ANNUAL REPORT
2009-2010
DEPARTMENT OF MOLECULAR BIOMEDICAL SCIENCES
COLLEGE OF VETERINARY MEDICINE
NORTH CAROLINA STATE UNIVERSITY
M. Christine McGahan, Professor and Department Head
Prepared May 2010
Table of Contents
Page
Departmental Report
3
I.
Changes in Environment
3
II.
Compact Plan
3
III.
Diversity
4
IV.
Instructional Program
10
V.
Faculty
18
VI.
Students
19
VII.
Research
20
VIII.
Administration and Staff
21
IX.
Recommendations and concerns for the future
21
X.
The University’s Five Focus Areas
27
Appendix I
List of Faculty/EPA Employees Including Graduate Students
31
Appendix II
List of Administrative and Staff Personnel
32
Appendix III
Courses Offered by Departmental Faculty Including DVM courses
Presented by Departmental Faculty and Graduate Courses Offered by and
Participated in by Departmental Faculty
35
Appendix IV
Clinical Service Offered by Departmental Faculty
37
Appendix V
Publications, Presentations, Intellectual Property by Departmental Faculty
63
Appendix VI
76
Appendix VII
Professional Activities by Departmental Faculty (Includes Memberships on Research
Grant and Study Reviews, Memberships on Editorial Boards, and Ad hoc Manuscript
Reviews, Committee Memberships within MBS, CVM, NCSU, and National
Committees
Research Grants Awarded to Departmental Faculty
2
I.
Change in Environment
Faculty retirement: no retirements
Faculty resignations: Prema Arasu – 5/24/2010; Adjunct appointment 5/24/2010
Faculty hires: Gabriela Seiler – Assoc Professor of Radiology; appointed 7/1/2009
The budget cuts of the past year and projected cuts for the upcoming year have left us with a loss of 4.5 faculty
positions and over $100K in staff positions. This represents a cut in state-funded faculty positions of about 13%.
We are now in a serious situation when it comes to covering the teaching mission of the department. We are
critically short in a number of areas, including Pharmacology, Toxicology, Cell Biology/Histology. The loss of
staff positions also gravely undermines the teaching and research missions of the College. We now have only a
handful of state-funded research tech support positions left, and it was necessary to RIF one of our two
teaching techs who work in the Anatomy Lab. We are indeed in perilous times and facing even more cuts in the
future. Quite frankly, there is nothing more to cut. Despite these terrible times, and decreasing federal
resources, our faculty and staff continue to strive successfully for extramural dollars to keep their programs
running. This is testimony to their skill and hard work, we indeed have a dedicated and talented pool of people
in the department.
II.
Compact Plan: For 2008-2010 the Compact Plan was developed at the College level.
III.
Diversity
Kenneth Adler was awarded a supplement to his NIH grant for “underrepresented minorities” for Ms. Teresa
Green, a graduate student in his laboratory. He is the PI on a grant submitted to NIH called IRACDA that
supports partnering of NCSU with traditionally black colleges in the state and providing research resources for
minority candidates.
Prema Arasu, within context of diversity strategies as defined by NCSU Office of Diversity
(http://www.ncsu.edu/odi/initiatives/Diversity_Advisory.pdf), she has: 1) coordinated outreach meetings and
seminars within North Carolina and with partner institutions in India focused on the multi-disciplinary intersection
of livestock production, biofuels and health with NCSU faculty and students and external stakeholders (through
USDA funded award; teamed with CVM Faculty Maria Correa and Isabel Gimeno and CALS faculty Vivek
Fellner and Ratna Sharma); 2) served as Park Faculty Scholar for Class of 2011 and facilitating diversity
experiences together with Professor Clifford Griffin, Political Science; 3) organized inter-institutional meetings
with faculty from Durham Technical Community College, NC Central University and NC A&T University with
NCSU and with other regional institutions (e.g. RTI International); 4) served as NCSU representative to the
Triangle Global Health Consortium; 5) continued to serve on NCSU College of Management Biosciences
Management/Industry (external) Advisory Board; 6) facilitated various international partnerships for NC State
University including Zhejiang University and China Agricultural University in China, recruitment of graduate
students from Malawi through a USAID sub-contract to NCSU; 7) coordinated conception and organization of
NCSU Health and Well-being Initiative together with Dr. Mitzi Montoya (College of Management) and Dr. Liana
Fryer (now Research Analyst with NCSU Research Office); and 8) coordinated and led NCSU's first Global
Health Case Competition bringing together interdisciplinary teams of undergraduate and graduate students from
different colleges to compete and develop an innovative solution for a global/local issue.
Jill Barnes, member Ad hoc Diversity Committee (NCSU CVM); Faculty Diversity Award, 2009; USDA,
Veterinary Career Pathways Program, May 2009, mentored six minority students in the program in veterinary
anatomy “short course”, consisted of 5 weeks of 7 hrs of instruction/week on the limbs/ thoracic cavity /head
/abdominal cavity; and SAVE program, NC A&T students, heart dissection lab.
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Gregg Dean, faculty mentor for NC State Initiative for Maximizing Student Diversity (IMSD); participation in
DVM/PhD admissions, molecular biology training program, DVM/PhD training program, and GAANN program;
recruited and hired undergraduate minority student, objective is to provide mentorship prior to application to
DVM program.
Shila Nordone, 1) mentor, Project SEED, summer 2009. Project SEED, the American Chemical Society's social
action program, places talented, disadvantaged high school students in research laboratories for 8-10 weeks
during the summer to experience "hands-on" research; 2) the ability to have diverse universities at the student
and faculty level has its roots in adequate education for minority children in our public schools. She currently
serves as the Hill Street Homework Haven’s liaison to the Wake County Public School System. The Haven is
located in SE Raleigh, and serves underprivileged African American children in K-12. They provide one-on-one
tutoring and advocate for children at both the school level and in public policy at the county level.
Jorge Piedrahita, Co-PI in NIH training grant to bring minority undergraduate and graduates into sciences; PI is
Trudy McKay. The program is “Initiative for Maximizing Student Diversity” (IMSD;
http://www.ncsu.edu/grad/imsd/index.php) . He is a member of the steering committee and of the admission
committee for this program. He participated as a panel member for the BFF “Building Future Faculty” program.
Barbara Sherry participated in the “Initiative for Maximizing Student Diversit” (IMSD) program at NCSU, funded
by the NIH. The IMSD program is designed to increase the number of students from underrepresented
minority groups who receive PhD's in the biomedical and behavioral sciences, and ultimately pursue research
careers in these fields. Ms. Phoebe Cruz, an undergraduate student at NCSU who is part of this program, is
conducting research in her laboratory.
Marcelo Rodriguez-Puebla has a minority supplement to his NIH Grant in support of Christopher Sistrunk.
IV.
Instructional Program Initiatives including curriculum development and program review
Curriculum Development
MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by
faculty to develop and introduce teaching innovations to enhance student problem-solving and communication
abilities. This is particularly evident in the selective courses taught at the end of each semester, which provide
a variety of offerings, which expand flexibility in the curriculum and new and varied experiences for students.
We are continuing to work on changes within existing courses to incorporate molecular medicine into the
curriculum. We are continuing to work on the Physiology course (VMA 913 and 923) to include genomics and
molecular medicine concepts, as well as to better align the subject matter in order to match more closely with
Anatomy.
Prema Arasu facilitated NCSU's partnership with TERI India on new global Master’s in Development Practice
through funding awarded to TERI by the MacArthur Foundation. She is serving as lead for the Global Health
course to be offered in this new program in March 2011 which will also be imported back to NCSU.
Jill Barnes, “Introduction to the Veterinary profession”, course coordinator, summer 2009, an on-line course
designed to better prepare first year vet students to anatomy and physiology.
Matthew Breen, serving his fourth year on the FCCCE. This committee has required a considerable time
commitment as they embarked on a comprehensive reevaluation of the DVM curriculum at NC State.
Gregg Dean, directed comparative medicine and translational research training program for specialty trained
post-DVM/PhD candidates. Initiated the incorporation of an online case based learning tool into VMP942. The
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“Diagnostic Pathway” program was developed by Dr. Holly Bender and colleagues. Dr. Bender will visit in June
2010 to facilitate the full implementation of the program.
Lloyd Fleisher, as an ex officio member of the CVM Curriculum Committee, has been actively involved in a
major revision of the veterinary teaching curriculum. As course director of VBM 933, Introductory
Pharmacology, he has been actively involved in the initial planning of the restructuring the veterinary curriculum
in order to accommodate at least 100 students.
Troy Ghashghaei, initiated the development of a new format of teaching the Neurophysiology portion of the
physiology course in the first year DVM curriculum.
Jon Horowitz, developed and is the course coordinator of a four credit graduate course, CBS771 “Cancer
Biology”, that was completed by eight students in the Fall of 2009. This course was taught by six professors,
two from MBS and four from the department of Environmental and Molecular Toxicology, and received very
strong evaluations from participating students. He wrote and presented 40% of the lectures in this course.
Mark Papich, served on the College Curriculum Committee (FCCCE), term started in the fall of 2007, as the
department representative. This committee has been charged with reviewing, reorganizing, and proposing
changes in the DVM curriculum to better prepare our future veterinarians. This committee meets every two
weeks and the focus on curriculum evaluation will continue into next year. In 2010, he completed the 3rd
edition of the book on veterinary drugs, “Handbook of Veterinary Drugs”, published by Elsevier-Saunders. This
is a widely used book by clinicians and students. It is in production and will be published in the fall of 2010. He
was the first faculty member at the CVM to implement the new NCSU web-based course development software
Moodle. His course is fully integrated with Moodle. The course web site contains practice quizzes for students,
reference materials, resources, and teaching materials.
Lysa Posner, course-leader subcommittee for Curriculum Review 2009-2010.
Ian Roberston, ongoing improvement of VMB 976 course for which he is the supervisor. This involved
generating extensive online quiz material via Blackboard Vista and generating other self directed learning
resources.
Korinn Saker, participated in numerous meetings/discussion groups for program implementation for Outpatient
Center Planning, which is targeted to be both a ‘service center’, as well as a ‘teaching-training’ center for house
officers and veterinary students. Participated with VTH college faculty in initiative to evaluate and improve DVM
curriculum - weekly meetings/seminars and discussion groups. Developed clinical nutrition course for extern
program veterinary technicians including basic nutrition concepts and applied (clinical) concepts and
techniques. It has become a mandatory component of the veterinary technician extern program here at the
VTH. Presented the idea to create dual training program for house officers that provides clinical residency
training in specialty (i.e. nutrition, etc) and MS in Adult Education. Discussions are ongoing between
administrators of the CVM and College of Education. Discussions are ongoing between Korinn Saker and
sponsor for the first dual residency MS, Adult Education training program.
Philip Sannes, actively participated in course coordinator meetings designed to develop changes in the
curriculum.
Cliff Swanson, participating in DVM curriculum revision being conducted by course coordinators. Gave invited
presentation related to teaching and learning in the clinical environment to this same group, Feb. 26, 2010.
Jeff Yoder, Graduate Education - CBS565 (F09) Course Director. He continues to be course director for and
lecture in the graduate course CBS565, Fundamentals of Biomedical Sciences. As course director, he
maintains the course web page, coordinates and administers exams and coordinates approximately 15 faculty
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members. Based on student evaluations for this course and with input from the CBS committee, a critical
evaluation of CBS565 was performed in the spring of 2009 and changes to reorganize the lecture topics were
implemented in the fall of 2009: these changes provided more focus and continuity for CBS565. CBS770 (S10)
Lecturer. He continues to provide lectures in the graduate course CBS770, Cell Biology. CBS570 Co-Course
Director, Matthew Breen and Jeff Yoder have developed a new one-credit course, CBS570, Methods in
Biomedical Research, which is designed to teach incoming graduate students about different molecular
methods. Jeff Yoder will be presenting six lectures on DNA, RNA, protein analyses, PCR strategies, cloning
cDNAs, expression constructs, transgenic strategies and knock-out strategies. The intent was to begin offering
this course in F09, but due to scheduling conflicts, it will be offered annually beginning F10. Veterinary
Education, VMB913 (F09) Lecturer. He continues to provide two lectures on gene regulation for VMB913,
Veterinary Physiology I.
Clinician Scientist Focus Area (CSFA) has been a departmental initiative which continues to develop and grow.
Prema Arasu, invited and hosted two professors from universities in China to conduct workshop on Traditional
Chinese Veterinary Medicine at the North Carolina Veterinary Conference (for continuing education credit).
Matthew Breen, leader of the Clinician Scientist Focus area, has continued to identify research oriented DVM
students that could be encouraged to become involved in research activities at NCSU. Dr. Breen meets with
the enrolled CSFA students one:one on a regular basis to gauge their feel for the program and to monitor their
progress in the research aspects of their DVM program.
John Gadsby, host/research mentor in his laboratory for 2 first year DVM students (Summer Kingery and
Shama Dunlow) for the one week “Introduction to Research at CVM” selective (VMB 990D), Fall 2009.
Korinn Saker, utilized the newly developed feline mammary gland organ culture system to evaluate
chemopreventive / chemotherapeutic aspects of selected nutrients. Designed and completed data collection for
a catheter parenteral nutrition safety study to help establish ‘safe use’ parenteral feeding protocols for intensive
care patients. Designed and completed study to evaluate efficacy (nutritional and safety) of various companion
animal diets: including a frozen canine pet food, a unique enteral critical care diet for dogs and cats. Revised
the clinical and research components of house officer, intern and resident, training programs in nutrition for: i.)
IAMS Rotating Nutrition Internship – a 1 year internship training in small animal disciplines as well as small
animal clinical nutrition; ii.) Nestle Purina Clinical Nutrition Residency, a 2 year clinical training program here at
NCSU-CVM. Procured a second cycle of funding for IAMS Rotating Nutrition Internship. Funding obtained for
2–1yr interships. Procured funding for a 2-year Clinical Nutrition Residency training program at NCSU-CVM.
As chair of the education committee of American College of Veterinary Nutrition: i.) created the Standard Core
Nutrition Competencies as the benchmark for ‘need to know’ clinical nutrition skills for all veterinary graduates;
ii.) Korinn Saker and 3 colleagues developed a full spectrum on-line veterinary nutrition course. The course is
module driven to provide either a complete comprehensive, basics to clinical applications, course for veterinary
students that do not have a nutrition course in their curriculum, or provide individual modules as CE materials
for practicing veterinarian, or provide individual modules for pre-veterinary students requiring fundamental
nutrition course as prerequisite for veterinary school application. Participated as one of the core group of
nutrition specialists to develop the Veterinary Specialty Training program in Nutrition. This is one of several
specialty certification programs for licensed veterinary technicians to obtain training in specialty areas, i.e.
nutrition, critical care, oncology, surgery.
Introduction to Research at the CVM
“Introduction to Research at the CVM” (VMB 991D) is offered in the fall semester as a one-week selective and
will be required for all students interested in the CSFA. Students are expected to take this selective in the fall of
the 1st yr of the DVM curriculum. This selective will be open to any student interested in exploring the possibility
of choosing the CSFA. All three departments participate in this Focus Area.
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In this selective, mentors in the different areas of clinical and basic research experience will present a summary
of ongoing projects in their laboratories. This selective will be divided into identifiable areas of research based
on the group of participating mentors (i.e. oncology, neurology, therio, etc., ideally combining both basic and
clinical aspects of research), with each group responsible for presenting their area of interest to the students.
Students will be required to interview briefly with three potential mentors during the time of the selective.
Students will also be required to prepare a personal statement indicating their personal and academic goals,
their reasons for choosing the CSFA, and their reasons for pursuing a particular mentor opportunity.
Other
Selectives will be chosen based upon the career goals and research interests of the individual student, in
consultation with their primary mentor and committee. Students are encouraged, although not required, to take
additional research-related selectives (i.e. Molecular Medicine Initiative selectives such as Trangenics,
Developmental Toxicology and Teratology and VMB 992E Biomedical Research Experience).
Students choosing the Clinician Scientist Focus Area (CSFA) will also declare a clinical interest (equine, small
animal, pathology, food animal, mixed animal, epidemiology and public health, laboratory animal) that will give
them priority in clinical rotation scheduling equal to that of students declaring a specific clinical focus area. The
clinical interest must be declared by the end of the second year. Alternatively, CSFA students may, in
consultation with their guidance committee, create a required list of clinical senior rotations. CSFA students will
then be given top priority for these rotations. This list much also be completed and approved by the guidance
committee by the end of the second year.
The following MBS Faculty members are available as mentors in this program:
Arasu, Prema Degrees/expertise: PhD, DVM
We use dog hookworm parasite as our model to study host-pathogen interactions and developmental aspects
of the hookworm nematode. Research in the lab spans the breadth of clinical, animal-based questions to basic
research approaches using genomics, molecular biology, immunology, cell biology and the mouse model. For
example, one project in the lab is focused on the pregnancy-induced reactivation and transmammary
transmission of hookworm infection to nursing puppies. What is the signaling mechanism between the
underlying molecular mechanisms and identify strategies of preventing this route of pathogen transmission?
Breen, Matthew Degrees/expertise: PhD, C Biol, MI Biol
Chromosome aberrations are hallmarks of the instability of the tumor genome. Our research program is focused
on the cytogenetics of canine cancers. In particular we have developed molecular cytogenetic tools and
reagents that allow us to interrogate canine tumors (individual tumor cells and tumor cell populations) to reveal
recurrent chromosome aberrations. We work closely with clinicians and pathologists so that we are able to
correlate cytogenetic findings with clinical features such as tumor subtype, tumor progression, response to
therapy etc. In this way we have begun to identify chromosome changes in canine cancers that have both
diagnostic and prognostic significance. As a consequence we are a) working towards offering the clinician a
means by which to improve the sophistication of clinical management of dogs with cancer and b) developing a
better understanding of the genes involved in cancer initiation and progression, which may ultimately lead to
improved therapies.
Dean, Gregg Degrees/expertise: DVM, PhD, DACVP
Students will be exposed to in vitro and in vivo work. Mice and cats are used to evaluate immunological
responses to novel vaccine strategies and cats are used in the study of feline immunodeficiency virus.
Students may be involved in collecting and processing samples, immunological and virologic assays, and
numerous molecular techniques. Specific assays may include flow cytometry, ELISA, ELISpot, western blot,
cloning, PCR, bacterial culture, cell culture, and bioassays.
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Gadsby, John Degrees/expertise: PhD
Students could be exposed to animal surgeries (ovariectomies and ovarian infusions), tissue dissociation, cell
isolation/separation and cell culture, steroid and peptide hormone analysis (RIA or ELISA), enzyme activity
(protein kinase C) assays, mRNA extraction and analysis by RT-PCR, protein extraction and analysis by
Western blotting, microarray analysis and possibly RNA interference (in the near future). Specifically he could
partner with Theriogenology (he already collaborates with Carlos Pinto) or Swine (he also collaborates with
Glen Almond) faculty.
Piedrahita, Jorge Degrees/expertise: PhD
Dr. Piedrahita's laboratory is primarily interested in understanding the role of imprinted genes in embryo
development and in disease, and in the development of transgenic animals for use in human and veterinary
medicine, and in agriculture. Towards this end, his laboratory combines techniques in functional genomics, cell
biology, embryo manipulation, and molecular biology. Specifically, students would be introduced to a range of
recombinant DNA, and genomic technologies as they relate to a clinically-relevant phenotype.
Contributions to Selectives:
Prema Arasu: MBS was home for the 'International veterinary medicine selective' which was offered in Spring
2010. We had 11 students (10 first years, 1 second year). It was a combination of lecture/discussion from
CVM faculty across all 3 departments, team work on a case study and country reports, as well as site visit to
NC Zoo/discussion with Mike Loomis on his work in Africa. In essence, the students learned about potential
international experiences, career opportunities, global issues relevant to veterinary medicine and met some
individuals as contacts for follow up (including USDA Barbara Porter Spalding, Werner Dorgeloh from CNR,
Fabian Ekue who was visiting from the Cameroon and is provost of a new university there).
