Troy Ghashghaei, PhD
Jonathan Horowitz, PhD
Kristina Howard, DVM
Lola Hudson, DVM, PhD
Linda Martin, PhD
M. Christine McGahan, PhD
Nanette Nascone-Yoder, PhD
Shila Nordone, PhD
Mark Papich, DVM
Anthony Pease, DVM
Jorge Piedrahita, PhD
Lysa Posner, DVM
Doodipala S. Reddy, PhD
Ian Robertson, BVSc
Marcelo Rodriguez-Puebla, PhD
Korinn Saker, PhD, DVM
Philip Sannes, PhD
Barbara Sherry, PhD
James E. Smallwood, DVM
Clifford Swanson, DVM
Rachael Thomas, FD
Donald Thrall, DVM, PhD
Jeffrey Yoder, Ph.D.
Professor; Cell Biology, Physiology, Environmental Science & Toxicology
Professor; Infectious Disease; Assoc Vice Provost, Office of International Affairs;
Director, Global Health Initiatives; Director, CVM International Programs; promotion to
Professor 7/1/08; promotion to Assoc Vice Provost 7/1/08
Clinical Assistant Professor; Anesthesiology
Teaching Associate Professor; Cell Biology & Anatomy
Professor; Cell Biology, Physiology, & Genomics
Research Professor; Respiratory Biology
Clinical Assistant Professor, Radiology
Clinical Assistant Professor; Anesthesiology
Professor; Infectious Disease; Director, Center for Comparative Medicine and
Translational Research; promotion to Professor 7/1/08
Professor of Physiology, Associate
Dean
Research and
DirectorDean
of Research
and and Director
Professor
of of
Physiology,
Associate
of Research
Graduate Programs
Clinical Assistant Professor; Radiology
Professor; Pharmacology
Professor; Cell Biology, Physiology, Reproductive Biology
Assistant Professor; Developmental Neurobiology, Adult Neurogenesis, Gene Therapy
Associate Professor; Cancer Biology, & Cell Biology
Research Assistant Professor; Infectious Disease
Professor; Cell Biology & Anatomy; promotion to Professor 7/1/08
Assistant Professor; Cell Biology, Physiology, Environmental Science & Toxicology;
resigned 7/1/08
Professor & Department Head; Cell Biology, Pharmacology, Environmental Science &
Toxicology
Assistant Professor; Developmental Biology
Research Assistant Professor
Professor; Clinical Pharmacology
Assistant Professor; Anesthesiology; resigned 9/2/08
Professor; Genomic & Reproductive Biology
Clinical Associate Professor; Anesthesiology; promotion to Clinical Associate Professor
7/1/08
Assistant Professor; Neuroscience & Pharmacology; resigned 7/1/08
Clinical Associate Professor; Radiology
Associate Professor; Cancer Biology, Cell Biology, & Physiology
Associate Professor; Clinical Nutrition
Professor; Cell Biology, Physiology, Environmental Science & Toxicology
Professor; Infectious Disease; Director, Genomic Sciences Graduate Program
Professor; Anatomy
Associate Professor; Anesthesiology
Research Assistant Professor
Professor; Radiology & Cancer Biology
Assistant Professor; Immunology
23
EMERITUS PROFESSORS
Robert A. Argenzio, PhD
Arthur L. Aronson, DVM, PhD
Peter J. Bentley, PhD
Cecil Brownie, DVM, PhD
Terrence M. Curtin, DVM, PhD
Charles E. Stevens, DVM, PhD
Professor Emeritus
Professor Emeritus
Named Professor Emeritus
Professor Emeritus
Professor Emeritus
Professor Emeritus
EPA PROFESSIONALS
Dieldrich Bermudez, PhD
Chad Blystone,PhD
Katherine Bortoff, PhD
Seema Briyal, PhD
Kathryn Byler, BS
Beth Case, BS
Anne Crews, MS
Demetrio Dichoso, BS
Michael Dush, PhD
Shijing Fang, MD
Laila Farzana, MS, PhD
Omkaram Gangisetty, MS, PhD
Jillian Gee, PhD
Margaret Goralska, PhD
Alexandra Hamilton, BS
Benoit Hedan, DVM, PhD
Andrew Hotchiss, PhD
Lisa Jesse, DVM
Apparao Kummarapurugu, PhD
Susan Lankford, PhD
Julie Long, BS
Jeffrey Miller, PhD
Steven Nagar, PhD
Donna Newman, PhD
Joungjoa Park, MS
Cynthia Rider, PhD
Keith Salazar, PhD
Raul Salinas-Mondragon, FM, PhD
Amy Tanner, DVM
Nicole Tinfo, PhD
Poem Turner, BS
Jenora Waterman, PhD
Christina Williams, BS
Alice Wright, BS
Tiffany Yelverton, MS, PhD
Qi Yin, PhD
Lin Zhang, FM, MS
Leah Zorilla, PhD
Post Doc Research Associate (Adler)
Post Doc Research Assoc (Adler); resigned 5/1/08
Research Associate (Sannes); appointed 8/1/08
Research Assoc (Reddy); resigned 7/1/08
Research Asst (Breen)
Research Asst (Thrall)
Laboratory Supervisor (Adler)
Laboratory Supervisor (Piedrahita)
Research Assoc (Nascone-Yoder)
Research Asst (Adler)
Post Doc Research Assoc (Yoder); appointed 2/1/09
Post Doc Research Assoc (Reddy); resigned 7/1/08
Post Doc Research Assoc (Adler); resigned7/4/08
Research Assoc(McGahan)
Research Asst (Breen)
Post Doc Research Associate (Breen)
Post Doc Research Assoc (Adler); resigned 6/21/08
Lecturer (McGahan); appointed 7/1/08
Research Assoc (Sannes); resigned 4/5/08
Research Assoc (Brody)
Research Assistant (Dean); appointed 7/21/08
Post Doc Research Associate (Brody); appointed 8/18/08
Research Assoc( McGahan)
Research Assoc (Sannes)
Research Assoc (Adler)
Post Doc Research Assoc (Adler); resigned 12/12/08
Post Doc Research Assoc (Brody); resigned 7/4/08
Research Asst (Ghashghaei )
Research Asst (Saker); resigned 8/2/08
Post Doc Research Assoc (Adler)
Research Associate (Yoder); appointed 8/18/08
Post Doc Research Assoc (Adler); resigned 10/1/08
Research Asst (Breen)
Research Asst (Piedrahita); resigned 9/1/08
Post Doc Research Associate (Adler); appointed 9/22/08
Post Doc Research Assoc (Brody)
Research Assistant (Dean); appointed 6/23/08
Post Doc Research Assoc (Adler)
24
RESIDENT PROGRAM
Jerome Benoit, VMD
Jennifer Carter, DVM
Christina Copple, DVM
Julianne Davis, MS, DVM
Erica Fields, VMD
Lisa Jesse, DVM
William Lee, DVM
Kristen Messenger, VMD
James Montgomery, DVM
Kerensa Rechner, DVM
Keijiro Shiomitsu, BVS
Sarena Sunico, DVM
Resident in Radiation Oncology (Thrall); completed 7/1/09
Resident in Anesthesiology (Posner); completed 9/30/09
Resident in Radiology (Robertson); appointed 7/1/08
Resident in Nutrition (Saker); appointed 7/1/08
Resident in Radiology (Robertson)
Resident in Radiology (Pease); completed 7/1/08
Resident in Radiology (Robertson); completed 7/1/09
Resident in Anesthesiology (Posner)
Resident in Radiology (Robertson); appointed 7/1/08
Resident in Radiation Oncology (Thrall); appointed 7/1/08
Resident in Radiation Oncology (Thrall); completed 8/1/08
Resident in Radiology (Robertson)
ADJUNCT FACULTY
Vikram Arora, PhD
Stephanie Berry, MS, DVM
Stacy Branch, DVM, PhD
Richard Broadstone
Fidel O. Castro, MAGRI, PhD
Carmen Colitz, DVM, PhD
Ralph Cooper, PhD
Sally Perreault Darney, PhD
Mark W. Dewhirst, DVM, PhD
Darlene Dixon, DVM, PhD
Kevin L. Dreher, PhD
Thomas E. Eling, PhD
Bernard Fischer, DVM, PhD
Dori R. Germolec, PhD
Gerald Huntington, PhD
Donna Matthews Jarrell, DVM
Gary J. Jesmok, PhD
Hillel Koren, PhD
Christopher S. Lau, PhD
Rick Meeker, PhD
Indu Parikh, PhD
James A. Raleigh, PhD
Peifeng Ren, PhD
John Rogers, PhD
David A. Schwartz, MD
Gregory Sempowski, PhD
Robert Smart, PhD
Jerry Wayne Spoo, DVM
William Stokes, DVM
Robert Voyksner, PhD
Xiangdong Wang, MD, PhD
Frank Welsch, DVM
Fulton Wong, PhD
Darryl Zeldin, MD
Robert Zucker, PhD
Adjunct Assistant Professor (Talecris Biotherapeutics)
Adjunct Assistant Professor (VA Tech)
Associate D.A.B.F.M. (NCSU; Environmental & Molecular Toxicology)
Adjunct Professor (IAMS); appointed 12/1/08
Adjunct Associate Professor (University of Concepcion, Chile; University of Havana,
Cuba)
Adjunct Associate Professor (Animal Eye Specialty Clinic, West Palm Beach, FL)
Adjunct Professor (EPA)
Adjunctor Professor (EPA)
Adjunct Professor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Adjunct Professor (EPA)
Adjunct Associate Professor (NIEHS)
Adjunct Instructor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Associate Member (NCSU; Animal Science)
Adjunct Associate Professor (Massachusetts General Animal Hospital)
Adjunct Professor (Bayer Corporation)
Adjunct Professor (EPA)
Adjunct Professor (EPA)
Adjunct Professor (UNC Chapel Hill)
Adjunct Professor (Biomarck Pharmaceuticals)
Adjunct Professor (UNC School of Medicine)
Adjunct Assistant Professor (BASF Plant Science LLC)
Adjunct Professor (EPA)
Adjunct Professor (NIEHS)
Adjunct Assistant Professor (Duke Univ)
Associate Member (NCSU; Environmental & Molecular Toxicology)
Adjunct Assistant Professor (RJ Reynolds)
Adjunct Professor (NIEHS)
Adjunct Associate Professor (LCMS Limited)
Adjunct Professor (AstraZeneca R&D Lund, Sweden)
Adjunct Professor (Orbitox)
Adjunct Professor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Adjunct Associate Professor (EPA)
25
GRADUATE STUDENTS MAJORING WITH DEPARTMENTAL FACULTY
Steve Bischoff
Stephanie Bloom
Sara Burngardner
Mark Cesta
Shannon Duke
Teresa Green
Amy Heffelfinger
Susan Irvin
Ben Jacquet
Sun-Hye Kim
Tae-Hyung Kim
Sehown Koh
W. Randall Lampe
Peter Landis
Lianna Li
Huixuan Liang
Ko Wei Lin
Jananne Matheson
Allison R. Morckel
Kimberly Raiford
Eric Seiser
Rahika Shah
Rita Simoes
Christopher Sistrunk
Sarah R Smithberg
Stacey Snyder
Laura Stoeker
Amy Tanner
Pei-Chien Tsai
Shengdar Tsai
Melissa Ventevogel
Wang Xian
Jianzhen Xie
Jibing Yang
Haifeng Yin
Andrea Young
Huiying Zhang
Jennifer Zurney
PhD candidate in Comparative Biomedical Sciences (Piedrahita)
PhD candidate in Comparative Biomedical Sciences (Nascone-Yoder/Horowitz)
PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Cell Biology (Sannes)
PhD candidate in Comparative Biomedical Sciences (Breen)
PhD candidate in Comparative Biomedical Sciences (Adler)
PhD candidate in Immunology (Yoder)
PhD candidate in Comparative Biomedical Sciences (Sherry)
PhD candidate in Zoology (Ghashghaei)
PhD candidate in Comparative Biomedical Sciences (Rodriguez)
PhD candidate in Comparative Biomedical Sciences (Horowitz)
PhD candidate in Genomic Sciences (Piedrahita)
PhD candidate in Toxicology (Adler)
PhD candidate in Genomic Sciences (Horowitz)
PhD candidate in Genomic Sciences (Sherry)
PhD candidate in Physiology (Ghashghaei)
PhD candidate in Comparative Biomedical Sciences (Adler); PhD awarded 2008
MVPH candidate for Masters in Veterinary Public Health (Arasu)
PhD candidate in Comparative Biomedical Sciences (Nascone-Yoder)
PhD candidate in Genomic Sciences (Adler)
PhD candidate in Func Genomics (Breen)
PhD candidate in Immunology (Yoder)
PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Toxicology (Rodriguez)
PhD candidate in Immunology (Dean)
PhD candidate in Comparative Biomedical Sciences (Breen)
PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Nutrition (Saker)
PhD candidate in Comparative Biomedical Sciences (Breen)
PhD candidate in Genomic Sciences (Piedrahita)
MS candidate in Immunology (Dean)
PhD candidate in Functional Genomics (Rodriguez)
PhD candidate in Genomic Sciences (Horowitz)
PhD candidate in Immunology (Yoder)
PhD candidate in Genomic Sciences (Horowitz)
PhD candidate in Func Genomics (Breen)
PhD candidate in Toxicology (Sannes)
PhD candidate in Microbiology (Sherry); PhD awarded December 2008
26
Appendix II
List of Administrative & Staff Personnel
ADMINISTRATION
M. Christine McGahan
Professor and Department Head
Department of Molecular Biomedical Sciences
STAFF
Shannon Chiera
Brenda Colby
Melissa D’Annibale-Tolhurst
Delta Dise
Wrennie Edwards
Erin Egan
Jenny Ferrell
Xiaoying (Steve) Fu
Kara Hoffert Goeres
Jill Harned
Becky Hupp
Lauren Gast Jackson
Marilyn Lall
Alora LaVoy
Teresa Nichols
Timothy Orcutt
Jennifer Pollard
Stacie Reckling
Beth Simmons
Rita Simoes
Kelly Snyder
Grady Spoonamore
Blair Therit
Heidi Thompson
Tony Whitaker
Bill Wise
Research Technician (Horowitz); appointed 6/16/08
Research Specialist (Hudson)
Research Technician (Gadsby); appointed 10/13/08
Research Specialist (Papich)
Research Specialist (Sherry)
Research Specialist (Dean); resigned 7/17/08
Research Specialist (McGahan)
Research Specialist (Martin); resigned 7/1/08
Research Specialist (Case)
Research Specialist (McGahan)
Accounting Technician III (McGahan)
Research Specialist (Piedrahita); appointed 3/15/07
Research Specialist (McGahan)
Research Specialist (Dean)
Research Technician (Horowitz); resigned 4/26/08
Research Specialist (Yoder); resigned 8/19/08
Executive Assistant I(McGahan)
Research Specialist (Dean); resigned 6/17/08
Administrative Support Associate (Pollard)
Research Specialist (Arasu); transferred to Graduate Program 7/3/08
Administrative Support Associate (Pollard)
Research Specialist (Case)
Research Specialist (Ghashghaei); resigned 8/5/08
Administrative Support Specialist (Hupp)
Research Technician (Barnes/Wise)
Research Operation Manager (Barnes)
27
Appendix III
Course
Number
Courses Offered by Departmental Faculty
Course Title
Credit
Hrs
Semester
# students
Team
taught
Course Director
Faculty Participation
J Barnes, L Hudson, E Smallwood, J Brown (1h), T
Pease (1 lecture)
