Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Follow the formats and instructions below for all key personnel.
NAME
POSITION TITLE
Tamara Hershey, Ph.D.
Associate Professor
CDI USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Earlham College; Richmond, IN
Washington Univ in St. Louis; St. Louis, MO
Long Island Jewish Medical Center, Glen Oaks, NY
B.A.
Ph.D.
Intern
1988
1996
1995-6
Psychology
Neuropsychology
Neuropsychology
Washington Univ. School of Medicine, St. Louis, MO
Postdoc
1996-2000
Neuroimaging
A. Positions and Honors.
1995-96:
Clinical Neuropsychology Intern. Long Island Jewish Medical Center, Glen Oaks, NY
1996-2000:
Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO
2001-2003:
Instructor in Psychiatry, Washington University School of Medicine, St. Louis, MO
2003:
Instructor in Neurology, Washington University School of Medicine, St. Louis, MO
2003-2008:
Assistant Professor of Psychiatry, Washington University School of Medicine, St. Louis, MO
2004-2008:
Assistant Professor of Radiology and Neurology, Washington University School of Medicine, St. Louis, MO
2008-present: Associate Professor (with tenure) of Psychiatry, Radiology and Neurology, Washington University School
of Medicine, St. Louis, MO
Honors:
Phi Beta Kappa; Senior Thesis, Departmental, College Honors; Earlham College (1988), Washington University
Graduate Fellowship (1992), James S. McDonnell Summer Institute in Cognitive Neuroscience Travel Award (1992),
Washington University Dissertation Fellowship (1995), Epilepsy Foundation of America Postdoctoral Award (1996-97),
Long Island Jewish Medical Center Research Award (1996-97), Alzheimer’s Disease and Related Disorders Program
Research Award (1998-99), Juvenile Diabetes Foundation International, Research Award (1998-00), James S.
McDonnell Higher Brain Function Postdoctoral Award (1999), National Research Service Award, National Institute of
Neurological Disorders and Stroke (1999-01), Career Development Award, National Institute of Neurological Disorders
and Stroke (2001-06), John Merck Scholar Nominee from Washington University School of Medicine (2003), Dorismae
and Harvey A. Friedman Award for Aging Research (2005), Licensed Psychologist and Health Care Provider, Missouri
(1999-present; Tourette Syndrome Association Scientific Advisory Board (2008-present).
C. Selected peer-reviewed publications (in chronological order).
1. Wu J.C., Gillin J.C., Buchsbaum M.S., Hershey T.G., Hazlett E., Sicotte N., Bunney W.E. Jr. (1991). The effect of sleep
deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography.
Sleep, 14(7),155-67.
2. Wu J.C., Buchsbaum M.S., Hershey T.G., Hazlett E., Sicotte N., Johnson, J.C. (1991). PET in generalized anxiety
disorder. Biological Psychiatry, 29, 1181-99.
3. Wu J.C., Gillin J.C., Buchsbaum M.S., Hershey T., Johnson, J.C., Bunney W.E. Jr. (1992). Effect of sleep deprivation on
brain metabolism of depressed patients. American Journal of Psychiatry, 149(4), 538-43.
4. Wu J.C., Buchsbaum M.S., Johnson J.C., Hershey T.G., Wagner E.A., Teng C., Lottenberg S. (1993). Magnetic
resonance and positron emission tomography imaging of the corpus callosum size, shape, and metabolic rate in
unipolar depression. Journal of Affective Disorders, 28(1), 15-25.
5. Newcomer, J.W., Craft, S., Hershey, T., Askins, K., Bardgett, M.E. (1994). Glucocorticoid-induced impairment in
declarative memory performance in adult humans. Journal of Neuroscience, 14(4), 2047-53.
6. Hvidberg, A., Fanelli, C.G., Hershey, T., Terkamp, C., Craft, S., & Cryer, P.E. (1996). Impact of recent antecedent
hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans. Diabetes, 45, 1030-1036.
