MASSACHUSETTS
GENERAL HOSPITAL
HARVARD
MEDICAL SCHOOL
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2003-2004
GRAND ROUNDS COURSE NUMBER 2116

7/3/04 -- VOLUME AND OUTCOME IN NEUROSURGERY -- Frederick G. Barker, M.D., Assistant
Professor of Surgery – Neurosurgery, Harvard Medical School

7/10/2003 - MOOD STABILIZERS AND TROPHIC FACTORS - Husseini Manji, M.D., Chief of the
Laboratory of Molecular Pathophysiology, National Institute of Mental Health

7/17/2003 - NEUROMODULATION: CLINICAL AND RESEARCH FRONTIERS - Emad S. Eskandar,
M.D., Ph.D., Assistant Professor of Neurosurgery, Harvard Medical School

7/24/2003 DESIGN AND IMPLEMENTATION OF A CLINICAL DATABASE FOR MGH NEUROSURGERY Michael D. Medlock, M.D., Assistant Professor of Neurosurgery, Harvard Medical School

August –No Grand Rounds

9/4/2003-CYTOKINES PROMOTE PATTERN RECOGNITION BY IMMUNE CELLS -- Michael Lotze, M.D.,
Professor of Surgery, Molecular Genetics and Biochemistry, University of Pittsburgh; Director
of Translational Research, Molecular Medicine Institute, University of Pittsburgh

9/11/2003-- THREE NEUROSURGICAL CASE STUDIES - Joseph Neimat, MD, Manish Aghi, MD,
Clark Chen, MD, Massachusetts General Hospital

9/18/2003 -CHALLENGES IN THE M ANAGEMENT OF CUSHING'S DISEASE - Brooke Swearingen, MD,
Assistant Professor of Surgery (Neurosurgery), Harvard Medical School and Beverly M.K
Biller, MD, Associate Professor of Medicine. Harvard Medical School

9/25/2003 -- THE OUTLOOK TOWARD BETTER INVASIVE MONITORING IN THE NEURO ICU William E.
Butler, Assistant Professor, Harvard Medical School:

10/2/2003-NEUROSCIENCE GRAND ROUNDS 8:30 A.M. Markell-Balkin Lecture in NeuroOncology - DEFECTIVE RECEPTOR SIGNALING IN GLIOMAS DRIVES TUMOR HETEROGENEITY Webster K. Cavenee, PhD; Director of the Ludwig Institute for Cancer Research and
Professor of Medicine, University of California, San Diego

10/9/2003--William H. Sweet Lecture - PAIN: ITS MECHANISMS AND NEUROSURGICAL CONTROL -
Donlin M. Long, M.D., Ph..D., Distinguished Service Professor of Neurosurgery, Johns
Hopkins University School of Medicine

10/16/2003-Abstract Preview for congress of Neurological Surgeons-- William T. Curry, Brian L.
Hoh and Joseph Neimat (attendings Frederick G. Barker, Robert L. Martuza, Emad N. Eskandar)

10/23/2003 --Congress of Neurosurgeons--No Rounds

10/30/2003 --Academy of Neurological Surgeons – No Rounds

11/6/2003--NEUROSCIENCE GRAND ROUNDS 8:30 A.M. IMAGING THE INNER WORKINGS OF SOLID
TUMORS: A 25 YEAR ODYSSEY Rakesh K. Jain, PH.D., A. Werk Cook Professor of Radiation
Oncology (Tumor Biology). Harvard Medical School; Director of Steele Laboratories Department of Radiation Oncology, Massachusetts General Hospital

11/13/2003--CASE STUDY: RECURRENT MENINGIOMA IN A 70-YEAR-OLD MALE -- William T. Curry,
Jr., M.D., Chief Resident in Neurosurgery
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2003-2004
GRAND ROUNDS COURSE NUMBER 2116

11/20/2003 --INTERLEUKIN 13 SYSTEM IN BRAIN TUMORS DIAGNOSIS AND TREATMENT, Waldemar
Debinski, M.D., Ph.D, Vice-Chair for Neurosurgical Research; Department of Neurosurgery
Pennsylvania State University College of Medicine

