Curriculum Vitae
Part I:
General Information
Name:
Steven K. Grinspoon
Office Address:
Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital,
Boston, MA 02114, 617-726-3870
Fax:
617-726-5072
Education:
1983 B.A.
1988 M.D.
Cornell University
University of Rochester School of Medicine and Dentistry
Post-doctoral Training:
Internships and Residencies:
1988-1991 Resident in Medicine, Columbia-Presbyterian Hospital, New York
1991-1992 Chief Resident in Medicine, Columbia-Presbyterian Hospital, New York
Clinical and Research Fellowships:
1992-1993 Clinical Fellow, Endocrine Unit, Massachusetts General Hospital
1993-1995 Research Fellow, Neuroendocrine Unit, Massachusetts General Hospital
Licensure and Certification:
1991
1992
1995
American Board of Internal Medicine Certificate
Massachusetts License Registration
Endocrinology and Metabolism
Academic Appointments:
1992-1995 Postdoctoral Research Fellow in Medicine, Harvard Medical School
1995-1996 Instructor in Medicine, Harvard Medical School
1997Assistant Professor of Medicine, Harvard Medical School
Hospital and Affiliated Institution Appointments:
Steven Grinspoon, M.D.
1992-1993
Hospital
1993-1995
1995-1996
1996-1998
19981998-
Essential Clinical Fellow, Department of Medicine, Massachusetts General
Research Fellow, Department of Medicine, Massachusetts General Hospital
Clinical Assistant in Medicine, Massachusetts General Hospital
Assistant in Medicine, Massachusetts General Hospital
Assistant Physician, Massachusetts General Hospital
Associate Physician to the Affiliate Staff, Brigham and Women’s Hospital
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Steven Grinspoon, M.D.
Other Professional Positions and Major Visiting Appointments:
1998-
Visiting Scientist, Massachusetts Institute of Technology
Hospital and Service Responsibilities:
199519951996-
Attending Physician, Neuroendocrine Unit, Massachusetts General Hospital
Attending Physician, Baker Service, Massachusetts General Hospital
Attending Physician, Endocrinology Consult Service, Massachusetts General
Hospital
Major Administrative Responsibilities:
1999-
Assistant Director, General Clinical Research Center, Massachusetts Institute of
Technology
Major Committee Assignments:
Local/Regional
1995-1997
1997-
Member, Executive Committee, Boston Obesity Nutrition Research Center
Member, Scientific Advisory Committee, General Clinical Research Center,
Massachusetts General Hospital
National
1997
19981998199919991999-
Member, American Association of Clinical Endocrinologists AMAP Accreditation
Self Assessment Committee - Pituitary Section
Member, AIDS Clinical Trials Group Metabolic Focus Section
Vice Chairman, AIDS Clinical Trial Group Protocol 5005S, Glucose Metabolism,
Lipid Disorders, and Body Composition Changes in Subjects Treated with
Efavirenz or Nelfinivir
Member, University of California, Universitywide AIDS Research Program,
Study Section: Clinical Studies: HIV/OI/Malignancies
Member, National Institutes of Health - Review Committee Member, National
Center for Research Resources
Section Leader, Department of Health and Human Services - Expert Panel on
National HIV/AIDS Nutrition Guidelines
Professional Societies:
1992199619961998-
Member, American College of Physicians
Member, Endocrine Society
Member, American Society for Bone and Mineral Research
Member, American Association of Clinical Endocrinologists
3
Steven Grinspoon, M.D.
1998-
Member, The Pituitary Society
Editorial Boards:
2000-2004 Member, Editorial Board, Journal of Clinical Endocrinology and Metabolism
4
Steven Grinspoon, M.D.
Awards and Honors:
1980
1982
1983
College Scholar, Cornell University
Phi Beta Kappa
Magna Cum Laude
Report of Teaching
Continuing Medical Education Courses
1995-
Endocrine Postgraduate Course, Harvard Medical School
Lecturer -"HIV and the Endocrine System: What We Need to Know"
Preceptor - Pituitary Problem Session
1996-
AIDS Postgraduate Course, Harvard Medical School
Lecturer - “Wasting and Endocrine Disorders”
Clinical Supervisory Responsibilities
1991-1992
Attending physician, ward medical service, Columbia-Presbyterian Hospital
1995-
Preceptor, Neuroendocrine Clinic, Massachusetts General Hospital
1995-
Teaching attending, Baker Service, Massachusetts General Hospital
1996-
Teaching attending, Endocrinology Consult Service, Massachusetts General
Hospital
Teaching Leadership Roles
1995-1996
Endocrinology Lecture Series, Institute of Health Professions, Massachusetts
General Hospital
1998
Chairperson, “Massachusetts General Hospital Symposium on Medical and Bone
Complications of Eating Disorders”
1998
Fat
Chairperson, “Massachusetts General Hospital Symposium on Muscle Loss and
Redistribution in HIV Disease: An Endocrine Approach”
1998
Emergency Lecture Series, Massachusetts General Hospital
1999
Chairperson, “Massachusetts General Hospital Symposium on Novel Treatment
Strategies for Anorexia Associated Bone Loss in the Year 2000”
National/International Contributions
5
Steven Grinspoon, M.D.
