CURRICULUM VITAE
Name:
Fatemeh Sadeghi
E-mail:
sadeghif@mums.ac.ir or fatemehsadeghi@yahoo.com
Address:
School of Pharmacy, Mashhad University of Medical Sciences, P.O Box:
91775-1365, Mashhad, Iran
Academic Qualifications
1993-1996:
Doctor of Philosophy degree (PhD) in Pharmaceutical Technology from School
of Pharmacy, Liverpool John Moores University, Byrom st., Liverpool, L3 3AF, UK
1985-1990: Doctoral course of pharmacy (Pharm. D.), School of Pharmacy, Mashhad
University of Medical Sciences, Mashhad, Iran
Positions Held
2003- now Associate professor in Pharmaceutics, School of Pharmacy, Mashhad University of
Medical Science, Iran.
1997-2003 Assistant professor, School of Pharmacy, Mashhad University of Medical Science,
Iran.
Research experiences and interests








Formulation of sustained and controlled release matrices and reservoirs for oral delivery
Development of technique to increase the solubility and dissolution rate of poorly water
soluble drugs in order to increase their bioavailability
Coating
Solid dispersion systems
Microencapsulation of solid and liquid drugs
Pelletization using extrusion-spheronization technique
Formulation of colon delivery systems
Formulation of solid dosage forms
Reviewer for following journals
I have been chosen as an international referee for papers submitted for publication in international
journals such as:







European Journal of Pharmaceutics and Biopharmaceutics (Switzerland)
Drug Development and Industrial Pharmacy (USA)
Journal of Microencapsulation (UK)
Iranian J. Pharm. Sci. (Iran)
Iranian J. Pharm. Res. (Iran)
Daru (Iran)
Pharmaceutical Sciences (Iran)
Publications
1- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Design and study of ibuprofen
disintegrating sustained release tablets comprising coated pellets. Eur. J. Pharm. Biopharm. 68
(2008) 747-759.
2- Sadeghi, F., Eidi, M., Ansaripoor, N., Afrasiabi Garekani, H. Preparation and evaluation of
microcapsules containing diclofenac sodium and Eudragit RS or RL as oral sustained release
multiparticulate delivery system. Pharmaceutical Sciences. Journal of Faculty of Pharmacy,
Tabriz University of Medical Sciences. 1 Spring (2008) 9-18.
3. Sadeghi, F., Mosaffa, F., Afrasiabi Garekani, H. Effect of particle size, compaction force and
presence of aerosil 200 on the properties of matrices prepared from physical mixture of
propranolol hydrochloride and Eudragit RS or RL. Iranian Journal of Basic Medical Sciences. 10
(2007) 197-205.
4. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Thermal treating as a tool to produce
plastic pellets based on Eudragit RS PO and RL PO aimed for tableting. Eur. J. Pharm.
Biopharm. 67 (2007) 260-267.
5. Akhagri, A., Sadeghi, F., Afrasiabi Garekani, H. Combination of time-dependent and pHdependent polymthacrylates as a single coating formulation for colonic delivery of indomethacin
pellets. Int.J. Pharm. 320 (2006) 137-142.
6. Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F.,
Permeability and swelling studies on free films containing inulin in combination with different
polymethacrylates aimed for colonic drug delivery. Eur. J. Pharm. Sci. 28 (2006) 307-314.
7- Sadeghi, F., Afrasiabi Garekani, H. Ghodsi, S.A. Evaluation of solid dispersion systems of
acetaminophen and ethylcellulose, Eudragit RS or RL and the effect of solvent used in
preparation of these systems on characteristics of matrices. Pharmaceutical Sciences. Journal of
Faculty of Pharmacy, Tabriz University of Medical Sceinces. 1 Spring (2006) 47-54.
8- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Preparation and characterization of
ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. Int. J. Pharm., 303
(2005) 88-94.
9- Akhgari A., Afrasiabi Garekani, H., Sadeghi, F. and Azimaie, M. Statistical optimization of
indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug
delivery. Int. J. Pharm.,305 (2005) 22-30.
10- Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Tableting of Eudragit RS and propranolol
hydrochloride solid dispersion: Effect of particle size, compaction force and plasticizer addition
on drug release. Drug Dev. Ind. Pharm. 30 (2004) 759-766.
11- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Effect of drug loading on
physicomechanical and release properties of ibuprofen pellets prepared by extrusionspheronization. Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of
Medical Sceinces. 2 Autumn & Winter (2005) 55-64.
12- Afrasiabi Garekani, H.,Sadeghi, F. Salary, M. 2004, Dissolution study of acetaminophen
crystallized in the presence of polyvinylpyrrolidone., J. Drug Del. Sci. Tech. 14 (2004) 141-146.
13- Sadeghi, F., Afrasiabi Garekani, H., Sadr, A. Influence of polymer viscosity and plasticizer
addition on ethylcellulose matrix characteristics prepared from solid dispersion system. S.T.P.
PHARMA SCIENCE. 13 (2003) 105-110.
14- Sadeghi, F. Afrasiabi Garekani, H., Sadeghi, R. Comparison of ethylcellulose matrix
characteristics prepared by solid dispersion technique or physical mixing. DARU, 11 (2003) 713.
15- Sadeghi, F., Ford, J.L., Rajabi-Siahboomi, A.R. The influence of drug type on the release
profiles from Surelease coated pellets. Int. J. Pharm. 254 (2003) 123-135.
16- Garekani, H.A., Sadeghi, F., Firouzpoor, A. The influence of propylene glycol and moisture
on the compaction properties of acetaminophen granules. S.T.P. PHARMA SCIENCE. 13 (2003)
335-339.
17- Garekani, H.A., Sadeghi, F., Ghazi, A. Increasing the aqueous solubility of acetaminophen
in presence of polyvinylpyrolidone and investigation of the mechanisms involved. Drug Dev.
Ind. Pharm. 29 (2003) 173-179.
18- Sadeghi, F., Afrasiabi Garekani, H., Hajiaghapoor, N., Evaluation of Eudragit RS and RL
solid dispersion systems in preparation of diclofenac sodium sustained release matrices.
Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of Medical
Sciences. 2 Autumn & Winter (2003) 49-62
19- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Study of drug release
from pellets coated with Surelease containing hydroxypropylmethylcellulose. Drug Dev. Ind.
Pharm. 27 (2001) 416-427.
20- Garekani, H.A., Sadeghi, F., Badiee, A., Mostafa, S.A., Rajabi-Siahboomi, A.R. Crystal
habit modifications of ibuprofen and their physicomechanical characteristics. Drug Dev. Ind.
Pharm. 27 (2001) 803-809.
21- Sadeghi, F., Afrasiabi Garekani, H., Farzadnia, Z., Effect of polymer viscosity, polymer
particle size and compaction force on diclofenac sodium release from ethylcellulose matrices.
Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of Medical
Sciences. 2 Spring & Summer (2001) 45-56.
22- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Comparative study of
drug release from hydroxpropylmethylcellulose or Surelease coated pellets. Drug Dev. Ind.
Pharm. 26 (2000) 651-660.
Presentations in international conferences
1- F. Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. The effect of coating level on
mechanical and release properties of cured Eudragit based ibuprofen pellets. Pharmaceutical
Science World Congress, Amsterdam, Netherland, April 2007.
2- H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi. Comparison of permeability and swelling
characteristics of free films containing pectin or inulin in combination with time dependent
polymethacrylate aimed for colonic drug delivery. Pharmaceutical Science World Congress,
Amsterdam, Netherland, April 2007.
3- F.Sadeghi, M.R. Abbaspour, F., Tayarani, H. Afrasiabi Garekani. Mechanical and release
behavior of ibuprofen pellets based on Eudragit RL plasticized with triethylcitrate. Biritish
Pharmaceutical Conference, Manchester, UK, September 2006.
4- H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi. Combination of Inulin as a bacterially
degradable polysaccharide and Eudragit RS to achieve colon delivery of indomethacin pellets.
British Pharmaceutical Conference, Manchester, UK, September 2006.