J Gadsby, M Breen, C Swanson, J Yoder (2h), L Posner
(1 lecture, 1 lab), T Ghashghaei, L Hudson (1 lecture, 1
lab)
PL Sannes
J Smallwood, L Hudson, J Barnes
N Nascone-Yoder, J Barnes (1h)
L Posner, T Ghashghaei, C McGahan, J Gookin, C
Swanson. Clinical participants in lab: N Olby (1 lab), K
Munana (1 lab). Brief participations by B Sherman, D
Lasselles
C Swanson, N Campbell, L Posner, B Hansen (2h)
L Fleisher, R Baynes, M Papich, J Gadsby (2 hrs), S
Marks (1 hr), K Tolbert (1 hr), R Hanel (1 hr), D LeVine (1
hr)
MG Papich
D Thrall, I Robertson, J Brown
K Saker, J Davis (2hrs), M Taylor (1h)
D Thrall, I Robertson, J Douglass, T Pease, J Brown
D Thrall, I Robertson, J Douglass, T Pease, J Brown
N Campbell, L Posner, C Swanson, M Asakawa
DVM Courses presented by departmental faculty
VMB911
Veterinary Anatomy I
6
Fall
80
Yes
L Hudson
VMB913
Veterinary Physiology I
5
Fall
80
Yes
J Gadsby
VMB914
VMB921
VMB922
VMB923
Veterinary Histology and Cytology
Veterinary Anatomy II
Veterinary Embryology and Teratology
Veterinary Physiology II
3
4
2
5
Fall
Spring
Spring
Spring
78
78
78
78
Yes
Yes
No
Yes
PL Sannes
J Smallwood
N Nascone-Yoder
L Posner
VMB930
VMB933
Anesthesia
Introductory Pharmacology
2
5
Fall
Fall
76
77
Yes
Yes
C Swanson
L Fleisher
VMB943
VMB960
VMB965
VMB976
VMB976A
VMB977
Pharmacology and Veterinary Therapeutics
Veterinary Radiology and Radiobiology
Veterinary Nutritional Health
Radiology
Ultrasound
Clinical Anesthesia
3
3
3
2
2
2
Spring
Spring
Spring
Fall/Spring
Fall/Spring
Fall/Spring
76
80
76
113
113
80
Yes
Yes
no
Yes
Yes
Yes
MG Papich
Don Thrall
K Saker
Ian Robertson
James Brown
N Campbell
K Mathews
Participation in Other DVM Courses
VMC932
Principles of Surgery
3
Fall
78
Yes
VMC962
2
Spring
~80
Yes
VMC965
Animal Welfare, Ethics and Societal
Responsibility
Large Animal Surgery & Diagnostic Techniques
1
Spring
76
Yes
J Tate
VMP912
Evidence Based Medicine
2
Fall
80
Yes
Jay Levine
Adam Birkenheuer
VMP924
VMP925
VMP932
Veterinary Medical Virology
Veterinary Immunology Case Studies
Veterinary Parasitology
3
3
5
Spring
Spring
Fall
75
10/group
76
Yes
No
Yes
F Fuller
S Tonkonogy
B Hammberburg
VMP942
Clinical Pathology
3
Spring
78
Yes
K Matthews, L Posner, C Swanson, N Campbell, M
Asakawa, E Hardie, L Hudson , Small Animal Surgery
Faculty and House Officers
D Dunning, B Taylor, S Marks, L Posner (2 hr)
J Tate, N Campbell, Equine Medicine Faculty, Equine
and Small Animal Surgery Faculty
J Levine, J Gadsby, L Hudson, M Gruen, L Posner, C
Swanson, K Saker, (numerous faculty, House officers
and Graduate students from DOCS, MBS and PHP)
F Fuller, B Sherry, J Guy
S Tonkonogy, K Howard
B Hammerburg, M Levy, J Flowers (Lab Coordinator), P
Arasu
G Dean
28
Course
Number
VMP977
Course Title
Necropsy and Clinical Laboratories
VMP978
Clnical Pathology, Parasitology and Immunology
2
VMP978
Clinical Pathology, Parasitology, and
Immunology (Senior Rotation)
Clinical
Conference
2
VMP995
Credit
Hrs
2
1
Small Animal Medicine Senior Rounds
Team
taught
Yes
Course Director
8-10 per
rotation
9
Yes
C Grindem
No
76
Yes
S Tonkonogy (IMM),
C Grindem (Path)
N Campbell
8-10 per
session
Yes
K Saker
Yr Round
2-6 per
session
Yes
K Saker
Yr Round
8-10 per
session
Yes
K Saker
10
3
15
No
Yes
Yes
C Swanson
S Nordone
M Breen
2
28
8
Yes
No
Yes
J Yoder
JE Smallwood
L Hudson
4
No
K Saker
2
Varies (all
years)
24 (freshmanjuniors)
Yes
No
N Campbell
P Arasu
Yes
P Arasu
Semester
Fall/Spring/
Summer
Monthly
Rotation
Spring
# students
Summer
Fall
Spring
Yr Round
(once every 4
wk rotation)
Oncology Rounds
(once every 2
wk rotation)
Necropsy/Clin Path/Immuno/Pharmacol/Clin Nutr
Sr Rounds
(once every 4
wk rotation)
Faculty Participation
M Papich
C Grindem, P Arasu (Co-Course coordinator), B
Hammberburg (Co-Course coordinator)
S Tononogy, C Grindem, K Howard
N Campbell, M Gerard, J Guy
Selective Courses presented by departmental faculty
VMB991A
VMB991B
VMB991D
Fish Physiology
Immunodiagnostics
Introduction to Research at CVM
1
1
1-2
VMB991E
VMB991G
VMB991I
Transgenics
Avian Anatomy
Farriery and Veterinary Medicine
1
1
1
Fall
Spring
Fall (1 full
wk
semester)
Spring
Spring
Spring
VMC991R
1
Fall
VMC992Z
VMM991S
Advanced
Small Animal Clinical Nutrition
Active Learning in the VTH (Anesthesia)
International Veterinary Medicine Experience
1
1-2
Fall/Spring
VMP991Y
International Veterinary Medicine
1
Fall/Spring
1
1
1
Spring
Fall
Fall
8
18
~30
Yes
Yes
Yes
R Mansmann
G Lewbart
M Stoskopf
3
3
Fall
Spring
@16
13
Yes
Yes
J Yoder
L Fleisher
C Swanson
S Nordone, A Birkenheuer, S Orton (UNC), S Suter (1 hr)
M Breen, J Piedrahita, J Gadsby, E Breitshwerdt, M
Hauck, N Olby, S Suter, D Lascelles, P Farin, B
Hammerberg
J Yoder, J Horowitz , M Breen, J Piedrahita
JE Smallwood, L Degernes (1 lab)
L Hudson, R Mansmann, 1 local equine practitioner, 8
local farriers
K Saker
N Campbell, C Swanson, L Posner, M Asakawa
P Arasu (China trip, 2 week, 24/7; India trip, 2 weeks,
24/7)
P Arasu
Participation in Other Selective Courses
VMC991O
VMC991Q
VMC991U
Equine Podiatry
Fish Medicine
Advanced Primate
R Mansmann, LC Hudson, 1 local farrier
G Lewbart, J Yoder (1hr)
M Stoskopf, L Posner
Graduate Courses presented by departmental faculty
CBS565
CBS762
Fundamentals of Biomedical Sciences
Principles of Pharmacology
J Yoder, M Matthews, G Dean, K Saker, C Swanson
L Fleisher, D Dorman, M Papich, R Baynes, R Smart, Y
29
Course
Number
Course Title
Credit
Hrs
Semester
# students
Team
taught
Course Director
3
Spring
@18
Yes
M Breen
CBS770
Cell Biology
CBS771
CBS810
CBS810
CBS810B
Cancer Biology
Grant writing
Seminar
Infectious Disease Pathogenic Mechanisms
Journal Club
Special Topics in Cell Biology
Instrumentation in Pharmacological Research
4
1-3
1
1
Fall
Spring
Spring
Spring
13-20
3
13
8
Yes
No
No
Yes
J Horowitz
K Adler
J Piedrahita
P Orndorff
1
2
Spring
Fall
15
2
No
Yes
J Horowitz
N Monteiro-Riviere
Doctoral supervised research for T Green, K
Raiford, K Lin, WR Lampe
Resident Board Review; Topic: Review of
current topics in clinical nutrition
1-9
CBS810C
CBS860
CBS893
4
K Adler
Spring
15
Yes
1-6
1-6
1
Fall
Spring
Fall/Spring
23
@24
15-20
Yes
Yes
Yes
S Tonkonogy
1
Fall/Spring
Faculty Participation
Tsuji
M Breen, J Yoder, P Sannes, T Ghashghaei, C
McGahan, J Piedrahita, N Nascone-Yoder, M
Rodriguez-Puebla, T Ghashghaei
J Horowitz, M Rodriguez-Puebla
K Adler
J Piedrahita
P Orndorff, B Sherry, F Fuller, M Levy, B Hammerberg
J Horowitz
N Monteiro-Riviere, L Fleisher (1 hr lecture, 3 hrs lab),
several other faculty and staff
K Adler
K Saker
Participation in Other Graduate Courses
BIT815D
BIT815N
IMM816
PHI816
Biotechnology Professional Development
Biotechnology Capstone Course
Advanced Topics In Immunology and
Biotechnology
Research Ethics
R Kelly
R Kelly, B Sherry (2 lectures), G Dean (2 lectures)
G Dean (1 lecture, 1 discussion session)
S Tonkonogy, L Hudson, G Dean (weekly 1 hr), K
Howard
J Barnes – Invited to participate in discussion on
Research Misconduct
Participation in Other Courses
ANS330
Laboratory Animal Science
3
Spring
17
Yes
B Petters
TOX710
VM9095
Biochemical Toxicology
Comparative Oncology (at VMRCVM,
Blacksburg, VA)
Animal Symbiosis
VMA Residency Program – Diagnostic Imaging
3
2
Spring
Spring
~10
30
Yes
Yes
A Wallace
3
20
6
No
Yes
C Lytle
James Brown
Graduate School Preparing the Professoriate
Workshop Series
1
Fall
Summer/
Fall/Spring
Spring
~30 students
No
R Rufty
ZOO512
B Petters, L Fleisher (1hr), several other faculty from
main campus participate
A Wallace, N Nascone-Yoder (2 hrs)
K Saker
C Lytle, K Howard (1 lecture)
D Thrall, I Robertson, J Douglass, T Pease, J Brown
R Rufty, B Sherry (1 lecture)
30
Appendix IV
Clinical Services Offered by Departmental Faculty
Anesthesiology: There are currently 4 MBS faculty members who provide Anesthesiology service to the VTH, Drs. Lysa
Posner, Cliff Swanson, Nigel Campbell and Makoto Asakawa. They participate in teaching a number of courses in the
DVM curriculum that are administered by the MBS department including VMB 930 Principles of Anesthesia, VMB 977
Clinical Anesthesia, VMB 913 Physiology I, and VMB 923 Physiology II. The anesthesiology faculty are responsible for
overseeing the training and clinical service activities of residents, students, and hospital staff anesthetists delivering
clinical anesthesia services in the VTH, and directly supervise these activities while on duty. Primary emergency
coverage is provided by two anesthesia residents and five VTH staff anesthetists. The four faculty anesthesiologists split
the responsibility for backup consultation with the primary emergency coverage personnel. This assignment requires the
faculty anesthesiologist covering backup call duty to be available to the primary personnel for consultation and guidance
after normal hospital hours during weekdays, and during weekends and holidays.
Clinical Pharmacology: Mark Papich has no direct clinical assignment (that is, responsibility for patient care). However,
he is the faculty supervisor of the VTH Clinical Pharmacology Laboratory (Room C-268). This laboratory supports one
hospital technician at 0.5 FTE. His supervision of this laboratory carries with it the responsibility for clinical service
emanating from approximately 1,500 samples per year for monitoring of drug concentrations and various hormones in
patients subsequent to therapy. Many of these samples require direct consultation with the clinician in charge of the
patient. In addition to the service work associated with responsibility of the Clinical Pharmacology Laboratory, as the VTH
Clinical Pharmacologist, he receives consultations each day via phone calls and e-mail consultations from anywhere in
the U.S., and direct requests for consultation from our own clinical faculty.
For more information: http://www.cvm.ncsu.edu/vth/vthsupportclinicalpharmacology.htm
Radiology: The Radiology faculty comprises Drs James Brown, Jim Douglass, Ian Robertson, Gabriella Seiler and Don
Thrall. Dr Brown is Director of the Radiology Residency Program, Dr Robertson is Radiology Service Chief. Dr Seiler
joined the faculty in July 2009. The Radiology service requires two FTEs each day, one radiologist directing ultrasound
and one radiologist directing all other imaging modalities. Radiology is fully digital in all modalities, across all species. The
Radiology Information System (RIS) catalogues over 115,000 studies and the service generates over million images a
year.
Radiation Oncology: There are two radiation oncologists who provide support to radiation oncology. Dr. Amy Pruitt
(DOCS) is the major contributor, and Dr. Donald Thrall (MBS) provides backup support when needed. Radiation therapy
is a critical component of cancer treatment for many animals, and this service is a part of the overall oncology effort in the
veterinary teaching hospital. There is a residency training program in veterinary radiation oncology and one trainee
completes the program each year; these trainees have all been successful in becoming board certified in radiation
oncology and have gone on to an academic career, or to a specialized veterinary practice. Residents in medical
oncology, and students rotating through the oncology service, also receive instruction in the practice and principles of
radiation oncology. Radiation therapy is also a component of some prospective trials of new cancer therapy methods that
have the potential to improve response of both animal and human cancer to treatment.
Clinical Nutrition: Dr. Korinn Saker (boarded in Veterinary Clinical Nutrition) joined the MBS faculty in Feb. 2007. She
has no direct clinical assignment (that is, responsibility for patient care). However, she is the director of the VTH Clinical
Nutrition Consultation Service and faculty supervisor of the Nutrition Research Program (Room B 219D) at the CVM. The
clinical nutrition program has been recently established (March 2007). It provides a variety of nutrition services for both
small and large animal critical care patients, chronic disease patients, and recommendations for appropriate life-stage
and performance/production feeding management protocols for in-house cases. As part of the clinical nutrition service,
she is initiating an Obesity Management Program for overweight and obese companion pets. In addition, she receives
consultations each day via phone or e-mail from referring veterinarians, pet owners and producers requesting nutritionrelated information about appropriate diet choices, feeding guidelines, recent media concerns, homemade diet
31
formulations and evaluations.