Invited Presentations - Regional
1991-1992
1991-1992
Speaker, (Bi-weekly presentations), Morbidity and Mortality Conference
Columbia-Presbyterian Hospital, NY, NY
Speaker, Morning Report
Columbia-Presbyterian Hospital, NY, NY
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Steven Grinspoon, M.D.
Invited Presentations - Regional (Cont’d)
1992
1992
1995
1996
1996
1996
1996
1997
1997
1997
1997
1997
1997
1998
Speaker, Medical Grand Rounds
Columbia Presbyterian Hospital, NY, NY
"Salt-Sensitive Hypertension”
Speaker, Endocrine Grand Rounds
Columbia Presbyterian Hospital, NY, NY
"Endocrine Manifestations of HIV Disease"
Speaker, Research Update
Boston Researchers in Eating Disorders, Boston, MA
"Use of rhIGF-I to Stimulate Bone Formation in Anorexia Nervosa"
Speaker, Research Update
Fenway Community Health Center, Boston, MA
"The Role of Hormones and Metabolism in AIDS Wasting"
Speaker, Boston Nutrition Seminar Series
Massachusetts Institute of Technology, Boston, MA
“Effects of Acute and Chronic Undernutrition on Bone”
Speaker, Endocrine Grand Rounds
Boston University Medical Center, Boston, MA
“Anabolic Strategies in AIDS Wasting”
Speaker, Monthly HIV Update
Dimmock Community Health Center, Boston, MA
“Endocrine Manifestations of HIV Disease”
Speaker, Endocrine Grand Rounds
Columbia Presbyteriian Medical Center, New York, NY
“Anabolic Strategies in AIDS Wasting”
Speaker, Research Update,
Multicultural AIDS Coalition of Boston, MA
“Use of Testosterone in Men and Women with AIDS Wasting”
Speaker, Research Update, Anorexia Research Group
Westwood Lodge, Westwood, MA
“Update on Mechanisms and Therapeutic Strategies for Osteoporosis in Anorexia
Nervosa”
Speaker, Research Update
Boston Researchers in Eating Disorders, Boston, MA
“ Effects of rhIGF-I on Bone in Anorexia Nervosa”
Speaker, Adolescent Medicine Series
University of Massachusetts Medical Center, Worcester, MA
“Mechanisms and Treatment Options for Bone Loss in Anorexia Nervosa”
Speaker, AIDS Conference
New England Medical Center, Boston, MA
“HIV-Related Endocrinopathies”
Speaker, Clinical Seminar Series
Boston Obesity Research Center, Boston, MA
7
Steven Grinspoon, M.D.
1998
1999
“Practical Considerations in the Design and Implementation of a Clinical Research
Study”
Speaker, Health Education Seminar Series
Wellesley College, Wellesley, MA
“Treatment Strategies for Osteoporosis in Anorexia Nervosa”
Speaker, Combined AIDS Seminar,
Lemuel Shattuck Hospital,Boston, MA
“Hypogonadism in the AIDS Wasting Syndrome”
8
Steven Grinspoon, M.D.
Invited Presentations - Regional (Cont’d)
1999
1999
1999
1999
1999
Speaker, Research Seminar Series
USDA Human Nutrition Research Center on Aging
Tufts University, Boston, MA
“Strategies to Build Lean Body Mass and Reduce Fat Mass in HIV-Infected
Patients”
Speaker, New England AIDS Education and Training Seminar,
Dimmock Health Center, Boston, MA
“HIV/AIDS Update: A Program for Community Health Center Providers.”