Matthew Breen, in the past year he has re-offered the full week selective, “Introduction to Research at the CVM”
(VMB991D), providing a group of 16 DVM students with a ‘taster’ of the range of research activities ongoing at
the CVM. The course is team-taught and covers a variety of research exposures. In response to feedback from
the previous two years, this year he changed the course to one in which groups of two students were assigned
to a mentor and lab for the full week. During this time each pair of students had a more intensive week of
research. At the end of the week the class came together and each group provided a presentation outlining the
research in which they had been involved during the week. Overall this worked very well and the feedback was
positive.
Nigel Campbell, VMC 992Z Active Learning in the VTH. Students become an active member of the clinical
anesthesia service for 2 weeks.
John Gadsby host research mentor in his laboratory for 2-first year DVM students, Summer Kingery and Shama
Dunlow, for the one week “Introduction to Research at CVM” selective (VMB 990D).
Jon Horowitz presented a single hour-long lecture in an ongoing selective (VMB 991E Section 004:
Transgenics).
Nanette Nascone-Yoder continues to offer the selective course, VMB 992, “Developmental Toxicology and
Teratology”. Exposure of pregnant animals to chemicals and other environmental agents can induce abnormal
embryonic development, leading to birth defects. In this course, chemical teratogens are used in the laboratory
to induce abnormal organ formation in live aquatic animal models. Molecular biological assays are then
performed to examine the effects of these chemical treatments on gene expression patterns and the
development of organ anatomy in the embryo.
Shila Nordone, “Immunodiagnostics”.
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Jorge Piedrahita helped teach Jeff Yoder’s transgenic selective; helped teach Peter Farin’s reproductive
selective.
Lysa Posner, VMC 991B Advanced Ferret Medicine Selective, Anesthesia for ferrets (1 hr) 11-2009;
Anesthesia and Surgery Laboratory (5 hr) 11-2009. VMC 991Q Advanced Fish Medicine Selective, Anesthesia
in fish (1 hr)11-2009; Anesthesia and Surgery Laboratory (2 hr) 11-2009. Advanced Primate Medicine VMC991
Korinn Saker, revised syllabus and course program for: “Advanced Small Animal Clinical Nutrition” offered in
Fall 2009 and Spring 2010 and “Equine Nutrition” offered Fall 2009.
Gabriela Seiler, VMC 991 “Advanced Ferret Medicine” 2009; lecture and wet lab in ferret imaging.
Ed Smallwood continues to offer and teach VMB 991G, Avian Anatomy.
Rachael Thomas, “VMB991 Introduction to Research”, Nov 30 – Dec 4, 2009 (course co-ordinator, Matthew
Breen). Designed, organized and ran two full-time, week-long laboratory-based selective projects for DVM
students within VMB991, training four of the 16 participating students in a range of molecular genomics
techniques, including multicolor fluorescence in situ hybridization analysis and high-resolution microarray
analysis of canine lymphoma/leukemia cell lines
Jeff Yoder continues as course director of the selective course VMB991E,“Transgenics”, which explores the
reasoning and methodology behind transgenic animals. This one-week course involves both lecture/discussions
as well as laboratory experience (cell culture and injecting transgenes into zebrafish embryos) for veterinary
students in Jeff's research laboratory. Jeff also is a participating faculty in VMC991Q (F09) "Fish Medicine". For
this selective, Jeff provides a ~1 hr tour of the CVM zebrafish facility and discusses the utility of zebrafish as a
model for biomedical research, fish health, fish reproduction, and potential hazards (pathogens and water
quality).
A listing of courses presented by MBS faculty in the professional curriculum and graduate courses presented by
MBS faculty can be found in Appendix III (p. 32).
MBS Selectives taught by MBS faculty
Faculty
Barnes/Fletcher
Barnes/Fletcher
Breen
Khosla
Arasu
Nordone
Smallwood
Yoder
Semester
Fall
Fall
Fall
Fall
Spring
Spring
Spring
Spring
Title
Avian Path I (VMP991W)
Avian Path II (VMP991W
Intro to Research (VMB991D)
Histo Tech (VMB991B)
International Veterinary Medicine (VMB991-001)
Immunodiagnostics (VMB991-002)
Avian A & P (VMB991-004)
Transgenics (VMB991-003)
Program Reviews
MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by
faculty to develop and introduce teaching innovations to enhance student problem-solving and communication
9
abilities. This is particularly evident in the selective courses taught at the end of each semester, which provide
a variety of offerings, which expand flexibility in the curriculum and new and varied experiences for students.
V.
Faculty
Honors
Accomplishments of MBS faculty have been recognized at national, international, state and campus levels.
Documentation of several faculty invitations and recognition’s of scholarly activity, not included below, can be
found in Appendix VI (p. 61) that includes memberships on editorial boards, ad hoc manuscript reviews, and
membership on research grant and study reviews.
Kenneth Adler
NIH NHLBI MERIT Award (5 R37 HL-36982): 2004–2014
Prema Arasu
Invited for second year to serve on review panel for USDA International
Science and Education Grants Program. Selected to chair newly formed
Triangle Global Health Consortium (linking NCSU with Duke, UNC CH, RTI,
IntraHealth, Family Health International and NC Biotechnology Center;
declined due to move to new position at Washington State.
NCSU Diversity award
Jill Barnes
Matthew Breen
John Gadsby
Chris McGahan
Nannette Nascone-Yoder
Mark Papich
Jorge Piedrahita
Philip Sannes
Barbara Sherry
In 2009 he was nominated and elected a Fellow of the Institute of Biology,
now the Society for Biology.
Chair/primary organizer of, and invited speaker at, the 2010 Triangle
Consortium for Reproductive Biology (TCRB) Annual Conference “Immune
mechanisms in Reproduction” held at NIEHS, RTP, February 6th 2010.
Member, National Advisory Eye Council
ARVO Fellow, Gold level, inducted April 2010
Huffman Leadership Award, CVM/NCSU, April, 2010
Appointed associate faculty member in the Department of Environmental and
Molecular Toxicology. Preceptor, recently funded NIEHS training grant
“Molecular Pathways to Pathogenesis in Toxicology”
American Academy of Veterinary Pharmacology and Therapeutics (AAVPT)
Teaching Award, in recognition of 25 years devoted to teaching veterinary
professional and graduate students; contribution to clinical pharmacology
through authoring books, book chapters, reviews, abstracts, proceedings;
and numerous CE programs for graduate veterinarians, 2009
NIH Study Section, DEV-1 NICHHD, regular member, October 2006-2010
College recipient of the Board of Governors’ Award for Excellence in
Teaching Outstanding Teacher Award. Nominated for the Alumni
Distinguished Undergraduate Professorship. Bayer Animal Health Teacher
of the Year – Class of 2012.
Served as Chair for a plenary session at the Keystone Symposium, Cell
Biology of Virus Entry, Replication and Pathogenesis, Taos, NM; February
2010
Accomplishments related to research efforts: (Does not include grants and publications which are listed in Appendix VII
(p. 76) and Appendix V (p. 37).
Kenneth Adler - A start-up company, BioMarck, that has been licensed through the NCSU technology transfer office has
developed a drug based on technology from his laboratory. The drug has been approved by the FDA and is to be tested
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in human patients suffering from chronic bronchitis starting at the end of April 2008. Phase 2a studies have been started
and the final cohort of patients should be finished before the summer.
Prema Arasu - Focused her efforts on building multidisciplinary teams (across NCSU colleges and with regional
institutions) particularly in areas of food safety and security, and zoonotic/emerging diseases and also with cloud
computing and health systems strengthening, logistics and supply chain, biofuels, etc.
Matthew Breen - During the current reporting period he has continued to grow his lab and to explore means to engage
other CVM faculty in a broader programmatic effort. In addition to a number of ongoing funded projects in his lab, he has
been awarded almost $500,000 in new extramural grant income during this annual reporting period. Research activity in
this past year has led to 11 peer-reviewed publications, nine in quality journals and two book chapters. On seven of
these his is the senior or first author. During the reporting year his work has been featured several times on the CVM and
NCSU website and also picked up by the local and national media.
Gregg Dean - Demonstrated NK cell migration and functional defects as well as proliferative and apoptotic abnormalities
in FIV infected cats; developed a novel Lactobacillus-based vaccine vector that co-expresses antigen and adjuvant;
cloned canine desmocolin-1, an autoantigen associated with canine blistering skin disease;determined effect or
regulatory T cells during acute phase of FIV infection; determined immunomodulatory effects of Lactobacillus on
dendritic cells; determined the relationship of mucosal IgA and stress in cats within the shelter environment; validated an
in vivo imaging strategy to evaluate targeted drug delivery by nanoparticles; developed a mathematical model to predict
immunopathogenesis of HIV in the intestine; and established two models of inflammatory bowel disease/colitis and
tested a lipotechoic acid knockout mutant of Lactobacillus acidophilus for ability to induce mucosal immune tolerance.
Jon Horowitz - Co-coordinated a new high school, undergraduate, and graduate training program in cancer research
(Jimmy V-NC State Cancer Therapeutics Training Program). This program has recruited seven graduate students,
seven undergraduates, and five high school students, and these students have been or are being trained in various
aspects of cancer research. This novel training program has been featured on the NCSU home page, in the NCSU
alumni magazine, in the NCSU graduate school's Results magazine, and the CVM magazine. Results reported in a
research paper by his lab were featured on the NCSU homepage, CVM homepage, as well as in the Raleigh News and
Observer.
Lola Hudson - Continuation of NIH subcontract, resubmission and award of an R21 as PI, and submission of a CFAR
grant as PI, one manuscript published (first author), and one review article in press, and 4 abstracts.
Chris McGahan - Received a $368,875 grant for the purchase of a state-of-the-art microscope with environmental
controls and TIRF and FRET capabilities
Nanette Nascone-Yoder – A recent publication, “Morphogenesis of the primitive gut tube is generated by
Rho/ROCK/myosin II-mediated endoderm rearrangements.” Developmental Dynamics, 238(12): 3111-3125, 2009, was
featured on the main NCSU webpage, the NCUS CVM webpage and NCSU twitter. In addition, the press release was
picked up by the WRAL editorial blog Local Tech Wire, and was reported in the online News blog of Laboratory
Equipment. This publication will also be recognized in the Highlights section in the May issue of the journal
Developmental Dynamics.
Mark Papich - There were seven new research manuscripts published in refereed journals. Two research abstracts were
presented at National meetings and conferences. The number of research reports in published journals is down slightly
from last year, but completion of two books last year decreased the amount of productive time that could have been
spent writing research papers. His publication citations remain strong, with over 250 citations in 2009.
Jorge Piedrahita - Has two active R01’s, one active R21 as PI, one active R21 as co-PI, one subcontrcat NIH, and a
pending R01. He has published four articles and two review papers this year. In addition he has two manuscripts
11
presently being reviewed (already submitted) and two in preparation. Has given four invited presentation this year and
has three additional invitations for the remaining of 2010. Two of those are international conferences.
Lysa Posner - Development of a novel model to study analgesics in fish have provided pilot data for pending grants and
further direction for the study of pain reduction in fish.
Philip Sannes - Recipient of NIH Director’s Bridge Award (R56); RO1HL-44497-17 competitive renewal funded through
2014; and RO3HL-95411-01 funded through 2011.
Gabriela Seiler - Invitation to speak at the UNC-CH Intramural Medical and Biomedical Ultrasonic Imaging Symposium
and invitation to be on a discussion panel about contrast enhanced ultrasound at the 2010 ACVR annual meeting in
Asheville, NC. Established collaborations with Dr. Paul Dayton, PhD at UNC, Chapel Hill. Dr. Dayton’s lab is focused on
research or microbubble contrast media.
Barbara Sherry - Was awarded an ARRA-funded one-year grant from NIH to study cardiac innate responses to viral
infection (R56AI083333). She was invited to present five seminars (University of Maryland, University of Montana,
Triangle Virology Association, Research Triangle Institute, and Cornell University).
Rachael Thomas - Received year 2 renewal of Morris Animal Foundation Established Investigator Funding Award in
feline lymphoma genomics; published first paper as PI (arising from prior Morris Animal Foundation First Award)
describing the identification of potential diagnostic markers for feline injection-site sarcomas; developed a second novel
feline injection-site sarcoma cell-line; published two additional peer-reviewed papers (one as first author); three further
papers pending imminent submission (one as first author, one as joint first author and one as second author); varied
contributions to additional research on canine osteosarcoma, histiocytic tumors and a range of other internal and
national/international collaborative studies, including generation of pilot data for several new funding applications; invited
reviewer of America Kennel Club Canine Health Foundation funding awards.
Jeff Yoder - Trainer for NCSU/NIH “Biotechnology” Training Grant. Trainer for CVM/NIH “Interdisciplinary Biomedical
Research Training Program for Veterinary Students” Training Grant.
Research Achievements and Honors of Trainees:
Kenneth Adler - The program manager for the cooperative agreement between NCSU and the U.S. EPA that provides
support for numerous graduate students and postdoctoral trainees to work on collaborative projects between the 2
institutions.
Matthew Breen - In the summer of 2009 Dr. Stephanie Montgomery, DVM Class of 2011, was selected as the 1st prize
winner by the Morris Animal Foundation for the work she conducted in his lab as a MAF Scholar in 2008.
Gregg Dean - Rochelle Mikkelsen: Awarded PhD in Immunology; Laura Stoeker: Morris Animal Foundation Veterinary
Student Scholar Award; Sara Gundersen: George H. Hitchings New Investigator Award in Health Research; Rita
Simoes: International Feline Retrovirus Research Symposium Travel Award; Jaime Tarigo: CMTR Training Program
fellowship.
John Gadsby - Leah Zorrilla, former graduate student, has had three papers published, two as first author and one as
co-author. Raja Sriperumbudur, former graduate student, has had two papers published, one as first author, and one as
co-author. Heather Faircloth and Shelley Swing, NCSU undergraduate students, presented posters on their research
projects at 2010 Triangle Consortium for Reproductive Biology (TCRB) Annual Conference “Immune mechanisms in
Reproduction” held at NIEHS, RTP, February 6th 2010. Heather Faircloth and Shelley Swing, NCSU undergraduate
students, presented posters on their research projects at NCSU Undergraduate Research Symposium, McKimmon
Center, April 2010.
12
Jon Horowitz - A graduate trainee, Tae-Hyung Kim, continued the characterization of a series of transgenic mouse lines
that offer new insights into stem cell biology and tumorigenesis. A poster describing some of this work was presented at
an American Association for Cancer Research meeting in Boston in October 2009 and at a meeting of the Jimmy V
Foundation held at the Raleigh Convention Center in August 2009. Mr. Kim presented a talk on part of this work at the
2009 CVM Research Symposium as well as a meeting of students involved in the Jimmy V/NCSU Cancer Therapeutics
Training Program. A graduate trainee, Haifeng Yin, completed his characterization of a conditional "knockout" mouse
line that exhibits several extremely interesting phenotypes resulting from inactivation of the gene of interest. Mr. Yin
graduated with a PhD in 2009. A manuscript reporting some of Dr. Yin's findings was submitted in 2009. A graduate
trainee, Jianzhen Xie, characterized the expression of a gene of interest in early development and documented the
differential expression of this gene in adult tissues. It is this work that was featured prominently on the NCSU and CVM
homepages as well as the News and Observer. Four undergraduate trainees and one high school trainee, Olivia
Latham, Tojan Rahhal, Candis Cook, Scott Peacock, and Jonathan Douros, worked in the the laboratory in 2009. Olivia
and Tojan participated in the Jimmy V/NCSU Cancer Therapeutics Training Program, Candis was nominated as a
trainee in the Jimmy V/NCSU Cancer Therapeutics Training Program and was accepted.
Nanette Nascone-Yoder - Stephanie Bloom, graduate student, was awarded a 2-year NCSU Molecular Biotechnology
Training Program traineeship in July 2009. Stephanie was also selected to give an oral presentation at the National
Society for Developmental Biology meeting in San Francisco in July 2009. Allison Morckel, graduate student, was
selected to present a poster on her work at the National Society for Developmental Biology meeting in San Francisco in
July 2009. Xiao Ni, undergraduate research student, presented a poster at the NCSU Undergrad Research Symposium
in April 2009. Xiao also presented a “late-breaking abstract” poster at the 2009 National Society for Developmental
Biology meeting in San Francisco in July 2009.
Mark Papich - Dara DiGiovanni, veterinary student, 2010 George H. Hitchings New Investigator Award in Health
Research (MG Papich, Supervisor) $5,000, 2010.
Lysa Posner - PI for Anesthesia Resident Project: KM Messenger, JL Davis, DH LaFevers, BM Barlowe, LP Posner.
The pharmacokinetics of intravenous and sublingual buprenorphine in horses. ACVA Annual Meeting Scientific Session,
Chicago, IL, Septemer 2009. 1st Place Award Winner Oral Abstract Presentation/, manuscript accepted for publication
March, 2010.
Korinn Saker - Nutrition Intern, Julianne Davis: i.) oral abstract presentation of research at the AAVN Clinical Nutrition &
Research Symposium, in conjunction with ACVIM, in Montreal, CANADA (June, 2009) and ii.) winner of AAVN-ACVIM
Nutrition Abstract competition, invited to present abstract at European Nutrition meeting,EAVN, in Portugal, August 2009.
Nutrition Intern, Amanda Ardente: i.) abstract was accepted for oral presentation at the AAVN Clinical Nutrition &
Research Symposium, in conjunction with ACVIM, in Anaheim, CA and ii.) invited to attend International Pet Care
Academy meeting, held in Portland, OR and provided presentation of unique NCSU Nutrition Internship training program,
August 2009.
Gabrielle Seiler - Dr. Christina Copple won the ACVR research project award
Barbara Sherry - Lianna Li’s, graduate student, publication in the January 2010 issue of Virology was “recommended” by
the Faculty of 1000 in Biology (http://f1000biology.com/). Susan Irvin, graduate student, was awarded first prize for her
oral presentation in the NCSU CVM Research Symposium (March 2010).
Research Activities (Description of current/new research directions, development of new tools/reagents and new
collaborations):
Kenneth Adler - Collaborative endeavors have been set up between my laboratory and numerous other labs throughout
the country, including Duke, UNC-CH, NIEHS, EPA, UCLA, University of Pittsburgh, Dartmouth, etc.
13
Prema Arasu - My focus is on zoonotic diseases, food safety and the intersection of health with other disciplines
(including agriculture, engineering, environment, communications, community development, etc. 1) P.I., USDA
International Science and Education award, 2008-2012. Total $100,000. "Livestock production practices, biofuels, and
environmental and public health: lessons with India". Collaboration with Drs. Vivek Fellner, Ratna Sharma (CALS) and
Isabel Gimeno, Maria Correa (PHP). 2) Zoonotic diseases workshop with University of Surrey from June 2009 resulted
in a reciprocal follow up visit and evaluation of further research and training collaborations by Surrey with CVM and
NCSU faculty (November 2009 visit and March 2010 visits by Lisa Roberts and Roberto la Ragione from Surrey).