In July 2008, this program expanded to include a nutrition-focused rotating internship training position and residency
training program in clinical nutrition to begin in July 2009. The nutrition research program currently focuses on
relationships between nutrition and specific oxidant-directed disease states including cancer and obesity.
Toxicology: Dr. David Dorman joined the CVM this year and is a Boarded Veterinary Toxicologist. He is currently
working to redevelop the poisonous plant garden by the pond as an important adjunct to the Veterinary Toxicology course
which he teaches. Dr. Dorman was hired as Associate Dean for Research and Graduate programs and is a faculty
member in MBS.
32
Appendix V
Publications, Presentations, Intellectual Property by Departmental Faculty
1. Original works in peer-reviewed journals. [Include invited state-of-the-art papers; do not include case reports
or review articles.
Apparao KBC, Newman DR, Zhang H, Khosla J, Sannes PL
Sulfated extracellular matrix modulates differentiation of human alveolar type II cells in vitro.
Proc Amer Thor Soc
2008; 5:372
Aragon CL, Read MR, Gaynor JS, Barnhart MD, Wilson D, Papich MG
Pharmacokinetics of an immediate and extended release oral morphine formulation utilizing the spheroidal oral drug
absorption system in dogs.
Journal of Veterinary Pharmacology & Therapeutics
2009 Apr; 32(2):129-136. PMID: 19290942
Arguedas MG, Hines MT, Papich MG, Farnsworth KD, Sellon DC
Pharmacokinetics of butorphanol and evaluation of physiologic and behavioral effects after intravenous and
intramuscular administration to neonatal foals.
Journal of Veterinary Internal Medicine
2008 Nov-Dec; 22(6):1417-26. PMID: 18976284
Arthur JJ, Kleiter MM, Thrall DE, Pruitt AF
Characterization of normal tissue complications in 51 dogs undergoing definitive pelvic region irradiation.
Veterinary Radiology & Ultrasound
2008; 49:85-89
Beddies G, Fox PR, Papich MG, Kanikanti VR, Krebber R, Keene BW
Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs.
American Journal of Veterinary Research
2008 Dec; 69(12):1659-63. PMID: 19046015
Bischoff SR, Tsai, S, Hardison NE, York AM, Freking BA, Nonneman D, Rohrer G, Piedrahita JA
Identification of SNPs and INDELS in swine using short oligonucleotide microarrays.
BMC Genomics
2008; 9:252-263. PMC2442091
Bizikova P, Papich MG, Olivry T
Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of
hydroxyzine to healthy dogs.
Veterinary Dermatology
2008 Dec; 19(6):348-357. PMID: 18980631
Blond L, Thrall DE, Roe SC, Chailleux N, Robertson ID
Diagnostic accuracy of magnetic resonance imaging for meniscal tears in dogs affected with naturally occurring cranial
cruciate ligament rupture.
Veterinary Radiology & Ultrasound
2008: 49:425-431
Blond L, Thrall DE, Roe SC, Chailleux N, Robertson ID
Diagnostic accuracy of magnetic resonance imaging for meniscal tears in dogs affected with naturally occuring cranial
cruciate ligament rupture.
Veterinary Radiology & Ultrasound
2008; 49(5):425-431
33
Breen M, Modiano J
Evolutionarily conserved cytogenetic changes in hematologic malignancies of dogs and humans - man and his best
friend share more than companionship.
Chromosome Research
2008; 16:145-154
Campoy L, Martin-Flores M, Looney AL, Erb HN, Ludders JW, Stewart JE, Gleed RD, Asakawa M.
Distribution of a lidocaine-methylene blue solution staining in brachial plexus, lumbar plexus and sciatic nerve blocks in
the dog.
Veterinary Anesthesia and Analgesia
2008 Jul; 35:275-362
Chen X, Epling-Burnette PK, Sokol L, Bai F, Zhou J, Painter JS, Sallman DA, Yoder JA, Djeu JY, Loughran TP, Wei S
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.
Blood. (2007 Impact factor: 10.896)
2009; 113:3226-3234
Clark-Price SC, Posner LP, Gleed RD
Recovery of horses from general anesthesia in a darkened or illuminated recovery stall.
Veterinary Anesthesia and Analgesia
2008; 35:473-479
Cole LK, Papich MG, Kwochka KW, Hillier A, Smeak DD, Lehman AM
Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage
otitis externa after intravenous administration of enrofloxacin.
Veterinary Dermatology
2009 Feb; 20(1):51-59. PMID: 19152587
Cook VL, Jones Shults J, McDowell M, Campbell NB, Davis JL, Blikslager AT
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
Equine Vet J
2008; 40:353-357
Davis JL, Kirk LM, Davidson GS, Papich MG
Effects of compounding and storage conditions on stability of pergolide mesylate.
Journal of the American Veterinary Medical Association
2009 Feb 1; 234(3):385-389. PMID: 19210262
Desai S, Heffelfinger AK, Orcutt TM, Litman GW, Yoder JA
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable
domains.
BMC Evolutionary Biology (2007 Impact factor: 4.09)
2008; 8:177
Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovish MA, Melchert M, Ku E, Zou J, Painter JS, Edwards TD,
Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP, Wei S.
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with
imbalanced NK receptor signaling.
Blood (2007 Impact factor: 10.896)
2008; 112:4694-4698
Estrada JL, Collins B, York A, Bischoff SR, Sommer J, Tsai S, Petters RM, Piedrahita JA
Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients.
34
Cloning and Stem Cells
2008; 10:287-296
Fischer BL, Ludders JW, Asakawa M, Fubini SL, Nixon AJ, Radcliffe RM, Erb HN
A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral
stifle arthroscopy.
Veterinary Anesthesia and Analgesia
2009 Jan; 36:67-76
Gilliam JN, Streeter RN, Papich MG, Washburn KE, Payton ME
Pharmacokinetics of florfenicol in serum and synovial fluid after regional intravenous perfusion in the distal portion of the
hind limb of adult cows.
American Journal of Veterinary Research
2008 Aug; 69(8):997-1004. PMID: 18672962
Goralska M, Nagar S, Colitz C, Fleisher L, McGahan M
Changes in ferritin H- and L-chains in canine lenses with age-related nuclear cataract.
Invest Ophthalmol Vis Sci (Cover Article)
2009; 50:305-310
Guedes AG, Papich MG, Rude EP, Rider MA
Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs.
Journal of Veterinary Pharmamcology and Therapeutics
2008 Aug; 31(4):334-43. PMID: 18638294
Hudson LC, Tompkins MB, Meeker RB
Endothelial cell suppression of in vitro peripheral blood mononuclear cell trafficking during acute exposure to feline
immunodeficiency virus.
Cell & Tissue Research
2008; 334: 55-65
Jamadar-Shroff V, Papich MG, Suter SE
Soy-derived isoflavones inhibit the growth of canine lymphoid cell lines.
Clinical Cancer Research
2009 Feb 15; 15(4):1269-1276. PMID: 19228730
Jima D, Shah R, Orcutt TM, Galloway T, Law JM, Litman GW, Trede N, Yoder JA
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity.
Molecular Immunology (2007 Impact factor: 3.742)
2009; 46:1505-1516
Kraft M, Adler KB, Ingram JL, Crews AL, Atkinson TP, Cairns CB, Krause DC, Chu HW
Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.
Eur Resp J
2008; 34:43-46
Lee E, Estrada JL, Piedrahita JA
A comparative study on the efficiency of two enucleation methods in pig somatic cell nuclear transfer: effects of the
squeezing and the aspiration methods.
Animal Biotechnology
2008; 19:71-79
Lin KW, Park JJ, Li Y, Adler KB
Protease-activated receptor – 2(PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in
35
vitro.
Int J Bioch Cell Biol
2008; 40:1379-1388
Lin TY, Thomas R, Tsai PC, Breen M, London CA
Generation and characterization of novel canine malignant mast cell line CL1.
Veterinary Immunology and Immunopathology
2009; 127:114-124
Modiano JF, Breen M
Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution.
Cancer Therapy
2008; (6):239-246
Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum.
Exp Cell Res
2009; 315(1):110-8
Papich MG
An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals.
Veterinary Clinics of North America Small Animal Practice
2008 Nov; 38(6):1243-66. PMID: 18954683
Papich MG, Schooley EK, Reinero CR
Pharmacokinetics of cetirizine in healthy cats.
American Journal of Veterinary Research
2008; 69:670-674
Park JJ*, Fang S*, Crews AL, Lin K-W, Adler KB (*Co-first authors)
MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins.
Am J Resp Cell Mol Biol
2008; 102:949-955
Patil M, Lee S, Macias E, Lam E, Xu C, Jones K, Ho C, Rodriguez-Puebla ML, Chen X
Role of cyclin D1 as a downstream signaling molecule of beta-catenin in hepatocarcinogenesis.
Cancer Research
2009; 69(1):253-261
Posner LP
Management of acute pain.
NAVC Clinicians Brief
2009; pp 13-18
Posner LP, Asakawa M, Erb HN
Propofol anesthesia in cats with hepatic lipidosis.
JAVMA
2008 Jun; 232:12; 1841-1843
Sekis I, Ramstead K, Rishniw M, Schwark WS, McDonough SP, Goldstein RE, Papich M, Simpson KW
Single-dose pharmacokinetics and genotoxicity of metronidazole in cats.
Journal of Feline Medicine & Surgery
2009 Feb; 11(2):60-8. Epub 2009 Jan 19. PMID: 19155181
36
Sellon DC, Papich MG, Palmer L, Remund B
Pharmacokinetics of butorphanol in horses after intramuscular injection.
Journal of Veterinary Pharmacology & Therapeutics
2009 Feb; 32(1):62-65. PMID: 19161457
Sullivan DE, Pociask D, Ferris MB, Brody AR
The latent form of TGF-beta1 is induced by TNF-alpha through an ERK specific pathway and is activated by asbestosderived reactive oxygen species in vitro and in vivo.
J Immunotox
2008; 5:145-9
Thomas R, Duke SE, Karlsson K, Evans A, Ellis P, Lindblad-Toh K, Langford CF, Breen M
Development of a 1Mb resolution, cytogenetically-validated genomic microarray for canine CGH analysis.
Cytogenetic and Genome Research
2008; 122:110-121
Wang X, Adler KB
Epithelial brush border proteomics and associated dysfunction.
J Epithelial Biology & Pharmacology
2008; 1:27-33
Wells SM, Glerum LE, Papich MG
Pharmacokinetics of butorphanol in cats after intramuscular and buccal transmucosal administration.
American Journal of Veterinary Research
2008 Dec; 69(12):1548-54. PMID: 19045999
Whang HS, Vendeix FAP, Gracz HS, Gadsby JE, Tonelli AE
NMR studies of the inclusion complex of cloprostenol sodium salt with beta-cyclodextrin in aqueous solution.
Pharm Res
2008 May; 25(5):1142-9. Epub 2007 Dec 5
Yoder JA, Cannon JP, Litman RT, Murphy C, Freeman JL, Litman GW.
Evidence for a transposition event in a second NITR gene cluster in zebrafish.
Immunogenetics (2007 Impact factor: 2.741)
2008; 60:257-265
Young AC, Kirkness E, Breen M
Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: The
canine PAR and PAB.
Chromosome Research
2008; 16:1193-1202
Young DD, Garner RA, Yoder JA, Deiters A
Light activation of gene function in mammalian cells via ribozymes.
ChemCommun (2007 Impact Factor: 4.52)
2009; 568-570
Young DD, Lusic, H, Lively MO, Yoder, JA, Deiters A.
Gene Silencing in mammalian cells with light-activated antisense agents.
ChemBioChem (2007 Impact factor: 3.446)
2008; 9:2937-2940
Zaunbrecher G, Mir B, Dunne PW, Breen M, Piedrahita JA
Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination
37
(HR) to non-homologous end joining (NHEJ).
Animal Biotechnology
2008; 19:6-21
Zorrilla LM, Irvin MS, Gadsby JE
Protein Kinase C Isoforms in the porcine corpus luteum: temporal and spatial expression patterns.
Domestic Animal Endocrinology
2009; 36:173-185. Epub Dec 2008
Zurney J, Kobayashi T, Holm G, Dermody T, Sherry B
The reovirus 2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of
interferon regulatory factor-9.
J Virology
2009; 83:2178-2187
2. Case reports in peer-reviewed journals.
Sudo K, Asakawa M, Nagata M
Disseminated flush after ovariohysterectomy in a miniature dachshund.
The Japanese Journal of Veterinary Dermatology
2008 Mar; 14:9-12
Taylor MB, Geiger DA, Saker KE, Larson MM
Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix and raw ground
beef.
JAVMA
2009; 234(8)
3. Review articles in peer-reviewed journals.
Breen M
Canine cytogenetic – from band to basepair.
Cytogenetics and Genome Research
2008; 120:50-60
Goralska M, Ferrell J, Harned J, Lall M, Nagar S, Fleisher LN, McGahan MC
Iron metabolism in the eye: a review.
Exp Eye Res
2009; 88:204-15
Martinez MN, Papich MG
Factors influencing the gastric residence of dosage forms in dogs.
Journal of Pharmaceutical Sciences
2009 Mar; 98(3):844-60. Review. PMID: 18661535
Wang Y, Bai C, Li K, Adler KB, Wang X
Role of airway epithelial cells in development of asthma and allergic rhinitis.
Resp Med
2008; 102:949-955
Yoder JA
Form, function and phylogenetics of NITRs in bony fish.
Dev Comp Immunol
2009; 33:135-144
38
4. Books
Riviere JE, Papich MG (Editors)
Veterinary Pharmacology and Therapeutics, 9th Edition.
Wiley-Blackwell Publishing, Ames, Iowa, USA
2009; 1524 pages
5. Chapters in Book
Breen M, Langford CF
Comparative cytogenetics.
In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://www.els.net/
2008
Brody AR
Asbestosis and silicosis.
In: Interstitial Lung Disorders, J Lynch (ed.)
2008
Davis JL, Papich MG, Heit MC
Chapter 39. Antifungal and antiviral drugs.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Guardabassi L, Houser GA, Frank LA, Papich MG
Chapter 11. Guidelines for antimicrobial use in dogs and cats.
In: Guide to Antimicrobial Use in Animals, Guardabassi L, Jensen LB, Kruse H (eds.), Blackwell Publishing,
LTD
2008
KuKanich B, Papich MG
Chapter 12. Opioid analgesic drugs.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Modiano JF, Breen M
Genetic basis of cancer.
In: Clinical Oncology, Elsevier
2008
Papich MG
Chapter 20. Anticonvulsant drugs.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG
Chapter 46. Immunosuppressive drugs and cyclosporine.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
39
2009; 1524 pages
Papich MG
Chapter 47. Drugs affecting gastrointestinal function.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG
Chapter 49. Drugs that affect the respiratory system.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG
Chapter 51. Therapeutic drug monitoring.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG, consulting editor
Appendix I, Table of common drugs: approximate dosages.