Speaker, Endocrine Grand Rounds
New England Medical Center, Boston, MA
“Endocrine Manifestations of HIV Disease”
Speaker, Advanced Clinical Seminar on HIV/AIDS
Dartmouth-Hitchcock Medical Center, Lebanon, NH
“Wasting, Lipodystrophy and Other Issues in HIV Care”
Speaker, McGill University AIDS Centre Rounds, Montreal, Canada
“ Endocrine Disorders in HIV Disease”
Invited Presentations - National
1997
1997
Anorexia
1997
1998
1998
1998
1998
1999
Panelist, NIH Conference on AIDS Wasting Syndrome, Bethesda, MD
“Endocrinology of AIDS, Growth Hormone and Testosterone”
Speaker, Annual Meeting, New England College Health Associations, Boston, MA
“Mechanisms and Therapeutic Options for the Treatment of Bone Loss in
Nervosa”
Speaker, Annual Meeting of the New England Consortium of Student Health
Practitioners, Boston, MA
“Bone Loss in Anorexia Nervosa”
Speaker, Annual Meeting, Advances in Mineral Metabolism, Aspen, CO
“Effects of IGF-I on Bone”
Speaker, “Symposium on Clinical Care Issues for Women Living with HIV/AIDS
in the United States, “ Harvard AIDS Institute, Boston, MA,
“Endocrine Disorders in HIV-Infected Women”
Speaker, “Current Challenges in HIV Disease, “ International AIDS Society-USA ,
New York, NY
“Metabolic and Hormonal Complications of Protease Inhibitor Use”
Speaker, Annual Meeting, National Primary Care Conference of Nurse
Practitioners, Boston, MA
“Treatment Strategies for Bone Loss in Anorexia Nervosa”
Speaker, International AIDS Society USA, Improving the Management of HIV
Disease: An Advanced Course in HIV Pathogenesis, Antiretrovirals and Other
Selected Issues in HIV Disease, Cleveland, Ohio
“Long-Term Complications of Antiviral Therapy
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Steven Grinspoon, M.D.
1999
1999
1999
Chair, Breakout Session, Glucose Metabolism, 1st International Workshop on
Adverse Drug reactions and Lipodystrophy in HIV, San Diego, CA
Speaker, Twenty-Seventh AIDS Clinical Trials Group Meeting, Washington, D.C.
“Fasting Hyperinsulinemia and Regional Body Composition Changes in HIVInfected Men and Women”
Speaker, 1999 National Conference on Women and HIV/AIDS
“Gender Specific Differences in Body Composition and Substrate Metabolism: the
Role of Testosterone and Insulin in HIV-infected Women” in the the
Symposium
“HIV, Nutrition and Metabolics”
10
Steven Grinspoon, M.D.
Invited Presentations - International
1996
Speaker, International Symposium on Insulin-Like Growth Factor -I, Institut
Scientifique Roussel, Paris, France,
“Role of Growth Factors in Skeletal Tissue”
Speaker, Revolutionizing Women’s Healthcare: A Consensus Conference,
Cancun, Mexico,
“Determinants of Bone Accretion in Anovulatory Women”
Speaker, Symposium on Wasting, Metabolism and Altered Body Shape,
12th World AIDS Conference, Geneva, Switzerland,
“Testosterone and Testosterone Analogues”
Speaker, University College Dublin, Medical Research Forum
Dublin, Ireland
“Endocrine Manifestations of HIV Disease: Old and New”
Speaker, 3rd International Conference on Nutrition and HIV Infection, Cannes,
France
“Endocrine Disorders in HIV Disease - Relationship to the Wasting and
Lipodystrophy Syndromes”
1998
1998
1999
1999
Professional and Educational Leadership Roles
1998
Faculty, 1998 Endocrine Sociey Clinical Endocrinology Update, Boston, MA
1999
American Association of Clinical Endocrinologists, Patient Assessment
Guidelines, “Growth Hormone Deficiency and It’s Therapy in the Adult”
1999
Chairperson, Diabetes and Lipid Metabolism, Oral Session, Annual Meeting of the
Endocrine Society
Bibliography:
Original Articles
1.
Grinspoon S, Bilezikian J. AIDS and the endocrine system. N Engl J Med. 1992;
327:1360-65.
2.
Siegel L, Grinspoon S, Garvey G, Bilezikian J. Sepsis and adrenal function. Trends in
Endocrinology and Metabolism. 1994; 5:324-28.
3.
Grinspoon S, Clemmons D, Swearingen B, Klibanski A. Serum IGFBP-3 levels in the
diagnosis of acromegaly. J Clin Endocrinol Metab. 1995; 80:927-32.
4.
Grinspoon SK, Daniels GH. Increased levothyroxine requirement in a patient with cryptic
celiac-sprue disease. Endocrine Practice. 1995;1:88-90.
11
Steven Grinspoon, M.D.
5.
Grinspoon SK, Baum HBA, Peterson S, Klibanski A. Effects of rhIGF-I administration on
bone turnover during short-term fasting. J Clin Invest. 1995; 96: 900-6.
6.
