MASSACHUSETTS
GENERAL HOSPITAL
HARVARD
MEDICAL SCHOOL
DEPARTMENT OF NEUROSURGERY
REPORT OF COURSE FOR 2004-2005
GRAND ROUNDS COURSE NUMBER 2116
7/1/04 -- PROTON THERAPY IN PEDIATRIC NEURO-ONCOLOGY --William E. Butler, M.D.
Assistant Professor of Surgery – Neurosurgery, Harvard Medical School
7/8/04 -- DEEP BRAIN STIMULATION FOR INTRACTABLE OBSESSIVE COMPULSIVE DISORDER AND
DEPRESSION -- Benjamin D. Greenberg, MD, PhD, OCD, Research Unit, NIMH, Bethesda, MD
7/15/04 -- SYMPATHETIC NERVOUS SYSTEM DISORDERS -- Harold Wilkinson, MD, PhD
Massachusetts General Hospital, Newton-Wellesley Hospital
7/22/04 -- LABORATORY EFFORTS WITH NOVEL STRATEGIES TO TREAT ANEURYSMS --Brian
L. Hoh, M.D., Massachusetts General Hospital
AUGUST – BREAK-9/2/04 – NEUROSCIENCE GRAND ROUNDS -- LEARNING AND MEMORY MECHANISMS
OF THE BASAL GANGLIA -- ANN M. GRAYBIEL, PH.D., Walter A Rosenblith Professor of
Neuroscience, Department of Brain and Cognitive Sciences, Massachusetts Institute of
Technology
9/9/04 --CAROLYN FRYE HALLORAN SYMPOSIUM ON NEURO-ONCOLOGY
PRIMARYCNS LYMPHOMA: FROM BENCH TO BEDSIDE. NEUROLOGY AND
NEUROSURGERY GRAND ROUNDS

8:30 am -- My Experience with PCNSL, Lisa DeAngelis, MD,
Professor of Neurology, Weill College of Medicine, Cornell
University, Chairman, Department of Neurology, Memorial SloanKettering Cancer Center
9:00 am -- Overcoming Resistence to Chemotherapy, Henry S.
Friedman,James B. Powell Jr. Professor of Neuro-Oncology, CoDirector Neuro-oncology Program, the Brain Tumor Center,
Professor of Pediatrics, Associate Professor of Surgery and
Medicine, Duke University
9/16/04 -- TRAUMATIC BRAIN INJURY: POST-ACUTE MEDICAL COMPLEXITIES OF THE
MINIMALLY CONSCIOUS STATE -- David Burke, M.D., Medical Director, Spaulding
Rehabilitation Hospital Brain Injury Program
9/23/04 -- INTRAMEDULLARY SPINAL CORD TUMORS -- Lawrence Borges, MD
Associate Professor of Surgery (Neurosurgery), Harvard Medical School
9/30/04 – NEUROSCIENCE GRAND ROUNDS (William H, Sweet Lecture)-FUNCTIONAL INHIBITION OF DEEP BRAIN STRUCTURES BY HIGH FREQUENCY STIMULATION:
APPLICATION TO MOVEMENT DISORDERS AND OTHER NERVOUS DISEASES, AND MECHANISM
OF ACTION, Professor Alim Louis Benabid, MD, PhD, Professor at Grenoble University, \
neurosurgery and biophysics, Director of the research laboratory INSERM unit 318,
(Preclinical Neurosciences), and has been Head of the Neurosurgery Department at the
University Hospital of Grenoble, Professor of Biophysics (exceptional class) at the
Joseph Fourier University since 1988. He is also Coordinator of the Claudio Munari
center for surgery of epilepsy and movement disorders, at hospital Ni Guardia in Milan,
Italy since 1998. He is also a staff consultant at the Cleveland Clinic Foundation
10/7/04--THE BRAIN-MACHINE INTERFACE: AN EVOLVING PARADIGM OF NEUROSCIENCE
AND NEUROSURGERY, Parag Patil, MD, PhD, Dept of Neurosurgery, Duke University
10/14/04 -

8:00 a.m.--CNS RESIDENT PRESENTATIONS
8:30 a.m.-- MODIFIED BORON NEUTRON CAPTURE THERAPY (BNCT) FOR
MALIGNANT GLIOMAS USING EPITHERMAL NEUTRON AND TWO BORON
COMPOUNDS WITH DIFFERENT ACCUMULATION MECHANISMS -- Shin-Ichi
Miyatake, M.D., Ph.D., Associate Professor. Dept. of Neurosurgery Osaka
Medical College
10/21/04—CANCELLED –CONGRESS OF NEUROLOGICAL SURGEONS ANNUAL
MEETING
10/26/04 – BRIAN D. SILBER MEMORIAL LECTURE – CELLULAR SCALPELS DERIVED
FROM GENETICALLY-MODIFIED T-CELLS FOR EXCISING INVASIVE TUMOR CELLS OF MALIGNANT
GLIOMA—MICHAELC.V. JENSEN, MD, Assistant Professor in Pediatrics at the City of Hope
National Medical Center and Division of Molecular Medicine, Beckman Research Institute;
Director of the Pediatric Neuro-Oncology Program and Director of the Zagoria Laboratory for
Pediatric Cancer Research, Division of Molecular Medicine; Associate Director of the Cancer
Immunotherapeutics Program, Cancer Center.
