Principal Investigator/Program Director (Last, First, Middle): Marr, David W.M. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE David W.M. Marr Professor, Chem. Eng. Dept. Colorado School of Mines eRA COMMONS USER NAME davemarr EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE (if applicable) INSTITUTION AND LOCATION University of California, Berkeley Georg-August Universität, Göttingen, Germany Stanford University Stanford University Raychem Corporation BS MS Ph.D. Postdoc YEAR(s) 1983-1988 1986-1987 1989 1990-1993 1993-1995 FIELD OF STUDY Chemical Engineering Chemistry/Math/Physics Chemical Engineering Chemical Engineering Chemistry/Physics David W.M. Marr Chemical Engineering Department, Colorado School of Mines, Golden, CO 80401-1887 (303) 273-3008; FAX: (303) 273-3730; e-mail: dmarr@mines.edu; http://www.mines.edu/~dmarr A. Positions and Honors Positions 1988 Summer Intern, Bayer GmbH, Leverkusen, Germany. 1988-1993 Graduate Research Assistant, Stanford University, Stanford, CA. 1993-1995 Postdoc, Chem. Research Group, Raychem Corp., Menlo Park, CA. 1995-2000 Assistant Professor, Chem. Eng. Dept., Colorado School of Mines, Golden, CO. 2000-2006 Associate Professor, Chem. Eng. Dept., Colorado School of Mines, Golden, CO. 2006-present Professor, Chem. Eng. Dept., Colorado School of Mines, Golden, CO. Other Experience and Professional Memberships Review panels for NSF, NASA, and the NIH including 3 P41 site visits in the past 3 years (one as panel chair). Co-chair 80th annual ACS Colloid and Surface Science Symposium, June 2006. American Institute of Chemical Engineers, American Physical Society, American Chemical Society Honors Dean’s Excellence Award, 2007 Humboldt Research Fellowship, Alexander von Humboldt Foundation, 2005-2007 Space Act Award, NASA Inventions and Contributions Board, 2006. National Academy of Sciences, Frontiers of Science, Speaker 11/2004, Participant 8/1998 Outstanding Faculty Member, Chem. Eng. Dept., Colorado School of Mines, 2004 Dow Outstanding New Faculty Award, ASEE, 2000 NSF CAREER Award, 1998-2002 NSF Graduate Fellowship, 1989-1992 Phi Beta Kappa B. Related Publications Emily A. Gibson, Dawn Schafer, Wafa Amir, David W.M. Marr, Jeff A. Squier, and Ralph Jimenez, “Measuring protein folding kinetics with UV-visible absorption and UV fluorescence in a microfluidic mixer”, submitted to Analytical Chemistry. PHS 398/2590 (Rev. 05/01) Page 43 Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Marr, David W.M. R.W. Applegate Jr., Dawn Schafer, Wafa Amir, J. Squier, T. Vestad, J. Oakey, D.W.M. Marr, “OpticallyIntegrated Microfluidic Systems for Cellular Characterization and Manipulation”, Journal of Optics A: Pure and Applied Optics (invited), in press. S. Bleil, D.W.M. Marr, C. Bechinger “Field Mediated Self Assembly and Actuation of Highly Parallel Microfluidic Devices”, Applied Physics Letters, 88, 263515, (2006). J. Santana-Solano, D.T. Wu, D.W.M. Marr, “Direct Measurement of Colloidal Particle Rotation and Field Dependence in AC Electrohydrodynamic Flows”, Langmuir, 22, 5932, (2006). M. Brown, T. Vestad, J. Oakey, D.W.M. Marr, “Optical Waveguides via Viscosity-Mismatched Microfluidic Flows”, Applied Physics Letters, 88, 134109, (2006). R. Applegate, J. Squier, T. Vestad, J. Oakey, D. Marr, P. Bado, M. Dugan, A. Said, “Microfluidic Sorting Based on Optical Waveguide Integration and Diode Laser Bar Trapping,” Lab on a Chip, 6, 