Matthew Breen - The main focus of his lab is on the molecular cytogenetic evaluation of canine cancers, using the
unique demographics of purebred dog populations to identify cancer-associated genes that remain ‘hidden’ in human
populations. He also has retained an ongoing interest in chromosome evolution, especially as it relates to chromosome
changes occurring during speciation that may be associated also with cancer development. This work is ongoing, is
funded by several extramural grants and forms the basis of his lab’s research efforts. He has taken a new interest in
evaluating the genomics of cancers affecting wildlife. This provides an opportunity to access new sources of funding and
to use the technologies we have developed for the dog for the benefit of other veterinary species. He has continued his
interest in genome mapping and in 2009 has continued to anchor the genome of the Guinea Pig, Green Anole and the
African Elephant as part of the large genome projects for these three species. These should come to completion mid2010. To embrace new technologies and maintain pace with the rapid developments in these fields, he has continued to
engage in collaborations with a variety of leading investigators major US institutions including Duke, UNC-Chapel Hill,
The Broad Institute, Harvard/Mass Gen Hospital, John’s Hopkins, Fred Hutchinson Cancer Research Center, University
of Minnesota Masonic Cancer Center (and others) to bring new opportunities to the graduate students/post docs etc in
his lab and also to provide new avenues for future collaborative funding. These have started to come to fruition and I am
involved in several pending mutli-institutional projects that are submitting large grants to NIH.
Jamie Brown – 1) “Development of Computed Tomography Abdominal Scanning Protocols in the Sedated Canine
Patient and Comparison to Abdominal Ultrasound” project data collection is complete. Manuscripts are being written
currently. 2) Submitted grant as co-investigator to Canine Health Foundation. “Evaluation of post-operative risk factors
for the development of aspiration pneumonia in dogs diagnosed with laryngeal paralysis”. 3) “Comparison of
radiography and computed tomography for determining appropriate tracheal stent diameter in dogs” project initiated with
plans to complete within the calendar year. 4) Submitted grant as co-investigator to the Medical Library Association
Research, Development and Demonstration Project Grants. “Usefulness of clinical images as provided by ILL/DD
services.” December 2009. 5) Image consultation for Chronic arthropathy in hemophilia: MRI evaluation of joints in
hemophilic dogs. P Monahan (PI). Department of Pediatrics, UNC-Chapel Hill School of Medicine.
Gregg Dean – 1) Continuing to determine the effects of FIV on innate immune function; 2) developing lactobacillus as a
vaccine vector; 3) developing lactobacillus as therapeutic for inflammatory bowel disease; 4) developing a model to
investigate inflammatory bowel disease in cats; 5) expressing recombinant IL15 to treat FIV infected cats; 6) cloning and
expressing DSC-1 to explore the pathogenesis and develop a diagnostic test for canine pemphigous; 7) collaborating to
develop mathematical models to predict HIV infection outcome; 8) collaborating to develop mathematical models to
predict whether Lactobacillus strains are tolerogenic versus immunogenic; 9) collaborating to develop red clover mosaic
virus as a delivery system for chemotherapeutic agents; 10) ollaborating to reduce stress in shelter cats; and 11)
collaborating to explore the immunomodulatory characteristics of L. plantarum.
Troy Ghashghaei – 1) Internal collaborations ongoing: Jonathan Horowitz, CVM, MBS; Kenneth Adler, CVM, MBS;
Marcelo Rodriguez-Puebla, CVM, MBS; Jorge Piedrahita, CVM, MBS; Natasha Olby, CVM, DOCS; David Muddiman,
CALS, Chemistry; David Threadgill, CALS, Genetics and 2) External Collaborations: Magdalena Gotz, Germany; Hannah
Monyer, MD, Heidelberg, Germany; Kenneth Campbell, PhD, Cincinnati Children’s Hospital, Cincinnati, OH; Steven L.
Brody, MD, Washington University, St. Louis, MS; Jill Weimer, PhD, Sanford Children's Health Research Center, Sioux
Falls, SD; Mike Thomson, PhD, Vanderbilt-Ingram Cancer Center, Nashville, TN; Perry Blackshear, PhD, NIEHS,
Durham, NC.
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Jon Horowitz - 1) characterized a conditional "knockout" mouse line and a bevy of transgenic mouse and zebrafish lines
that have offered insights into the functions of several gene of interest; 2) continued a collaboration with Dr. Troy
Ghashghaei (MBS Dept.) that utilizes one of our mouse lines to understand the differentiation of neuronal stem cells; 3)
continued a collaboration with Drs. Adam Hawkridge and David Muddiman (NCSU Dept. of Chemistry) to identify early
biomarkers of ovarian cancer; 4) continued collaboration with Dr. Rob Smart (NCSU Dept. of Environmental and
Molecular Toxicology) and Ms. Carol Trempus (NIH, NIEHS) to help us study skin phenotypes in our transgenic mice; e.
initiated a collaboration with Dr. David Muddiman (NCSU Dept. of Chemistry) to identify cancer gene-specific markers in
vivo via mass spectrometry; 5) initiated a collaboration with Dr. Eric Everrett (U.N.C.-Chapel Hill) to study dental
phenotypes in a handful of our transgenic mouse lines; 6) initiated a collaboration with Dr. Terry Lechler (Duke Univ.
Medical Center) to study stem cell phenotypes in a handful of our transgenic mouse lines; and 7) initiated a collaboration
with Drs. Stefan Franzen and Dick Guenther (NCSU Dept. of Chemistry) to study the in vivo distribution of a novel
cancer therapeutic in some of our transgenic mice.
Lola Hudson - Continuing testing various cognitive-motor/behavioral tasks with Drs Sherman and Gruen to determine
measureable, significant alterations in FIV-infected cats within a year of infection. Open field testing including habituation
and vocalization, and T-maze latencies with weaves and hoops have shown promising initial results. We have also
started a collaboration with Dr Heidi Kay of Jericho Sciences and are currently performing a pilot study on the efficacy,
and side effects of FX101 for treatment of FIV. This proprietary compound has been effective in vitro with interfering virus
assembly of lentivirus with loss cell death.
Chris McGahan - With the new microscope that is still being installed, we are making a new strategic plan for the
competing continuation of our NIH grant. The proposal is due in November, 2010. Members of all three departments are
working on a Perspectives article for the New England Journal of Medicine which will summarize/emphasize the
availability of naturally occurring models of disease in Veterinary Teaching Hospitals.
Nanette Nascone-Yoder - Current research directions: frog embryo-based chemical genetic screening to identify
mechanisms of gut morphogenesis; the role of Wnt/PCP pathway signaling in gut morphogenesis; and the role of Pitx2
in left-right asymmetric gut looping and rotation. Tools/reagents: in collaboration with Alex Dieters (NCSU Chemistry),
we are continuing to develop photoactivatable reagents (small molecules, morpholinos) for spatial control of gene
expression and protein activity within target tissues of living embryos.
Shila Nordone - New ongoing collaborations: NCSU-CVM Dr. Jeff Yoder, TMEM150 gene discovery research & NITR9
expression & function in zebrafish; NYU Dr. David Levy, HIV Treg latency model development; UNC Dr. David Margolis,
Treg Immunopathogenesis in HIV+ patients; NCSU CVM Dr. Gregg Dean, Development of Lactobacillus as a vaccine
vector for HIV. New collaborations: NCSU Microbiology Dr. Frank Scholle, plasmacytoid dendritic cell function during
West Nile infection; Ontario Veterinary College Dr Marie Holowaychuk, Alterations in calcium homeostasis in dogs during
endotoxemia.
Mark Papich - The research laboratory, Clinical Pharmacology Laboratory, has continued to develop new assays and
capabilities in 2009-2010. They have developed drug assays for several new drugs, in addition to many more that have
already been validated. These efforts have led to research projects, successful funding, and several publications. They
have successfully collaborated with investigators at several other institutions with publications and research grants
submitted in collaboration with those investigators. 1) Research Grants Submitted - pending: “Genetic variation of drug
metabolism in swine and implications on withdrawal time”; C Maltecca, Animal Science, PI; M Ashwell and MG Papich,
Co-I; $23,751; submitted to NC Pork Council. “Drug metabolism in swine: genetic variation of plasma disposition
kinetics, cytochrome P450 genes expression and implications on withdrawal time”; C Maltecca, Animal Science, PI; M
Ashwell, W Flowers, and MG Papich, Co-I; $51, 893; submitted to National Pork Board. 2) Research Grants Funded:
“The effect of aspirin and clopidogrel on equine platelet function and serotonin release”; BM Brainard, VMD, PI,
University of Georgia; MG Papich, Co-I, NCSU-CVM; $48,484, Morris Animal Foundation. “Distribution of enrofloxacin,
and it’s active metabolite, using an in-vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs”;
MG Papich, PI; $26,567; Bayer Health Care. “Retrospective analysis of convenia - a review of clinical case utilization”;
MG Papich, PI; $7,450; Pfizer Animal Health. “Diazepam pharmacokinetics with nasal drop and atomized nasal
15
administration”; CL Mariani, PI; SE Musulin, and MG Papich, Co-I; $7,849; 2008-2009; ACVIM Research Foundation,
Denver, Colorado. “George H. Hitchings New Investigator Award in Health Research”; MG Papich, PI; $5,000; Triangle
Community Foundation.
Jorge Piedrahita - Development of transgenic swine that can house human tissues; identification of PEG3 as a gene
affecting human intrauterine growth restriction; development of the first ever lacZ pig, and the first ever Nk cell deficient
pig; completion of the most comprehensive survey of imprinted genes in swine to date. Manuscript has been submitted
for publication; and development of, to my knowledge, the first ever porcine induced pluripotential stem cells (iPS).
Korinn Saker - Current project focus: Molecular 1) Nutritional interventions for breast cancer utilizing the cat as both an
animal model for human breast tumors and for the species itself as specific breeds of domestic felines have an
increased risk for mammary tumor development. a. development of mammary gland organ culture system to evaluate
pomegranate and CLA as potential chemo-preventive agents. 2) Obesity management in the companion animal (canine,
feline, equine). a. establishment of primary species specific cell lines for culture work. This has been a collaborative
effort with Dr. Ben Buehrer, Zen-Bio, Research Triangle; b. establishment of adipokine – oxidative stress assay series to
utilize in basic and clinical obesity studies as well as screening tool for obesity clinic patients. Collaborative efforts with
Dr. Buehrer, Zen-Bio and Dr. Swecker, VMRCVM; and c. completion of collaborative study with Dr. Pratt, NCSU-AnSc
Dept, focusing on insulin sensitivity with body composition in the horse. 3) Evaluation of intestinal tight junction proteins
in relation to understanding disease mechanisms of IBD and identifying efficacious nutritional intervention protocols for
management of the IBD patient. This is a collaborative research effort with pathologists and GI researchers in the CVM.
This has been a new research area for m, but likely will not be an area that I pursue further work in from the IBD
perspective, but possibly from the critical care-glutamine and/or GI lymphoma perspective. Clinical 1) PN safety efficacy
study to determine most appropriate admixture formulation and delivery combinations for both ICU and Intermediate
Care patients. Study evaluates the correlation between nutrient profile of admixture, catheter type, incidence of
complications (infection rate, thromboplebitis, etc), patient location and length of PN administration. Based on results,
appropriate PN protocols can be established for the VTH. 2) Specialty companion animal diet studies. a. commercial
frozen treat- formulated ‘recipe’ for frozen dog treat and evaluated safety and nutritional value of treat through a feeding
trial. This treat has been produced and marketed in grocery stores through sponsor, Hunter Farms. b. enteral critical
care diet – evaluated the nutritional value and safety of 3 versions of a new unique form of commercial critical care diet
for the canine and feline. This diet is available to veterinary hospitals through sponsor, FreshPet. c. Probiotic study to
evaluate benefit of short-term probiotic in mitigating stress-related enteritis/colitis in shelter dogs. Collaborators include
NCSU-CVM Shelter veterinarians, (alternative tract) nutrition resident, Wake and Orange County Animal Shelters and
Merck Merial summer research fellow. Molecular & Clinical 1) Neuroprotection through nutritional support. This project
focuses on the benefit of ketogenic diet and or selected calorie-restriction protocols to recovery ofd spinal cord injury
patients. The model is the dog. This is a collaborative project focus with Dr. Olby, NCSU-CVM and Dr. Pan, Nestle
Purina. 2) Obesity and mammary (breast) cancer. This project area focuses on the relationship between the obese
state and incidence and progression rate of mammary tumors. Cats are the study model to evaluate selected
nutrient/dietary components for their potential role in mitigating obesity and how that correlates with tumor growth.
Philip Sannes - Continued studies on defining signaling and genetic mechanisms that control the differentiation of
epithelial cells in the pulmonary alveolus, (RO1); and continued studies on determining the role of alveolar epithelial
differentiation and repair in pulmonary fibrosis. (RO3)
Gabriela Seiler - The goal of these past 9 months was to build up research collaborations in her area of interest “contrast
enhanced ultrasound” and “molecular imaging of tumor perfusion”. Research collaboration has been established with
Paul Dayton at the joint department of biomedical engineering at NC State and UNC. Dr. Dayton’s research lab focuses
on development of novel imaging techniques to image perfusion, and specifically to image tumor angiogenesis. Many of
these techniques are being tested in rodent models, and our collaboration enables use of molecular imaging techniques
in larger patients such as the dog. A CVM research grant to investigate the use of targeted contrast ultrasound to image
VEGF in dogs with lymphoma is being submitted with Paul Dayton and Laurel Williams as co-investigators. Other
collaborative efforts within the college of veterinary medicine include Dr. Amy Pruitt in radiation oncology, a project is
ongoing to investigate the effect of radiation therapy on tumor perfusion using contrast enhanced ultrasound. An
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emerging collaboration is the use of contrast ultrasound in drug delivery to the eye with Dr. Brian Gilger, they are
currently discussing possible projects. She has also been involved in a project investigating radiofrequency ablation of
hepatocellular carcinoma in woodchucks with Dr. John Cullen. Other ongoing projects include evaluation of the HASTE
MRI sequence to evaluate the subarachnoid space in canine spinal MRI.
Barbara Sherry - Generated RNA lysates for a new collaboration with Dr. Adolfo Garcia-Sastre (Mt. Sinai School of
Medicine) to investigate reovirus components recognized by cells during the innate protective response to viral infection;
received transgenic mice from Dr. Wolfgang Dillmann (UC San Diego) for a new collaboration to determine the role of
Hsp25/27 in innate responses to viral infection; generated clones for Dr. Tal Kafri (UNC-Chapel Hill) and in turn he
generated stable cell lines for us in a new collaboration to determine the role of Hsp25/27 in innate responses to viral
infection; provided clones to Dr. Giulio Superti-Furga (CeMM, Vienna, Austria) for a new collaboration investigating cell
protein interactions with reovirus components during the innate protective response to viral infection.
Cliff Swanson - Completed study using thrompboelastography in examining the mechanism of purported inhibitory
affects of acepromazine upon blood clotting.This is a resident research project for Dr. Bobbi Conner, Critical Care
Resident.
Rachael Thomas - Development and molecular characterization of a second new feline injection-site sarcoma cell line;
continuation of first funding proposal as an established investigator in feline genomics and the application of cytogenetic
profiling for molecular classification of feline lymphoma; expansion of departmental, interdepartmental and international
collaborations on feline abdominal lymphoma, initiated collaborations with clinicians/researchers at the Veterinary
Schools of UC Davis, Oklahoma State, Auburn University, Kansas State and Tufts; prepared and submitted funding
application to develop high-resolution genomic microarray technology for the cat, and for application of this technology
for refinement of previously-identified potential diagnostic biomarkers; invited to assist with ongoing development and
refinement of the feline genome sequence assembly; expansion of laboratory-based studies on canine lymphoma
cytogenetics as a model for human lymphoma; performed laboratory-based analysis of specimens derived from an
ongoing forensics investigation; assisted with collation of CVM contribution to proposal for development of NC-based
Forensic Science Institute; continued/published a series of other collaborative canine and comparative cancer/genomics
studies.
Don Thrall - The competing renewal of the hyperthermia program grant will not be funded. The project scores were
highly competitive but the overall direction was judged to be problematic and votes were cast outside of the
recommended range leading to a non-fundable score. We do not have the formal written critique as yet. We will submit
a revised application in the Fall of 2010 for possible funding in July of 2011.
Jeff Yoder – New direction: the lab is now developing a novel cytotoxicity assay using transgenic zebrafish T cell
leukemia cells as target cells and splenocytes as a source of killing cells. They will be able to evaluate the roles of both
candidate ligands and receptors in the process of cytotoxicity. He has an NSF grant proposal pending based on these
experiments. NIH R01: “Switchable systems for Spatio-Temporal Control of Gene Expression in Zebrafish” PI: Deiters
(NCSU Chemistry); co-I: Yoder. Aug 1, 2007- July 31, 2012. We continue this collaboration with Dr. Alex Deiters on
developing novel methods for photo-regulation of gene expression in zebrafish embryos. We recently submitted a
manuscript on photo-caged morpholinos to the Angewandte Chemie, and are pursuing other methodologies. NIH R01:
“Novel innate immune receptors in zebrafish” PI: Litman (Univ. South Florida); Sr-I: Yoder. Dec 1, 2006- Nov 30, 2010.
Continue this collaboration with Dr. Gary Litman. They have had seven consecutive years of NIH funding on this project
(1 yr R21 and 5 yr R01 with 1 yr no-cost extension) and have submitted a renewal for this grant which received a score
of 27 (27th percentile) on the 2nd submission: it is currently not clear if this will be funded. He is in discussions with Dr.
Litman about possibly submitting a new R01 for similar studies. NIH R21: “Whole organism transcriptional profiling of
innate immune response” PI: Yoder. June 15, 2008 – May 31, 2010. Nearing completion of this grant. Completed
microarray studies of zebrafish larvae dosed with multiple immune stimuli and are currently evaluating the gene lists from
these studies. Morris Animal Foundation: “Evaluation of TREM-1 as a Specific Biological Marker for Sepsis in Dogs” PI:
Nordone (NCSU MBS); co-PI Yoder. Sept 1, 2008 – Aug 31, 2011. Helped this project by building multiple plasmids for
expressing canine TREM-1 in mammalian cells as a well as in bacteria as a GST-fusion.
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Publications and Other Professional Activities
Please refer to Appendix V (p. 37) for details. MBS faculty contributed the following scholarly works during the past year:
84
Original works in peer-reviewed journals
7
Case reports in peer-reviewed journals
13
Review articles in peer-reviewed journals
3
Books
14
Book chapters, peer-reviewed
73
Abstracts from scientific and professional veterinary conferences
54 citable and 19 not citable
Invited presentations (including CE) where the primary audience was professionals
79
3
3
1
Works prepared for presentation and distribution through electronic media, including CD-ROMS, audio
and video disks and tapes, computer generated presentations, broadcast videos, etc
Continuing education presentations/papers/proceedings where the primary audience was not
professionals
Copyrighted software and other copyrighted scholarly material.
Professional activities by MBS faculty (Editorial Boards, Ad hoc Manuscript Reviews, Memberships on Research Grant
and Study Reviews, Committee Memberships). Please refer to Appendix VI (p. 63) for specific details.
14
Faculty appointed or elected to research study sections
11
Faculty serves as members of editorial boards of journals
27
Faculty served as ad hoc reviewers for journals
15
Faculty served on MBS committees
22
Faculty served on CVM committees
15
Faculty served on NCSU committees
20
Faculty served on other committees
Minority Representation and Recruitment Efforts
Dr. McGahan continues to participate in the “Buliding a Future Faculty” program that is held at NCSU each year with the
goal of recruiting minority faculty to the University/College/Department.
The 34 departmental faculty positions (tenure and non-tenure track) include 10 White females, 19 White males, 1
American Indian female, 2 Hispanic males, 1 Asian female, and 1 Asian male.
VI.
Students
Honors and other measures of quality
Professional Degree Program
Most activities involving veterinary students will be considered in detail in the annual report from the Office of
the Associate Dean of Academic Affairs. A complete list of courses presented and participated in by
departmental faculty is given in Appendix III (p. 32).