In: Kirk’s Current Veterinary Therapy XIV, Bonagura JD, Twedt DC (eds.), Saunders-Elsevier
2009; pp. 1306-1334
Papich MG, Riviere JE
Chapter 33. Sulfonamides and potentiated sulfonamides.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG, Riviere JE
Chapter 34. Beta-Lactam antibiotics: penicillins, cephalosporins, and related drugs.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG, Riviere JE
Chapter 35. Tetracycline antibiotics.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG, Riviere JE
Chapter 37. Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antimicrobials.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Papich MG, Riviere JE
Chapter 38. Fluoroquinolone antimicrobial drugs.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
40
Papich MG, Riviere JE
Chapter 36. Aminoglycoside antibiotics.
In: Veterinary Pharmacology and Therapeutics, 9th Edition , Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Park JA, Crews AL, Raiford KL, Adler KB
Mucus and mucus-secreting cells in COPD.
In: Chronic Obstructive Lung Diseases, Voelkel NF, McNee W (eds.)
2008, pp. 141-152
Posner LP, Burns PM
Sedatives: veterinary pharmacology and therapeutics
In: Veterinary Pharmacology & Therapeutics, Reviere JE, Papich MG
2008 pp. 337-380
Posner LP, Burns PM
Induction agents: veterinary pharmacology and therapeutics.
In: Veterinary Pharmacology & Therapeutics, Reviere JE, Papich MG
2008 pp. 265-300.
Reddy DS, Gadsby JE
Chapter 28. Hormones affecting reproduction.
In: Veterinary Pharmacology, 9th Edition, Riviere J, Papich MG (eds.), Blackwell, New York, USA
2009; pp. 717-733
Riviere JE, Papich MG
Chapter 1. Veterinary pharmacology: an introduction to the discipline.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Sherman BL, Papich MG
Chapter 21. Drugs affecting animal behavior.
In: Veterinary Pharmacology and Therapeutics, 9th Edition, Riviere JE, Papich MG (eds.), Wiley-Blackwell
Publishing, Ames, Iowa, USA
2009; 1524 pages
Sherry B, Patton JT, Dermody TS
Innate immune responses elicited by reovirus and rotavirus.
In: Cellular Signaling and Innate Immune Responses to RNA Virus Infections, Brasier AR, Garcia-Sastre A,
Lemon SM (eds.), American Society for Microbiology Press
August 2008
Waterman J, Adler KB
Reactive oxygen species and mucus production.
In: Free Radical Effects on Membranes, in series, Current Topics in Membranes, Matalon S (ed.)
2008; Volume 61, pp. 243-251
6. Titles of abstracts from scientific and professional veterinary conferences (i.e. abstracts submitted for
presentation as papers or posters at scientific/clinical conferences)
a. proceedings that are citable
Abbott J, Saker KE
41
Plasma chemistry variables of healthy cats receiving spironolactone.
Proceedings of the ACVIM
2008
Benoit J, Pruitt AF, Thrall DE
Use of wet gauze for bolus material for 6MV photons: impact of wetness level and air gap.
2008 Scientific Conference, American College of Veterinary Radiology, San Antonio TX
2008 Oct 21-25
Biskiova P, Papich MG, Olivry T
Pharmacokinetics and pharmacodynamics of hydroxyzine and cetirizine after hydroxyzine administration to
healthy dogs.
2008 ACVD Meeting, Veterinary Dermatology
2008; 19:106; Abstract
Bloom SK, Infante C, Everly A, Hanken J, Nascone-Yoder NM
Small molecule-mediated “phenotypic engineering” reveals a role for retinoic acid in anuran gut evolution.
Developmental Biology
2008; 319(2):497-498
Carter JC, Campbell NB, Posner LP, Swanson C
Hemodynamic affects of medetomidine continuous rate infusions in the dog.
Veterinary Anesthesia and Analgesia
2009; 36(2):188
Carter JE, Campbell NB, Posner LP, Swanson CS
The hemodynamic effects of medetomidine continuous rate infusion in the dog.
American College of Veterinary Anesthesiology Annual Meeting, Phoenix, AZ
2008 Sept 18-19
Crews AL, Potts E, Voynow JA, Fischer BM, Bumgardner S, Adler KB, Foster WM
A MARCKS-related peptide attenuates both mucin hypersecretion and inflammatory cell infiltration in an
elastase model of chronic bronchitis.
Am J Resp Crit Care Med
2008; 177:A332
Duke SE, Graphodatsky AS, Wayne RK, Breen M
A member of the pack: Insights into chromosome evolution in the canidae may reveal common breakpoints
in speciation and cancer.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Fang S, Crews AL, Chen W, Ren XR, Adler KB
Interactions between MARCKS and the chaperone Hsp70 in airway epithelium.
Amer J Resp Crit Care Med
2009
Fang S, Parikh I, Takashi S, Crews AL, Adler KB
BIO-11006, a truncated form of a MARCKS-related peptide, inhibits secretion of mucin and degranulation of
leukocytes in vitro.
Amer J Resp Crit Care Med
2009
Gavin K, Sarver A, Scott M, Vijjeswarapu M, Getzy DM, Newman RA, Cutter GR, Hunter L, Breen M,
42
Modiano JF
Expression profile of cancer-related genes associated with poor clinical outcome in canine osteosarcoma.
Invited Presentation; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Ghashghaei T
FoxJ1-specifies the adult neural stem cell niche.
Posters - Ben Jacquet presenter; Gordon Conference on Neural Development and the American Society for
Cell Biology
2008-2009
Goralska M, Nagar S, Colitz C, Fleisher L, McGahan M
Characteristics of ferritin H- and L-chains in canine lenses with age-related nuclear cataracts
XVIII International Congress on Eye Research
2008; pp. 204; Abstract P409
Goralska M, Nagar S, Fleisher L, McGahan M
Distribution of ferritin chains in noncataractous and cataractous canine lenses.
Experimental Biology
2009 Apr; pp. 18-22
Green TD, Park J, Jones SL, Adler KB
A MARCKS-related peptide inhibits migration of murine macrophages.
Amer J Resp Crit Care Med
2009
Hauck ML, Snyder SA, Dewhirst MW, Thrall DE
Evaluation of carbonic Anhydrase IX as a marker for changes in oxygenation in canine tumors.
99th Meeting of the American Association for Cancer Research, San Diego, CA
2008 Apr 12-16; ACR Meeting Abstracts:2038
Hedan B, Breen T, Nielsen, Motsinger-Reif AA, Thomas R, Cullen J, Breen M
Analysis of abnormalities in histiocytic tumors of bernese mountain dog and flat coated retriever by
comparative genomic hybridization.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Howard KE, Reckling SK, Dean GA
Regulatory T cell populations are altered in cats following acute infection with feline immunodeficiency virus
(FIV).
Experimental Biology (American Association of Immunologists), San Diego, CA
2008 Apr; Poster
Levine DN, Papich MG, Gookin JL, Davidson GS, Davis JL, Stagner WC, Goldman R, Williamson L
Ronidazole pharmacokinetics in cats after IV administration and oral administration of an immediate release
capsule and a colon-targeted delayed release tablet.
Journal of Veterinary Internal Medicine, 2008 ACVIM Forum, San Antonio, Texas
2008; 22:745; Abstract #148
Lin K, Park JJ, Fang S, Adler KB
MARCKS protein regulation of mucin secretion in airway epithelial cells: binding of MARCKS to chaperones
and to MyosinV.
Am J Resp Crit Care Med
2008; 177:A993
43
Lindblad-Toh K, Karlsson E , Tonomura N, Barber L, Burgess K, Breen M, Modiano J, McNiel E, Ostrander
E, London C, Comtock K, Azuma C
Mapping genetic risk factors for osteosarcoma and hemangiosarcoma.
Invited Presentation; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Macias E, Kin SH, Liu F, Rodriguez-Puebla ML
CDK4 overexpression as an epigenetic mechanism for loss of TGF-B/Smad3 signaling in mouse
keratinocytes and skin tumors.
Annual Meeting of the American Association for Cancer Research, San Diego, CA
2008
McGahan MC, Ferrell J, Fleisher LN, Nagar S, Lall MM, Harned J
Proteins integral to iron metabolism are regulated by hypoxia-inducible factor-1 in retinal pigmented
epithelial cells.
Invest Ophthalmol Vis Sci (Suppl)
2008; Abstract #1380
McGahan MC, Ferrell J, Nagar S, Lall M, Goralska M, Fleisher LN, Harned J
Ceruloplasmin alters intracellular iron metabolism and increases ferritin levels and glutamate secretion in
lens epithelial and retinal pigmented epithelial cells.
Invest Ophthalmol Vis Sci (Suppl)
2009; Abstract #1464
McMullen, Jr RJ, Salmon JH, Campbell NB, Davidson MG, Gilger BC
In vitro and in vivo evaluation of an equine intraocular lens.
American College of Veterinary Ophthalmology Conference, Boston, MA
2008 Oct 15-18
Moore SA, Munana KR, Papich MG, Nettifee-Osborne
The pharmacokinetics of levetiracetam in healthy dogs following single and multiple oral doses.
Journal of Veterinary Internal Medicine, 2008 ACVIM Forum, San Antonio, Texas
2008; 22:745; Abstract #83
Olby NJ, Papich MG, Parke N, Spinapolis K, Mehta PM, Harris T, Shi R, Smith D
Safety and pharmacokinetics of 4-Aminopyridine deravitives in dogs.
Journal of Veterinary Internal Medicine, 2008 ACVIM Forum, San Antonio, Texas
2008; 22:745; Abstract #75
Olby NJ, Parke N, Spinapolis K, Mehta PM, Harris T, Papich MG, Shi R, Smith D
Phase I clinical trial of 4-aminopyridine derivatives in dogs.
Journal of Veterinary Internal Medicine, 2008 ACVIM Forum, San Antonio, Texas
2008; 22:745; Abstract #76
Panetteiri RA, Jester WF, Jiang M, Zhao H, Liang J, Parikh I, Murphy T, Adler KB
Inhibition of ozone-induced airway inflammation by decreasing myristoylated alanine-rich C kinase substrate
function.
Am J Resp Crit Care Med
2008; 177:A495
Park J, Fang S, Crews AL, Chen W, Adler KB
The C-terminus of cysteine string protein (CSP) affects mucin secretion in normal human bronchial epithelial
(NHBE) cells.
44
Amer J Resp Crit Care Med
2009
Park JJ, Crews AL, Alper S, Schwartz DA, Adler KB
A potential role for airway epithelial cell mucin genes in fibrogenesis.
Am J Resp Crit Care Med
2008; 177:A727
Parr MA, Young D, Dush MK, Dieters A, Nascone-Yoder NM
Heterotaxin: a novel pyridine compound that perturbs left-right asymmetric organ morphogenesis.
Developmental Biology
2008; 319(2):513
Reed RA, Womble MA, Dush MK, Bloom SK, Tull RR, Morckel, AR. Nascone-Yoder NM
Luminobasal endoderm intercalation: a geometrically unique execution of convergent extension during gut
tube elongation.
Developmental Biology
2008; 319(2):513
Saker KE, Wilson A, Tanner AE
Feline mammary gland organ culture model for evaluation of nutritional chemoprevetive agents.
Proceedings of Compendium on Continuing Education for the Practicing Veterinarian
2009
Sannes PL, Apparao KB, Zhang H, Khosla J, Randell SH, Newman DR
Changes in expression of Wnt7A, FoxA1, and FoxA2 by isolated adult human alveolar epithelial cells in
vitro.
Proc Amer Thoracic Soc
2008: 177:A196
Sannes PL, Apparao KB, Zhang H, Khosla J, Randell SH, Newman DR
Changes in expression of forkhead transcription factors and TGF-β1 and Wnt signaling during differentiation
of alveolar epithelial cells in vitro and in Bleomycin-induced fibrosis.
Proc Amer Thoracic Soc
2009
Seiser EL, Thomas R, Breen TE, Richards KL, Suter SE, Breen M
Comprehensive characterization of structural and functional changes in canine lymphoid cell lines using
array-based comparative genomic hybridization, multicolor FISH analysis and gene expression profiling.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Sherry B, Zurney J, Kobayashi T, Holm GH, Dermody T
Reovirus inhibits interferon signaling through a novel mechanism involving nuclear accumulation of IRF9.
7th Joint Meeting of the International Cytokine Society and the International Society for Interferon and
Cytokine Research, Montreal, Canada
2008 Oct 12-16
Shiomitsu K, Johnson CL, Malarkey DE, Pruitt AF, Thrall DE
Expression of epidermal growth factor (EGFR) in malignant canine epithelial nasal tumors.
Vet Radiol Ultrasound
2008; 49:106
Sistrunk C, Macias E, Rodriguez-Puebla ML
45
Skp2 deficiency induces hair follicular apoptosis through p53 stabilization mediated by CBP/p300.
Annual Meeting of the American Association for Cancer Research, San Diego, CA
2008
Snyder SA, Thrall DE, Dewhirst MW, Qwzar K, Hauck ML
Gene expression canine sarcomas treated with radiation and hyperthermia.
99th Meeting of the American Association for Cancer Research, San Diego CA
2008 Apr 12-16; AACR Meeting Abstracts:1753
Thomas R, Duke SE, Wang HJ, Breen TE, Higgins RJ, Linder KE, Ellis P, Langford CF, Dickinson PJ, Olby
NJ, Breen M
Putting our heads together’ on brain tumors: Microarray-based comparative genomic hybridization analysis
of 60 canine intracranial tumors provides insights into conservation of cytogenetic profiles with their human
counterparts.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Thrall DE, Viglianti BL, MacFall J
Diffusion weighted imaging in canine sarcomas.
2008 Scientific Conference, American College of Veterinary Radiology, San Antonio,TX
2008 Oct 21-25
Tsai P-C , Breen TE , Lana SE, Nielsen D, Motsinger-Reif AA, Breen M
Canine lymphoma - the prognostic significance of cytogenetic changes.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Turnwald G, Stone E, Bristol D, Fuentealba C, Hardie E, Hellyer P, Jaeger L, Kerwin S, Kochevar D,
Lissenmore K, Olsen C, Rogers K, Sabin B, Swanson C, Warner A
Assessing clinical competency: Our professional responsibility.
J Vet Med Ed
2008; 35(3):343-353
Wang Y, Adler K, Slade DJ, Church TD, Webb RF, Chu HW, Jinwright D, Crews A, Kraft M
A MARCKS-related peptide inhibits MUC5AC expression in airway epithelial cells isolated from asthmatic
subjects.
Am J Resp Crit Care Med
2008; 177:A814
Waterman JT, Adler KB
Differential effects of albuterol and formoterol isomers on NF-κB activation in human airway epithelial cells.
Amer J Resp Crit Care Med
2009
Waterman JT, Jones JN, Adler KB
Albuterol-induced oxidant stress in primary cultures of normal human bronchial epithelial cells.
Am J Resp Crit Care Med
2008; 177:A469
Wilson A, Saker KE, Tanner AE
Feline mammary gland organ culture model for analysis of pomegranate juice as a chemopreventive.