422, (2006). T. Stiles, R. Fallon, T. Vestad, J. Oakey, D.W.M. Marr, J. Squier, R. Jimenez, “Hydrodynamic Focusing for Vacuum-Pumped Microfluidics”, Microfluidics and Nanofluidics, 11, 280, (2005). R.W. Applegate Jr., J. Squier, T. Vestad, J. Oakey, D.W.M. Marr, “Optical Trapping, Manipulation, and Sorting of Cells and Colloids in Microfluidic Systems with Diode Laser Bars”, Optics Express, 12, 4390, (2004). T. Vestad, D.W.M. Marr, J. Oakey, “Flow Control for Capillary-Pumped Microfluidic Systems”, Journal of Micromechanics and Microengineering, 14, 1503, (2004). T. Vestad, D.W.M. Marr, T. Munakata, “Flow Resistance for Microfluidic Logic Operations”, Applied Physics Letters, 84, 5074, (2004). (cover article). T. Gong, D.W.M. Marr, “Photon-Directed Colloidal Crystallization”, Applied Physics Letters, 85, 3760, (2004). T. Gong, D.T. Wu, D.W.M. Marr, “Electric Field Reversible Three-Dimensional Colloidal Crystals”, Langmuir, 19, 5967, (2003). (cover article). P. Viravathana, D.W.M. Marr, “Synthesis of Colloidal Aluminosilicate for Light Scattering Investigations”, Journal of Colloid and Interface Science, 265, 15, (2003). A. Terray, J. Oakey, D.W.M. Marr, “Microfluidic Control Using Colloidal Devices”, Science, 296, 1841, (2002). T. Gong, D.T. Wu, D.W.M. Marr, “Two-Dimensional Electrohydrodynamically-Induced Colloidal Phases”, Langmuir, 18, 10064, (2002). A. Terray, J. Oakey, D.W.M. Marr, “Fabrication of Linear Colloidal Structures for Microfluidic Applications”, Applied Physics Letters, 81, 1555, (2002). J. Oakey, J. Allely, D.W.M. Marr, “Laminar Flow-Based Separations at the Microscale”, Biotechnology Progress, 18, 1439, (2002). H. Haruff, J. Munakata Marr, D.W.M. Marr, “Directed Bacterial Surface Attachment via Optical Trapping”, Colloids and Surfaces B: Biointerfaces, 27, 189, (2002). T. Gong and D.W.M. Marr, “Electrically Switchable Colloidal Ordering in Confined Geometries”, Langmuir, 17, 2301, (2001). C. Mio, T. Gong, A. Terray, D.W.M. Marr, “Morphological Control of Mesoscale Colloidal Models”, Fluid Phase Equilibria, 185, 157, (2001). C. Mio and D.W.M. Marr, “Optical Trapping for the Manipulation of Colloidal Particles”, Advanced Materials, 12, 917, (2000). C. Mio, T. Gong, A. Terray, D.W.M. Marr, “Design of a Scanning Laser Optical Trap for Multiparticle Manipulation”, Review of Scientific Instruments, 71, 2196, (2000). P. Viravathana and D.W.M. Marr, “Optical Manipulation of Core-Shell Colloidal Particles”, Journal of Colloid and Interface Science, 221, 301, (2000). PHS 398/2590 (Rev. 05/01) Page 44 Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Marr, David W.M. J. Oakey, D.W.M. Marr, K.B. Schwartz, M. Wartenberg, “An Integrated AFM and SANS Approach Toward Understanding Void Formation in Conductive Composite Materials”, Macromolecules, 33, 5198, (2000). K. Swaminathan and D.W.M. Marr, “Morphology Characterization of High-Impact Resistant Polypropylene using AFM and SALS”, Journal of Applied Polymer Science, 78, 452, (2000). J. Oakey, D.W.M. Marr, K.B. Schwartz, M. Wartenberg, “The Influence of Polyethylene and Carbon Black Morphology on Void Formation in Conductive Composite Materials - A SANS Study”, Macromolecules, 32, 5399, (1999). C. Mio and D.W.M. Marr, “Tailored Surfaces using Optically Manipulated Colloidal Particles”, Langmuir, 15, 8565, (1999). Patents D.W.M. Marr, T. Gong, J. Oakey, A. Terray, “Microfluidic Valve with a Colloidal Particle Element”, Patent No. 6,802,489, 10/12/04. D.W.M. Marr, J. Oakey “Switchable Microfluidic Optical Waveguides”, Patent No. 7,155,082, 12/26/06. Pending: D.W.M. Marr, J. Squier “Microfluidic Systems Incorporating Integrated Optical Waveguides” Patent Application #11/329,491 filed 1/10/06. Published 8/3/06 #20060171846 D.W.M. Marr, T. Gong, J. Oakey, A. Terray “Devices Employing Colloidal-Sized Particles”, Patent Application #10/711,767 filed 10/4/04. Published 8/11/05 #20050175478 T. Gong, D.T. Wu, D.W.M. Marr “Colloidal Crystallization via Applied Fields”, Patent Application #10/838,908, filed 5/3/04. Published 2/3/05 #20050022723 J. Oakey, D.W.M. Marr “Laminar Flow-Based Separations of Colloidal and Cellular Particles”, Patent Application #10/248,653, filed 2/4/03. Published 8/3/06 #20060169642 C. Research Support (last 3 years) Current Support NSF0454763 Jimenez (PI) 6/1/05 – 5/31/08 NSF/DBI Collaborative Research: Development of a Novel Multiphoton Microscope for Measuring Biomolecular Dynamics Over 15 Orders of Magnitude in Time Major goal: To integrate novel femtosecond nonlinear optical techniques with novel microfluidic flow control and design for the study of protein unfolding kinetics. Role: co-PI Completed Support 1 R21 EB001722-01 Squier (PI) 9/1/03 – 8/31/06 NIH/NIBIB Light-Powered Microfluidic Cell Separator and Imager Major goal: To develop improved optical methods for direct cell manipulation in microfluidic devices. Role: co-PI NAG9-1364 Marr (PI) 9/1/00 – 8/31/05 NASA A Novel Colloidal Microfluidics Platform for Spaceborne Micro Total Analysis Systems Major goal: To create colloid-based microfluidic devices. Role: PI CTS-0097816 Marr (PI) PHS 398/2590 (Rev. 05/01) 4/1/01 – 3/31/04 Page 45 Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Marr, David W.M. NSF/Eng Sensing, Actuation, and Flow Control with Colloidal Devices Major goal: To create novel colloid-based microsensors for incorporation into microfludic devices. Role: PI CTS-0304158 Marr (PI) 7/1/03 – 6/30/04 NSF/Eng NER: 3D Nano-colloidal Crystallization via Electrokinetic Flows Major goal: To study the three-dimensional ordering of nanoscale colloidal particles using applied electric fields. Role: PI XDJ-2-30630-27 Williamson (PI) 6/1/02 – 9/30/04 DOE/NREL Structure of Silicon-Based Thin-Film Solar Cell Materials Major goal: To investigate the morphology of silicon-based photovoltaic materials using a combination of small angle x-ray and small angle neutron scattering techniques. Role: co-PI Metafluidics, Inc. Support With Dr. John Oakey, founded Metafluidics, Inc. to commercialize the microfluidic technologies developed within the academic laboratory. HHSN268200525224C Oakey (PI) 9/1/05 – 5/31/06 NIH/NHLBI A Microfluidic Platform for Complete Hemostasis Management Major goal: To develop portable microfluidic networks for coagulation analysis. Role: co-PI 1 R43 HL082276 Oakey (PI) 8/15/05 – 2/14/06 NIH/NHLBI Fluid Waveguides for Microfluidic Flow Cytometry Major goal: To develop microfluidic optical networks for cell sensing applications. Role: co-PI 1 R43 EB000952-01 Oakey (PI) 6/01/03 – 5/31/05 NIH/NIBIB Precision Microfluidic Control for Nanobiotechnology Major goal: To develop single-cell microfluidics separations. Role: co-PI 1 R43 HL079741-01 Oakey (PI) 12/15/04 – 5/14/05 NIH/NHLBI Cell Culturing BioChips for Pulmonary Vasculature Mimics Major goal: To develop microfluidic networks for model tissue growth and study. Role: co-PI PHS 398/2590 (Rev. 05/01) Page 46 Continuation Format Page