18
Graduate degree and Residency Programs
Departmental faculty actively participate in the NCSU Physiology, Immunology, Toxicology, Biotechnology,
Genomic Sciences, Animal Science, and UNC-CH School of Pharmacy graduate degree programs in addition
to the CVM’s Comparative Biomedical Sciences (CBS) program.
12 faculty served as major advisors to 34 PhD students, 3 DVM/PhD students, and 1 MVPH student.
18 faculty served on the graduate committees of 68 PhD students and 3 MS students.
Minority Representation and Recruitment Efforts
Diversity among the graduate students majoring with departmental faculty is shown in the following table:
VII.
White
African-American
Hispanic
Asian
American Indian
Totals
Male
4
1
0
6
0
11
Female
17
2
1
7
0
27
Totals
21
3
1
13
0
38
Research
Volume of Activity
Extramural and intramural research grants awarded to each departmental faculty member are in listed in
Appendix VII (p. 76).
Extramural Grant Activity
The total for current year awards for MBS PIs on 47 extramural grants in effect this past year was $7,641,594.
The following table summarizes the distribution among extramural funding agencies:
Agency Source
Number Grants
Total - Current Year Awards
Direct - Current Year Awards
US Government
31
6,827,110
4,901.542
Industry
5
177,165
127,011
Foundations
10
492,752
457,733
Trust
0
0
0
Other
1
144,567
144,567
The following table summarizes distribution of the $7,641,594 into departmental research programs.
Program
Number Grants
Total - Current Year Awards
Cell biology/respiratory
5
1,079,113
Cell biology/ocular
2
616,966
Cell biology/stem cell
1
322,745
Gastrointestinal
1
120,000
Oncology/cancer
7
898,566
Genomics
10
1,988,089
19
Program
Number Grants
Total - Current Year Awards
Infectious Disease
13
2,122,730
Immunology
3
428,020
Pharmacology
3
39,017
Nutrition
2
26,348
NIH accounted for 28 of the 31 US government research awards. Of the remaining governmental grants, USDA
funded 1, EPA funded 1, and NSF funded 1. Included in these summaries is 1 training grants which total
$232,540 in total cost for the current year.
The total for current year awards for MBS Co-Is on 9 extramural grants and 1 NCSU grants this past year was
$1,886,054.
Specific Achievements of Significance
Extramural grant submissions during 2009-2010: MBS PI faculty submitted 33 proposals for extramural grant
support in the amount of $29,743,564 (total cost for total grant period).
The following table summarizes distribution of the grant submissions into departmental research programs.
Extramural
Program
VIII.
Number Grants
Total - Total Grant Period
Cell biology/respiratory
2
1,750,000
Cell biology/stem cell
4
5,795,778
Gastrointestinal
3
2,688,277
Oncology/cancer
5
5,199,638
Genomics
3
2,230,399
Infectious Disease
5
5,214,746
Immunology
6
4,093,790
Nutrition
2
1,056,800
Other
3
1,714,136
Administration and Staff
Personnel
Department Head, Associate Dean of Research and Director of Research and Graduate Programs, Associate
Vice Provost for the Office of International Affairs, Director for the Comparative Medicine and Translational
Research Center. A complete list of Administrative and Staff Personnel appears in Appendix II (p. 31).
New Faculty Appointments
Gabriela Seiler; Associate Professor of Radiology; appointed July 1, 2009.
20
Staff
A total of 19 SPA employees and 38 non-faculty EPA employees worked in the department this past year. The
overall performance of this staff in supporting the teaching, research and professional service activities of this
department is excellent. The staff complement currently stands at 16 with 0 new appointments, 1 resignation, 1
retirement, and 1 RIF. The non-faculty EPA currently stands at 33 with 10 new appointments, 4 resignations, 2
interdepartmental transfers, and 1 transfer to DOCS department.
IX.
Recommendations and concerns for the future
The Department will continue to pursue updating the curriculum with an emphasis on molecular medicine and in
enhancing the Clinician Scientist Focus area with the development of new Selectives. In addition, the
Department will continue to encourage efforts in Translational Research, specifically with an increase in
emphasis and support (time and resources) of meaningful Scholarly Activity of faculty who have a significant
clinical effort. Many MBS faculty members of the department are members of the Center for Comparative
Medicine and Translational Research and make contributions to the Center.
Our ability to continue to grow extramural research funding continues to be challenging. This is especially with
the loss of 4.5 open faculty positions, and SPA staff positions due to cuts in the State budget. The stimulus
funding ends this year and there is not any good news coming forth about an improved NIH funding situation.
Despite these factors we continue to maintain approximately the same amount of extramural funding as in
previous years, thanks to the efforts, hard work and ingenuity of our faculty. Fortunately, hospital revenue has
not decreased significantly so far this year and is thus a positive factor in the departmental budget and is due to
the hard work and dedication of the Clinical faculty.
However, despite our past successes, the impact on the Department of continued pressure on both the state
and national budget is of grave concern for the future. The effect of these economic pressures may eventually
result in less flexibility in supporting research programs, difficulty in raising funds for faculty start-up packages,
an inability to provide assistance to faculty for the purchase of equipment, and less available funds to provide
technical and teaching support in the Department. It is important that the MBS department continue to maintain
a financial “war chest” of at least $250K in order to off-set the negative impact of reductions in the state budget.
However this is only a temporary solution, even deeper cuts in our budget from the state of North Carolina that
are anticipated can only be offset for one-two years, then our cash reserves could be used up, and we will have
to make alternative budgetary plans in order to bridge productive programs and help them survive through
future tough times.
X.
University’s Five Focus Areas
1.
Producing leaders for the state, nation, and world
Kenneth Adler - Numerous leadership positions held by Dr. Adler: chair of numerous study sections, invited
speaker at numerous meetings and at different academic, industrial and government institutions. Training of
students and postdoctoral fellows to do environmental research via the EPA/NCSU cooperative agreement
managed by Dr. Adler. Kenneth Adler has received supplements from NIH for minority students working on his
R37 grant from HNLBI.
Prema Arasu - Working with Park Scholars, Class of 2011, and NCSU students interested in Global Health and
health opportunities in general.
Matthew Breen – His leading role in the fields of canine and comparative genomics provide members of his lab,
permanent and temporary, with good opportunities to become involved in cutting edge research that plays a key
role in major international collaborations.
21
Arnold Brody - After two years in Brody’s laboratory, Keith Salazar accepted a highly competitive position as a
staff scientist with the US Environmental Protection Agency. We are very proud that Keith qualified for this
research position and moved on to national service.
Gregg Dean - The Comparative Medicine and Translation Research Training Program is a recently created
program that targets individuals trained as veterinarians (have already earned a doctorate in veterinary
medicine, DVM) and that have specialty training. This means they have completed a residency in specialty area
such as pathology, internal medicine, dermatology, ophthalmology, etc. In this program, individuals will earn a
PhD and will focus on the use of animals in research for the purpose of generating knowledge, drugs, therapies
or diagnostic techniques that will direct application to veterinary and possibly human patients. The unique
combination of training will equip graduates to become leaders in biomedical research. This program is the first
of its kind and as such represents an innovative approach to meet the national need for veterinary scientists.
John Gadsby - As a teacher of veterinary, undergraduate and graduate students, in the classroom and in the
laboratory, it is his hope and expectation that he is training and inspiring future leaders of this State, Nation and
World.
Troy Ghashghaei - Initiated collaborations with leading neural stem cell groups in Germany, New York State,
and Cincinnatti.
Jon Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program.
Nannette Nascone-Yoder - Provided both undergraduate and graduate students with opportunities to perform
research in her lab, attend professional conferences, make scientific presentations and network with top
scientists.
Lysa Posner – Part of a team that trains students, interns and residents as veterinarians. Veterinarians serve
throughout the word; not just healing companion animals but protect our food sources, monitor biosafety as well
as contribute to scientific advancement. Furthermore, the training of Veterinary Anesthesia Specialists helps
create the next generation of Veterinary Leaders.
Korinn Saker - Amy Tanner, PhD student is a project leader for Virginia Tech. Julianne Davis, completed
specialized nutrition internship (2009). Amanda Ardente, will complete specialized nutrition internship (2010),
accepted unique exotics clinical residency training program and plans to complete PhD in nutrition and establish
herself in academia. Janine Oliver, an alternative track nutrition resident, is on the executive board of the
national AAVN . Kelly Owens, completed her Masters and is now a science high school teacher in rural North
Carolina as part of a rural education growth initiative. Susan Wynn, an alternative track nutrition resident has
published an alternative medicine ext for veterinarians.
Barbara Sherry - Continues training 2 graduate students pursuing PhD; Li (Functional Genomics PhD), 1stauthored publication was recommend by the Faculty of 1000 in Biology (http://f1000biology.com/), currently
employed as a Postdoctoral Fellow at Tulane University; and Irvin (CBS PhD), was awarded 1st prize for her
oral presentation in the NCSU CVM Research Symposium (March 2010). Barbara Sherry participated in the
Initiative for Maximizing Student Diversity (IMSD) program at NCSU, funded by the NIH. The IMSD program is
designed to increase the number of students from underrepresented minority groups who receive Ph.D.'s in the
biomedical and behavioral sciences, and ultimately pursue research careers in these fields. Ms. Phoebe Cruz,
an undergraduate student at NCSU who is part of this program, is conducting research in her laboratory
Jeff Yoder - By educating and training Immunology, Comparative Biomedical Sciences and Functional
Genomics graduate students (in classes and in his laboratory) he is contributing to the development of future
scientific leaders.
22
2. Creating educational innovation
Prema Arasu - Launching first (and hopefully annual) Global Health Case Competition to stimulate interdisciplinary thinking and team building skills.
Matthew Breen – He is asked frequently to provide presentations to the audiences comprising the general
public and/or veterinarians and will continue to use this as an avenue to provide educational input to these
audiences to raise awareness of the activities of the CVM and the CCMTR. His lab’s work with the canine
genome is being use as part of a new exhibit in the new NC Museum of Natural Sciences in Raleigh and so this
provide considerable accessibility to genomic sciences to a large population within the State of NC.
James Brown - Creating the NCSU Radiology YouTube channel provides veterinary students and continuing
education course participants with a resource for ultrasound by presenting video clips of various diseases and
normal studies. These clips are referenced in current courses, including those in the DVM curriculum and for
continuing education. A strength of this resource is the ease by which it can be accessed universally, using the
popular and free video hosting site, youtube.com, avoiding any potential complications with viewing
compatibility encountered with previous video distribution methods. Video clips are embedded with the NCSUCVM logo to ensure recognition of the college when viewed. This resource is under continual revision, primarily
adding new educational material for viewers.
Gregg Dean - The Comparative Medicine and Translation Research Training Program is a recently created
program that targets individuals trained as veterinarians (have already earned a doctorate in veterinary
medicine, DVM) and that have specialty training. This means they have completed a residency in specialty
area such as pathology, internal medicine, dermatology, ophthalmology, etc. In this program, individuals will
earn a PhD and will focus on the use of animals in research for the purpose of generating knowledge, drugs,
therapies or diagnostic techniques that will direct application to veterinary and possibly human patients. The
unique combination of training will equip graduates to become leaders in biomedical research. This program is
the first of its kind and as such represents an innovative approach to meet the national need for veterinary
scientists.
Troy Ghashgahei - Implementing improvements in the neurophysiology and cell biology curricula at CVM.
Jon Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program.
Korinn Saker - Developed and continue to develop nutritional education materials for non-traditional learning
environments and creating a dual clinical residency, graduate Adult Education training program, to enhance the
formal educational training of future clinicians and academics.
Phil Sannes - Continue to work with the Curriculum Committee through the Course Coordinator Group to
develop a new and innovative veterinary curriculum.
3. Improving health and well being
Kenneth Adler - A drug developed from Dr. Adler's research and licensed through the university to a start-up
biotechnology company (BioMarck, Raleigh, NC) is now in phase 2a human clinical trials and could become a
new treatment for chronic bronchitis in the U.S. and worldwide.
Prema Arasu - Championed and helped organize NCSU's 'Health and wellbeing' Initiative.
Matthew Breen - Research in his lab is identifying regions of the canine genome that are associated with
response to therapy in cancer patients. Simultaneously, they are translating these canine changes to the human
genome and further testing corresponding region of the human genome for their association to prognosis.
23
Gregg Dean - The Center for Comparative Medicine and Translational Research (CCMTR) was conceived and
implemented by faculty that recognize strong multidisciplinary collaborative teams are necessary to accelerate
translational research. Translational research is process of moving laboratory observations into the clinical
setting through the creation of new therapeutics, vaccines, diagnostics, and biomedical devises. The Center
concept was proposed in 2003, given permission to organize in 2005 and was formally recognized as an official
UNC Center by the Board of Trustees in February 2006. The CCMTR has at present over 100 tenure-track
faculty representing 16 departments from 5 colleges, with approximately 50% of the participants residing on the
Centennial Biomedical Campus. In addition to the traditional biological disciplines found in the Colleges of
Veterinary Medicine and Agriculture and Life Sciences, truly multidisciplinary collaborations come through the
addition of faculty with expertise in biomedical engineering, biomedical textiles, mathematical modeling, nontraditional statistics, chemical engineering, molecular modeling and more. This brings together faculty that
speak different scientific languages but share the desire to bring medical solutions to the clinic. In the short
time since it’s inception, the CCMTR has accomplished the following: provided incentives and support to
encourage truly multidisciplinary collaborations and accelerate the translation of laboratory research to
improved patient care; engaged external academic and corporate advisors to identify research goals and
strategies; provided access to sophisticated research equipment ; offered facilities and technical assistance to
perform clinical trials; awarded seed grant money to launch new ideas and collaborations; hosted workshops
and symposia to help faculty remain innovative and knowledgeable; provided educational opportunities for
undergraduate and graduate students (including veterinarians) in translational research; developed ties with
biomedical researchers at other UNC institutions; and created a powerful research enterprise to attract
corporate partners to the Centennial Biomedical Campus.
John Gadsby - Research studies relating to attempts to identifying novel approaches for estrous cycle
regulation/synchronization should allow a significant increase reproductive efficiency in swine, as well as the
reduction in swine herd size which in turn should lead to a reduction in waste production and the environmental
hazards that this creates, as well as leading to potential improvements in animal welfare; research into uterine
disease in cattle should also lead to improvements in reproductive efficiency, animal welfare and reduction in
animal waste with significant environmental impacts; and research into control of luteolysis/luteinization in
human granulosa-lutein cells should lead to improvements into human IVF procedures as well increase our
understanding of control of the human menstrual cycle and lead to greater understanding of, and possible
interventions to, prevent early pregnancy loss.
Troy Ghasghaei - Research relevant to development of regenerative treatments for brain injury and disease.
Nannette Nascone-Yoder – Her lab conducts federally funded research aimed at understanding the etiology of
birth defects.
Jorge Piedrahita - Continues to work towards solving issues related to human and animal well and health being.
He has grants that focus on understanding the role of imprinted genes in intrauterine growth restriction. As part
of that work they identified a genotype in the PEG3 gene that is associated with increased incidence of IUGR.
They applied for a provisional patent application for that assay and they are continuing to develop it further to
determine its usefulness as a biomarker of IUGR. They have also denitrified biomarkers fro preeclamptic,
another placental disease in humans. In another funded project they are working to develop human
hematopoietic stem cell and hepatic cells as part of a transplantation project. While this is a very long-term
project, successful completion will result in the ably to develop transplantable tissues from stem cells. Finally,
they have also focused on developing stem cell technology in dogs so as to develop clinical methods that can
improve the health and well being of this species.
Lysa Posner - Veterinarians are major contributors to maintaining the world’s heath through food surveillance
and biosafety (bacterial, viral and toxilogical). The training of the next generation of protectors is vital.
24
Korinn Saker - Working collaboratively and individually to establish infrastructure support for an Obesity Clinic
and for WOLF (Wellness, Obesity, Lifestyle and Fitness (WOLF) Program l and for the larger Wellness
Outpatient Center at NCSU-CVM.
Phil Sannes - Continue our work directed toward understanding the role of alveolar epithelial differentiation in
pulmonary fibrosis.
Gabriela Seiler - Cancer research is relevant for the health of both our veterinary patients and for human
medicine. Her contributions in this field will hopefully benefit both.
Barbara Sherry - Was awarded a new one-year NIH ARRA-funded grant to study cardiac innate responses to
viral infection; generated two peer-reviewed research publications and one peer-reviewed research review
publication; initiated four new collaborations (with Drs. Garcia-Sastre, Dillmann, Kafri, and Superti-Furga, in NY,
CA, NC and Austria, respectively) to study innate responses to viral infection; was invited to present five
seminars describing our research on innate responses to viral infection; chaired a session at a national meeting
on viral infections; served as editor, associate editor, and on editorial board for research journals relating to
viral infections; and continued collaboration with ImmunoBiosciences, Inc. to study vaccine for efficacy against
influenza infection.
Don Thrall – Assessing the biologic effects of tumor hyperthermia in terms of alteration of tumor physiology that
may be beneficial, and the optimum manner in which to prescribe hyperthermia. Results of these studies have
the potential to refine the use of hyperthermia as a cancer treatment modality in animals and humans.
Jeff Yoder - The research in his laboratory includes basic functional studies of evolutionarily conserved novel
immune response genes. These functional studies will likely form the basis for clinical based studies
investigating the roles of these genes in human disease. Ultimately, an understanding of how all genes
contribute to the response to and recovery from infection will promote better drug designs for improving human
health.
4. Fueling economic development
John Gadsby – Results should lead to improvements in reproductive management and efficiency which should
have important economic impact for swine and cattle producers in the state, nation and the world.
Troy Ghashghaei - Funding through NIH – has hired up to 5 staff at any given time.
Korinn Saker - Developing and nurturing relationships between NCSU-CVM and the pet industry to promote
collaborations to support all aspects of the Outpatient Wellness Center at NCSU-CVM, which will provide a
service for the college and the greater communities and ultimately create necessary positions; and promote
research funding.
Barbara Sherry - Hired two new research technicians (full-time EPA employees Lance Johnson and Renee
Rawson).
5. Driving innovation in energy and the environment
Prema Arasu - Our USDA International Science and Education award for 2008-2012 bridges sustainable
livestock production practices with biofuels and environmental and public health. They have begun talking with
various companies (PermaFuel, Inc.; Orbit, Inc.).
25
John Gadsby - The improvements in Reproductive efficiency which should result from our studies, should also
have environmental impacts via reduction in animal waste production and thus reducing concerns about waste
disposal and its effects on the environment (e.g. water ways and water supplies).
