Course Name: Course Number: Credit Hours: Pharmacology and Therapeutics -II 700238 3 Hrs. ( 2 Lect. + 1 Pract. ) Introduction Pharmacology is a specialty, which has grown in importance with the increase in both the number and the complexity of drugs. The subject should bridge the gap between purely basic sciences and clinical sciences to promote a safe and effective drug use optimizing benefits and minimizing risks. Rational drug use embraces not only rational drug prescribing by the clinical practitioner but also rational drug dispensing by the pharmacist and rational drug consumption by the patient. The pharmacist can play an important role in achieving rational drug use and educating the patients about the various aspects of how to handle drugs. With such views in mind, the present course is designed as a clinically oriented subject rather than a purely basic one. Therefore, therapeutic applications of drugs and their adverse effects are emphasized throughout the course. In addition the importance of monitoring plasma concentrations of many drugs and the beneficial outcomes of conducting drug utilization studies to serve as a feedback to medical practitioners are also stressed through seminars and tutorials. Moreover, a separate course is taught covering the mechanisms of action, therapeutic indications and adverse effects of anti-microbial agents, and drug treatment of cancer and general principles of toxicology. It is hoped that these courses will provide a clear understanding not only of how but also of when to use drugs. Theory lectures • Drugs acting on cardiovascular system Pharmacotherapy of hypertension Treatment of angina pectoris Treatment of congestive heart failure Classification and pharmacology of antiarrhythmic drugs Pharmacotherapy in hyperlipoproteinemia • • • Renal system General physiology Control of acid base balance Diuretics and antidiuretics • • • • • 15 4 2 3 4 2 5 1 1 3 Haematopoitic system Pharmacotherapeutic of anaemia and blood disorders (Iron preparations, uses, acute & chronic toxicity) 1 6 • • Folic acid & Vitamin B12 Anticoagulants, fibrinolytics, antithrombotics & antagonists 1 4 • • • • Drugs acting on Gastro-instinal tract Pharmacotherapeutics of peptic ulcer Pharmacotherapeutics of constipation Pharmacotherapeutics of diarrhea Emetic and antiemetics 5 • • • • • • • • • • • • • Labs & Tutorials Effect of drugs in blood pressure part 1 (computer simulation) Effect of drugs on blood pressure part 2 (computer simulation). Effect of drugs on rat blood pressure (experimental demonstration) Clinical case studies on CV disorders - 1 Clinical case studies on CV disorders - 2 Clinical case studies on CV disorders - 3 Coronary circulation part 1 (computer simulation) Coronary circulation part 2 (computer simulation) Effect of diuretics on rats (experimental) Diseases of gastrointestinal tract part 1 (computer simulation) Diseases of gastrointestinal tract part 2 (computer simulation) Introduction of ulcer in rats (experimental) Tutorial on haematopoietics and G.I.T. drugs + test 3 2 1 1 1 Main Text Book: Basic and Clinical Pharmacology 6th ed, Bertrand G. Katzung Librairie Du Liban Publisher, 1995 (we prefer the latest edition) Additional Reference: 1. Pharmacology, Rang Dale 2. The Pharmacological Basis of Therapeutics, Goodman & Gilman