Proceedings of the NCSU CVM Research Symposium
2008
46
Woolard K, Totonchy M, Thomas R, Breen M, Son MJ, Beederman M, Clark E, Simpson S, Lee J, Fine H
Canine gliomas are driven by tumor stem cells, which share significant similarities to their human
counterparts.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Young AC, Thomas R, Tsai P-D, Kisseberth WC, Motsinger-Reif A, Couto CG, Subramanian S, Nielsen
DM, Modiano JF, Breen M
Heritable and breed specific genetic abnormalities in canine osteosarcoma.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
b. proceedings that are not citable
Breen M
The dog – a genome with two tails.
Invited Speaker; Skippy Frank Translational Medicine Fund Multipdisciplinary Cancer Conference
2009 Jan 15
Breen M, Modiano JF
Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution.
Invited Speaker; Theilen Tribute Symposium at UC Davis
2008 May 31-Jun 1
Desai S, Heffelfinger A, Orcutt T, Litman G, Yoder J
Extreme diversity between zebrafish and medaka novel immune-type receptor (NITR) genes.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Garner A, Lusic H, Orcutt T, Yoder J, Deiters A
Light-activated morpholinos and their application in spatio-temporal gene regulation.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Garner RA, Lusic H, Orcutt TM, Yoder JA, Deiters A
Light-activated morpholinos and their application in spatio-temporal gene regulation.
Third Strategic Conference of Zebrafish Investigators, Asilomar, CA
2009 Jan 24-28; Poster
Goralska M, Nagar S, Colitz C, Fleisher LN, McGahan MC
Characteristics of ferritin H-and L-chains in canine lenses with age-related nuclear cataracts.
Presented at the XVIII International Congress of Eye Research, Beijing, China
2008 Sept
Goralska M, Nagar S, Fleisher LN, McGahan MC
Distribution of ferritin chains in noncataractous and cataractous canine lenses.
Experimental Biology Meeting, New Orleans, LA
2009 Apr
Hauck ML, Mahoney JA, Snyder SA, Thrall DE
Preliminary results of transcriptosome analysis of metastatic and non-metastatic canine soft tissue
sarcomas.
Veterinary Cancer Society Annual Meeting, Seattle, WA
2008 Oct 18-21
47
Hedan B, Breen T, Nielsen D, Motsinger-Reif A, Thomas R, Cullen J, Breen M
Analysis of abnormalities in histiocytic tumors of the Bernese Mountain Dog and Flat-Coated Retriever by
comparative genomic hybridization.
American Kennel Club Canine Health Foundation 5th annual meeting- Genes, Dogs and Cancer, Orlando,
FL
2009 Feb
Horowitz J
Cloning and characterization of the developmental expression and biochemical and functional properties of
zebrafish (Danio rerio) Sp2 and Sp3.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-28
Horowitz J
Comparative investigation of the chicken and human plasma proteome: Implications for biomarker discovery
in epithelial ovarian cancer.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-28
Howard KE, Reckling SK, Dean GA
Loss of regulatory T cells following acute mucosal infection with feline immunodeficiency virus (FIV).
Ninth International Feline Retrovirus Research Symposium, Vienna, Austria
2008 Aug; Poster
Howard KE, Suter SE
Identification of B-cell lymphomas in the cat/feline immunodeficiency virus model prior to the development of
macroscopic or histologic tumors: An animal model for AIDS-related Non-Hodgkin’s lymphoma.
Eleventh International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies,
Washington DC
2008 Oct; Poster
Jima D, Shah R, Orcutt T, Joshi D, Law M, Litman G, Trede N, Yoder J
Enhanced transcription of complement and coagulation cascade genes in the absence of adaptive
immunity.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Law M, Cheely C, Yoder J
Caution, new paradigm ahead: fish eggs, molecular dosimetry, and new trends in safety testing.
American College of Veterinary Pathologists Annual Meeting, San Antonio, TX
2008 Nov15-19; Poster
Li L, Sevinsky J, Stephenson JL, Sherry B
Using proteomic approaches to investigate reovirus-induced changes in mouse primary cardiac myocyte
cultures.
American Society for Virology, 27th annual meeting, Cornell University, Ithaca, NY
2008 Jul12-16
Messenger KM, Davis JL, LaFevers DH, Barlowe BM, Posner LP
The pharmacokinetics of intravenous and sublingual buprenorphine in horses.
NCSU CVM Research Forum, 2nd Place Graduate Student Award Winner
2009 Mar
48
Morckel A, Young D, Deiters A, Nascone-Yoder N
Light activated modulation of protein activity (LAMP): a tool for spatiotemporal control of signaling
components in living embryos.
Southeastern Regional Society for Developmental Biology Meeting
2009; Abstract
Newman DR, Apparao KB, Zhang H, Khosla J, Sannes PL
Changes in expression of forkhead transcription factors and Wnt signaling in bleomycin-induced fibrosis.
International Colloquium on Pulmonary Fibrosis, Sunset Beach, NC
2008
Nordone S
TLR8 stimulation of HIV-1-infected regulatory T cells uncouples dendritic cell control of suppression.
Keystone Regulatory T cell meeting proceedings, Keystone, CO
2009 Mar
Sannes PL, Apparao KB, Zhang H, Khosla J, Newman DR
Changes in expression of forkhead transcription factors and TGF-β1 and Wnt signaling during differentiation
of alveolar epithelial cell in vitro.
International Colloquium on Pulmonary Fibrosis, Sunset Beach, NC
2008
Seiser EL, Thomas R, Richards KL, Breen TE, Moore P, Suter SE, Breen M
Comprehensive characterization of structural and functional changes in canine lymphoid cell lines using
array-based comparative genomic hybridization, multicolor FISH analysis and gene expression profiling.
American Kennel Club Canine Health Foundation 5th annual meeting- Genes, Dogs and Cancer, Orlando,
FL
2009 Feb
Shah R, Eason D, Haire R, Mueller G, Traver D, Litman G, Yoder J
Anti-Nitr9 monoclonal antibodies define relative levels of three Nitr9 isoforms in zebrafish tissues.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Thomas R, Duke SE, Wang H, Breen T, Higgins RJ, Linder K, Ellis P, Langford CF, Dickinson P, Olby NJ,
Breen M
Putting our heads together: microarray-based CGH analysis provides insights into genomic conservation
between human and canine intracranial tumors.
American Kennel Club Canine Health Foundation 5th annual meeting- Genes, Dogs and Cancer, Orlando,
FL
2009 Feb
Ward JL, McCartney S, Chinnadurai S, Posner LP
Effects of analgesics on minimum anesthetic concentration (MAC) of tricaine methanesulfonate (MS 222) in
goldfish.
NCSU CVM Research Forum
2009
Woolard K, Totonchy M, Thomas R, Breen M, Son MJ, Beederman M, Clark E, Simpson M, Lee J, Fine H
Canine Gliomas are driven by tumor stem cells, which share significant similarities to their human
counterparts.
American Kennel Club Canine Health Foundation 5th annual meeting- Genes, Dogs and Cancer, Orlando,
FL
2009 Feb
49
Xie J, Hast B, Yin H, Nichols T, Yoder J, Horowitz J
Cloning and characterization of the developmental expression and biochemical and functional properties of
zebrafish (Danio rerio) Sp2 and Sp3.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Yang J, Charette J, Sullivan M, Runft D, Kim C, Neely M, Yoder J
Transcriptional response of zebrafish immune-related lectin like receptors (ILLRs) to immune challenge.
8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-29; Poster
Young AC, Thomas R, Tsai P-C, Kisseberth W, Subramanian S, Modiano JM, Breen M
Heritable and breed specific genetic abnormalities in canine osteosarcoma.
American Kennel Club Canine Health Foundation 5th annual meeting- Genes, Dogs and Cancer, Orlando,
FL
2009
7. Titles of invited presentations papers (including CE) where the primary audience was professionals
(veterinarians, scientists, etc.)
Adler KB
Cell proliferation, differentiation and carcinogenesis.
Invited Session Chair; European Respiratory Society meeting, Estoril, Portugal
2009 Mar
Adler KB
University of North Carolina, Chapel Hill, NC, Cystic Fibrosis Center; Host: Dr. Martina Gentzsch
2009 Feb
Adler KB
Session Chair and Speaker; Organizing Committee Member, 5th International Symposium on Respiratory
Disease, Shanghai, China
2008 Nov
Adler KB
Lovelace Respiratory Research Institute, Albuquerque, NM; Host: Dr. Yohannes Tesfaigzi
2008 Oct
Adler KB
Differential effects of albuterol and formoterol isomers on generation of internal oxidants in human airway
epithelial cells.
Session Chair and Invited Speaker; Sepracor Scientific Research Forum, New Orleans, LA
2008 Sept
Adler KB
Targeting the MARCKS protein in COPD
Invited Speaker; 15th International Conference of the Inflammation Research Association, Chantilly, VA
2008 Sept
Adler KB
Co-Chair; International Conference on Pulmonary & Airway Fibrosis, Sunset Beach, NC
2008 Sept
50
Adler KB
University of Illinois at Chicago, Chicago, IL; Host: Dr. Usha Raj
2008 Aug
Adler KB
Invited Speaker and Session Chair; 2008 FASEB Summer Research Conference on Lung Epithelium in
Development and Disease, Saxtons River, Vermont
2008 Aug
Adler KB
Co-Chair and Invited Speaker; Pacific Rim Airway Mucus Symposium 2008, Seoul, Korea
2008 Mar
Arasu P
Invited Speaker and Guest of Honor; Food Safety, Quality Assurance & Global Trade: Concerns and
Strategies, Organized by G. B. Pant University of Agriculture and Technology, Pantnagar, India in
collaboration with Michigan State University
Indian Association of Veterinary Public Health Specialists Annual Meeting
2008; Nov 17-21
Arasu P
Food allergies: a battle with the immune system.
VII Annual Conference of the Association of Indian Veterinary Public Health Specialists
2008 Nov 7-9
Asakawa M
Analgesia technique for orthopedic surgery.
Perioperative opioid analgesia.
Western Veterinary Conference, Las Vegas
2009 Feb
Breen M
The dog – a genome with two tails.
Invited Speaker; Skippy Frank Translational Medicine Fund Multipdisciplinary Cancer Conference
2009 Jan 15
Breen M, Modiano JF
Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution.
Invited Speaker; Theilen Tribute Symposium at UC Davis
2008 May 31-Jun 1
Brody AR
Invited Speaker; University of Southern California, Department of Pulmonary and Critical Care Medicine,
Los Angeles
2008 Jan
Brody AR
Invited Speaker; Hopital Bichat, Department of Lung Biology, Paris
2008 Jun
Brody AR
Visiting Scientist; UC Davis College of Medicine, Davis, CA
2008 Oct
51
Brody AR
Invited Speaker; University of South Alabama
2009 Jan
Brody AR
Co-Chair; Symposium on Stem Cells in Interstitial Disease and Lung Cancer, Annual Meeting of the
American Thoracic Society
2009 May
Brody AR
Invited Speaker; Francoise and Guy Basset Memorial Conference, Paris
2009 Jun
Brody AR
Co-Chair; Conference and Named Lecturer, Annual Aspen Lung Conference, The Environment and the
Lung
2009 Jun
Brown J
Urinary tract imaging.
Oncology case discussion.
2008 NC Veterinary Conference
2008
Brown J
CR and DR: What’s the difference?
Avoiding digital imaging artifacts.
Digital Radiography Seminar Program, NCSU, CVM
2008
Brown J, Robertson ID, Thrall DE
Digital imaging for the veterinary practitioner: practitioners already having a digital radiographic system.
North Carolina State University, Raleigh, NC
2008 Sept 28
Brown J, Robertson ID, Thrall DE
Digital imaging for the veterinary practitioner: practitioners considering the acquisition of a digital
radiographic system.
North Carolina State University, Raleigh, NC
2008 Oct 4
Campbell NB
Provide sedation services for dogs and cats for the small animal abdominal ultrasound course and advice to
course participants.
NCSU, CVM
2007-present
Campbell NB
How to anesthetize the critical patient.
Intern Orientation, NCSU, CVM
2008 Jun
Campbell NB
52
Clinical use of alpha-2 agonists.
Collaboration with Dr. D. Grenville Stansfield (Senior Specialty Hospital Liaison, Pfizer), NCSU, CVM
2008 Nov
Duke SE, Graphodatsky AS, Wayne RK, Breen M
A member of the pack: insights into chromosome evolution in the canidae may reveal common breakpoints
in speciation and cancer.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Gadsby J
Intra-luteal and Immune system factors in control of the corpus luteum.
Invited Seminar; Reproduction Group at the Royal Veterinary College, Hawkshead Campus, UK
2008 Apr 21
Gadsby J
Control of “luteolytic sensitivity” by TNF-.
Invited Seminar; LINK (Sheldon Research Project) meeting, Institute of Life Science, School of Medicine,
Swansea University, Wales, UK
2008 Jun 2
Gadsby J
Intra-luteal and Immune system factors in control of the corpus luteum.
Invited Seminar, Reproduction Physiology Group at the School of Biosciences, University of Nottingham,
Sutton Bonington Campus, UK
2008 May 15
Gadsby J
Regulation of the porcine corpus luteum; so many factors….so little time…!
Invited Seminar; College Seminar Series, Royal Veterinary College, Camden Town Campus, UK
2008 Apr 23
Gavin K, Sarver A, Scott M, Vijjeswarapu M, Getzy DM, Newman RA, Cutter GR, Hunter L, Breen M,
Modiano JF
Expression profile of cancer-related genes associated with poor clinical outcome in canine osteosarcoma.
Invited Presentation; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Hedan B, Breen T, Nielsen D, Motsinger-Reif AA, Thomas R, Cullen J, Breen M
Analysis of abnormalities in histiocytic tumors of bernese mountain dog and flat coated retriever by
comparative genomic hybridization.
Invited Presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Howard KE
Mucosal pathogenesis of feline immunodeficiency v irus: Is the game over before it starts?
University of Georgia, Athens, GA
2008 Apr
Howard KE
Mucosal immune dysfunction and oncogenesis in feline immunodeficiency virus infection.
Louisiana State University, Baton Rouge, LA
2008 Jul
Lindblad-Toh K, Karlsson E, Tonomura N, Barber L, Burgess K, Breen M, Modiano J, McNiel E, Ostrander
53
E, London C, Comtock K, Azuma C
Mapping genetic risk factors for osteosarcoma and hemangiosarcoma.
Invited Presentation; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Nascone-Yoder N
Basolumenal endoderm intercalation: a geometrically unique execution of convergent extension during gut
tube elongation.
Southeast Regional Society for Developmental Biology Meeting
2008
Nascone-Yoder N
Mechanisms of endoderm morphogenesis: a gut reaction.
Invited Presentation; University of Miami, Biology Department Seminar Series, Miami, FL
2008
Nordone S
The prospects for immunizing against Bartonella species: strategies for vaccine development in the absence
of a relevant animal model.
2008 Conference on Vaccine Development against Carrion’s Disease by the Peruvian Institute of Health
2008
Papich MG
Optimizing antimicrobial therapy: strategies for improving patient care and minimizing resistance.
North American Veterinary Conference (NAVC), Orlando, Florida
2009 Jan 19
Papich MG
Antimicrobial drug therapy: myths & misconceptions.