11/27/2003-Thanksgiving Holiday--No Rounds

12/4/2003--NEUROSCIENCE GRAND ROUNDS 8:00 -10 a.m.
8:00 am Annual James H. White Lecture, GENETICS AND BIOLOGY OF MALIGNANT GLIOMAS,
Ronald A DePinho, Ph.D. Professor of Medicine, Harvard medical School
9:00 am Annual Brian Silber Lecture, NEW APPROACHES TO TREATMENT OF MALIGNANT
GLIOMAS, Darrell Bigner, M.D., Ph.D. Edwin L. Jones, Jr., and Lucille Finch Jones Cancer
Research Professor, Chairman for investigator pathology and Director pro tempore , Duke
Comprehensive Cancer Center

12/11/2003 -- THE M AKING OF A NEUROSURGEON: ULTIMATE TRIPLE-H THERAPY - Steven N.
Kalkanis, M.D., Instructor, Harvard Medical School, Massachusetts General Hospital

12/18/2003 -- NEURORADIOLOGY OF BRAIN TUMOR THERAPY-- John Henson, M.D., Associate
Professor of Neurology, Harvard Medical School

12/25/2003 -- Christmas

01/01/2004 -- New Year

01/08/2004 – NEUROSCIENCE GRAND ROUNDS 8:30 A.M. THE NEUROBIOLOGY OF
SCHIZOTYPAL PERSONALITY DISORDER -- Martha Elizabeth Shenton, Ph.D., Professor and
Director, Clinical Neuroscience Division. Laboratory of Neuroscience, Department of
Psychiatry, VA Boston Healthcare System and Harvard Medical School; Professor of
Radiology and Director of Psychiatry and Behavioral Science Imaging, Surgical Planning
Laboratory, MRI Division, Department of Radiology Brigham and Women’s Hospital, Harvard
Medical School

01/15/2004 -- SUNDARAM LECTURE WITH ANESTHESIA. Dr. Geoff Manley, Chief of Neurotrauma,
San Francisco General Hospital.

01/22/2004 --VENOUS OCCLUSIVE PROBLEMS IN NEUROSURGERY -- Paul Chapman, M.D., MGH,
Nicholas T. Zervas Professor of Neurosurgery, Harvard Medical School

01/29/2004 -- THE NEUROSURGEON'S ROLE IN THE M ANAGEMENT OF ATHLETIC INJURIES - Arthur
Day, MD; Professor of Surgery, Harvard Medical School

02/05/2004 – NEUROSCIENCE GRAND ROUNDS - TRANSCRANIAL MAGNETIC STIMULATION,
DISRUPTING THE BRAIN TO IMPROVE BEHAVIOR -- Alvaro Pascual-Leone, PhD. M.D., Associate
Professor of Neurology, Harvard Medical School; Department of Neurology, Beth IsraelDeaconess medical Center

02/12/2004 -- USING NEW IMAGING TECHNOLOGY TO BETTER UNDERSTAND PERSISTENT
VEGETATIVE AND MINIMALLY CONSCIOUS STATES -- Nicholas D. Schiff, M.D.. Director,
Laboratory of Cognitive Neuromodulation; Assistant Professor of Neurology and
Neuroscience, Department of Neurology and Neuroscience, Weill Medical College of Cornell
University; Assistant Attending Neurologist, New York Presbyterian Hospital-Weill Cornell
Medical Center
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2003-2004
GRAND ROUNDS COURSE NUMBER 2116

02/19/2004 -- NERVE TUMORS, NERVE STIMULATORS, BRAIN TUMORS AND RESEARCH -- E. A.
Chiocca M.D., PhD, Associate Professor of Neurosurgery, Harvard Medical School)

02/26/2004 – VASOSPASM – Johnny C. Pryor, Instructor of Surgery, Harvard Medical School,
Co-Director, Interventional Neuroradiology/Endovascular Neurosurgery, MGH

03/04/2004 -- NEUROSCIENCE GRAND ROUNDS - A Neurotrophic Hypothesis of
Depression - Ronald S. Duman, Ph.D., Professor of Psychiatry and Pharmacology, Director,
Abraham Ribicoff Research Facilities Laboratory of Molecular Psychiatry, Yale University
School of Medicine

