3D Modeling of Biological Macromolecules
Miniterm 2011
Examining LasR: The Movie Script
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Opening Shot: overview of whole molecule with sidechains, hets and mainchains
Zoom in for a closer view, total 720 degree rotational view of entire molecule
After panning out, zoom into the active site of the molecule, where the
autoinducer (the het) has been placed within the sidechains
Zoom all the way out for transition to ribbon molecule
Rotational view of ribbon structure shows the alpha-beta structure of the molecule
(green beta sheets surrounded by sharp red alpha helices)
Transition to backbone of molecule only
Rotational view shows full molecule again, faster spinning only for effect
Rotation ends in merging of two groups, making the molecule appear as a
dimmer, with both groups superimposed on each other, lapsing perfectly
Zoom in again to the active site for a look at the autoinducers superimposed on
top of one another
Transition to view of autoinducer, appearing as pink colored het
Transitions begin to other chemicals
o Calmidazolium (chloride)
o Fendaline
o Pimethixene
o Sertraline
o Tamoxifen
o Terfenadine
Transition to view of autoinducer in active site with H-bonds (green), Hydrogens
(cyan); and amino acids (red):
o Asparagine
o Tryptophan
o Tyrosine
o Serine
Zoom in for closer overview, revealing interactions between the received
autoinducer and the amino acids
Transitions begin to animation Kinemage of all six chemicals superimposed upon
a pair of autoinducers in empty space
o Calmidazolium (chloride)
o Fendaline
o Pimethixene
o Sertraline
o Tamoxifen
o Terfenadine
Zooms in on the a single terfenadine-autoinducer superimposed image, animates
backwards in reverse order:
o Terfenadine
o Tamoxifen
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o Sertraline
o Pimethixene
o Fendaline
o Calmidazolium (chloride)
Transition to view of molecule, revealing only sidechains and clashes created
from the placement of the different chemicals into the molecular structure
After rotation, cycles through each of the chemicals superimposed into the active
site, with clashes shown in hot pink
Movie ends with final overview of entire molecule showing sidechains (cyan),
mainchain (yellow and white), and het/autoinducer (pink)