11/04/04—NEUROSCIENCE GRAND ROUNDS – COMPUTING WITH NEURAL
ENSEMBLES -- Miguel AL Nicolelis, MD, PhD, Professor in the Departments of
Neurobiology, Biomedical Engineering and Psychological and Brain Science CoDirector, Center for Neuroengineering at Duke University Medical Center in Durham,
North Carolina
11/11/04 -- FROM SYMPHONY TO CACOPHONY: THE PATHOPHYSIOLOGY OF PARKINSON
DISEASE, Emad N. Eskandar, M.D., Assistant Professor, Harvard Medical School
11/18/04 -- CONUNDRUMS IN STROKE DISEASE, Robert Ackerman, MD, Associate
Professor of Radiology, Harvard Medical School, MGH
11/25/04 –HOLIDAY--CANCELLED
12/2/04--NEUROSCIENCE GRAND ROUNDS -- THE ROLE OF NEUROSCIENCE IN THE
DEVELOPMENT OF A RETINAL PROSTHESIS TO RESTORE VISION TO THE BLIND-- Joseph F.
Rizzo, III, MD, Associate Professor of Ophthalmology; Harvard Medical School,
Department of Ophthalmology, Mass Eye and Ear Infirmary
12/9/04-- CURRENT MANAGEMENT OF ACROMEGALY -- Brooke Swearingen, MD
Assistant Professor of Surgery/Neurosurgery, Harvard Medical School
Karen Miller, MD, Assistant Professor of Medicine, Harvard Medical School
12/16/04 –THE NORTH REPORT—Joseph S. Neimat, M.D., Instructor, Harvard Medical
School
12/23/04 -- holiday-- cancelled
12/30/04 -- holiday - -cancelled
1/06/05 -- NEUROSCIENCE GRAND ROUNDS -- CONSCIOUS EXPERIENCE IN A
DISTRIBUTED CORTICAL NETWORK, Michael S. Gazzaniga, Ph.D., David T. McLaughlin
Distinguished University Professor, Director of the Center for Cognitive Neuroscience,
and Professor of Psychological and Brain Sciences, Dartmouth College
1/13/05 – NO GRAND ROUNDS
1/20/05 – NEW ENGLAND JOURNAL OF MEDICINE GRAND ROUNDS ON TRIGEMINAL
NEURALIGIA – A 61-YEAR OLD MAN WITH FACIAL PAIN by Emad Eskandar, M.D., Assistant
Profesor of Neurosurgery, Harvard Medical School, Massachusetts General Hospital
1/27/05 -- Grand Rounds: THE COSGROVE REPORT; Dr. G Rees Cosgrove will
deliver a final grand rounds and report on the functional and stereotactic program at
MGH.