North American Veterinary Conference (NAVC), Orlando, Florida
2009 Jan 19
Papich MG
Update on antimicrobial drugs for 2009.
North American Veterinary Conference (NAVC), Orlando, Florida
2009 Jan 19
Papich MG
Your patient is still in pain – now what? (presented jointly with Dr. Lysa Posner)
North American Veterinary Conference (NAVC), Orlando, Florida
2009 Jan 19
Papich MG
Analgesic treatment for small animals .
Western Veterinary Conference (WVC), Las Vegas, Nevada
2009 Feb 16-18
Papich MG
Antimicrobial drug therapy: myths & misconceptions.
Western Veterinary Conference (WVC), Las Vegas, Nevada
2009 Feb 16-18
Papich MG
Update on antimicrobial drugs for 2009.
54
Western Veterinary Conference (WVC), Las Vegas, Nevada
2009 Feb 16-18
Papich MG
Your patient is still in pain – now what? (presented jointly with Dr. Lysa Posner)
Western Veterinary Conference (WVC), Las Vegas, Nevada
2009 Feb 16-18
Papich MG
Strategies for antibiotic treatment in small animals.
Washington State Veterinary Medical Association Annual Meeting, Spokane, Washington
2008 Oct 4
Papich MG
Treatment of resistant infections and use of new antibiotics; An update on the existing and new antiinflammatory drugs.
Washington State Veterinary Medical Association Annual Meeting, Spokane, Washington
2008 Oct 4
Papich MG
The most common myths about drug therapy.
Washington State Veterinary Medical Association Annual Meeting, Spokane, Washington
2008 Oct 4
Papich MG
Case presentations: managing resistant infections.
American College of Veterinary Internal Medicine (ACVIM) Annual Forum, San Antonio, Texas
2008 Jun 5
Papich MG
New drugs and therapies for 2008.
North Carolina Veterinary Conference, Research Triangle Park, NC
2008 Nov 6
Papich MG, Riviere JE
Veterinary and comparative pharmacokinetic principles (2 day workshop).
Food and Drug Administration Center for Veterinary Medicine, Rockville, Maryland
2008 May 15-16
Piedrahita JA
iPS cells in swine.
Invited Speaker; International Embryo Transfer Society Annual Meeting, Special Stem Cell Session,San
Diego, CA
2009 Jan
Piedrahita JA
Epigenetics and reproduction.
Invited Speaker; Texas A&M University, Department of Pathobiology Seminar Series
2009 Jan
Piedrahita JA
SCNT and biomedical applications.
Invited Speaker; Triangle Reproductive Biology Symposium, NIEHS
2009 Jan
55
Posner L
Rescue analgesia
.
Constant rate infusion and pain.
Anesthesia misconceptions.
Anesthesia for emergencies.
NAVC, Orlando Florida
2009 Jan
Posner L
Rescue analgesia.
Anesthetic induction agents.
Anesthesia for emergencies.
Western Veterinary Conference
2009 Feb
Posner L
Standing sedation in horses.
Anesthesia for cardiac patient.
NCVC, Raleigh, NC
2008 Nov
Posner L
Anesthesia & analgesia topics.
VT Veterinary Medical Association
2008 Jun
Robert son I
Digital imaging.
Veterinary MRI, VSRP Annual Conference
2009 Mar
Robertson I
Digital imaging.
Webster Veterinary Supplies, Charlotte, NC
2008 Oct
Robertson I
Image storage, retrieval, backup and transmission.
Digital Radiography Seminar, NC State
2008 Oct
Robertson I
Digital image distribution and dissemination.
Veterinary Neuro MRI Course, NC State
2008 Jul
Robertson I
Myelography.
Neuroscience Course, NC State
2008 Jul
Robertson I
CT.
56
Neuroscience Course, NC State
2008 Jul
Piedrahita JA
Role of epigenetics in placental function.
Invited Speaker, Molecular Reproduction and Development, Brown University, Rhode Island
March 2009
Saker K
A nNutritional component of wellness care.
Community Practice Service Conference
2008 May
Saker K
Feline mammary gland organ culture model for evaluation of nutritional chemoprevetive agents.
2008 Nestle Purina Nutrition Forum
2008 Oct
Saker K
Deciphering diet labels.
Alternative diet culture.
Nutritional support roadmap for disease management.
Post-colic nutrition.
Helping the dam feed her newborn.
The NC Veterinary Continuing Education Program
2008 Nov
Sannes PL
Sulfated extracellular matrices in the modulation of gene and protein expression in the pulmonary alveolus.
Symposium on Extracellular Matrix, American Thoracic Society Meeting, Toronto, CA
2008 May
Sannes PL
Developmental pathways in the differentiation of adult human alveolar epithelial cells in vitro.
University of California at Davis, College of Medicine
2009 Jan
Seiser EL, Thomas R, Breen TE, Richards KL, Suter SE, Breen M
Comprehensive characterization of structural and functional changes in canine lymphoid cell lines using
array-based comparative genomic hybridization, multicolor FISH analysis and gene expression profiling.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Sherry B
Straight from the heart: the cardiac response to viral infection.
University of Michigan Medical School, Department of Microbiology and Immunology
2008 Nov 6
Sherry B
Cell type-specific innate immunity.
State-of-the-Art presentation at the American Society for Virology, 27th annual meeting, Cornell University,
Ithaca, NY
2008 Jul 12-16
57
Sherry B, Zurney J, Li L, O’Donnell S, Sevinsky J, Stephenson J, Dermody T
The cardiac innate response to viral infection.
Kansas State University symposium: Emerging Infections: A Tribute to the One Medicine, One Health
Concept, Manhattan, KS
2008 No 13-14
Swanson C
Ideal anesthesia: tailoring premedication and intravenous induction choices to the needs of patients and the
people who handle them.
Veterinary Forum, NC State University College of Veterinary Medicine, Raleigh, NC
2008 Sept 17
Swanson C
Fish ecology and physiology.
Fish Health Management Course, NC State University College of Veterinary Medicine, CMAST, Morehead
City, NC
2008 Oct 9-11
Thomas R, Duke SE, Wang HJ, Breen TE, Higgins RJ, Linder KE, Ellis P, Langford CF, Dickinson PJ, Olby
NJ, Breen M
Putting our heads together’ on brain tumors: microarray-based comparative genomic hybridization analysis
of 60 canine intracranial tumors provides insights into conservation of cytogenetic profiles with their human
counterparts.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Tsai P-C, Breen TE, Lana SE, Nielsen D, Motsinger-Reif AA, Breen M
Canine lymphoma - the prognostic significance of cytogenetic changes.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Woolard K, Totonchy M, Thomas R, Breen M, Son MJ, Beederman M, Clark E, Simpson M, Lee J, Fine H
Canine gliomas are driven by tumor stem cells, which share significant similarities to their human
counterparts.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Yoder JA
Assessing infection and immunity in zebrafish.
Invited Talk; 8th International Meeting on Zebrafish Development and Genetics, Madison, WI
2008 Jun 25-28
Yoder JA
Light-activatable morpholinos for spatio-temporal gene regulation.
Invited Talk; 3rd Strategic Conference of Zebrafish Investigators, Asilomar, CA
2009
Young AC, Thomas R, Tsai P-C, Kisseberth WC, Motsinger-Reif A, Couto CG, Subramanian S, Nielsen DM,
Modiano JF, Breen M
Heritable and breed specific genetic abnormalities in canine osteosarcoma.
Invited presentation – Trainee; Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
58
8. Works prepared for presentation and distribution through electronic media, including CD-ROMS, audio and
video disks and tapes, computer-generated presentations, broadcast videos, etc.
Arasu P
A roadmap for combating Zoonotic Diseases in India.
Helped organize and formulate report resulting from the June 23, 2008, workshop held in New Delhi India at
the offices of the Public Health Foundation of India. Workshop participants included Dr. Peggy Bentley,
UNC Chapel Hill School of Public Health, RTI International (Dr. Scott Wetterhall), USAID, USDA and US
Embassy staff in India as well as 23 human health and animal health related agencies in India. This was
the first effort at convening this disparate group in India focused on the US initiative of One Health.
Barnes J
Be the Veterinarian, DVD – designed to introduce middle school youth to the veterinary profession.
9. Titles of continuing education presentations/papers/proceedings where the primary audience was not
professionals (livestock producers, dog breeders, horse owners, etc.)
Campbell N
Sedation and general anesthetic techniques in equine practice.
VTH Technician Forum, NCSU, CVM
2008 Jun
Piedrahita JA
Updates on cloning and transgenic in swine.
Invited Speaker; Sigma Xi lunch seminar series, RTP
2009 Mar
Saker K
Topic area: obesity management
Developed a syllabus and course materials for an on-line CE program for veterinary practitioners.
Sponsored by IAMS Pet Nutrition
10. Bulletins, booklets, and similar educational material developed for distribution.
Arasu P
Food allergies: a battle with the immune system.
Invited paper; AVPH Annual Symposium, GB Pant University, India
IAVPH Proceedings
2008 Nov 7-9
Papich M
USP (United States Pharmacopeia) Pharmacist’s Pharmacopeia, Second Edition.
Sponsor of two monographs: Sodium bromide injection, veterinary and sodium bromide oral solution,
veterinary.
2009
Papich M
Clinical Laboratory Standards Institute (CLSI), Performance Standards for Antimicrobial Disk and Dilution
Susceptibiltiy Tests for Bacteria Isolated from Animals; approved Standard – M31-A3, Third Edition, Volume
28, Number 8. MG Papich, Co-author of third edition, and member of subcommittee, 2008.
Clinical and Laboratory Standards Institute (CLSI), 940 West Valley Road, Suite 1400, Wayne,
Pennsylvania 19087
Papich M
59
Clinical Laboratory Standards Institute (CLSI), Development of in vitro Susceptibility Testing Criteria and
Quality Control Parameters for Veterinary Antimicrobial Agents; Approved Guideline – Third Edition. M37A3. Volume 28, Number 7. MG Papich, Co-author of third edition, and member of subcommittee, 2008.
Clinical and Laboratory Standards Institute (CLSI), 940 West Valley Road, Suite 1400, Wayne,
Pennsylvania 19087
Papich M
Managing microbes.
Pfizer Animal Health and distributed to veterinarians, developed by MG Papich.
Wall Poster
Saker K
Nutrition and the cancer patient: where to start?
Veterinary Cancer Society Newsletter
2009; 33(1):9-10
60
Appendix VI
Other Professional Achievements
APPOINTMENT OR ELECTION TO RESEARCH STUDY SECTIONS AND NATIONAL ADVISORY COUNCILS
Adler KB
Member, NIH Special Review Committee Study Sections; June, August, September, January, February, March
Chair, California Tobacco-Related Diseases Pulmonary Research Study Section, March 2009
Member, Nebraska DOH Respiratory Review Panel, April 2009
Chair, Flight Attendants’ Medical Research Institute Study Section, October 2008
Other Reviews, Florida Biomedical Research Program
Arasu P
Member, USDA International Science and Education Grant Review Panel, March 2009
Breen M
Member, Morris Animal Foundation Scientific Advisory Board (continuation), 2005-2009
Cancer Research UK Reviewer (continuation), Ad-Hoc
AKC Canine Health Foundation Grant Reviewer (continuation), Ad-Hoc
Wellcome Trust (U.K.) Grant Reviewer (continuation), Ad-Hoc
BBSRC Grant Reviewer (continuation), Ad-Hoc
Cancer Research UK Reviewer (continuation), Ad-Hoc
Netherlands Organization for Scientific Research (new), Ad-Hoc
Brody A
National Institute of Allergy and Infectious Diseases Study Section, Bethesda, February 2008
National Institute of Environmental Health Sciences Study Section, RTP, NC, April 2008
National Heart Lung and Blood Institute Study Section, Bethesda, August 2008
Dean GA
Full Member, NIH/NIAID AIDS Immunology and Pathogenesis (AIP)
NIH/NIDCR Special Emphasis P01 Panel
Wellcome Trust
Horowitz J
Chairman, U.S. Army Medical Research and Development Command (USAMRDC) Ovarian Cancer Study Section, (CAR;
2008)
McGahan MC
Appointed to National Advisory Eye Council, term 2007-2010
Nascone-Yoder N
Grant Review Panel Member, American Heart Association, Cardiovascular Development, March 2009
Ad Hoc Grant Reviewer, NSF
Nordone S
Journal of Leukocyte Biology
Infection and Immunity
Piedrahita JA
NIH SBRI, April 2006
Ad-Hoc Reviewer for the Maryland Agricultural Research Station Research Program, 2008
Ad-Hoc Reviewer for the Danish Research Council
Ad-Hoc Reviewer for AKC foundation
61
Rodriguez M
NIH/NCI Study Section, Tumor Cell Biology, permanent member since June 2006
Sannes PL
National Institutes of Health:
Special Emphasis Panel, National Institute for Environmental Health Sciences, Superfund
Special Emphasis Panel, National Institute for Environmental Health Sciences, Manufactured Nanoparticles
Thrall D
Editor-In-Chief, Veterinary Radiology & Ultrasound, Official Journal of the American College of Veterinary Radiology, the
European College of Veterinary Radiology, the European Association of Veterinary Diagnostic Imaging and the
International Veterinary Radiology Association
Yoder J
Ad-Hoc Member, NIH/NIAID Special Emphasis Panel/Scientific Review Group 2009/01 AITC, October 2008
APPOINTMENT TO EDITORIAL BOARDS
Adler KB
American Journal of Respiratory Cellular and Molecular Biology:
Associate Editor, 4/2003 Deputy Editor, 10/2003 –
Editor-In-Chief, 10/2008 American Journal of Physiology, Lung Cellular & Molecular Physiology
International Journal of Biochemistry and Cell Biology
Expert Review of Respiratory Medicine
Aspen Lung Conference International Advisory Board, 1999Respiratory Research: Associate Editor, 2004 –