7. Hershey, T., Craft, S., Bhargava, N, & White, N. (1997). Memory and insulin dependent diabetes mellitus (IDDM): Effects
of childhood onset and severe hypoglycemia. Journal of the International Neuropsychological Society, 3, 509-520.
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Hershey, Tamara
Program Director/Principal Investigator (Last, First, Middle):
8. Hershey, T., Craft, S., Glauser, T. & Hale, S. (1998). Short-term and long-term memory following early temporal lobe
dysfunction. Neuropsychology, 12(1), 52-64.
9. Newcomer, J.W., Craft, S., Askins, K., Hershey, T., Bardgett, M., Csernansky, J.G., Gagliardi, A.E. (1998). Decreased
sensitivity to glucocorticoid-induced impairment in declarative memory performance in schizophrenia.
Psychoneuroendocrinology, 23(1) 65-72.
10. Ovalle, F., Fanelli, C.G., Paramore, D.S., Hershey, T., Craft, S., Cryer, P.E. (1998). Brief twice weekly episodes of
hypoglycemia reduce detection off clinical hypoglycemia in type 1 diabetes mellitus. Diabetes, 47, 1472-1479.
11. Hershey, T., Black, K.J., Stambuk, M.K., Carl, J.C., McGee-Minnich, L., Perlmutter, J.S. (1998). Altered thalamic
response to levodopa in Parkinson s disease patients with dopa-induced dyskinesias. Proceedings of the National
Academy of Sciences, 95(20), 12016-12021.
12. Hershey, T. and Perlmutter, J.S. (1998). Estimating the preclinical parkinsonian period with positron emission
tomography. Neurology Network Commentary, 2(3), 157-161.
13. Fanelli, C.G., Paramore, D.S., Hershey, T., Craft, S., Cryer, P.E. (1998). Impact of nocturnal hypoglycemia on
hypoglycemic cognitive dysfunction in type 1 diabetes mellitus. Diabetes, 47, 1920-1927.
14. Newcomer, J.W., Farber, N.B., Jevtovic-Todorvic, V., Selke, G., Kelly, A., Hershey, T., Craft, S., Olney, J.W. (1999).
Ketamine-induced NMDA receptor hypofunction as a model of memory impairment in schizophrenia.
Neuropsychopharmacology, 20(2), 106-118.
15. Newcomer, J.W., Selke, G., Melson, A.K., Hershey, T., Craft, S., Richards, K., Alderson, A. (1999). Dose-dependent
cortisol-induced decrease in declarative memory in humans. Archives of General Psychiatry, 56(6), 527-33.
16. Hershey, T., Bhargava, N., Sadler, M., White, N., Craft, S. (1999). Standard vs. Intensive insulin treatment in children
with type 1 diabetes mellitus: Effects on memory and motor speed. Diabetes Care, 22(8), 1318-1324.
17. Hershey, T., Black, K.J., Carl, J., Perlmutter, J.S. (2000). Dopa-induced blood flow responses in non-human primates.
Exp Neurol, 166(2), 342-349
18. Black, K.J., Hershey, T., Perlmutter, J.S. (2000). Diffuse temporal lobe activation by a dopamine D 1 full agonist
in primates. J Neurophysiol, 84(1), 549-557
19. Racette BA, Hartlein JM, Hershey T, Mink JW, Perlmutter JS, Black KJ: Clinical features and comorbidity of
mood fluctuations in Parkinson's disease. J Neuropsychiatry Clin Neurosci 14(4), 438-442.
20. Perlmutter, J.S., Mink, J.W., Bastian, A.J., Zackowski, K., Hershey, T., Miyawaki, E., Koller, W.,
Videen, T.O. (2002). Blood flow responses to deep brain stimulation of thalamus. Neurology, 58(9), 1388-1394.
21. Black, K.J., Hershey, T., Koller, J.M., Videen, T.O., Mintun, M.A., Price, J.L., Perlmutter, J.S. (2002). A possible
substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring
dopamine agonist. Proceedings of the National Academy of Sciences, 99(26), 17113-17118.