03/11/2004 -- MECHANISM OF PACEMAKING IN SUBTHALAMIC NEURONS: RELEVANCE TO DEEP
BRAIN STIMULATION FOR PARKINSON'S DISEASE -- Michael Tri Hoang Do, PhD., Harvard Medical
School

03/18/2004 -- SV AMPLICON VECTORS FOR GENE THERAPY AND FUNCTIONAL GENOMICS -Yoshinaga Saeki, M.D., Ph.D., Assistant Professor of Surgery, Harvard Medical School

03/25/2004 -- INTRACRANIAL DURAL AVM'S --Christopher S. Ogilvy, M.D., Professor of
Neurosurgery, Harvard Medical School, Johnny C. Pryor, M.D., Instructor of Neurosurgery,
Harvard Medical School, Brian L. Hoh, M.D., Massachusetts General Hospital

04/01/2004 -- NEUROSCIENCE GRAND ROUNDS --ADVANCES IN THE NEUROBIOLOGY OF
OBSESSIVE COMPULSIVE DISORDER: FROM NEUROIMAGING TO NEUROTHERAPEUTICS -- Scott L.
Rauch, M.D., Psychiatrist, Massachusetts General Hospital; Associate Chief of Psychiatry for
Neuroscience Research; Director of the Psychiatric Neuroimaging Research Program and the
Division of Psychiatric Neuroscience and Neurotherapeutics; Associate Professor of
Psychiatry, Harvard Medical School

04/08/2004, MECHANISMS OF SECONDARY INJURY IN BRAIN TRAUMA -- Donald W. Marion, M.D.,
Professor and Chairman, Department of Neurosurgery, Boston University School of Medicine

04/15/2004 -- SUPERIOR SEMICIRCULAR CANAL DEHISCENCE SYNDROME-- Michael J. McKenna,
M.D., Associate Professor of Otology and Laryngology, Mass Eye and Ear Infirmary


04/22/2004 -- JOINT GRAND ROUNDS SYMPOSIUM WITH NEUROLOGY 8:30 A.M;
STROKE AND THE NEUROVISUAL SYSTEM, Dr. Robert Daroff and Dr. David Zee. Organized to
celebrate Dr. Shirley H Wray's 30th anniversary on the C. Miller Fisher Stroke Service

04/29/2004 -- AANS Abstracts

05/06/2004 – NEUROSCIENCE GRAND ROUNDS NEURAL SYSTEMS INVOLVED IN FEAR,
ANXIETY AND EXTINCTION -- Michael Davis, M.D., Robert W. Woodruff Professor of Psychiatry,
Behavioral Sciences and Psychology, Emory University School of Medicine –

05/13/2004 -- IMAGING AND EPILEPSY: A NEUROSURGEON'S PERSPECTIVE -- G. Rees Cosgrove,
M.D., Associate Professor of Surgery, Harvard Medical School

05/20/2004 – THE BOSTON SYMPHONY OORCHESTRA-- Nicholas Zervas, M.D., Distinguised
Higgins Professor of Neurosurgery, Harvard Medical School, Member Board of Trustees,
Boston Symphony Orchestra)

05/27/2004 -- THORACIC AND LUMBAR INSTABILITY -- Jean Valery Coumans, M.D., Instructor of
Surgery, Harvard Medical School
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2003-2004
GRAND ROUNDS COURSE NUMBER 2116

06/03/2004 -- NEUROSCIENCE GRAND ROUNDS - GENES, COGNITION AND EMOTION -Daniel R. Weinberger, Chief, Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda,
Maryland

06/10/2004 -- North Service Chief Rounds -- NEUROSURGERY REPORT- Dr. William T. Curry,
Jr., M.D., Instructor of Surgery, Harvard Medical School

06/17/2004 – IMAGING ADVANCES IN PEDIATRIC BRAIN DISORDERS -- Ellen Grant, M.D., Assistant
Professor Pediatric Neuroradiology, Harvard Medical School

06/24/2004 – SIGNIFICANCE AND THERAPEUTIC TARGETING OF THE PLEIOTROPHIN / ALK
TYROSINE KINASE RECEPTOR -- Anton Wellstein, MD PhD, Professor Oncology &
Pharmacology, Lombardi Cancer Center, Georgetown University
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2003-2004
GRAND ROUNDS COURSE NUMBER 2116