Journal of Organ Dysfunction, Editor, 2005 Breen M
Veterinary and Comparative Oncology (continuation)
Brody A
American Journal of Pathology
American Journal of Physiology, Lung, Cellular, and Molecular Physiology
American Journal of Respiratory, Cell, and Molecular Biology
Current Respiratory Medicine Reviews
Journal of Environmental Pathology, Toxicology, and Oncology
Journal of Inflammopharmacology
Journal of Organ Dysfunction
Section Editor (Pathology), Journal of Lipid Mediators and Cell Signaling
Dean G
Journal of Veterinary Clinical Pathology
Gadsby J
Domestic Animal Endocrinology, August 2006-present
Horowitz J
Biochemical Journal
62
McGahan MC
Experimental Eye Research
Ocular Pharmacology & Therapeutics
Papich MG
Member, Editorial Review Board, Veterinární Medicína Vet Med – Czech, 2007-present
Appointed as Editor of Review Manuscripts, Journal of Veterinary Pharmacology and Therapeutics, 2005-present
Member, Editorial Review Board, Journal of Veterinary Pharmacology and Therapeutics, 1988-present
Member, Editorial Review Board, Journal of the American Animal Hospital Association, 1985-present
Member, Editorial Review Board, Journal of Feline Medicine and Surgery, 2003-present
Piedrahita JA
Journal of Biomedicine and Biotechnology
Sannes P
Board of Review, The Anatomical Record
Editorial Board, Journal of Organ Dysfunction
Editorial Board, American Journal of Respiratory Cell and Molecular Biology
Sherry B
Associate Editor, PLoS Pathogens, 2008-present
Editor, Virology, 2005-present
Editorial Board, Virology, 2004-present
AD HOC MANUSCRIPTS REVIEWS
Adler KB
AmerJ Physiol, Lung Cellular and Molecular Physiology
Amer J Physiol, Gastrointestinal and Liver Physiology
Amer J Resp Cell Molec Biology
Amer J Resp Crit Care Med
Amer J Pathology
Biochemical Pharmacology
Cancer Letters
Cell Biology International
Chest
Cytokine
European Respiratory Journal
FASEB J
Inflammation Research
Internat J Biochem Cell Biol
J Allergy Clin Immunol
J Appl Physiology
J Clin Invest
J Immunology
J Medicinal Chemistry
J Pharmacol Exper Therap
Molecular & Cellular Biology
Respiratory Physiology & Neurobiology
Respir Res
Barnes J
AJVR
63
Breen M
Chromosome Research
Cytogenetic and Genome Research
Genome Research
Genomics
Journal of Animal Breeding and Genetics
Journal of Heredity
Journal of the American Veterinary Medical Association
Journal of Veterinary Internal Medicine
Mammalian Genome
Veterinary and Comparative Oncology
Veterinary Journal
Brody A
American Journal of Respiratory and Critical Care Medicine
Chemico-Biological Interactions
Environmental Health Perspectives
Environmental Research
FASEB Journal
Journal of Cellular Physiology
Journal of Clinical Investigation
Journal of Immunology
Journal of the American Physiological Society
Laboratory Investigation
Chest
Brown J
Veterinary Radiology and Ultrasound
Dean G
Vaccine
Journal of Immunology
Veterinary Pathology
Journal of Virology
Blood
Veterinary Immunology and Immunopathology
Journal of Veterinary Clinical Pathology
Gadsby J
Biology of Reproduction
Reproduction
Domestic Animal Endocrinology
Journal of Veterinary Pharmacology and Therapeutics
Ghashghaei T
Nature Neuroscience
Cerebral Cortex
Horowitz J
Biochemical Journal
Nucleic Acids Research
Tissue Engineering
64
Hudson L
Vet Rad & Ultrasound
Alcohol and Alcoholism
McGahan MC
Experimental Eye Research
Investigative Ophthalmology and Visual Science
Molecular Vision
Biochemical Journal
Papich M
Journal of the American Veterinary Medical Association
American Journal of Veterinary Research
Journal of Veterinary Internal Medicine
Veterinary Dermatology
Piedrahita J
Ad-Hoc Reviewer, Biology of Reproduction
Ad-Hoc Reviewer, Nature Genetics
Ad-Hoc Reviewer, Nature Biotechnology
Ad-Hoc Reviewer, Nucleic Acid Research
Ad-Hoc Reviewer, Proceedings National Academy of Sciences
Ad-Hoc Reviewer, Mammalian Genome
Ad-Hoc Reviewer, Animal Genetics
Ad-Hoc Reviewer, Theriogenology
Posner L
JAA for Laboratory Animal Science
AJVR
JAAHA
Veterinary Anesthesia and Analgesia
JAVMA
Robertson I
Veterinary Radiology and Ultrasound
Rodriguez M
Carcinogenesis
Molecular Carcinogenesis
Cancer Research
Oncogene
Saker K
Journal of Lipids
Journal Veterinary Internal Medicine
Journal American Veterinary Medical Association, Timely Topics in Nutrition
Sannes PL
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory and Critical Care Medicine
American Journal of Physiology, Lung Cell and Molecular Biology
Journal of Pharmacy and Pharmacology
Sherry B
65
Cell Host and Microbe
Journal of Virology
Smallwood J
Veterinary Radiology and Ultrasound
Journal of Veterinary Medical Education
Swanson C
Veterinary Anesthesia and Analgesia
Thomas R
Journal of Heredity
Veterinary Pathology
Thrall D
International Journal of Hyperthermia
Yoder J
Developmental Cell, 2008
Developmental and Comparative Immunology, 2008-2009
Genome Biology, 2009
Journal of Immunology, 2008-2009
Nature Methods, 2008
Marine Biotechnology, 2009
MBS DEPARTMENTAL COMMITTEES
Adler K
MBS Executive Committee
Breen M
MBS Committee for Review of Tenured Faculty
MBS Executive Committee
Dean G
MBS Committee for Review of Tenured Faculty
Fleisher L
Chair of Search Committee, Assistant of Associate Professor of Pharmacology
Horowitz J
MBS Executive Committee
MBS Committee for Review of Tenured Faculty
Hudson L
MBS Committee for Review of Tenured Faculty
MBS Executive Committee
Nascone-Yoder N
MBS Executive Committee
Papich M
Search Committee Member, Assistant/Associate Professor of Pharmacology, MBS Department, 2008
66
Posner L
Alternate, MBS Executive Committee, 2009
Rodriguez M
Organization of MBS Research in Progress Seminar Series
Sannes PL
MBS Committee for Review of Tenured Faculty
Sherry B
MBS Executive Committee, 2006 - present
Swanson C
MBS Executive Committee
Thrall D
MBS Executive Committee
Yoder J
MBS Executive Committee, 2006CVM COMMITTEES
Arasu P
International Programs
CVM Curriculum Sub-Committee, Core (headed by Dr. Jennifer Neel)
Chair, One Health Intellectual Exchange Group Steering
Barnes J
Diversity Committee
Curriculum Committee
Admissions Committee
Breen M
CBS Graduate Admissions Committee
Co-Coordinator, Molecular Medicine Course Initiative
Faculty Committee on Curriculum and Course Evaluation
Brody A
Compact Planning
Library Committee
CVM Research Committee
Campbell N
Admissions Committee
Service Chief, Anesthesia and Radiology, NCSU-CVM Hospital Board
Search Committee, Clinical Assistant Professor of Ophthalmology, Summer 2008
Dean G
Member, DVM Admissions Committee
Chair, CCMTR Executive Committee
Chair, CCMTR Symposium Organizing Committee
Fleisher L
67
Member, Faculty Committee on Curriculum and Course Evaluation (non-voting)
Member, CBS Graduate Studies Committee (non-voting)
Horowitz J
Web Site Design Committee
Information Technology Committee
Comparative Biomedical Sciences Graduate Program, Graduate Studies Committee, Cell Biology Concentration Leader
Hudson L
Safety, year 2
Ad-Hoc Bylaws
Academic Performance
Papich M
Committee Member, Pharmacy and Central Supply Committee, VTH Standing Committee
Chairman and Committee Member, Infectious Disease Control Committee, VTH Standing Committee
Committee Member, Curriculum Committee, Faculty Committee on College Curriculum Evaluation, 2007-present
Chair and Committee Member, College Leadership and Program Review, CVM, NCSU, 2008-2009
Search Committee Member, Assistant/Associate Professor of Bacteriology, PHP Department, 2008
Piedrahita J
Executive Committee CBS Program, Cell Biology Focus Area Leader, 2008-present
Posner L
IACUC Ad-Hoc Veterinary Reviews, 2009
Outpatient Center Steering Committee, 2007-present
Chair, FCHOP Committee, 2007-2008
Admissions Committee, 2006-present
Rodriguez M
CVM Research Committee, since January 2008
Sherry B
Search Committee, PHP Department Head, January 2008-October 2008
Chair, CVM Re-Appointment, Promotion and Tenure Committee, August 2006-present
Swanson C
Awards Committee
Thrall D
Faculty Committee on House Officer Programs
Building Committee, Randall Terry Veterinary Medical Center
Ad-Hoc Committee to Establish Brachytherapy in VTH
Yoder J
Research Committee, 2006Member, Comparative Biomedical Sciences Graduate Program Committee, 2008-present
UNIVERSITY COMMITTEES
Adler K
Postdoctoral Advisory Committee
Arasu P
68
Member, International Operations Council
Member, MBA Biosciences/ Industry Advisory Board
Member, Research Operations Council
Member, Graduate Operations Council
Member, India Working Group
Member, Africa Working Group
Search Committee, Vice Chancellor for Research and Graduate Studies
Search Committee, Director, Park Scholarship Program
Breen M
Steering Committee, CCMTR Clinical Studies Core
Director, CCMTR, Clinical Genomics Resources Lab
CVM Representative on the NCSU Hearings Committee
Dean G
Member, GAANN Fellowship Executive Committee
Member, Biotechnology Training Grant Executive Committee
Member, Scientific Misconduct Investigation Committee
Executive Committee Member, Center for Quantitative Sciences in Biomedicine
Member, Department of Biomedical Engineering Pilot Grant Review Committee
Fleisher L
Chair, Institutional Animal Care and Use Committee;
CVM Representative to the Administrative Board of the Graduate School
CVM Representatives to the Faculty Senate
Faculty Senate Resources and Environment Committee
University Registration, Records and Calendar Committee
University Campus Safety and Emergency Planning Committee
Emergency Planning Committee, Advisory to David Rainer, Associate Vice Chancellor for Environmental Health and
Public Safety
Chair, University O. Max Gardner Award Committee
Gadsby J
Member, NCSU Physiology Program Graduate Student Admissions Committee, Aug 2008-present
Horowitz J
DVM/PhD Program Admissions Committee
Pre-Proposal Selection Committee for Packard Foundation Fellowships
Pre-Proposal Selection Committee for Beckman and Pew Foundations Fellowships
Genomic Sciences Graduate Program, Admissions Committee
Center for Comparative Medicine and Translational Research Executive Committee
Core Leader, Center for Comparative Medicine and Translational Research Oncology
McGahan MC
Department Heads Steering Committee
Nascone-Yoder N
Review Panel Member, Proposal Developmental Unit, Research and Graduate Studies, 2008
Piedrahita J
IPC, CVM Representative to the Intellectual Property Committee
Member of the Executive Committee and Director of the Clinical Genomics Core, CCMTR
Functional Genomics Admission Committee, 2006-present
IMSD Executive Committee
69
Posner L
Evaluation of College Leadership and Programs Committee, Dean Arden, 2008-present
Robertson I
Radiation Safety Committee
Sherry B
Chair, Misconduct Investigation Committee, 6/08-present
Alumni Association Distinguished Graduate Faculty Award Committee, Winter 2009
University Research Committee, 8/07-present
GAANN Training Grant Executive Committee, 11/02-present
Co-Director, Biotechnology Training Program, 1/99-present
Expanding Your Horizons Organizational Committee, 7/98-present
Awards Committee, GAANN Fellowships, 8/94-present
OTHER COMMITTEES
Adler KB
Member, Triangle Visiting Pulmonary Scholar Committee
Member, CIIT Science Advisory Committee, 2008
Arasu P
Member, International Affairs Committee (IAC), American Association of Veterinary Medical Colleges
Member, Committee on International Affairs (CIVA), AAVMC Rep to Am. Assoc. of Vet. Medicine (AVMA)
Triangle Global Health Consortium
Asakawa M
Japanese Veterinary Pain Management
Barnes J
Secretary-Treasurer, Psi Chapter of Phi Zeta
Breen M
Member, Board of Directors and Treasurer, Canine Comparative Oncology and Genomics Consortium (CCOGC), Inc
Member, Steering Committee, CCOGC Inc
Member, CCOGC Biospecimen Committee
Member, CCOGC PR subcommittee
Member, American Kennel Club Canine Health Foundation, President’s Council
Member, American College of Veterinary Pathology Oncology Subcommittee on Myeloid Neoplasms
Member, American College of Veterinary Pathology Oncology Subcommittee on Lymphoma
Member, Morris Animal Foundation, Scientific Advisory Board
Brody A
American Thoracic Society, Program Committee for the 2008 and 2009 Annual Meetings
Dean G
Translational Research Advisory Board
Triangle Immunology Interest Group, Steering Committee
International Feline Retrovirus Research Symposium Organizing Committee
Fleisher L
Member of the Search Committee, Director of Environment Health and Safety
70
Gadsby J
Member of the Society for the Study of Reproduction Nominating Committee, 2008-2009
Chair, Triangle Consortium for Reproductive Biology (TCRB), 2009-2010
Howard K
Volunteer, NCVMA Public Education Events, State Fair
McGahan MC
Appointed Member (by Michael Leavitt, Secretary of the Department of Health and Human Services), National Advisory
Eye Council, Dec 2006-Dec 2010
Elected Secretary, International Society for Eye Research, http://iser.org/governance.html, term 2008-2011
Papich M
Advisory Boards:
Pfizer Pharmaceuticals, Expert Advisory Panel for Antimicrobial Drugs
Boehringer-Ingelheim, Pain Medication Advisory Board
Schering-Plough Corporation, Consulting and Speaker’s Bureau
Bayer Animal Health, Consulting Activity
Putney Pharmaceuticals, Consultant and Advisory Panel
Vet Med Labs, Advisory Panel