22. Hershey, T., Lillie, R., Sadler, M., White, N.H.. (2002) The effect of severe hypoglycemia on cognition and memory
in children and adolescents with Type 1 diabetes mellitus. Diabetes, Nutrition and Metabolism 15(6), 426-429.
23. Hershey, T, Lillie, R., Sadler, M., White, N. (2003) Severe hypoglycemia and long-term spatial memory in children with
type 1 diabetes mellitus: A retrospective study. Journal of the International Neuropsychological Society. 9, 740750.
24. Hershey, T., Black, K.J., Carl, J.L., McGee-Minnich, L., Perlmutter, J.S. (2003) Chronic treatment and disease severity
alter brain responses to levodopa in PD. Journal of Neurology, Neuroscience and Psychiatry, 74, 844-851.
25. Black, K.J., Carl, J.L., Hartlein, J.M., Warren, S., Hershey, T., Perlmutter, J.S. (2003) Rapid intravenous loading of
levodopa for human research: Clinical results. Journal of Neuroscience Methods. 127(1), 19-29.
26. Hershey, T., Revilla, F., Loepker, A., McGee-Minnich, L., Antenor, J., Videen, T., Mink, J.W., Perlmutter, J.S.
(2003). Cortical and subcortical blood flow effects of subthalamic nucleus stimulation in PD. Neurology, 61(6),
816-821.
27. Hogue, C.W., Lillie, R., Hershey, T., Birge, S., Nassief, A.M., Thomas, B., Freedland, K. (2004). Gender influence
on cognitive function after cardiac surgery. Annals of Thoracic Surgery, 76(4), 1119-11125.
28. Lyons-Warren, A., Lillie, R., Hershey, T. (2004). Short and long-term spatial delayed response performance across
the lifespan. Developmental Neuropsychology, 26(3):661-78.
29. Hershey, T., Lillie, R., Sadler, M., White, N. (2004). A prospective study of severe hypoglycemia and spatial
delayed response in children with T1DM. Pediatric Diabetes, 5(2), 63-71.
30. Hershey, T., Revilla, F., Schneider Gibson, P., Wernle, A., Dowling, J., Perlmutter, J.S. (2004) Stimulation of STN
impairs aspects of cognitive control in PD. Neurology, 62(7), 1110-4.
31. Hershey, T., Black, K.J., Hartlein, J., Barch, D.M., Braver, T., Carl, J.L., Perlmutter, J.S. (2004) Cognitivepharmacological fMRI in Tourette syndrome: A pilot study. Biological Psychiatry, 55(9), 916-925.
32. Hershey, T., Black, K.J., Hartlein, J., Braver, T., Barch, D.M., Carl, J.L., Perlmutter, J.S. (2004) Dopaminergic
modulation of response inhibition: An fMRI study. Brain Research, Cognitive Brain Research, 20(3), 438-448.
33. Black, K.J., Hershey, T, Hartlein, J.M., Carl, J.L., Perlmutter, J.S. (2005) Parkinson’s disease patients with
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Hershey, Tamara
Program Director/Principal Investigator (Last, First, Middle):
levodopa-related mood fluctuations have increased posterior cingulate response to acute levodopa.
Neuropsychopharmacology, 30(3):590-601.
34. Hershey, T., Perantie, D.C., Warren, S.L., Zimmerman, E.C., Sadler, M., White, N.H. (2005). Frequency and
timing of severe hypoglycemia (SH) affects spatial memory in children with type 1 diabetes mellitus (T1DM).
Diabetes Care, 28, 2372-2377.
35. Hogue, C.W., Hershey, T. Dixon, D. Fucetola, R., Nassief, A. Freedland, K.E., Thomas, B. Schechtman, K. (2006).
Preexisting cognitive impairment in women before cardiac surgery and its relationship with C-reactive protein
concentrations. Anesth Analg, 102:1602–1608.