26
Appendix I
List of Faculty/EPA Employees Including Graduate Students
FACULTY
Kenneth B. Adler, PhD
Prema Arasu, DVM
Makoto Asakawa, BVSc
Jill A. Barnes, PhD
Matthew Breen, PhD
Arnold R. Brody, PhD
James Brown Jr, DVM
Nigel B. Campbell, PhD
Gregg A. Dean, DVM
David C. Dorman, DVM, PhD
James P. Douglass, DVM
Lloyd N. Fleisher, PhD
John E. Gadsby, PhD
Troy Ghashghaei, PhD
Jonathan M. Horowitz, PhD
Kristina Howard, DVM
Lola C. Hudson, DVM, PhD
M. Christine McGahan, PhD
Nanette M. Nascone-Yoder, PhD
Shila K. Nordone, PhD
Mark G. Papich, DVM
Jorge A. Piedrahita, PhD
Lysa P. Posner, DVM
Ian D. Robertson, BVSc
Marcelo Rodriguez-Puebla, PhD
Korinn E. Saker, PhD, DVM
Philip L. Sannes, PhD
Gabriela S. Seiler, DVM
Barbara Sherry, PhD
James E. Smallwood, DVM
Clifford R. Swanson, DVM
Rachael Thomas, FD
Donald E. Thrall, DVM, PhD
Jeffrey A. Yoder, PhD
Professor; Cell Biology, Physiology, Environmental Science and Toxicology
Professor; Infectious Disease; Assoc Vice Provost, Office of International Affairs;
Director, Global Health Initiatives; Director, CVM International Programs;
resigned 5/24/10
Clinical Assistant Professor; Anesthesiology
Teaching Associate Professor; Cell Biology and Anatomy
Professor; Cell Biology, Physiology, and Genomics
Research Professor; Respiratory Biology
Clinical Assistant Professor, Radiology
Clinical Assistant Professor; Anesthesiology
Professor; Infectious Disease; Director, Center for Comparative Medicine and
Translational Research
Professor of Physiology, Associate
Dean
of Research Associate
and DirectorDean
of Research
Professor
of Physiology,
of Research and Director o
and Graduate Programs
Clinical Assistant Professor; Radiology
Professor; Pharmacology
Professor; Cell Biology, Physiology, Reproductive Biology
Assistant Professor; Developmental Neurobiology, Adult Neurogenesis, Gene
Therapy
Associate Professor; Cancer Biology, and Cell Biology
Research Assistant Professor; Infectious Disease
Professor; Cell Biology and Anatomy
Professor & Department Head; Cell Biology, Pharmacology, Environmental
Science and Toxicology
Assistant Professor; Developmental Biology
Research Assistant Professor
Professor; Clinical Pharmacology
Professor; Genomic and Reproductive Biology
Clinical Associate Professor; Anesthesiology
Clinical Associate Professor; Radiology
Associate Professor; Cancer Biology, Cell Biology, and Physiology
Associate Professor; Clinical Nutrition
Professor; Cell Biology, Physiology, Environmental Science and Toxicology
Associate Professor of Radiology; appointed 7/1/2009
Professor; Infectious Disease; Director, Genomic Sciences Graduate Program
Professor; Anatomy
Associate Professor; Anesthesiology
Research Assistant Professor; Genomics
Professor; Radiology and Cancer Biology
Assistant Professor; Immunology
EMERITUS PROFESSORS
Robert A. Argenzio, PhD
Arthur L. Aronson, DVM, PhD
Professor Emeritus
Professor Emeritus
27
Peter J. Bentley, PhD
Cecil Brownie, DVM, PhD
Terrence M. Curtin, DVM, PhD
Charles E. Stevens, DVM, PhD
Named Professor Emeritus
Professor Emeritus
Professor Emeritus
Professor Emeritus
EPA PROFESSIONALS
Dieldrich S. Bermudez, PhD
Katherine Bortoff, PhD
Kathryn K. Byler, BS
Beth C. Case, BS
Anne L. Crews, MS
Demetrio D. Dichoso, BS
Michael K. Dush, PhD
Shijing Fang, MD
Laila Farzana, MS, PhD
Malgorzata (Margaret) Goralska, PhD
Alexandra Hamilton, BS
Benoit Hedan, DVM, PhD
Benoit Jacquet, MS, PhD
Lisa Jesse, DVM
Lance C. Johnson, BS
Katherine A. Kennedy, BS
Jyotsna (Jody) Khosla, MS
Susan M. Lankford, PhD
William R. Lee, DVM
Julie M. Long, BS
Kristen A. Maloney, MS
Jeffrey D. Miller, PhD
Helena Morales-Johansson, MS, PhD
Steven Nagar, PhD
Donna R. Newman, PhD
Joungjoa Park, MS
Renee R. Rawson, BS
Ivan Rodiguez-Nunez, PhD
Raul Salinas-Mondragon, FM, PhD
Nicole S. Tinfo, PhD
Poem M. Turner, BS
Ying Wang, MS, PhD
Christina ML Williams, BS
Tiffany Yelverton, MS, PhD
Na Young Yi, DVM, PhD
Qi Yin, PhD
Lin Zhang, FM, MS
Leah Zorilla, PhD
Post Doc Research Associate (Adler)
Research Associate (Sannes); resigned 8/1/09
Research Assistant (Breen)
Research Assistant (Thrall)
Laboratory Supervisor (Adler)
Laboratory Supervisor (Piedrahita)
Research Associate (Nascone-Yoder)
Research Assistant (Adler)
Post Doc Research Associate (Yoder)
Research Associate (McGahan)
Research Assistant (Breen)
Post Doc Research Associate (Breen); resigned 10/1/09
Research Associate (Ghashghaei)
Lecturer (McGahan); resigned 7/1/09
Research Associate (Sherry); appointed 8/14/09
Research Assistant (Breen); appointed 9/21/09
Lecturer (McGahan); appointed 8/1/09
Research Associate (Dean); transferred 2/22/10
Lecturer (McGahan); appointed 7/1/09
Research Assistant (Dean)
Research Assistant (Breen); appointed 9/8/09
Post Doc Research Associate (Brody)
Research Assistant (Sannes); appointed 9/1/09
Research Associate ( McGahan)
Research Associate (Sannes)
Research Associate (Adler)
Research Asst (Sherry); appointed 9/28/09
Post Doc Research Associate (Yoder); appointed 1/15/10
Research Assistant (Gadsby); transferred 3/22/10
Post Doc Research Associate (Adler)
Research Associate (Yoder)
Research Associate (Piedrahita); appointed 1/25/10
Research Assistant (Breen)
Post Doc Research Associate (Adler); resigned 3/1/10
Post Doc Research Associate (Sannes); appointed 10/26/09
Post Doc Research Associate (Brody)
Research Assistant (Dean)
Post Doc Research Associate (Adler)
28
RESIDENT/INTERN PROGRAM
Amanda J. Ardente, DVM
Jerome Benoit, VMD
Mary-Keara Boss, DVM
Jennifer Carter, DVM
Sathya Kimaran Chinnadurai, DVM, MS
Christina Copple, DVM
Julianne Davis, MS, DVM
Erica Fields, VMD
William R. Lee, DVM
Kristen Messenger, VMD
James Montgomery, DVM
Trisha J. Oura, DVM
Kerensa Rechner, DVM
Sarena Sunico, DVM
Intern in Nutrition (Saker); appointed 6/22/09
Resident in Radiation Oncology (Thrall); completed 7/1/09
Resident in Radiology (Pruitt); appointed 6/30/09
Resident in Anesthesiology (Posner); completed 9/30/09
Resident in Anesthesiology (Posner); appointed 7/1/09
Resident in Radiology (Robertson)
Resident in Nutrition (Saker); resigned 7/1/09
Resident in Radiology (Robertson)
Resident in Radiology (Robertson); completed 7/1/09
Resident in Anesthesiology (Posner)
Resident in Radiology (Robertson)
Resident in Radiology (Brown); appointed 7/1/09
Resident in Radiation Oncology (Thrall)
Resident in Radiology (Robertson)
ADJUNCT FACULTY
Vikram Arora, PhD
Stephanie Berry, MS, DVM
Richard Broadstone
Fidel O. Castro, MAGRI, PhD
Carmen Colitz, DVM, PhD
Ralph Cooper, PhD
Sally P. Darney, PhD
Mark W. Dewhirst, DVM, PhD
Darlene Dixon, DVM, PhD
Kevin L. Dreher, PhD
Thomas E. Eling, PhD
Bernard Fischer, DVM, PhD
Dori R. Germolec, PhD
Gerald B. Huntington, PhD
Donna M. Jarrell, DVM
Gary J. Jesmok, PhD
Hillel Koren, PhD
Christopher S. Lau, PhD
Rick Meeker, PhD
Indu Parikh, PhD
James A. Raleigh, PhD
Peifeng Ren, PhD
John Rogers, PhD
David A. Schwartz, MD
Gregory Sempowski, PhD
Robert C. Smart, PhD
Jerry W. Spoo, DVM
Adjunct Assistant Professor (Talecris Biotherapeutics)
Adjunct Assistant Professor (VA Tech)
Adjunct Professor (IAMS)
Adjunct Associate Professor (University of Concepcion, Chile; University of
Havana, Cuba)
Adjunct Associate Professor (Animal Eye Specialty Clinic, West Palm Beach,
FL)
Adjunct Professor (EPA)
Adjunct Professor (EPA)
Adjunct Professor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Adjunct Professor (EPA)
Adjunct Associate Professor (NIEHS)
Adjunct Instructor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Associate Member (NCSU; Animal Science)
Adjunct Associate Professor (Massachusetts General Animal Hospital)
Adjunct Professor (Bayer Corporation)
Adjunct Professor (EPA)
Adjunct Professor (EPA)
Adjunct Professor (UNC Chapel Hill)
Adjunct Professor (Biomarck Pharmaceuticals)
Adjunct Professor (UNC School of Medicine)
Adjunct Assistant Professor (BASF Plant Science LLC)
Adjunct Professor (EPA)
Adjunct Professor (NIEHS)
Adjunct Assistant Professor (Duke Univ)
Associate Member (NCSU; Environmental & Molecular Toxicology)
Adjunct Assistant Professor (RJ Reynolds)
29
William Stokes, DVM
Robert Voyksner, PhD
Xiangdong Wang, MD, PhD
Frank Welsch, DVM
Fulton Wong, PhD
Darryl Zeldin, MD
Robert Zucker, PhD
Adjunct Professor (NIEHS)
Adjunct Associate Professor (LCMS Limited)
Adjunct Professor (AstraZeneca R&D Lund, Sweden)
Adjunct Professor (Orbitox)
Adjunct Professor (Duke University Medical Center)
Adjunct Associate Professor (NIEHS)
Adjunct Associate Professor (EPA)
GRADUATE STUDENTS MAJORING WITH DEPARTMENTAL FACULTY
Andrea Y. Angstadt
Shannon D. Becker
Steven R. Bischoff
Petra Bisikova
Stephanie Bloom
Sarah Culver
Hayley Dirscherl
Teresa D. Green
Sara Gundersen
Amy Heffelfinger
Susan C. Irvin
Ben Jacquet
Sun-Hye Kim
Tae-Hyung Kim
Sehown Koh
W. Randall Lampe
Sung Hyun Lee
Lianna Li
Huixuan Liang
Odesa Marks
Jananne Matheson
Allison Mazepa
Sarah R. Mikkelson
Allison R. Morckel
Laura Ott
Eric LR Seiser
Rahika Shah
Rita D. Simoes
Christopher M. Sistrunk
Stacey Snyder
Laura L. Stoeker
Jaime L. Tarigo
Pei-Chien Tsai
Shengdar Tsai
Wang Xian
Jibing Yang
Haifeng Yin
Huiying Zhang
PhD candidate in Functional Genomics (Breen)
PhD candidate in Comparative Biomedical Sciences (Breen)
PhD candidate in Comparative Biomedical Sciences (Piedrahita)
PhD candidate in Immunology (Dean/co-advisor)
PhD candidate in Comparative Biomedical Sciences (Nascone-Yoder/Horowitz)
DVM/PhD candidate in Comparative Biomedical Sciences (Breen)
PhD in Comparative Biomedical Sciences (Yoder)
PhD candidate in Comparative Biomedical Sciences (Adler)
DVM/PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Immunology (Yoder)
PhD candidate in Comparative Biomedical Sciences (Sherry)
PhD candidate in Zoology (Ghashghaei); degree awarded 2009
PhD candidate in Comparative Biomedical Sciences (Rodriguez)
PhD candidate in Comparative Biomedical Sciences (Horowitz)
PhD candidate in Genomic Sciences (Piedrahita)
PhD candidate in Toxicology (Adler)
PhD candidate in Physiology (Rodriguez)
PhD candidate in Genomic Sciences (Sherry); degree awarded 2009
PhD candidate in Physiology (Ghashghaei)
PhD candidate in Comparative Biomedical Sciences (Piedrahita)
MVPH candidate for Masters in Veterinary Public Health (Arasu)
PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Immunology (Dean); degree awarded 2009
PhD candidate in Comparative Biomedical Sciences (Nascone-Yoder)
PhD candidate in Comparative Biomedical Sciences (Yoder/co-chair)
PhD candidate in Functional Genomics (Breen)
PhD candidate in Immunology (Yoder)
PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Toxicology (Rodriguez)
PhD candidate in Comparative Biomedical Sciences (Breen)
DVM/PhD candidate in Comparative Biomedical Sciences (Dean)
PhD candidate in Comparative Biomedical Sciences (Dean/co-advisor)
PhD candidate in Comparative Biomedical Sciences (Breen)
PhD candidate in Genomic Sciences (Piedrahita)
PhD candidate in Functional Genomics (Rodriguez)
PhD candidate in Immunology (Yoder)
PhD candidate in Genomic Sciences (Horowitz); degree awarded 2009
PhD candidate in Toxicology (Sannes)
30
Appendix II
List of Administrative & Staff Personnel
ADMINISTRATION
M. Christine McGahan
Professor and Department Head
Department of Molecular Biomedical Sciences
STAFF
Shannon L. Chiera
Brenda A. Colby
Melissa D’Annibale-Tolhurst
Delta R. Dise
Wrennie Edwards
Jenny Ferrell
Kara H. Goeres
Jill A. Harned
Rebecca (Becky) W. Hupp
Lauren G. Jackson
Marilyn M. Lall
Alora S. LaVoy
Jennifer H. Pollard
Elizabeth (Beth) A. Simmons
Kelly G. Snyder
Grady S. Spoonamore
Heidi G. Thompson
Tony Whitaker
William (Bill) A. Wise
Research Technician (Horowitz)
Research Specialist (Hudson)
Research Technician (Gadsby)
Research Specialist (Papich)
Research Specialist (Sherry); resigned 6/24/09
Research Specialist (McGahan); retired 12/1/09
Research Specialist (Case)
Research Specialist (McGahan)
Accounting Technician III (McGahan)
Research Specialist (Piedrahita)
Research Specialist (McGahan)
Research Specialist (Dean)
Executive Assistant I (McGahan)
Administrative Support Associate (Pollard)
Administrative Support Associate (Pollard)
Research Specialist (Case)
Administrative Support Specialist (Hupp)
Research Technician (Barnes/Wise); RIF 10/16/09
Research Operation Manager (Barnes)
31
Appendix III
Course
Number
Courses Offered by Departmental Faculty
Course Title
Credit
Hrs
Semester
# students
Team
taught
Course Director
Faculty Participation
L Hudson, J Smallwood, J Barnes, W Lee
J Gadsby, C Swanson, J Yoder, M Breen, T
Ghashghaei, L Posner, L Hudson
P Sannes
J Barnes, L Hudson, JE Smallwood
N Nascone-Yoder
L Posner, C Swanson, MC McGahan, J Gookin
C Swanson, N Campbell, L Posner, B Hansen
L Fleisher, R Baynes, M Papich, J Gadsby, S Marks, K
Tolbert, R Hanel, D LeVine
M Papich
D Thrall, I Robertson, G Seiler, J Brown
K Saker, A Ardente, C Gartrell
I Robertson, D Thrall, J Douglass, J Brown
DVM Courses presented by departmental faculty
VMB911
VMB913
Veterinary Anatomy I
Veterinary Physiology I
6
5
Fall
Fall
79
78
Yes
Yes
L Hudson
J Gadsby
VMB914
VMB921
VMB922
VMB923
VMB930
VMB933
Veterinary Histology and Cytology
Comparative Veterinary Anatomy
Veterinary Embryology and Teratology
Veterinary Physiology II
Principles of Anesthesia
Introductory Pharmacology
3
4
2
5
2
5
Fall
Spring
Spring
Spring
Fall
Fall
78
78
78
74
78
79
Yes
Yes
No
Yes
Yes
Yes
P Sannes
J Barnes
N Nascone-Yoder
L Posner
C Swanson
L Fleisher
VMB943
VMB960
VMB965
VMB976
Pharmacology and Veterinary Therapeutics
Veterinary Radiology and Radiobiology
Veterinary Clinical Nutrition
Radiology – Senior Rotation
3
M Papich
D Thrall
K Saker
I Robertson
Small Animal Veterinary Ultrasound
Yes
J Brown
VMB977
Clinical Anesthesia
80
80
78
95 (3-5 per
rotation)
113 (1-4 per
rotation)
80
Yes
Yes
Yes
Yes
VMB976A
Spring
Spring
Spring
Fall/Spring/
Summer
Fall/Spring/
Summer
Fall/Spring/
Summer
Yes
N Campbell
3
2
D Thrall, I Robertson, J Douglass, J Brown
C Swanson, M Asakawa, N Campbell, L Posner
Participation in Other DVM Courses
VMC932
Principles of Surgery
3
Fall
76
Yes
K Mathews, E Hardie
VMC957
Introduction to Clinical Practice (Perfect Pet
Surgery Lab)
Ethics
Advanced Principles of Surgery
1
Fall/Spring
76
Yes
S Marks, E Hardie
2
1
Spring
Spring
~80
76
Yes
Yes
J Tate
5
5
76
8-10 students
per rotation
79
B Hammerburg
C Grindem
2
Fall
Monthly
Rotation
Fall
Yes
Yes
VMP912
Veterinary Parasitology
Clnical Pathology, Parasitology and
Immunology
Evidence Based Learning
Yes
J Levine
VMP924
VMP942
Veterinary Medical Virology
Clinical Pathology
3
3
Spring
Spring
75
78
Yes
Yes
F Fuller
VMC962
VMC965
VMM932
VMM978
K Mathews, E Hardie, N Campbell, L Posner, C
Swanson, M Asakawa, Small Animal Surgery Faculty
and House Officers
S Marks, E Hardie, Numerous DOCS faculty and
Anesthesia faculty
D Dunning, B Taylor, S Marks, L Posner
J Tate, N Campbell, Equine Medicine Faculty, Equine
and Small Animal Surgery Faculty
B Hammerburg, M Levy, J Flowers, P Arasu
C Grinden, P Arasu (co-course coordinator), B
Hammberburg (co-course coordinator)
J Levine, L Hudson, J Gadsby, C Swanson, several
other faculty including House Officers and Graduate
students from DOCS, MBS, and PHP
F Fuller, B Sherry, J Guy
G Dean
32
VMP977
Necropsy and Clinical Laboratories
VMP995
Clinical Conference
1
VMP912
Clinical Problem Solving in Veterinary Practice
Necropsy/Clin Path/Immuno/Pharmacol/Clin
Nutr Sr Rounds
Oncology Rounds
2
Small Animal Medicine Senior Rounds
Fall/Spring
/Summer
Fall/Spring
/Summer
Fall
Fall/Spring
/Summer
Fall/Spring
/Summer
Fall/Spring
/Summer
Yes
J Guy
M Papich
76
Yes
N Campbell
8
8-10 per
rotation
2-6 per
rotation
8-10 per
rotation
Yes
Yes
K Saker
K Saker
Yes
K Saker
Yes
K Saker
N Campbell, M Gerard, J Guy
Selective Courses presented by departmental faculty
VMB991B
VMB991D
VMB991-001
VMB991-002
VMB991-003
VMB991-004
Histo Tech
Introduction to Research at CVM
1
1
Fall
Fall
16
Yes
J Khosla
M Breen
J Khosla
M Breen, M Hauck, N Olby, S Suter, D Lascelles, J
Piedrahita, J Gadsby, P Farin, R Thomas
P Arasu
S Nordone, A Birkenheuer, S Orton (UNC), S Suter
J Yoder, J Horowitz, J Piedrahita
J Smallwood, L Degernes
International Vet Medicine
Immunodiagnostics
Transgenics
Avian Anatomy
1
1
1
1
Spring
Spring
Spring
Spring
3
2
30
Yes
Yes
No
P Arasu
S Nordone
J Yoder
J Smallwood
1
1
1
Fall
Fall
Fall
~30
~30
8
Yes
Yes
No
C Harms
G Lewbart
K Saker
C Harms, L Posner
G Lewbart, M Stoskopf, LP Posner, J Yoder
K Saker
1
1
1
1
Fall
Spring
Spring
Fall
2
Yes
4
12
Yes
Yes
N Campbell
C Hales
B Brehaus
R Fish
N Campbell, C Swanson, L Posner, M Asakawa
C Hales, G Seiler
B Brehaus, K Saker
R Fish, J Barnes
Participation in Other Selective Courses
VMC991B
VMC991Q
VMC991R
VMC992Z
VMC991-19
Ferret Medicine
Fish Medicine
Advanced
Small Animal Clinical Nutrition
Active Learning in the VTH (Anesthesia)
Advanced Ferret Medicine
Senior Equine Selective
Lab Animal Medicine
Graduate Courses presented by departmental faculty
CBS565
CBS762
Biomedical Sciences
Principles of Pharmacology
3
3
Fall
Spring
9
13
Yes
Yes
J Yoder
L Fleisher
CBS770
Cell Biology
3
Spring
11
Yes
T Ghashghaei
CBS771
CBS800
CBS810
CBS810
Cancer Biology
Seminar
Grant Writing
Seminar
4
1
1
1
Fall
Fall
Spring
Spring
13
20
3
13
Yes
Yes
No
No
J Horowitz
S Jones
K Adler
J Piedrahita
J Yoder, L Posner, K Saker, B Sherry, C Swanson
L Fleisher, R Baynes, D Dorman, R Smart, Y Tsuji, M
Papich
T Ghashghaei, C McGahan, N Nascone-Yoder, J
Horowitz, J Yoder, P Sannes, M Rodriguez-Puebla, M
Breen, J Piedrahita
J Horowitz, M Rodriguez
S Jones, B Sherry
K Adler
J Piedrahita
33
CBS810B
CBS810C
CBS880
CBS893
Infectious Disease Pathogenic Mechanisms
Journal Club
Special Topics in Cell Biology
Guest Lecture
Doctoral supervised research for Teresa
Green, W. Randall Lampe
1
Spring
7
Yes
P Orndorff
P Orndorff, B Sherry
1
1
6
Spring
Spring
15
20
4
No
Yes
J Piedrahita
S Jones
J Piedrahita, J Horowitz
S Jones, M Breen
K Adler
Seminar in Biology of Reproduction
2
Spring
8
Yes
J Gadsby, C Farin
Biotechnology Professional Development
Advanced Topics in Immunology
1
1
Fall
Spring
@24
@15
Advanced Topics in Immunology and
Biotechnology
Research Cell Biology
Resident Board Review; Topic: Review of
Immune Modulation of Gastrointestinal
Function.