2/3/05—NEUROSCIENCE GRAND ROUNDS – OUTCOMES OF EPILEPSY SURGERy
Susan Spencer, MD. , Director Epilepsy Program Yale University School of Medicine
Department of Neurology
02/10//05 – MODIFICATION OF HUMAN HEARING LOSS BY PLASMA-MEMBRANE CALCIUM
PUMP PMCA2 – John Penniston, MD, Lecturer, Harvard Medical School
2/17/05 -- RESEARCH IN SPINAL CORD INJURY-- Kevin O'Connor MD, Assistant Professor
of Physical Medicine & Rehabilitation, Harvard Medical School, Director of Spinal Cord
Injury Program, Spaulding Rehabilitation Hospital
3/3/05—NEUROSCIOENCE GRAND ROUNDS -- MONOAMINE TRANSPORTERS:
TARGETS FOR DIAGNOSTIC AND THERAPEUTIC AGENTS -- Bertha K. Madras, Ph.D.,
Professor of Psychobiology, Department of Psychiatry, Harvard Medical School
Chair, Division of Neurochemistry. New England Primate Research Center
3/10/05 – VASCULAR UPDATE -- Johnny C. Pryor, M.D., Instructor, Harvard Medical
School
3/17/05 -- FUSIFORM INTRACRANIAL ANEURYSMS--Christopher S. Ogilvy, M.D,. Professor
of Neurosurgery, Harvard Medical School, Director, Cerebrovascular Surgery,
Massachusetts General Hospital
3/24/05 -- CHIARI MALFORMATION-- William E. Butler, M.D., Assistant Professor of
Neurosurgery, Harvard Medical School
3/31/05 -- NEUROSCIENCE GRAND ROUNDS -- PSYCHIATRIC GENETICS: A CURRENT
PERSPECTIVE -- Kenneth S. Kendler, MD, Professor, Psychiatry, Human Genetics,
Medical College of Virginia; Director, Virginia Institute for Psychiatric and Behavioral
Genetics
4/7/05 -- NEUROSCIENCE GRAND ROUNDS -- MOLECULAR REGULATION OF
SYNAPTOGENESIS”-- Joshua R. Sanes, Ph.D., Professor of Molecular and Cellular
Biology; Director, Center for Systems Neuroscience, Harvard University
4/14/05 – RESIDENT AANS PRACTICE PRESENTATIONS
4/21/05 – AANS ANNUAL MEETING—NO GRAND ROUNDS
4/28/05 –

DRG UPDATE -- Elizabeth Mort, M.D., Associate Chief Medical Office,
Director of Clinical Care Management Unit, Decision Support Quality
Management Unit, MGH

ONCOLYTIC HSV MUTANTS EXHIBIT ENHANCED REPLICATION IN GLIOMA
CELLS EVADING CHEMOTHERAPY THROUGH DNA REPAIR -- Manish Aghi,
M.D., 4th year Resident, Massachusetts General Hospital
CODING OF SOUND IN THE HUMAN CENTRAL AUDITORY SYSTEM: INVESTIGATION USING
FUNCTIONAL AND STRUCTURAL MRI
5/12/05 UNKNOWN CEREBRAL MASSES – Herbert Cares, M.D., Department of
neurosurgery, Massachusetts General Hospital, Tessa Hedley-Whyte, M.D., Professor of
Pathology, Harvard medical School
5/19/05 – Ziv Williams, Resident, Massachusetts General Hospital
5/26/05 -- UNDERSTANDING HOW GROUPS OF NEURONS REPRESENT INFORMATION IN THE
BRAIN -- Emery N. Brown, M.D., Ph.D., Anesthetist, Department of Anesthesia & Critical
Care, Massachusetts General Hospital, Associate Professor of Anaesthesia, Health
Sciences and Technology, Harvard/MIT Division of Health Sciences and Technology
6/2/05 -- DEVELOPMENT OF A NOVEL THERAPY FOR TREATMENT RESISTANT DEPRESSION:
SELECTIVE MODULATION OF CG25 PATHWAYS USING DEEP BRAIN SIMULATION--Helen S.
Mayberg, M.D., Professor of Psychiatry, Emory University School of Medicine
6/9/05 -- PERIPHERAL NERVE SURGERY AND TISSUE ENGINEERING--Jason H. Huang, MD
Department of Neurosurgery, University of Pennsylvania
6/16/05 – THE NORTH REPORT— Ekkehard Kasper, M.D., DPhil., Instructor, Harvard
Medical School
6/23/05 -- DISSECTING ANEURYSMS OF THE VERTEBROBASILAR CIRCULATION -- James
Rabinov, M.D., Assistant Professor of Radiology, Harvard Medical School
6/30/05 -- QUANTITATIVE SENSORY TESTING--Didier Cros, M.D., Associate Professor of
Neurology, Harvard Medical School