36. Weiss, E.M., Hershey, T., Karimi, M., Racette, B., Tabbal, S., Mink, J.W., and Perlmutter, J.S. (2006). Relative risk
of spread of symptoms among the focal onset primary dystonias. Movement Disorders. 21(8):1175-81
37. Hershey, T and Mink, J.W. (2006). Using functional neuroimaging to study the brain’s response to deep brain
stimulation. Neurology, 66(8), 1142-1143.
38. Powers, W.J., Videen, T.O., Markham, J., McGee-Minnich, L., Antenor-Dorsey, J.V., Hershey, T., Perlmutter, J.S.
(2007) Selective defect of in vivo glycolysis in early Huntington’s disease striatum. Proceedings of the National
Academy of Sciences. 104(8):2945-9.
39. Hogue, C.W., Freedland, K., Hershey, T., Fucetola, R., Nassief, A., Barzilai, B., Thomas, B., Davila-Roman, V., Birge,
S., Dixon, D., Schechtman, K. (2007). Failure of 17ß-estradiol to provide protection against neurological
complications after cardiac surgery for postmenopausal women. Stroke 38(7):2048-54.
40. Powers, W.J., Haas, R.H., Le, T., Videen, T.O., Hershey, T., McGee-Minnich, L., Perlmutter, J.S. (2007) Normal
platelet mitochondrial complex I activity in Huntington's Disease. Neurobiology of Disease, 27(1):99-101.
41. Perantie, D., Wu, J., Lim, A., Warren, S. Koller, J., Black, K.J., Hershey, T. (2007) Brain volume differences
associated with severe hypoglycemia and chronic hyperglycemia in children with T1DM. Diabetes Care
30(9):2331-7.
42. Videen, T.O., Campbell, M.C., Tabbal, S.D., Karimi, M., Hershey, T., Perlmutter, J.S. (2008) Validation of a
fiducial-based atlas registration method for subthalamic nucleus localization and its application to deep brain
stimulation. J Neurosci Methods, 168(2):275-81.
43. Foster, E.R, Black, K.J, Antenor-Dorsey, J.A., Perlmutter, J.S, Hershey, T. (2008). Motor asymmetry and substantia
nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and Cognition.
Jun;67(1):1-10
44. Hogue, C.W. Jr, Fucetola, R.., Hershey, T., Nassief, A.., Dávila-Román, V.G., Barzilai, B., Thomas, B., Schechtman,
K.B., Freedland, K. (2008). The role of postoperative neurocognitive dysfunction on quality of life for
postmenopausal women 6 months after cardiac surgery. Anesth Analg. 2008 Jul;107(1):21-8.
45. Hershey, T., Wu, J., Perantie, D., Weaver, P., Karimi, M., Tabbal, S., Perlmutter, J.S. (2008). Unilateral vs. bilateral
STN DBS effects on working memory and motor function in Parkinson disease. Exp Neurol Apr;210(2):402-8.
46. Perantie, D., Lim, A., Wu, J., Warren, S.L., Hayden, T., Sadler, M., White, N.H., Hershey, T. (2008)
Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus.
Pediatr Diabetes. 2008 Apr;9(2):87-95.
47. Hogue CW, Fucetola R, Hershey T, Freedland K, Dávila-Román VG, Goate AM, Thompson RE. (2008). Risk factors
for neurocognitive dysfunction after cardiac surgery in postmenopausal women.
Ann Thorac Surg. Aug;86(2):511-6
48. Campbell, M.C., Karimi, M., Videen, T.O., Weaver, P.M., Tabbal, S.D., Perlmutter, J.S., Hershey,T. (2008). Neural
correlates of STN DBS-induced impairment in cognitive function. Neuropsychologia, 46(13): 3162-9.
49. Karimi, M., Golchin, N., Tabbal, S.D., Hershey, T., Videen, T.O., Mink, J.W., Perlmutter, J.S. (2008). Bilateral
subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs
in Parkinson disease. Brain, 131(Pt 10): 2710-9.
