Person Specification
CDF 3 years funded by EU
Criteria
identified:
Education, qualifications and
training
Essential
Desirable
A degree in
biological/biomedical
sciences and a higher
degree
PhD in a relevant field
Previous work experience
Laboratory experience in
human genetics,
molecular genetics, cell
biology and/or chromatin
biology
Previous experience in
high throughput
human mutation
analysis in a
CPA accredited clinical
lab.
Criteria 1:
DNA sequencing and DNA
sequence analysis. A
careful and consistent
approach to handling
patient DNA samples.
Experience with mutation
analysis in a clinical or
research context and
using mutation analysis
software such as
Mutation Surveyor.
Appreciation of the
techniques used to
analyse genomic copy
number.
Experience in new
sequencing
technologies (Solexa,
454 etc)
Mutation Analysis
Criteria 2:
Copy Number Analysis
Criteria 3:
Molecular Biology
Criteria 4:
Animal model work
Criteria 5:
Cell biology
DNA, RNA and Protein
extraction,
electrophosesis and
blotting. PCR and RTPCR
Experience in using
transgenesis in animal
model systems to
understand human
disease gene function.
Basic asceptic technique
and mammalian cell
culture experience.
Experience with
transfection of DNA into
mammalian cells
Experience in array
CGH analysis, MLPA
design and analysis,
metaphase FISH of
chromosome
anomalies
Culture and
differentiation of
mouse ES cells
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh
EH4 2XU
Tel: +44(0)131 467 8400 fax +44(0)131 467 8456
www.hgu.mrc.ac.uk
Person Specification
Criteria 6:
Scientific Communication
The ability to present
research data in a clear
and coherent manner
The ability to write a
scientific paper
Experience with Adobe
Illustrator or similar
package for
constructing highquality figures.
Criteria 7:
Bioinformatic Analysis
Confidence in retrieval of
DNA and protein
sequences and sequence
similarity searching.
Criteria 8:
Information Management
Basic database
management
Familiarity with R and
bioconductor packages
for statistical analysis
of biological data.
Advanced comparative
sequence analysis.
PERL programming.
Database programming
Personal style and behaviour:
We are looking for someone who combines an enthusiastic approach to scientific
projects with finishing abilities. The ability to work in a group setting is crucial.
Additional information:
In Human Genetics research it is important to be able to learn new techniques
quickly and work to a very high standard.
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh
EH4 2XU
Tel: +44(0)131 467 8400 fax +44(0)131 467 8456
www.hgu.mrc.ac.uk