5- F.Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. Effect of thermal treating on release and
physicomechanical properties of ibuprofen pellets based on Eudragit RS and RL. 2nd EUFEPS
Conference on optimizing drug delivery and formulation: Evaluation of drug delivery systems
issues and perspectives (Paris, France, November 2005)
6- H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi, Combination of time-dependent and pHdependent polymethacrylates as a single coating formulation for colonic delivery of
indomethacin pellets. 2nd EUFEPS Conference on optimizing drug delivery and formulation:
Evaluation of drug delivery systems issues and perspectives ( Paris, France, November 2005)
7-F. Sadeghi, H.A. Garekani, E.H. Moase, O. Meyer, T.M. Allen, Binding method for NGRtargeted liposomal doxorubicin using cells expressing the angiogenic marker CD13., Lipids,
Liposomes, and Biomembranes Conference (Vancouver, Canada, July 2005).
8-Sadeghi, F., Abbaspour, M.R., Afrasiabi Grekani, H. Preparation and characterization of
ibuprofen pellets based on Eudragit RS and RL or their combination. British Pharmaceutical
Conference, Manchester, UK, September 2004.
9- Afrasiabi Garekani, H., Akhgari, A., Sadeghi, F. Indomethacin release from pellets coated
with Eudragit S100 and Eudargit L100 combinations in media with different pH: an approach to
colon delivery. British Pharmaceutical Conference, Manchester, UK, September 2004.
10- Kazemian, H., Hadizadeh, F., Sadeghi, F., Esmail-Nazari, Z. A zeolite based formulation of
leukeran tablets: Synthesis, characterization and drug release evaluation. The 4th International
Postgraduate Research Symposium on Pharmaceutics (IPORSIP). Istanbul, Turkey, September
2004.
11- Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Solid dispersion of Eudragit RS and
propranolol hydrochloride: Effect of particle size, compaction pressure and plasticizer addition.
British Pharmaceutical conference, Harrogate, UK, September 2003.
12- Afrasiabi Garekani, Sadeghi, F., Salary, M. Dissolution study of paracetamol crystalised in
the presence of polyvinylpyrrolidon (PVP). British Pharmaceutical conference, Harrogate, UK,
September 2003.
13- Sadeghi, F. Sadr, A. Effect of plasticizer type and concentration on drug release from
ethylcellulose matrices prepared by solid dispersion technique. British Pharmaceutical
Conference, Manchester, UK, September 2002.
14- Sadeghi, F. Bakhshizadeh, M. Properties of granules and matrices of HPMC K4M prepared
by wet granulation using different combinations of water and ethanol. “British Pharmaceutical
Conference, Glascow, UK, September 2001.
15- Sadeghi, F. Preparation of ethylcellulose matrices by solid dispersion. 19 th Pharmaceutical
Technology Conference, Baveno- Stresa, Italy, April 2000. Published: Proceedings 19 th
Pharmaceutical Technology conference 2 (2000) 262-267.
16- Afrasiabi Garekani, H., Sadeghi, F., Badiee, A., Rajabi-Siahbomi, A.R. Crystal habit
modifications of ibuprofen and their physico-mechanical characteristics.19 th Pharmaceutical
Technology Conference, Baveno- Stresa, Italy, April 2000. Proceedings 19 th Pharmaceutical
Technology conference 2 (2000) 324-333.
17- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Drug release from HPMC
E15 and Surelease coated microcapsules. 12 th International Symposium on Microencapsulation.
London, 6-8 September 1999.
18- Sadeghi, F., Ford, J.L. Rubinstein, M.H., Rajabi- Siahboomi, A.R. "Effect of drug type on
release behaviour from coated pellets "23 rd International Symposium of Controlled Release of
Bioactive Materials, Kyoto, Japan, July, 1996). Published: Proceedings International Symposium
of Controlled Release of Bioactive Materials. 23 (1996)567-568.
19- Sadeghi. F., Ford, J.L., Rubinstein, M.H., Rajabi – Siahboomi, A.R., "Release Behaviour
from coated pellets: Effect of drug type. 15 th Pharmaceutical Technology Conference, Oxford,
U.K., March 1996. Published: Proceedings 15 th Pharmaceutical Technology conference 1
(1996) 289-306.
20- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. "Metoclopramide
hydrochloride release from coated pellets "14 th Pharmaceutical Technology Conference,
Barcelona.
Spain,
April,
1995.
Published:
Proceedings
14
th
Pharmaceutical Technology Conference, 1 (1995) 424-437.
21- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. "Effect of polymer type
and coating load on drug release from coated pellets "British Pharmaceutical Conference
(Warwick, U.K., September, 1995).