1
Fall/Spring
15-20
Yes
Journal
Club
Yes
Fall
Spring
Yes
Yes
P Hess
15
Participation in Other Graduate Courses
ANS/PHY/CBS
602/802
BIT815D
IMM816
IMM816
J Gadsby (co-director), C Farin (co-director)
G Dean
G Dean
S Tonkonogy
S Tonkonogy, L Hudson, Immunology graduate faculty
P Hess, M Rodriguez-Puebla
K Saker
Participation in Other Courses
ANS330
CALS Honors
Program
TOX710
VM9095
Laboratory Animal Science
3
Spring
20
Yes
B Petters
Guest Lecture
1
Spring
30
Yes
G Luginbuhl
Biochemical Toxicology
Comparative Oncology (at VMRCVM,
Blacksburg, VA)
VMA Residency Program – Diagnostic
Imaging
Graduate School Preparing the Professoriate
Workshop Series
3
2
Spring
Spring
~10
25
Yes
Yes
A Wallace
Summer/
Fall/Spring
Spring
2010
6
Yes
J Brown
~30
Yes
M Bostrom (The
Graduate School)
1
B Petters, L Fleisher, several other faculty from main
campus participate
G Luginbuhl, M Breen
A Wallace, N Nascone-Yoder
K Saker
J Brown, D Thrall, I Robertson, J Douglass
M Bostrom, B Sherry
34
Appendix IV
Clinical Services Offered by Departmental Faculty
Anesthesiology: There are currently 4 MBS faculty members who provide Anesthesiology service to the VTH, Drs. Lysa
Posner, Cliff Swanson, Nigel Campbell and Makoto Asakawa. They participate in teaching a number of courses in the
DVM curriculum that are administered by the MBS department including VMB 930 Principles of Anesthesia, VMB 977
Clinical Anesthesia, VMB 913 Physiology I, and VMB 923 Physiology II. The anesthesiology faculty are responsible for
overseeing the training and clinical service activities of residents, students, and hospital staff anesthetists delivering
clinical anesthesia services in the VTH, and directly supervise these activities while on duty. Primary emergency
coverage is provided by two anesthesia residents and five VTH staff anesthetists. The four faculty anesthesiologists split
the responsibility for backup consultation with the primary emergency coverage personnel. This assignment requires the
faculty anesthesiologist covering backup call duty to be available to the primary personnel for consultation and guidance
after normal hospital hours during weekdays, and during weekends and holidays.
Clinical Pharmacology: Mark Papich has no direct clinical assignment (that is, responsibility for patient care).
However, he is the faculty supervisor of the VTH Clinical Pharmacology Laboratory (Room C-268). This laboratory
supports one hospital technician at 0.5 FTE. His supervision of this laboratory carries with it the responsibility for clinical
service emanating from approximately 1,500 samples per year for monitoring of drug concentrations and various
hormones in patients subsequent to therapy. Many of these samples require direct consultation with the clinician in
charge of the patient. In addition to the service work associated with responsibility of the Clinical Pharmacology
Laboratory, as the VTH Clinical Pharmacologist, he receives consultations each day via phone calls and e-mail
consultations from anywhere in the U.S., and direct requests for consultation from our own clinical faculty.
For more information: http://www.cvm.ncsu.edu/vth/vthsupportclinicalpharmacology.htm
Radiology: The Radiology faculty comprises Drs. James Brown, Jim Douglass, Ian Robertson, Gabriella Seiler and Don
Thrall. Dr Brown is Director of the Radiology Residency Program, Dr Robertson is Radiology Service Chief. Dr Seiler
joined the faculty in July 2009. The Radiology service requires two FTEs each day, one radiologist directing ultrasound
and one radiologist directing all other imaging modalities. Radiology is fully digital in all modalities, across all species.
The Radiology Information System (RIS) catalogues over 115,000 studies and the service generates over million images
a year.
Radiation Oncology: There are two radiation oncologists who provide support to radiation oncology. Dr. Amy Pruitt
(DOCS) is the major contributor, and Dr. Donald Thrall (MBS) provides backup support when needed. Radiation therapy
is a critical component of cancer treatment for many animals, and this service is a part of the overall oncology effort in
the veterinary teaching hospital. There is a residency training program in veterinary radiation oncology and one trainee
completes the program each year; these trainees have all been successful in becoming board certified in radiation
oncology and have gone on to an academic career, or to a specialized veterinary practice. Residents in medical
oncology, and students rotating through the oncology service, also receive instruction in the practice and principles of
radiation oncology. Radiation therapy is also a component of some prospective trials of new cancer therapy methods
that have the potential to improve response of both animal and human cancer to treatment.
Clinical Nutrition: Dr. Korinn Saker (boarded in Veterinary Clinical Nutrition) joined the MBS faculty in Feb. 2007. She
has no direct clinical assignment (that is, responsibility for patient care). However, she is the director of the VTH Clinical
Nutrition Consultation Service and faculty supervisor of the Nutrition Research Program (Room B 219D) at the CVM. The
clinical nutrition program has been recently established (March 2007). It provides a variety of nutrition services for both
small and large animal critical care patients, chronic disease patients, and recommendations for appropriate life-stage
and performance/production feeding management protocols for in-house cases. As part of the clinical nutrition service,
she is initiating an Obesity Management Program for overweight and obese companion pets. In addition, she receives
consultations each day via phone or e-mail from referring veterinarians, pet owners and producers requesting nutritionrelated information about appropriate diet choices, feeding guidelines, recent media concerns, homemade diet
formulations and evaluations.
35
In July 2008, this program expanded to include a nutrition-focused rotating internship training position and residency
training program in clinical nutrition that began July 2009. The nutrition research program currently focuses on
relationships between nutrition and specific oxidant-directed disease states including cancer and obesity.
Toxicology: Dr. David Dorman joined the CVM last year and is a Boarded Veterinary Toxicologist. He is currently
working to redevelop the poisonous plant garden by the pond as an important adjunct to the Veterinary Toxicology
course which he teaches. Dr. Dorman was hired as Associate Dean for Research and Graduate programs and is a
faculty member in MBS.
36
Appendix V
1.
Publications, Presentations, Intellectual Property by Departmental Faculty
Original works in peer-reviewed journals. [Include invited state-of-the-art papers; do not include case
reports or review articles.
Adams WM, Kleiter MM, Thrall DE, Klauer JM, Forrest LJ, LaDue TA, Havighurst TC
Prognostic significance of tumor histology and computed tomographic staging for radiation treatment response of
canine nasal tumors.
Vet Radiol Ultrasound
2009; 50:330-335
Apparao KBC, Newman D, Zhang H, Khosla J, Randell SH, Sannes PL
Temporal changes in expression of FoxA1 and Wnt7A in isolated adult human alveolar epithelial cells enhanced by
heparin.
Anat Rec
2010; in press
Bagshaw H, Larenza M, Seiler G
A technique for ultrasound-guided paravertebral brachial plexus injections in dogs.
Vet Radiol Ultrasound
2009; 50(6):649-654
Benoit J, Pruitt AF, Thrall DE
Effect of wetness level on the suitability for Superflab® as a bolus material for use with 6MV photons.
Vet Radiol & Ultrasound
2009; 50:555-559
Bischoff SR, Tsai S, Hardison N, Motsinger-Reif A, Freking BA, Nonneman D, Rohrer G, Piedrahita JA
Characterization of conserved and non-conserved imprinted genes in swine.
Biol Reprod
2009; 81:906-920
Biswas S, Maggi RG, Papich MG, Breitschwerdt EB
Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin.
J Antimicrob Chemother
2010 Mar; 65(3):581-582. Epub 2009 Dec 18. No abstract available. PMID: 20022937
Biswas S, Maggi RG, Papich MG, Keil D, Breitschwerdt EB
Comparative activity of pradofloxacin, enrofloxacin, and azithromycin against Bartonella henselae isolates collected
from cats and a human.
J Clin Microbiol
2010 Feb; 48(2):617-8. Epub 2009 Dec 9. PMID: 20007401
Breen M
Genomics in veterinary oncology.
Topics in Companion Animal Medicine
2009; 24(3):113-121. NIHMSID 146068. PMCID: PMC2754151
Caballero I, Piedrahita JA
Evaluation of Serratia Marcescens nuclease (NucA) as a transgenic ablation system in porcine.
Animal Biotechnology
2009; 20:177-185
Carter JC, Campbell NB, Posner LP, Swanson C
Hemodynamic effects of medetomidine continuous rate infusions in the dog.
Veterinary Anesthesia and Analgesia
2010 Apr; in early view online edition; http://www3.interscience.wiley.com/journal/119882075/issue
37
Carter JE, Campbell NB, Posner LP, Swanson C
The hemodynamic effects of medetomidine continuous rate infusions in the dog.
Veterinary Anaesth Analg
2010; paper accepted
Carter JE, Campbell NB, Posner LP, Swanson C
The hemodynamic effects of medetomidine continuous rate infusions in the dog.
VAA
2010; in press
Chung M, Nascone-Yoder N, Grover S, Drysdale T, Wallingford J
Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut.
Development
2010; 137:1339-1349
Cook VL, Jones Shults J, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in
horses.
Am J Vet Res
2009; 70:1259-68
Cook VL, Meyer CT, Campbell NB, Blikslager AT
Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.
Am J Vet Res
2009; 70:992-1000
Cruz Cardona J, Milner R, Alleman AR, Williams C, Vernau W, Breen M, Tompkins M
Diagnosis and molecular characterization of chronic monocytic leukemia in a dog.
Veterinary Clinical Pathology
2010; in press
Eckert BS, Sharief Y, Crews AL, Adler KB, Jones SL
Myristoylated Alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration in vitro.
Am J Resp Cell Molec Biol
2009 Jul 2; doi:10.1165/rcmb.2008-0394OC
Evans MJ, Sannes PL
New perspectives on the structure and bioactivity of extracellular matrices in the lung.
Anat Rec
2010; in press
Freire M, Brown J, Robertson I, Pease A, Hash J, Hunter S, Simpson W, Sumrell A, Lascelles BDX
Meniscal mineralization in domestic cats.
Veterinary Surgery
2010; early view available on-line
Gookin J, McWhorter D, Vaden S, Posner LP
Outcome assessment of a computer animated model for learning about regulation of glomerular filtration rate.
Advances in Physiology Education
2010; in press
Goralska M, Nagar S, Fleisher LN, McGahan MC
Distribution of ferritin chains in canine lenses with and without age-related cataracts.
Mol Vis
2009; 20(15):2404-2410
Harned J, Ferrell JB, Lall MM, Fleisher LN, Nagar S, Goralska M, McGahan MC
Altered ferritin subunit composition changes iron metabolism in lens epithelial cells with downstream effects on
glutathione levels and vascular endothelial growth factor secretion.
Invest Ophthalmol Vis Sci
2010; in press
38
Harned J, Ferrell JB, Lall MM, Fleisher LN, Nagar S, Goralska M, McGahan MC
Altered ferritin subunit composition changes iron metabolism in lens epithelial cells with downstream effects on
glutathione levels and vascular endothelial growth factor secretion.
Invest Ophthalmol Vis Sci
2010; in press
Howard KE, Reckling SK, Egan E, Dean GA
Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats.
Retrovirology
2010; 7:2-15
Hudson LC, Colby BA, Meeker RB
Ethanol suppression of peripheral blood mononuclear cell trafficking across brain endothelial cells in
immunodeficiency virus infection.
HIV/AIDS: Research and Palliative Care
2010; 2:7-18
Hume C, Seiler G, Porat-Mosenco Y, Caceres A, Shofer F, Sorenmo K
Cystosonographic measurements of canine bladder tumors.
Veterinary and Comparative Oncology
2010; in press
Jacquet BV, Patel M, Iyengar M, Liang H, Therit B, Salinas-Mondragon R, Lai C, Olsen JC, Anton ES, Ghashghaei
HT
Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia
virus-based lentiviral vectors.
Gene Therapy
2009; 16(8):1021-1033
Jacquet BV, Salinas-Mondragon R , Liang HX, Therit B, Buie JD, Dykstra M, Campbell K, Ostrowski LE, Brody SL,
Ghashghaei HT
FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of
astrocytes in the postnatal brain.
Development
2009; 136(23):4021-4031
Kinns J, Aronson L, Hauptman J, Seiler G
Contrast enhanced ultrasound of the feline kidney.
Vet Radiol Ultrasound
2010; 51(2):168-172
Lai T-C, Pociask DA, Ferris MB, Nguyen HT, Miller III CA, Brody AR, Sullivan DE
Small interfering RNAs (siRNAs) targeting TGF-β1 mRNA suppress asbestos-induced expression of TGF-β1 and
CTGF in fibroblasts.
Experimental Lung Research
2009
Lascelles BDX, Henry III JB, Brown J, Sumrell A, Simpson W, Hansen B, Robertson I, Zamprogno H, Freire M,
Pease A
Cross-sectional study evaluating the prevalence of radiographic degenerative joint disease in domesticated cats.
Veterinary Surgery
2010; accepted for publication
Li L, Sevinsky J, Rowland M, Bundy J, Stephenson J, Sherry B
Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytes.
Journal of Proteome Research
2010; in press
39
Li L, Sherry B
IFN- expression and antiviral effects are subtype- and cell type-specific in the cardiac response to viral infection.
Virology
2010; 396:59-68. Publication was recommended by the Faculty of 1000 in Biology, http://f1000medicine.com/
Lin K-W, Park J, Fang S, Crews AL, Adler KB
MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells.
Am J Resp Cell Molec Biol
2010 Mar 4; doi:10.1165/rcmb.2010-0016RC
LinT-Y, Thomas R, Tsai P-C, Breen M, London CA
Generation and characterization of a novel canine malignant mast cell line, CL1.
Veterinary Immunology and Immunopathology
2009; 127:114-124
Maksaereekul S, Dubie RA, Shen X, Kieu H, Dean GA, Sparger EE
Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global
CD4 T lymphocyte function after challenge with FIV.
Vaccine
2009; 27(28):3754-3756
Mathews KG, Linder KE, Davidson GS, Goldman RB, Papich MG
Assessment of clotrimazole gels for in vitro stability and in vivo retention in the frontal sinus of dogs.
Am J Vet Res
2009 May; 70(5):640-647. PMID:19405904
McCall-Martin A, Chen X, Linder KE, Estrada JL, Piedrahita JA
Varying phenotypes in swine versus murine transgenic models consitutively expressing the same human sonic
hedgehog transcriptional activators, K5-hGLI2 delat N.
Transgenic Research
2010; in press
Messenger KM, Davis JL, LaFevers DH, Barlowe BM, Posner LP
The pharmacokinetics of intravenous and sublingual buprenorphine in horses.
VAA
2010; in press
Mikkelsen, SR, Reckling SK, Egan E, Dean GA
Transient depletion of CD4+CD25hi regulatory T cells in cats chronically infected with feline immunodeficiency virus
improves anti-viral and novel immune responses.
Virology
2010; in press
Miller JD, Lankford SM, Adler KB, Brody AR
Mesenchymal stem cells require MARCKS protein for directed chemotaxis in vitro.
Am J Resp Cell Mol Biol
2010; in press
Miller JF, Lankford SM, Adler KB, Brody AR
Mesenchymal stem cells require MARCKS protein for directed chemotaxis in vitro.
Am J Resp Cell Mol Biol
2010 Mar 11; doi:10.1165/rcmb.2010-0015RC
Moore SA, Muñana KR, Papich MG, Nettifee-Osborne J
Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses.
American Journal of Veterinary Research
2010; 71(3):337-341. PMID:20187836
40
Moy SS, Ghashghaei HT, Nonneman RJ, Weimer JM, Yokota YL, Daekee LC, Threadgill DW, Anton ES
Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia.
Journal of Neurodevelopmental Disorders
2009; 1(4):302-312
Newman DR, Zhang H, Borthoff K, Bonner J, Sannes PL
Alveolar epithelial differentiation during repair involves FoxA1, Wnt7A, and TGFΒ.
Proc Amer Thor Soc
2010; in press
Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum.
Experimental Cell Research
2009; 315(1):110-118
Olby NJ, Smith DT, Humphrey J, Spinapolice K, Parke N, Mehta PM, Dise D, Papich M
Pharmacokinetics of 4-aminopyridine derivatives in dogs.
J Vet Pharmacol Ther
2009 Oct; 32(5):485-91. PMID:19754916
Papich MG
Proposed changes to clinical laboratory standards institute interpretive criteria for methicillin-resistant
staphylococcus pseudintermedius isolated from dogs.
J Vet Diagn Invest
2010 Jan 22; (1):160. PMID:20093710
Papich MG
Thoughts on testing methods for bacterial isolates.
J Am Vet Med Assoc
2010 Jan 15; 236(2):162. PMID: 20074004
Papich MG, Davidson G, Schnatz RG
Appreciation for study on bromide administration in dogs.
J Am Vet Med Assoc
2009 Sep 15; 235(6):659. Author reply 659. PMID:19751165
Patil M, Lee S, Macias E, Lam E, Xu C, Jones K, Ho C, Rodriguez-Puebla ML, Chen X
Role of cyclin D1 as a downstream signaling molecule of beta-catenin in hepatocarcinogenesis.
Cancer Research
2009; 69(1):253-261
Posner LP
Introduction: pain and distress in fish: a review of the evidence.
ILAR J
2009; 50(4):327-328
Posner LP, Pavuk AA, Rokshar JL, Carter J, Levine J
Effects of opioids and anesthetic drugs on body temperature in cats.