50. Foster, E.R., McDaniel, M.A., Repovs, G., Hershey, T. (2009). Prospective memory is differentially impaired in
Parkinson disease across levels of executive demand in both the laboratory and everyday life. Neuropsychology,
23(3): 347-58.
51. DeAlwis, D., Myerson, J, Hershey, T., Hale, S. (2009). Children’s higher-order cognitive abilities and the
development of primary and secondary memory. Psychonomic Bulletin & Review, 16(5): 925-30
52. Hershey, T., Perantie, D., Wu, J., Weaver, P., Black, K.J., White, N.H. (2010). Hippocampal volumes in youth
with type 1 diabetes. Diabetes, 59(1): 236-41.
D. Research Support.
Ongoing:
R01 NS058797-02 Hershey
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7/1/08-6/30/13
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$263,681
Biographical Sketch Format Page
Hershey, Tamara
Program Director/Principal Investigator (Last, First, Middle):
Mapping mood in the subthalamic nucleus in PD
This study tests the hypotheses that DBS STN can alter mood acutely depending upon the precise location of
stimulation.
R01 DK064832-07 Hershey
8/1/03-7/31/13
$215,000
Glycemic control, brain structure and cognitive development in T1DM
This study continues to follow a cohort of adolescents with T1DM and their non-diabetic siblings to determine the
neurological consequences of hyperglycemia and hypoglycemia exposure.
DK064832-07S1 Hershey
8/1/03-7/31/11
$5,306
Glycemic Control, Brain Structure and Cognition in Youth with T1DM
This administrative supplement will provide a rich research experience in diabetes and clinical neuroscience to
promising summer undergraduate students, as well as enhancing the efficiency and productivity of the parent
grant.
U10 HD056526-01 (White, Study Chair) Role: Cognitive Core Director 09/27/07 – 08/31/12
$140,001
DirecNet-2
The overall purpose of DirecNet-2 is to develop strategies to prevent hypoglycemia during treatment of diabetes
in children and young adults.
U54 RR024992-02 (Polonsky) Role: Director of Neuropsych Service
Washington University Institute of Clinical and Translational Sciences
(Perlmutter) Brain, Behavior and Performance Unit (BBPU)
9/17/07 – 5/31/12
$109,923
R01 MH73856-04 (Black) Role: Co-Investigator
2/15/05-1/31/11
$259,795
Dopaminergic Effects on Cortical Function in Tourette’s
This study examines the ability of dopamine to modulate brain activity patterns induced by cognitive tasks in
patients with Tourette syndrome.
American Parkinson Disease Association (Perlmutter) Role: Investigator
APDA Advanced Research Center for PD
1999-2011
R01 NS41509-08 (Perlmutter) Role: Co-Investigator
5/01/04-7/31/11
Mechanism of deep brain stimulation
This study investigates how deep brain stimulation alters cognition and blood flow in PD
$100,000
$475,256
R01 NS040068-09 (Paulson) Role: PI of Subcontract
9/1/09-8/31/13
$84,520
Neurobiological Predictors of Huntington's Disease
PREDICT-HD is an international 30-site observational study of persons at-risk for Huntington's disease (HD).
The ultimate goal of PREDICT-HD is to define the neurobiology of HD sufficiently to allow clinical trials of
potential disease-modifying therapies before at-risk individuals have diagnosable symptoms of the disease.
Pending:
R01 DK085575-01 Hershey
7/1/10 – 6/30/15
$350,000
Central Dopamine Receptors in Obesity
The study examines D2 receptors in the brains of obese and lean individuals, how they are related to reward
sensitivity and how they change with time and weight loss.
1 P50 NS071667-01 (Perlmutter)
Role: PI of Project 4: Neuroimaging and Cognitive Phenotype of LRRK2 7/1/10-6/30/15
$1,493,384
PD Translational Research: From Mouse to Human
This Udall center focuses on providing a clear connection between neuroimaging biomarkers and
pathophysiology of parkinsonism with the ultimate goal of developing biomarkers to help identify early evidence of
underlying brain pathology that can be distinguished from evidence of later brain injury.
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