Monday, June 9th, 2008 Plenary lecture Microglia-mediated neurotoxicity Dr. Jau-Shyong Hong, National Institute of Environmental Health Sciences, USA Modification of L-dopa and dopamine metabolism as a basis of drug therapy of Parkinson’s Disease: key findings during the last 20 years PMR – Pharmaceutical manufacturing research Core competences in pharmacoeconomics Prof. David J. Brooks (Hammersmith Hospital, London, UK) Modification of L-dopa metabolism: benefits and problems Prof. Jouko Yliruusi (University of Helsinki, Finland) PMR – Pharmaceutical manufacturing research Alan Lyles (University of Baltimore, USA) Recent trends in pharmacoeconomics Dr. Erkki Nissinen (Orion Pharma, Espoo, Finland) Chemistry and biochemistry of COMT inhibitors Prof. Kozo Takayama (Hoshi University, Tokyo, Japan) Computer-aided design and optimisation of pharmaceutical formulations Anders Engström (Pricing Board, Sweden) Swedish model Dr. Markus Forsberg (University of Kuopio, Finland) Physicochemical and pharmacokinetic properties of COMT inhibitors Prof. Jamshed Anwar (University of Bradford, UK) (Topic related to molecular simulation) Prof. Chuang Chiueh (Center for Brain Diseases and Aging, Taipei Medical University, Taipei, Taiwan) Strategies for neuroprotection M.Sc.(Pharm) Merja H. Voutilainen (University of Helsinki, Finland) CDNF: A novel evolutionarily concerved neurotrophic factor for dopaminergic neurons in vivo M.Sc.(Pharm) Marjo Piltonen (University of Helsinki, Finland) TBA Prof. Jukka Rantanen (University of Copenhagen, Denmark) TBA Dr. Tero Närvänen (Orion Corporation, Finland) TBA Prof. Edward Hæggström (University of Helsinki, Finland) TBA Short communications Short views about situation in Finland: Suvi-Anne Siimes, Pharma Industry Finland Akseli Kivioja, Pricing Board, Finland Vesa Jormanainen, Pfizer N.N., Finnish Generic Pharmaceutical Industry Tuesday, June 10th, 2008 Plenary lecture Process and systems integration through minaturisation - functional tools for the future Prof. Steven Haswell, Univ. of Hull, UK Modification of L-dopa and dopamine metabolism as a basis of drug therapy of Parkinson’s Disease: key findings during the last 20 years Prof. Peter A. Lewitt (Wayne State University School of Medicine, Michigan, USA) Human pharmacokinetics of levodopa and impact of COMT inhibitors Prof. Vilho Myllylä (University of Oulu, Finland) Clinical trials with entacapone and tolcapone Dr. Tapani Keränen (University of Tampere, Finland) Comparative studies of dopamine agonists and other therapies Dr. Dag Nyholm (Uppsala university hospital, Uppsala, Sweden) Novel administration routes for levodopa and dopamine agonists Dr. Seppo Kaakkola (Helsinki University hospital, Finland) Growth factors in Parkinson’s disease Prof. Anders Björklund (Lund University, Sweden) Gene Therapy for PD Short communications PMR – Pharmaceutical manufacturing research Nano- and microtechnology in pharmacy Prof. Rudolf W. Kessler (Reutlingen University, Germany) Chemical imaging of tablets - Background, concepts and perspectives for online control Prof. Mark Bradley (University of Edinburgh, UK) Hurray for the Chemical Microarray - Massive Parallel Analysis of Proteases, Kinases and Cells on Glass Slides Prof. Chris Vervaet (Ghent University, Belgium) TBA Doc. Sami Franssila (Helsinki Univ. of Technology, Finland) Materials and technologies for analytical microsystems Prof. Jerzy Baldyga (Warsaw University of Technology, Poland) TBA Prof. Gary Siuzdak (The Scripps Research Institute, San Diego, USA) Nanostructure-Initiator Mass Spectrometry Dr. Sabir Mirza (University of Helsinki, Finland) Recent developments in co-crystal design and pharmaceutical properties Short communications Prof. Risto Kostiainen (University of Helsinki, Finland) Microchip Ionization Mass Spectrometry in Drug Analysis Doc. Marc Baumann (University of Helsinki, Finland) Proteomic microchips Short communications Wednesday, June 11th, 2008 Plenary lecture System thinking and the future of medicine and personal health Prof. Jan van der Greef, University of Leiden, The Netherlands Nano- and microtechnology in pharmacy Prof. Olli Ikkala (Helsinki University of Technology) Self-assembling nanostructures Prof. Wim Hennink (Utrecht University, The Netherlands) Nanoparticulate drug targeting systems Prof. Stefaan De Smedt (Ghent University, Belgium) Methods to study intracellular kinetics of nanoparticulate systems Prof. Ernst Wagner (Ludwig-Maximilians University Munich, Germany) Mechanisms of non-viral gene delivery Prof. Rainer H. Müller (Free University Berlin, Germany) Nanocrystals Prof. Jouni Hirvonen (University of Helsinki, Finland) Porous silica/silicon particles Short communications Recent development in metabolomics, lipidomics and proteomics Prof. Roman Zubarev (Laboratory for Biological and Medical Mass Spectrometry, Uppsala universitet, Sweden) Pathway search engine for proteomics - Dream, fact or fiction? Prof. Olli Kallioniemi (VTT, Turku, Finland) Functional genomic technologies for genome-scale molecular therapeutics research Prof. Gary Siuzdak (The Scripps Research Institute, San Diego, USA) A metabolomics platform for discovery and diagnosis Dr. Jules L. Griffin (Univ. of Cambridge, UK) Following PPAR agonists by comprehensive metabolomics Dr. Kim Ekroos (Astra Zeneca R&D, Sweden) Applications of lipidomics in pharmaceutical R&D Prof. Matej Orešič ( VTT, Espoo, Finland) Systems biology in pharmaceutical R&D Dr. Erkki J. Karjalainen (Department of Clinical Chemistry, University of Helsinki, Finland) Linking medicine to metabolomics and proteomics Short communications Green technologies and process engineering Prof. James Clark (University of York, UK) Greener pharmaceuticals N.N. (AstraZeneca International, Safety Health Environment, UK) TBA Short communications Panel discussion Closing remarks