Vet Anaesth Analg
2010 Jan; 37(1):35-43
Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A
Ancient origin of a transmissible cancer.
Evolution
2009; 63:2340-2349
Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A
Origins and evolution of a transmissible cancer.
Evolution
2009; 63(9):2340-2349
41
Reed R, Womble M, Dush M, Tull R, Bloom S, Morckel A, Devlin E, Nascone-Yoder N
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
Developmental Dynamics
2009; 238(12):3111-3125
Reitman ZJ, Olby NJ, Mariani CL, Thomas R, Breen M, Bigner DD, McLendon RE, Yan H
IDH1 and IDH2 hotspot mutations are not found in canine glioma.
Int J Cancer
2009 Oct 29; e-pub LINK
Reitman ZJ, Olby NJ, Mariani CL, Thomas R, Breen M, Bigner DD, McLendon RE, Yan H
IDH1 and IDH2 hotspot mutations are not found in canine glioma.
International Journal of Cancer
2010; in press
Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, Moss OR, Wong BA,
Dodd DE, Andersen ME, Bonner JC
Inhaled carbon nanotubes reach the subpleural tissue in mice.
Nature Nanotechnology
2009 Oct; in press
Salazar KD, Lankford SM, Brody AR
Mesenchymal stem cells produce Wnt isoforms and TGFb1 that mediate proliferation and pro-collagen expression
by lung fibroblasts.
Am J Physiol, Lung Cell Mol Physiol
2009; 297:1002-1011
Sanchez-Migallon Guzman D, Flammer K, Papich MG, Grooters AM, Shaw S, Applegate J, Tully TN
Pharmacokinetics of voriconazole after oral administration of single and multiple doses in Hispaniolan Amazon
parrots (Amazona ventralis).
Am J Vet Res
2010 Apr; 71(4):460-7. PMID: 20367055
Schnabel LV, Papich MG, Watts AE, et al.
Orally administered doxycycline accumulates in synovial fluid compared to plasma.
Equine Veterinary Journal
2010; 42(3):208-212
Seiler G, Nolan TJ, Withnall E, Reynolds C, Lok JB, Sleeper MM
Computed tomographic changes associated with the prepatent and early patent phase of dirofilariasis in an
experimentally infected dog.
Vet Radiol Ultrasound
2010; 51(2):136-140
Seiler G, Rhodes J, Cianciolo R, Casal M
Ultrasonographic findings in cairn terriers with pre-clinical renal dysplasia.
Vet Radiol Ultrasound
2010; in press
Shiomitsu K, Johnson CL, Malarkey DE, Pruitt AF, Thrall DE
Expression of epidermal growth factor receptor and vascular endothelial growth factor in malignant canine epithelial
nasal tumours.
Vet Comp Oncol
2009; 7:106-114
Smith GW, Gerard MP, Campbell NB, Foster DM, Smith SM, Davis J
Third-compartment cannulation in alpacas using a polyurethane gastrostomy tube.
Aust Vet J
2009; 87(12):487-91
42
Sriperumbudur R, Zorrilla LM, Gadsby JE
Transforming growth Factor-beta (TGFB) and its signaling components in peri-ovulatory porcine follicles.
Animal Reproduction Science
2010 Mar 3; Epub: doi:10.1016/j.anireprosci.2010.03.003
Sullivan DE, Ferris MB, Nguyen H, Brody AR
TNF- induces TGF- 1 expression in lung fibroblasts at the transcriptional level via AP-1 activation.
Journal of Cellular and Molecular Medicine
2009; 13:1866-1874
Thomas R, Duke SE, Wang H, Breen T, Higgins RJ, Linder K, Ellis P, Langford CF, Dickinson P, Olby NJ, Breen M
Putting our heads together - insights into genomic conservation between human and canine intracranial tumors
Journal of Neurooncology
2009; 94:333-349
Thomas R, Duke SE, Wang HJ, Breen TE, Higgins RJ, Linder KE, Ellis P, Langford CF, Dickinson PJ, Olby NJ,
Breen M
Putting our heads together - insights into genomic conservation between human and canine intracranial tumors.
Journal of NeuroOncology
2009; 94(3):333-349. PubMed# 19333554. NIHMSID#183408 (Cover Article)
Thomas R, Rebbeck C, Leroi AM, Burt A, Breen M
Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by
microarray-based CGH analysis.
Chromosome Research
2009; 7(17):927-934
Thomas R, Rebbeck CA, Leroi AM, Burt A, Breen M
Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by
microarray based CGH analysis.
Chromosome Research
2009; 17:927-934
Thomas R, Valli VE, Ellis P, Bell J, Karlsson EK, Cullen J, Lindblad-Toh K, Langford CF, Breen M
Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations
in feline sarcomas
Chromosome Research
2009; 17:8 987-1000
Thomas R, Valli VE, Saylor K, Smith E, Bell J, Cullen C, Langford CF, Breen M
Microarray-based cytogenetic profiling of feline injection-site sarcomas reveals recurrent and subtype-associated
genomic aberrations.
Chromosome Research
2009; 17:987-1000
Thomas R, Wang HJ, Tsai P-C, Langford CF, Fosmire SP, Jubala CM, Getzy DM, Cutter GR, Modiano JF, Breen M
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in
canine appendicular osteosarcoma.
Chromosome Research
2009; 17:365-377
Thomas R, Wang HJ, Tsai PC, Langford CF, Fosmire SP, Jubala CM, Getzy DM, Cutter GR, Modiano JF, Breen M
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in
canine appendicular osteosarcoma.
Chromosome Research
2009; 17:365-377
43
Viglianti BL, Lora-Michiels M, Poulson JM, Lan L, Yu D, Sanders L, Carciunescu O, Vujaskovic Z, Thrall DE, MacFall
J, Charles HC, Wong T, Dewhirst MW
Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous
soft tissue sarcomas treated with thermochemotherapy.
Clin Cancer Res
2009; 15:4993-5001
Wang X, Sistrunk C, Rodriguez-Puebla ML
Unexpected reduction of skin tumorigenesis upon expression of cyclin-dependent Kinase 6 in mouse epidermis.
2010; accepted
Xie J, Yin H, Nichols TD, Yoder JA, Horowitz JM
Sp2 Is a maternally inherited transcription factor required for embryonic development.
J Biol Chem
2010; 285:4153-4164
Xie J, Yin H, Nichols TD, Yoder JA, Horowitz JM
Sp2 is a maternally inherited transcription factor required for embryonic development.
J Biol Chem
2009; 285:4153-4164
Yoder JA, Turner PM, Wright PD, Wittamer V, Bertrand JY, Traver D, Litman GW
Developmental and tissue-specific expression of NITRs.
Immunogenetics
2010; 62:117–122
Zamprogno H, Hansen B, Bondell H, Sumrell A, Robertson I, Brown J, Pease A, Roe S, Hardie E, Wheeler S,
Lascelles BDX
Development of a questionnaire to assess degenerative joint disease-associated pain in cats: item generation and
questionnaire format.
American Journal Veterinary Research
2010; accepted for publication
Zorrilla LM, Irvin MS, Gadsby JE
Protein kinase C isoforms in the porcine corpus luteum: temporal and spatial expression patterns.
Domestic Animal Endocrinology
2009; 36:173-185. Epub. 2008 Dec
Zorrilla LM, Sriperumbudur R, Gadsby JE
Endothelin (ET) -1, endothelin-converting enzyme-1 and ET- receptors in the porcine corpus luteum: temporal and
spatial expression patterns.
Domestic Animal Endocrinology
2010; 38:75-85. Epub 2009 Dec 29
2.
Case reports in peer-reviewed journals.
Asakawa MG, Mackillop E, Olby NJ, Robertson ID, Cullen JM
Imaging diagnosis. Neuronal ceroid lipofuscinosis with a chronic subdural hematoma.
Veterinary Radiology & Ultrasound
2010 Mar/Apr; 51(2):155-158
Brown J, Chanoit G, Reeder J
Complex extrahepatic portocaval shunt with unusual caval features in a cat: computed tomographic characterization.
Journal of Small Animal Practice
2010; 51:227-230
Cervera V, O’Neill S, Seiler G
What is your diagnosis? Histiocytic sarcoma of the stifle joint.
J Am Vet Med Assoc
2010; in press
44
Cruse AM, Vaden SL, Mathews KG, Hill TL, Robertson ID
Use of computed tomography (CT) scanning and colorectal new methylene blue infusion in evaluation of an english
bulldog with a rectourethral fistula.
J Vet Intern Med
2009 Jul/Aug; 23(4):931-934
LeVine DN, Zhou Y, Ghiloni RJ, Fields EL, Birkenheuer AJ, Gookin JL, Robertson ID, Malloy PJ, Feldman D
Hereditary 1,25-dihydroxyvitamin D-resistant rickets in a pomeranian dog caused by a novel mutation in the vitamin
D receptor gene
J Vet Intern Med
2009; 23:1278-1283
Piperisova I, Neel JA, Papich MG
What is your diagnosis? Marked hyperchloremia in a dog.
Vet Clin Pathol
2009 Sep; 38(3):411-414. PMID:19392764
Taylor MB, Geiger DA, Saker KE, Larson MM
Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix and raw ground beef.
JAVMA
2009 Apr 15; 234(8)
3.
Review articles in peer-reviewed journals.
Apley M, Claxton R, Davis C, Deveau I, Donecker J, Lucas A, Neal A, Papich M
Exploration of developmental approaches to companion animal antimicrobials: providing for the unmet therapeutic
needs of dogs and cats.
Journal of Veterinary Pharmacology and Therapeutics
2010; 33(2):196-201
Bischoff S, Tsai S, Hardison N, Motsinger-Reif A, Freking B, Piedrahita JA
Functional genomic approaches for the study of fetal/placental development in swine with special emphasis on the
imprinted gene family.
Reprod Domestic Animals Soc Reprod Fertil
2009; 66:245-264
Brody AR
Asbestos and lung disease.
Am J Resp Cell and Mol Biol
2010; 42:131-132. Editorial Review
Fletcher NF, Meeker RB, Hudson LC, Callanan JJ
The neuropathogenesis of feline immunodeficiency virus infection: barriers to overcome.
The Veterinary Journal
2010; in press
Freire M, Brown J, Robertson ID, Pease AP, Hash J, Hunter S, Simpson W, Thomson Sumrell A, Lascelles BD
Meniscal mineralization in domestic cats.
Vet Surg
2010 Mar
Freking BA, Miles JR, Bischoff SR, Tsai S, Hardison N, Xia Y, Nonneman DJ, Vallet JL, Piedrahita JA
Impact of selection for uterine capacity on the placental transcriptome.
Soc Reprod Fertil
2009; Suppl 66:207-208
Gonzalez LM, Schramme MC, Robertson ID, Thrall DE, Redding RW
MRI features of metacarpo (Tarso) phalangeal region lameness in 40 horses.
Veterinary Radiology & Ultrasound
2010 Apr; early view
45
Labens R, Schramme MC, Robertson ID, Thrall DE, Redding WR
Clinical, magnetic resonance, and sonographic imaging findings in horses with proximal plantar metatarsal pain.
Vet Radiol & Ultrasound
2010 Jan/Feb; 51(1):11-18
Lo WY, Hornof WJ, Zwingenberger AL, Robertson ID
Multiscale image processing and antiscatter grids in digital radiography.
Vet Radiol & Ultrasound
2009 Nov/Dec; 50(6):569-576
Piedrahita JA, Bischoff S, Tsai S
The epigenome and its relevance to somatic cell nuclear transfer and nuclear reprogramming.
Reproductive Genomics of Domestic Animals
2009; in press
Sheldon IM, Price SB, Cronin J, Gilbert RO, White JO, Gadsby JE
Mechanisms of infertility associated with clinical and sub-clinical endometritis in dairy cattle.
Reproduction in Domestic Animals
2009; 44(3):1–9
Sherry B
Reovirus and rotavirus modulation of the interferon response.
Journal of Interferon and Cytokine Research
2009; 29:559-567
Thames RA, Robertson IA, Flegel T, Henke D, O’Brien DP, Coates JR, Olby NJ
Development of a morphometric magnetic resonance image parameter suitable for distinguishing between normal
dogs and dogs with cerebellar atrophy.
Veterinary Radiology & Ultrasound
2010 Feb; early view
4.
Books
Fletcher NF, Meeker RB, Hudson LC, Callanan JJ
The Neuropathogenesis of Feline Immunodeficiency Virus Infection: Barriers to Overcome.
The Veterinary Journal
2010; in press
Smallwood
A Guided Tour of Veterinary Anatomy: Twenty-Ten Edition
Millennium Print Group
2010; 453 pp
Thrall DE, Robertson ID
Atlas of Normal Radiographic Anatomy and Anatomic Variants in the Dog and Cat.
St. Louis, Elsevier/Saunders
2010; in press
5.
Chapters in Book
Barnes JA
Digestive and Circulatory system (two chapters).
In: Atlas of Feline Anatomy for Veterinarians
2010; in press
Barnes JA
Chapter for Teratognesis.
In: 4th Edition of Texbook of Modern Toxicology; Hodgson (ed)
2010; in press
46
Breen M
Clinical Genomics.
In: Textbook of Veterinary Internal Medicine, Seventh Edition; Ettinger, Feldman (eds), Elsevier
2010; Chapter 6, pg 28-31
Dennison S, Kinns J, Seiler G
Spinal Cord, Cauda Equina, Meninges, Spinal Nerves.
In: Veterinary Computed Tomography; Schwarz T, Saunders J (eds), Wiley-Blackwell
2010; in press
Modiano JF, Breen, M
Genetic Basis of Cancer.
In: Cancer management in Small Animal Practice; Henry C (ed), Saunders
2010; Chapter 2, pg 10-15
Papich MG
Antibacterial Drug Therapy.
In: Textbook of Veterinary Internal Medicine, 7th Edition; Ettinger SJ, Feldman EC (eds), Saunders Elsevier, St.
Louis, Missouri, USA
2010; Chapter 154, pg 589-595
Reddy DS, Gadsby JE
Hormones Affecting Reproduction.
In: Veterinary Pharmacology, 9th Edition; Riviere J, Papich M (eds), Blackwell, New York
2009; Chapter 28, pg 717-733
Remillard RL, Saker KE
Parenteral-Assisted Feeding.
In: Small Animal Clinical Nutrition, 5th Edition, Mark Morris Associates
2010; 477-498
Saker KE
Principles of Nutrition of the Cancer Patient.
In: BSAVA Manual of Canine and Feline Oncology
2010
Saker KE
Gastroenteritis/Vomiting in the Canine Patient.
In: Clinical Handbook on Nutrition
2010; in press
Saker KE , Remillard RL
Critical Care Feeding and Enteral Assisted Feeding.
In: Small Animal Clinical Nutrition, 5th Edition, Mark Morris Associates
2010; 439-476
Saker KE, Selting KA
Nutrition & Cancer.
In: Small Animal Clinical Nutrition, 5th Edition, Mark Morris Associates
2010; 587-607
Seiler G
Non-Cardiac Thoracic Ultrasound.
In: BSAVA manual of Canine and Feline Ultrasonography, BSAVA Ed., Gloucester, England
2010; in press
Seiler G
Ultrasonographic imaging – liver, pancreas.
In: Gastrointestinal and Liver Diseases of the Dog and Cat; Washabau RJ (ed)
2010; in press
47
6.
Titles of abstracts from scientific and professional veterinary conferences (i.e. abstracts submitted for
presentation as papers or posters at scientific/clinical conferences)
a. proceedings that are citable
Ardente A, Saker KE
GI tract: feast or famine.
Proceedings, Annual NCVMA Conference
2009 Nov
Berry CR, Giglio RF, Winter DJ, Reese DJ, Thrall DE, Graham JP
Radiographic characterization of presumed plate-like atelectasis in 37 dogs and 13 cats.
2009 Scientific Conference, American College of Veterinary Radiology, Memphis, TN
Vet Radiol & Ultrasound
2009 Oct 20-24; 51:227
Boitano S, Adler KB
MARCKS protein is involved in airway epithelial cell wound repair.
Proceedings, Meeting of American Thoracic Society
2010
Callanan JJ, Meeker RB, Hudson LC, Fletcher NF
The entry of immunodeficiency-inducing lentiviruses into the central nervous system: barriers to overcome.
10th IFRRS Meeting, Charleston, SC
2010 May 23-26
Clary G, Thomas-Summrell A, Smith S, Gruen M, Sherman B, Hudson L, Meeker R
Early cognitive decline following intracerebroventricular FIV inoculation.
10th IFRRS Meeting, Charleston, SC
2010 May 23-26
Conner B, Hanel R, Swanson C
The effects of acepromazine upon adenosine diphosphate- and arachidonic acid-mediated platelet activation in
healthy dogs.
ACVA Annual Conference, Chicago
2009 Sept
Davis JL, Sheats MK, Papich MG
Pharmacokinetics of intravenous enrofloxacin and its active metabolite ciprofloxacin in hospitalized horses. 2009
ACVIM Forum, Montreal, Quebec, Canada
Journal of Veterinary Internal Medicine
2009; 23:726. Abstract #142
Davis JM, Saker KE, Linder K, Bissett S, Vaden S
Characterization of tight junction complexes for dietary intervention models in small intestinal disease states.
JAPAN
2010
Duke SE, Graphodatsky AS, Wayne RK, Breen M
A member of the pack: insights into chromosome evolution in the canidae may reveal common breakpoints in
speciation and cancer.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Faircloth HA, D’Annibale MA, Farin PW, Sheldon IM, Gadsby JE
Toll-like receptor mRNA expression in the bovine corpus luteum.
19th Annual Conference of the Triangle Consortium for Reproductive Biology, NIEHS, RTP, NC
2010; pg 23, poster #8
48
Fang S, Park JJ, Crews AL, Adler KB, Ghashghaei T
MARCKS trafficking in airway epithelial cells: dynamics of phosphorylation and membrane/actin binding.
Proceedings, Meeting of American Thoracic Society
2010
Fields EL, Brown J, Robertson I, Osborne J
Comparison of abdominal ultrasound and abdominal computed tomography in the sedated canine.
ACVR Scientific Meeting
2009
Gadsby J, D’Annibale M, Gannon M, Albers L, Zorrilla L
Tumor necrosis factor (TNF)-a induces luteolytic sensitivity in porcine luteal cells by activating the intra-luteal
prostaglandin (PG) pathway.
42nd SSR Annual Meeting, Pittsburgh
2009; Abstract# 519
Gavin K, Sarver A, Scott M, Vijjeswarapu M, Getzy DM, Newman RA, Cutter GR, Hunter L, Breen M, Modiano JF
Expression profile of cancer-related genes associated with poor clinical outcome in canine osteosarcoma. Genes,
Dogs, Cancer –V, Orlando, Florida
2009 Feb
Goralska M, Nagar S, Fleisher LN, McGahan MC
Distribution of ferritin chains in noncataractous and cataractous canine lenses.
Meeting of Experimental Biology, New Orleans
2009 Apr
Green TD, Park JJ, Jones SL, Adler KB, Ghashghaei T
MARCKS protein is involved in migration of murine macrophages.
Proceedings, Meeting of American Thoracic Society
2010
Gunderson S, Nordone S, LaVoy A, Zhang L, Klaenhammer T, Dean D
Lactobacillus gasseri as an oral mucosal HIV vaccine adjuvant and vaccine.
Merck Merial, NCSU
2009; poster
Gunderson S, Nordone S, LaVoy A, Zhang L, Klaenhammer T, Dean G
Immunogenicity of lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV.
AIDS Vaccine, Paris, France
2009; poster
Gunderson SB, Nordone SK, LaVoy AS, Reckling S, Klaenhammer T, Dean GA
Immugenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant.