Grinspoon SK, Baum HBA, Kim V, Coggins C, Klibanski A. Decreased bone formation
and increased mineral dissolution during acute fasting in young women. J Clin Endocrinol
Metab. 1995; 80:3628-33.
12
Steven Grinspoon, M.D.
Original Articles (Cont’d)
7.
Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L,
Bowsher R, Herzog D, Klibanski A. Serum leptin levels in women with anorexia nervosa.
J Clin Endocrinol Metab. 1996;81:3861-3.
8.
Grinspoon S, Corcoran C, Lee K, Burrows B, Hubbard J, Katznelson L, Walsh M,
Guccione A, Cannan J, Heller H, Basgoz N, Klibanski A. Loss of lean body and muscle
mass correlates with androgen levels in hypogonadal men with AIDS wasting. J Clin
Endocrinol Metab. 1996;81:4051-8.
9.
Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term
rhIGF-I administration on bone turnover in osteopenic women with anorexia nervosa. J
Clin Endocrinol Metab. 1996;81:3864-70.
10.
Grinspoon S, Corcoran C, Miller K, Biller B, Askari H, Wang E, Hubbard J, Anderson E,
Basgoz N, Heller H, Klibanski A. Body Composition and Endocrine Function in Women
with AIDS Wasting. J Clin Endocrol Metab. 1997;82:1332-7.
11.
Grinspoon S, Askari H, Landt ML, Nathan DM, Schoenfeld DA, Hayden DL, Laposata M,
Hubbard J, Klibanski, A. Effects of Fasting and Glucose on Basal and Overnight Leptin
Concentrations in Normal Weight Women. Am J Clin Nutr. 1997;66:1352-6.
12.
Miller KK, Daly PA, Sentochnik D, Doweiko J, Samore M, Basgoz NO, Grinspoon SK.
Pseudo-Cushing’s Syndrome in HIV-infected Patients. Clin Inf Dis. 1998;27:68-72.
13.
Grinspoon S, Corcoran C, Askari H, Schoenfeld D, Wolf L, Burrows B, Walsh
M, Hayden D, Parlman K, Anderson E, Basgoz N, Klibanski A, .Effects of
Androgen Administration in Men with the AIDS Wasting Syndrome: A
Randomized, PlaceboControlled Trial. Ann Int Med. 1998;129:18-26.
14.
Miller KK, Parulekar MS, Schoenfeld E, Anderson E, Hubbard J, Klibanski A,
Grinspoon SK. Decreased Leptin Levels in Normal Weight Women with
Hypothalamic Amenorrhea: The Effects of Body Composition and Nutritional
Intake. J Clin Endocrinol Metab. 1998;83:2309-12.
15.
Grinspoon S, Corcoran C, Miller K, Wang E, Hubbard J, Schoenfeld D, Anderson
E, Basgoz N, Klibanski A. Determinants of Increased Energy Expenditure in
HIV- Infected Women. Am J Clin Nutr. 1998;68:720-5.
16.
Miller K, Corcoran C, Armstrong C, Caramelli K, Anderson A, Cotton D, Basgoz
N, Hirschhorn L, Tuomala R, Schoenfeld D, Daugherty C, Mazer N, Grinspoon
S. Transdermal Testosterone Administration in Women with AIDS Wasting: A
Pilot Study. J Clin Endocrinol Metab. 1998;83:2717-25.
13
Steven Grinspoon, M.D.
17.
Swearingen B, Barker FG, Katznelson L, Biller BMK, Grinspoon S, Klibanski A,
Moayeri N, Black P, Zervas NT. Long-term Mortality After Transsphenoidal
Surgery and Adjunctive Therapy for Acromegaly. J Clin Endocrinol Metab.
1998;83:3419-26.
18.
Grinspoon S, Corcoran C, Stanley T, Katznelson L, Klibanski A. Effects of
Androgen Administration on the GH-IGF-I Axis in Men with AIDS Wasting. J
Clin Endocrinol Metab. 1998;83:4251-6.
14
Steven Grinspoon, M.D.
Original Articles (Cont’d)
19.
Grinspoon S, Corcoran C, Rosenthal D, Stanley T, Parlman K, Costello M, Treat
M, Davis S, Burrows B, Basgoz N, Klibanski A. Quantitative Assessment of
Cross Sectional Muscle Area, Functional Status and Muscle Strength in Men with
the AIDS Wasting Syndrome. J Clin Endocrinol Metab. 1999;84:201-6.
20.
Grinspoon S, Corcoran C, Stanley T, Anderson E, Hubbard J, Basgoz N,
Klibanski A. Sustained Anabolic Effects of Long-Term Androgen Administration
in Men with AIDS Wasting. Clin Inf Dis. 1999;28:634-6.