Central Life Sciences (formerly Farnam Inc.), Consulting Activity for Animal Drugs
National and International Committees:
Organizing Committee, AAVPT Workshop on Antimicrobial Drugs, Rockville Maryland, October 2008
Tenure & Promotion Review for Dr. Nasir Mohammad Idkaidek, University of Petra, Amman Jordan, 2009
Vice Chair and Member (voting member), Subcommittee on Veterinary Antimicrobial Susceptibility Testing (VAST),
National Committee for Clinical and Laboratory Standards Institute (CLSI) (formerly the Clinical Laboratory
Standards, NCCLS), appointed to Vice-Chair in 2008, 2001-present
United States Pharmacopeia Convention (USP), Rockville, Maryland
USP Council of Experts, elected position, 2005-2010
USP Chairman of Expert Panel on Veterinary Drugs, 2005-2010
Panel Member, USP Expert Panel on Veterinary Drug Information, 2005-2010
Posner L
American College of Veterinary Anesthesiologists (ACVA)
ACVA Oral Exam Committee, 2006-present
ACVA Multiple Choice Exam Committee, 2006-present
Robertson I
Chair ACVR, Examination Committee
Member ACVR, Digital Imaging Standards Committee
Saker K
President, The American Academy of Veterinary Nutrition (AAVN), 2 yr term as president
Contributing Member, Education and Membership Committees, American College of Veterinary Nutrition (ACVN)
Sherry B
Guest Participant, “Assistant Professors’ Learning Community” Workshop Series, Host: Dr. Marcia Gumpertz, NCSU, Feb
6, 2009
Smallwood J
Society of Phi Zeta, Honor Society of Veterinary Medicine, National Secretary-Treasurer
Director, CVM Alumni Affairs
Swanson C
71
Chairman, American College of Veterinary Anesthesiologists, Appeals Committee, 2009
Thrall D
Member, Duke University Comprehensive Cancer Center
Yoder J
Ad-Hoc Grant Reviewer, All Children's Hospital Foundation Grant Program, St. Petersburg, FL, July 2008
Ad-Hoc Grant Reviewer, Sheffield Hospitals Charitable Trust, Sheffield, United Kingdom, January 2009
Ad-Hoc Grant Reviewer, Netherlands Genomics Initiative, The Hague, Netherlands, February 2009
Member, CCMTR, Clinical Studies Core Steering Committee, 2008Coordinator, Triangle Zebrafish Group, 2006Workshop Chair, Assessing Infection and Immune Response at 8th International Conference on Zebrafish Development
and Genetics, Madison, WI, June 2008
Workshop Discussant, Gene Inactivation II; MOs, TILLING and Zinc Finger Nucleases at 3rd Strategic Conference of
Zebrafish Investigators, Asilomar, CA, Jan 2009
72
Appendix VII
Research Grants
Granting
Agency
PI
Co-I(s)
Title
EPA
Adler KB (20%)
Sannes (10%),
Shea D (5%)
9/1/06-8/31/11
NC
Biotechnology
NIH
Adler KB
NIH
Adler KB
NIH
Adler KB (35%)
NIH 15th
International
Cooloquium on
Pulmonary and
Airway Fibrosis
PHS/NIH
Adler KB
Cooperative training in
environmental sciences research
Travel award for colloquium
conference
Mechanism of oxidant-induced
respiratory mucin secretion
Mechanism of oxidant-induced
respiratory mucin secretion
Mechanism of oxidant-induced
respiratory mucin secretion
Travel Award
Sepracor
Adler KB (<2%)
USDA
Arasu P (5%)
Morris An Fdn
Brainard B (Univ GA)
AKC Canine
Hlth Fdn
Breen M (3%)
AKC Canine
Hlth Fdn
Breen M (5%)
AKC Canine
Hlth Fdn
Breen M (5%)
AKC-CHF
Breen, M
(5%)
Breen M (15-25%)
Broad Inst
(MIT/NHGRI)
MAF
Adler KB
Adler KB (35%)
Breen, M
Minority suppl for
T Green
Minority suppl for
J Waterman
Horowitz (10%)
Horowitz J (10%),
Barnes J (10%)
Fellner V (5%),
Gimeno I (1%),
Correa M (1%),
Sharma R (1%)
Papich MG (2%),
Budsberg S
Date of
award
Total Costs for
Total Grant
Period
3,380,480
Total DC for Total
Grant Period
3,186,481
Total costs for
Current Year
Award
232,540
Total DC for
Current Year
Award
216,580
9/28/0810/01/08
3/1/05-2/28/09
1,500
1,500
1,500
1,500
158,879
116,022
39,876
27,312
3/1/08-2/28/09
83,160
56,000
83,160
56,000
3/1/09-2/28/14
1,929,115
1,296,160
385,823
259,232
6/15/086/14/09
15,000
15,000
15,000
15,000
Mechanism of oxidant-induced
respiratory mucin secretion
Differential effects of albuterol
and formoterol isomers on
transcription factor activation in
human airway epithelium
Sustainable livestock production
practices, biofuels and health:
lessons with India
3/1/04-2/28/09
1,767,437
1,226,605
334,925
244,796
6/1/07-5/31/09
110,000
73,852
7/2008-6/2012
100,000
80,000
25,000
20,000
Pharmacokinetic and
pharmacodynamic study of
clopidogrel in dogs
Cellular genomics – A molecular
cytogenetic investigation of
canine soft tissue sarcoma
Heritable and spontaneous
genetic lesions in canine
lymphoma
Canine lymphoma – The
prognostic significance of
chromosome aneuploidy
Heritable and sporadic genetic
lesions in canine osteosarcoma
Molecular cytogenetic anchoring
of vertebrate genomes
Comparative molecular
2007-2008
14,755
10/1/079/30/09
135,963
125,892
68,409
63,342
8/1/08-7/31/10
147,912
136,956
72,765
67,375
8/1/08-7/31/10
113,929
105,489
56,398
52,220
08/01/0807/31/10
5/1/07-4/30/09
149,369
139,157
73,980
69,352
545,705
392,359
356,187
249,950
01/01/09-
79,176
73,311
39,048
36,155
73
Granting
Agency
PI
Co-I(s)
Morris An Fdn
(5%)
Breen M (5%)
NIH/NCI
Breen M (22%)
UNC-LCCC
Breen, M
(10%)
NIH
Brody AR
NIH
Brody AR
NCSU CVM
Brown J
Fields E
V Foundation
for Cancer
Research
NIH/NIAID
Cavanagh J
Horowitz J
Dean GA (20%)
Klaenhamer T
(5%)
NIH-NIAID
Dean GA (25%)
NIH/NIAID
Dean GA (30%)
Nordone S (25%),
Tompkins MB
(5%)
Klaenhammer T
(5%), Nordone S
(50%), Howard K
(75%)
Am Quarter
Horse Fdn
Fortier LA, Divers TJ,
Papich MG (2%)
NCSU/CCMTR
Hawkins, EC
PHS/NIH
Hawkridge (80%)
Suter S,
Motsinger-Reif A
Yoder JA (1%),
Birkenheuer
A, Nordone S,
Cruse A,
Holowaychuk MK
Horowitz J (comentor-5%)
Title
Total Costs for
Total Grant
Period
Total DC for Total
Grant Period
Total costs for
Current Year
Award
Total DC for
Current Year
Award
114,151
105,695
57,753
53,475
10/1/076/30/12
01/01/0906/30/09
1,423,625
987,130
283,547
197,426
144,567
144,567
144,567
144,567
9/1/06-8/31/08
179,176
120,658
9/1/06-7/31/09
882,533
443,724
257,764
176,551
8/2008
14,988
9/1/08-8/31/12
1,000,000
1,000,000
250,000
250,000
2/15/081/31/10
408,375
275,000
222,750
150,000
7/1/07-6/30/11
1,338,750
900,000
334,125
225,000
Recombinanat lactobacillus as an
oral mucosal vaccine against
HIV-1
3/20/081/31/13
1,825,000
1,250,000
345,263
232,500
The pharmacokinetics and tissue
distribution of minocycline in
horses
Development of a biomarker
panel for the rapid identification
of bacterial infection
in dogs: TREM-1, PCT and
VEGFR-3
2008-2009
27,146
7/1/07-6/30/08
16,917
16,917
16,917
16,917
7/1/07-6/30/12
888,000
600,000
177,600
120,000
cytogenetics of the canidae
Canine lymphoma – the
prognostic significance of
cytogenetic changes
Spontaneous canine tumors as
models for gene discovery
Integrated molecular
characterization of naturally
occurring B-cell lymphomas in
dogs for use as a relevant large
animal model of human DLBCL
TGF-beta in interstitial lung
disease
TNF-Alpha to TGF-Beta signal
transduction
Development of computed
tomography abdominal scanning
protocols in the sedated canine
patient and comparison to
abdominal ultrasound
Jimmy V/NCSU cancer
therapeutics training program
Optimizing immunogenicity of
lactobacillus as a mucosal
vaccine against HIV-1
Basis and modulation of the
innate immune defect in FIV
Comparative proteomics applied
to the avian model of ovarian
cancer
Date of
award
12/31/10
1/1/06-2/28/09
14,988
74
Granting
Agency
PI
Co-I(s)
Title
PHS/NIH
Horowitz J
McGahan C,
Piedrahita J,
Yoder J, NasconeYoder N,
Rodriguez-Puebla
M, Sherry B
Nikon AZ100 macro/micro zoom
microscope
4/1/08-3/31/09
PHS/NIH
Horowitz J (40%)
NIH-NIAID
Howard K (100%)
Regulation of transcription and
cell growth by Nkx3.1
Role of mucosal immunity in
vaccine protection
UNC-CH/NIHNIMH
NIH
Hudson LC (5%)
NCSU/ CVM
Law JM
NIH
McGahan MC
NIH
McGahan MC (40%)
NSF
Nascone-Yoder N
(22%)
Nordone S (80%)
Choroid plexus macrophages in
FIV neuropathogenesis
Biotechnology training at NCSU
Determining the barrier function
of the chorion in the fish embryo
Trace element dynamics in the
vertebrate eye (supplement)
Trace element dynamics in the
vertebrate eye
Mechanisms of vertebrate gut
morphogenesis
Evaluation of TREM-1 as a
specific biological marker for
sepsis in dogs
Impact of TLR function on
regulatory T cell-mediated
suppression during HIV infection
Identificaton of mutations causing
hereditary cerebellar cortical
degeneration in american
staffordshire terriers and old
english sheepdogs
Gene discovery in hereditary
cerebellar abiotrophy of scottish
terriers
Pharmacokinetic and
pharmacodynamics of
hydroxyzine in healthy dogs
Development of swine model of
marfan syndrome
Imprinted genes and placental
function
Morris An Fdn
Kelly R
Dean GA
(sponsor),
Tompkins WA (cosponsor)
Tompkins MB
(5%)
Dean GA (mentor)
Yoder JA (3%)
Goralska M
(100%)
Yoder J (2%),
Birkenheuer A
UNC Ctr Aids
Res
Nordone S (100%)
Dean GA (Mentor)
AKC Canine
Hlth Fdn
Olby NJ
Breen M (1% c/s)
AKC Canine
Hlth Fdn
Olby NJ
Breen M (1% c/s)
Morris An Fdn
Olivry T
Papich MG (2%),
Bizikova P
NIH (R21)
Piedrahita J
Posner LP (5%)
NIHNCHHD
Piedrahita JA (20%)
Date of
award
Total Costs for
Total Grant
Period
107,644
Total DC for Total
Grant Period
107,644
Total costs for
Current Year
Award
107,644
Total DC for
Current Year
Award
107,644
1/1/0312/31/09
7/1/04-4/30/08
1,134,687
787,867
216,390
149,339
444,847
412,062
3/1/06-2/28/10
464,907
321,184
$124304
$85,142
7/1/05-6/30/10
1,356,805
7/1/08-6/30/09
7,500
7,500
7,500
7,500
7/1/08-6/30/09
50,000
50,000
50,000
50,000
7/1/06-6/30/11
1,238,072
851,302
243,129
166,527
4/1/07-3/31/10
464,907
321,184
111,632
76,199
9/1/08-8/31/11
224,078
207,481
70,683
65,447
6/1/07-5/31/09
15,000
15,000
No cost
No cost
2007-2009
64,800
2007-2009
54,810
2007-2008
19,995
9/1/07-8/31/09
347,688
233,920
188,050
126,420
3/2006-2/2011
1,529,463
1,047,577
291,442
199,618
75
Granting
Agency
PI
USDA
Piedrahita JA (10%)
NIH/NCI
NIH
Rodriguez-Puebla
ML
Rodriguez-Puebla
ML (35%)
Sannes PL
NIH
Sannes PL (35%)
PHS/NIH
Sannes, P
Horowitz J (15%)
BBSRC –
Underwood
Fellowship
Immuno
Biosciences
Sheldon IM
Gadsby JE
NIH (NIAID)
Sherry B (50%)
Morris An Fdn
Thomas R (25%)
Morris An Fdn
Thomas R (33%)
Duke/NIH
Thrall DE (29%)
NIH-NIAID
Tompkins WAF
(25%)
NCSU CVM
Williams L
NCSU/CCMTR
(Service Core
Grt)
Yoder JA (5%)
NIH/NCI
Co-I(s)
Sherry B (2%)
Hauck ML (9%),
Pruitt A (5%)
Williams L (4%),
Linder K (2%),
Case B (85%)
Dean GA (10%),
Tompkins MB
(20%)
Neel J, Brown J
Birkenheuer, A
Correa, M
Title
Date of
award
Association of imprinted genes
with reproductive efficiency in
swine
Roles of cyclin D3 (supplement)
1/1/0512/31/09
Roles of cyclin D3 in neoplastic
proliferation
Alveolar basement
membrane/cell interactions in the
lung
Alveolar basement
membrane/cell interactions in the
lung
Alveolar basement
membrane/cell interactions in the
lung
Molecular mechanisms of
immunity and infection in the
bovine corpus luteum
Continued development and
application of immune complex
vaccine (ICV) technology to
mammalian systems
The cardiac interferon response
to reovirus infection
Cytogenetic profiling – an aid to
subclassification of feline
abdominal lymphoma
Molecular cytogenetic evaluation
of feline fibrosarcoma by arrayCGH: a diagnostic tool?
Hyperthermia and perfusion
effects in cancer therapy
CD4+CD25+T cells: a reservoir
of productive FIV infection
Total DC for Total
Grant Period
672,000
Total costs for
Current Year
Award
No cost
Total DC for
Current Year
Award
No cost
9/15/082/28/11
4/1/06-2/28/11
113,230
76,086
27,666
18,630
1,135,037
780,218
226,471
155,117
6/1/08-3/31/09
371,250
250,000
371,250
250,000
12/1/035/31/08
1,260,106
854,220
No cost
No cost
4/1/09-3/31/14
1,856,250
1,250,000
371,250
250,000
1/2008-9/2008
47,905stg
47,905stg
76,748
76,748
2/1/07-1/31/13
530,400
363,288
116,800
80,000
5/15/044/30/09
12/1/0811/31/10
1,403,322
987,081
268,870
186,033
91,721
84,927
46,368
42,933
11/1/0610/31/08
103,152
95,511
52,990
49,065
7/1/05-6/30/10
2,527,508
1,731,170
461,649
316,198
9/1/04-8/31/09
1,289,260
884,685
404,55
225,000
1,350
1,350
1,350
Hematology/oncology case of the
month
Assessing immune response
genes as biomarkers for infection
Total Costs for
Total Grant
Period
840,000
1,700
7/1/07-6/30/08
1,350
76
Granting
Agency
NCSU/CCMTR
(Translational
Res Grt)
PI
Co-I(s)
Title
Yoder JA (5%)
Birkenheuer, A
Correa, M
Assessing immune response
genes as biomarkers for infection
NCSU/CVM
Yoder JA (5%)
NIH
Yoder JA (25%)
NIH/NCSU
Subcontract
(Deiters A,
Chemistry)
NIH/USF
subcontract
Morris An Fdn
Immune-related, lectin-like
receptor 3 (IIIr3) and
hematopoietic lineages in
zebrafish
Whole organism transcriptional
profiling of innate immune
response
Switchable systems for spatiotemporal control of gene
expression in zebrafish
Yoder JA (20%)
Yoder JA (5%)
Saker K (10%),
Pratt SE, Siciliano
PD, Eisemann J
Novel innate immune receptors in
zebrafish
Changes in insulin sensitivity with
body composition in the horse
Date of
award
Total Costs for
Total Grant
Period
Total DC for Total
Grant Period
Total costs for
Current Year
Award
Total DC for
Current Year
Award
7/1/07-6/30/08
15,000
15,000
15,000
15,000
7/1/07-6/30/08
15,000
15,000
15,000
15,000
7/1/08-6/30/10
390,407
275,000
245,070
175,000
8/1/07-7/31/12
609,856
422,840
140,790
102,840
212,000
155,206
48,000
32,877
12/15/0411/30/09
2007-2009
64,022
29,376
77