21.
Hadigan C, Miller K, Corcoran C, Anderson E, Basgoz N, Grinspoon S. Fasting
Hyperinsulinemia and Changes in Regional Body Composition in HIV-Infected
Women. J Clin Endocrinol Metab. 1999;84:1932-7.
22.
Swearingen B, Biller BMK, Barker FG, Katznelson L, Grinspoon S, Klibanksi A,
Zervas N. Long-Term Mortality after Transsphenoidal Surgery for Cushing
Disease. Ann Int Med. 1999;130:821-4.
23.
Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D,
Klibanski A. Severity of Osteopenia in Estrogen Deficient Women with Anorexia
Nervosa and Hypothalamic Amenorrhea. J Clin Endocrinol Metab.
1999;84:204955.
24.
Soyka L, Grinspoon S, Levitsky L, Herzog D, Klibanski A. The Effects of
Anorexia Nervosa on Bone Metabolism in Female Adolescents. J Clin Endocrinol
Metab 1999; 84: 4489-96.
25.
Hadigan C, Corcoran C, Stanley T, Piecuch S, Klibanski A, Grinspoon S. Fasting
Hyperinsulinemia in HIV-Infected Men: Relationship to Body Composition,
Gonadal Function and Protease Inhibitor Use . J Clin Endocrinol Metab. 2000; 85:
35-41.
26.
Hadigan CM, Anderson EJ, Miller KM, Hubbard JL, Herzog DB, Klibanski A,
Grinspoon S. Assessment of Macronutrient and Micronutrient Intake in Women
with Anorexia Nervosa. International Journal of Eating Disorders. 1999 (In Press).
27.
Grinspoon S. Hypermetabolism and Progression of HIV-infection. Am J Clin
Nutr. 1999;70:300 (letter).
28.
Grinspoon S, Corcoran C, Stanley T, Baaj A, Basgoz N, Klibanski A. Effects of
Hypogonadism and Testosterone Administration on Depression Indices in HIVInfected Men. J Clin Endocrinol Metab. 2000; 85: 60-5.
Reviews
15
Steven Grinspoon, M.D.
1.
Grinspoon S, Bilezikian J. Endocrine manifestations of AIDS. Trends in Endocrinology
and Metabolism 1993; 4:315-317.
2.
Grinspoon S, Bilezikian J. Endocrine abnormalities in HIV infection. The AIDS Reader
1993; 3:191-198.
3.
Grinspoon S, Bilezikian J. HIV infection and endocrine disease: Editorial review.
Current
Opinion in Endocrinology and Diabetes 1994; 1:3-6.
16
Steven Grinspoon, M.D.
Reviews (Cont’d)
4.
Grinspoon S, Bilezikian J. Clinical update: Metabolic and endocrinologic disturbances in
HIV Infection. ENDOtrends 1994; 4:1-3.
5.
Grinspoon S, Biller B. Laboratory assessment of adrenal insufficiency. J Clin Endocrinol
Metab. 1994; 79:923-931.
6.
Grinspoon S. AIDS: Endocrinologic and metabolic considerations. Ann Med. 1994;
26:321-323.
7.
Grinspoon S, Herzog D, Klibanski A. Mechanisms and treatment options for bone loss in
anorexia nervosa. Pharmacol Bul. 1997;3:399-404.
8.
Grinspoon S. Neuroendocrine manifestations of AIDS. The Endocrinologist. 1997;7:3238.
9.
Corcoran C, Grinspoon S. Diagnosis and Treatment of Endocrine Disorders in the HIVInfected Patient. Journal of the International Association of Physicians in AIDS Care.
February 1998:10-14,34.
10.
Grinspoon S. Effects of HIV infection on the hypothamic-pituitary-adrenal axis. The
AIDS Reader (editorial). 1999 (In Press).
11.
Corocoran C, Grinspoon S. The use of testosterone and testosterone analogues in the
AIDS wasting syndrome The AIDS Reader. 1999 (In Press).
12.
Becker A, Grinspoon S, Klibanski A. Herzog D. The Assessment and Management of
Eating Disorders. N Engl J Med. 1999; 340:1092-1098.
13.
Corocoran C, Grinspoon S. Treatments for wasting in patients with AIDS. N Engl J Med.
1999; 349:1740-50.
Chapters
1.
Grinspoon S, Donovon D, Bilezikian J. Etiology and Pathogenesis of Hormonal and
Metabolic Disorders in HIV Infection. In: Norbiato G, ed. Hormonal and Metabolic
Disorders in Acquired Immunodeficiency Syndrome. London: Bailliere Tindal, 1994;
8:735-737.
17