NCSU CVM Research Forum
2009; oral presentation
Hardin JW, Crews AL, Adler KB
MANS peptide decreases proliferation in two lung cancer cell lines.
Proceedings, Meeting of American Thoracic Society
2010
Hedan B, Breen T, Nielsen D, Motsinger-Reif AA, Thomas R, Cullen J, Breen M
Analysis of abnormalities in histiocytic tumors of bernese mountain dog and flat coated retriever by comparative
genomic hybridization.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Holowaychuk MK,1 Birkenheuer AJ, Li JJ, Marr H, Boll A, Nordone SK
Alterations in calcium homeostasis in dogs with induced endotoxemia.
International Veterinary Emergency and Critical Care Symposium
2010 Sept
49
Lampe WR, Adler KB
Calpain is a potential regulator of MARCKS protein function in airway epithelial cells.
Proceedings, Meeting of American Thoracic Society
2010
Lindblad-Toh K, Karlsson E, Tonomura N, Barber L, Burgess K, Breen M, Modiano J, McNiel E, Ostrander E,
London C, Comtock K, Azuma C
Mapping genetic risk factors for osteosarcoma and hemangiosarcoma.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
McGahan MC, Ferrell J, Nagar S, Lall M, Goralska M, Fleisher LN, Harned J
Ceruloplasmin alters intracellular iron metabolism and increases ferritin levels and glutamate secretion in lens
epithelial and retinal pigmented epithelial cells.
Invest Ophthalmol Vis Sci
2009; Suppl., Abstract #1464
McGahan MC, Harned J, Lall M
ERK 1/2 is an important mediator of oxidative stress and iron metabolism in lens and retinal pigmented epithelial
cells.
Invest Ophthalmol Vis Sci
2010; Suppl., Abstract #684
McGahan MC, Harned J, Lall M
ERK 1/2 is an important mediator of oxidative stress and iron metabolism in lens and retinal pigmented epithelial
cells.
Invest Ophthalmol Vis Sci
2010; Suppl., Abstract #684
Meeker RB, Gruen M, Hudson LC, Sherman BL
A feline model of HIV-associated cognitive decline.
14th Annual Canine Cognition, Aging and Neuropathology, Niagra-on-the-Lake, Ontario, Canada
J Vet Behavior: Clinical Applications and Research
2009; in press
Meeker RB, Hudson LC, Poulton W, Massa S, Longo FM
Novel neuroprotective strategies for FIV neuropathogenesis.
10th IFRRS Meeting, Charleston, SC
2010 May 23-26
Messenger KM, Davis JL, LaFevers DH, Barlowe BM, Posner LP
The pharmacokinetics of intravenous and sublingual buprenorphine in horses.
ACVA Scientific Meeting, Chicago
2009
Moore SA, Munana KR, Papich MG, Nettifee-Osborne JA
The pharmacokinetics of levetiracetam in dogs concurrently receiving phenobarbital.
2009 ACVIM Forum, Montreal, Quebec, Canada
Journal of Veterinary Internal Medicine
2009; 23:708, Abstract#79
Morckel A, Young D, Deiters A, Nascone-Yoder N
Light activated modulation of protein activity (LAMP): a tool for spatiotemporal control of signaling components in
living embryos.
Developmental Biology
2009; 331(2):482
50
Nascone-Yoder N, Dush M
Wnt/planar cell polarity signaling controls endoderm cell rearrangements during the morphogenesis of the primitive
gut tube.
Developmental Biology
2009; 331(2):450
Oliver J, Saker KE
Organic: is the bang worth your buck?
Proceedings, Annual NCVMA Conference
2009 Nov
Ott LE, Sung EJ, Keener JM, Sheats MK, Adler KB, Jones SL
Fibroblast migration is regulated by MARCKS protein.
Proceedings, Meeting of American Thoracic Society
2010
Park JJ, Adler KB
Vesicle associated membrane protein 8 (Vamp 8) plays a role in mucin secretion by airway epithelial cells.
Proceedings, Meeting of American Thoracic Society
2010
Saker KE
Proper nutrition for optimal postoperative recovery.
Proceedings, Western States Veterinary Conference
2010 Feb
Saker KE
Stone-walled by uroliths.
Proceedings, Annual NCVMA Conference
2009 Nov
Saker KE, Wilson A, Tanner AE
Feline mammary gland organ culture model for evaluation of nutritional chemopreventive agents.
Compend Contin Educ
2009
Sannes PL, Apparao KBC, Zhang H, Khosla J, Randell SG, Newman DR
Changes in expression of forkhead transcription factors and TGF-β1 and Wnt signaling during differentiation of
alveolar epithelial cells in vitro and in bleomycin-induced fibrosis.
Am J Respir Crit Care Med
2009; 179:A2404
Seiser EL, Thomas R, Breen TE, Richards KL, Suter SE, Breen M
Comprehensive characterization of structural and functional changes in canine lymphoid cell lines using array-based
comparative genomic hybridization, multicolor FISH analysis and gene expression profiling.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Shearin AL, Schmidt EV, Parker HG, Mellersh CS, Breen M, Ostrander EA
A whole genome association study and fine mapping of a locus for histiocytic sarcoma in the flat-coated retriever.
AACR
2010
Stoker L, Nordone S, LaVoy A, Zhang L, Dean G
Toll-like receptor activation profiles of wild-type, recombinant, and mutant lactobacillus: implications for vaccine
design.
Merck-Merial Veterinary Scholars Symposium
2009 Aug 1-2
51
Stoker L, Nordone S, LaVoy A, Zhang L, Dean G
Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine
design.
AIDS Vaccine
2009 Oct 19-22
Stoker L, Nordone S, LaVoy A, Zhang L, Dean G
Development of Lactobacillus gasseri as a vaccine vector against FIV/HIV.
International Feline Retrovirus Research Symposium
2010 May 23-26
Sunico S, Kornegay J,Smallwood JE, Styner M, Chen D, Thrall DE
Interactive web-based three-dimensional anatomic and MRI atlas of the canine pelvic limb.
American College of Veterinary Radiology, Memphis TN
2009 Oct 20-24
Vet Radiol & Ultrasound
2010; 51:231
Swing SE, D’Annibale MA, Zorrilla LM, Gadsby JE
Apoptosis-associated proteins in the porcine corpus luteum.
19th Annual Conference of the Triangle Consortium for Reproductive Biology, NIEHS, RTP, NC
2010; pg 40, poster#26
Thomas R, Duke SE, Wang HJ, Breen TE, Higgins RJ, Linder KE, Ellis P, Langford CF, Dickinson PJ, Olby NJ,
Breen M
Putting our heads together’ on brain tumors: microarray-based comparative genomic hybridization analysis of 60
canine intracranial tumors provides insights into conservation of cytogenetic profiles with their human counterparts.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Tsai P-C, Breen TE, Lana SE, Nielsen D, Motsinger-Reif AA, Breen M
Canine lymphoma - the prognostic significance of cytogenetic changes.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Ward JL, McCartney S, Chinnadurai S, Posner LP
Use of a minimum anesthetic concentration (MAC) depression model to evaluate the effects of various analgesics in
goldfish (Carassius Auratus).
ACVA Scientific Meeting, Chicago, IL
2009 Sept
Woolard K, Totonchy M, Thomas R, Breen M, Son MJ, Beederman M, Clark E, Simpson M, Lee J, Fine H
Canine gliomas are driven by tumor stem cells, which share significant similarities to their human counterparts.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Young AC, Thomas R, Tsai P-C, Kisseberth WC, Motsinger-Reif A, Guillermo Couto C, Subramanian S, Nielsen
DM, Modiano JF, Breen M
Heritable and breed specific genetic abnormalities in canine osteosarcoma.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb
Zhang H, Newman DR, Sannes PL
Over-expression of Hsulf-1 in human lung epithelial cells enhances the toxic effects of lead and cadmium.
The Toxicologist
2010; in press
52
Zurney J, Kobayashi T, Ooms L, Chappell J, Dermody T, Sherry B
A single amino acid determines reovirus strain-specific differences in novel modulation of IRF9 and inhibition of
interferon signaling.
Keystone Symposium, Cell Biology of Virus Entry, Replication and Pathogenesis, Taos, NM
2010
b. proceedings that are not citable
Caldwell J, Long J, Mikkelsen SR, Dean GA
Fecal cortisol and IgA determinations as indicators of stress and immunosupression in shelter cats.
National Veterinary Scholars Symposium, Raleigh, NC
2009 Aug 6-8
Cruse AM, Yoder JA, Nordone SK, Marr HS, Birkenheuer AJ
Evaluation of potential biomarkers for canine sepsis.
ACVIM Forum & Canadian Veterinary Medical Association Convention, Montréal, Québec
2009 June 3-6; poster
Faircloth HA, D’Annibale MA, Farin PW, Sheldon IM, Gadsby JE
Toll-like receptor mRNA expression in the bovine corpus luteum.
NCSU Undergraduate Research Symposim
2010 Apr
Galemore E, Mikkelsen SR, Dean GA
Humoral responses during acute feline immunodeficiency virus infection remain unchanged after regulatory T cell
depletion.
National Veterinary Scholars Symposium, Raleigh, NC
2009 Aug 6-8
GN Scott, LP Posner
Minimum anesthetic concentration (MAC) increases in goldfish, (Carassius auratus) following repeated exposures to
tricaine methanesulfonate (MS-222).
NCSU CVM Research Forum
2010 Mar
Gunderson SB, Nordone SK, Lavoy AS, Zhang L, Klaenhammer TR, Dean GA
Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV.
National Veterinary Scholars Symposium, Raleigh, NC
2009 Aug 6-8
Gunderson SB, Nordone SK, Lavoy AS, Zhang L, Klaenhammer TR, Dean GA
Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV.
AIDS Vaccine 2009, Paris, France
2009 Oct 19-22
Horowitz J
Sp2: a regulator of stem cell differentiation and tumorigenesis.
Kim S-H, Macias E, Sistrunk C, Rodriguez-Puebla ML
Cyclin-dependent Kinase 4 levels affects the number of hair follicle stem cells in mouse epidermis.
Annual Meeting of the American Association for Cancer Research, Washington, DC
2010
McIver AL, Young DD, Nascone-Yoder N, Deiters A
Developmental pathway modifiers based on pyridines.
237th National American Chemical Society Meeting, Salt Lake City
2009 Mar 22-26
53
Messenger KM, Davis JL, LaFevers DH, Barlow BM, Posner LP
The effect of sampling site on the plasma concentrations of buprenorphine following sublingual administration in
horses.
NCSU CVM Research Forum
2010 Mar
Ni X, Dush M, Nascone-Yoder N
The role of Pitx2 in Xenopus gut morphogenesis.
Society for Developmental Biology, 68th Annual Meeting, San Francisco, CA
2009 Jul
Richards K, Motsinger-Reif A, Neilson D, Smith C, Thomas R, Dave S, Breen M, Suter SE
Characterizing canine lymphoma as a potential large animal model of human diffuse large B-cell lymphoma.
Veterinary Cancer Society Conference, Austin, TX
2009 Oct
Simões RD, Howard KE, Dean GA
In vivo natural killer cell response in cats chronically infected with feline immune deficiency virus.
Fifth Annual NC State University Graduate Student Research Symposium, Raleigh, NC
2010 March 12
Stoeker LL, Nordone SK, Lavoy AS, Goh YJ, Tallon R, Klaenhammer TR, Dean GA
Toll-like receptor activation profiles of wild type, recombinant, and mutant lactobacillus: implications for vaccine
design.
National Veterinary Scholars Symposium, Raleigh, NC
2009 Aug 6-8
Stoeker LL, Nordone SK, Lavoy AS, Tallon R, Klaenhammer TR, Dean GA
Screening of Lactobacillus for use In a prohylactic HIV vaccine.
AIDS Vaccine 2009, Paris, France
2009 Oct 19-22
Swing SE, D’Annibale MA, Zorrilla LM, Gadsby JE
Apoptosis-associated proteins in the porcine corpus luteum.
NCSU Undergraduate Research Symposium
2010 Apr
Wang X, Sistrunk C, Rodriguez-Puebla ML
Reduced tumor formation by forced expression of cyclin-dependent Kinase 6 in mouse epidermis.
Annual Meeting of the American Association for Cancer Research, Washington, DC
2010
Wilson A, Saker KE, Tanner AE
Feline mammary gland organ culture model for analysis of pomegranate juice as a chemopreventive. Proceedings,
NCSU-CVM Research Symposium
2009
7.
Titles of invited presentations/papers (including CE) where the primary audience was professionals
(veterinarians, scientists, etc.)
Adler KB
Host: Dr. Charles Irvin
University of Vermont College of Medicine, Burlington, VT
2009 Dec
Adler KB
Host: Dr. Samithamby Jeyaseelan
Louisiana State University School of Veterinary Medicine, Baton Rouge, LA
2009 Dec
54
Adler KB
Lunderg-Kienlen lecture. Host: Dr. Lin Liu
The University of Oklahoma School of Veterinary Medicine, Stillwater, OK
2009 Sept
Adler KB
Host: Dr. Darryl Knight
The James Hogg iCAPTURE Centre, University of British Columbia, Vancouver, BC, Canada
2009 Sept
Adler KB
Host: Dr. Farhad Imani
National Institute of Environmental Health Sciences (NIEHS), RTP, NC
2009 Sept
Adler KB
Host: Dr. Iasha Sznajder
Northwestern University Feinberg School of Medicine, Chicago, IL,
2009 Aug
Adler KB
Cell proliferation, differentiation and carcinogenesis.
European Respiratory Society Meeting, Estoril, Portugal
2009 Mar; Invited Session Chair and Speaker
Adler KB
Host: Dr. Martina Gentzsch
University of North Carolina @ Chapel Hill, NC, Cystic Fibrosis Center
2009 Feb
Ardente A, Saker KE
GI tract: feast or famine.
Proceedings, Annual NCVMA Conference
2009 Nov
Breen M
The domestic dog: a genome with two tales.
The University of Illinois Translational Biomedical Research Seminar
2010 Mar; Invited Speaker
Breen M
Canine cancer & comparative genomics: new technologies, new opportunities.
AKC Parent Breed Conference, St. Louis, Missouri
2009 Oct; Invited Speaker
Breen M
The dog – a genome with two tails.
Skippy Frank Translational Medicine Fund Multipdisciplinary Cancer Conference
2009 Jan 15; Invited Speaker
Brody A
The environment and the lung.
Annual Aspen Lung Conference
2009 Jun; Co-Chair of Conference and Named Lecturer
Brody A
2009 Annual Meeting, American Thoracic Society Program Committee
2009 May
55
Brody A
Symposium on Stem Cells in Interstitial Disease and Lung Cancer
Annual Meeting of The American Thoracic Society
2009 May; Co-Chair
Brody A
Francoise and Guy Basset Memorial Conference, Paris
2009 Jun; Invited Speaker
Brown J
Nuclear Imaging in Small Animals
Introduction to Ultrasound
Ultrasound of the Liver
Ultrasound Case Presentations
2009 North Carolina Veterinary Conference, Small Animal Ultrasound Series, NCSU Continuing Education
2009 Nov
Campbell N
Introduction to multi-modal pain management
Urban myths in small animal anesthesia
Anesthesia of the geriatric patient
Anesthesia and Analgesia for the Small Animal Patient, NCSU-CVM
2009 May 2
Campbell N
Foal anesthesia and CPR.
North Carolina Veterinary Conference
2009 Nov
Duke SE, Graphodatsky AS, Wayne RK, Breen M
A member of the pack: insights into chromosome evolution in the canidae may reveal common breakpoints in
speciation and cancer.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
Gadsby J
Innate immune mechanisms in the corpus luteum.
Triangle Consortium for Reproductive Biology Conference, NIEHS, RTP
2010 Feb 6
Gavin K, Sarver A, Scott M, Vijjeswarapu M, Getzy DM, Newman RA, Cutter GR, Hunter L, Breen M, Modiano JF
Expression profile of cancer-related genes associated with poor clinical outcome in canine osteosarcoma. Genes,
Dogs, Cancer –V, Orlando, Florida,
2009 Feb; Invited Presentation
Ghashghaei T
Development of the adult neural stem cell niche.
Ludwig-Maximilians-Universität Münche, Germany
Ghashghaei T
Molecular mechanisms underlying postnatal neurogenesis.
Society for Neuroscience Minisymposium
Hedan B, Breen T, Nielsen D, Motsinger-Reif AA, Thomas R, Cullen J, Breen M
Analysis of abnormalities in histiocytic tumors of bernese mountain dog and flat coated retriever by comparative
genomic hybridization.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
56
Hudson L
Neuroanatomy for ophthalmologists.
Ophthalmology Short Course
2010 Jun
Lindblad-Toh K, Karlsson E, Tonomura N, Barber L, Burgess K, Breen M, Modiano J, McNiel E, Ostrander E,
London C, Comtock K, Azuma C
Mapping genetic risk factors for osteosarcoma and hemangiosarcoma.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation
Nordone S
Primary cell model of HIV-1 regulatory T cell infection.
UMDNJ Department of Pathology, Newark, NJ
2010 Mar 26
Oliver J, Saker KE
Organic: Is the bang worth your buck?
Proceedings, Annual NCVMA Conference
2009 Nov
Papich MG
Principles of pharmacokinetics for specialists.
23rd Annual Congress of the ESVD-ECVD, Bled, Slovenia
2009 Sept 17-19
Papich MG
Common myths in dermatological drug therapy.
23rd Annual Congress of the ESVD-ECVD, Bled, Slovenia
2009 Sept 17-19
Papich MG
Clinically relevant drug interactions in drug therapy.
23rd Annual Congress of the ESVD-ECVD, Bled, Slovenia
2009 Sept 17-19
Papich MG
Strategies to manage antibiotic-resistant infections.
23rd Annual Congress of the ESVD-ECVD, Bled, Slovenia
2009 Sept 17-19
Papich MG
Drug therapy for cats: why they are different from dogs.
23rd Annual Congress of the ESVD-ECVD, Bled, Slovenia
2009 Sept 17-19
Papich MG
Drug therapy problems for cats.
American Veterinary Medical Association Annual Convention, Seattle, Washington
2009 Jul 11-14
Papich MG
Drugs of abuse: what every veterinarian should know.
American Veterinary Medical Association Annual Convention; Seattle, Washington
2009 Jul 11-14
Papich MG
Analgesic drugs for small animals: beyond NSAIDs.
American Veterinary Medical Association Annual Convention, Seattle, Washington
2009 Jul 11-14
57
Papich MG
Avoiding and treating antimicrobial resistance.
American Veterinary Medical Association Annual Convention, Seattle, Washington
2009 Jul 11-14
Papich MG
Latest developments in pain management: analgesic treatment for small animals.
American Veterinary Medical Association Annual Convention, Seattle, Washington
2009 Jul 11-14
Papich MG
Antimicrobial drug options for difficult infections in dogs and cats.
American College of Veterinary Internal Medicine (ACVIM) Annual Forum, Montreal, Quebec, Canada
2009 Jun 4-5
Papich MG
Antibiotic drug therapy: the popular myths and misconceptions.
American College of Veterinary Internal Medicine (ACVIM) Annual Forum, Montreal, Quebec, Canada
2009 Jun 4-5
Papich MG
Medication precautions for the neurological patient.
American College of Veterinary Internal Medicine (ACVIM) Annual Forum, Montreal, Quebec, Canada
2009 Jun 4-5
Papich MG
Translational pharmacology in animals: extrapolating across species.
Translational Biomedical Research Seminar Series, University of Illinois, College of Veterinary Medicine, Urbana,
Illinois
2009 Apr 27
Piedrahita J
Special Stem Cell Session, International Embryo Transfer Society Annual Meeting, San Diego, CA
2009 Jan; Invited Speaker
Piedrahita J
Seminar Series, Texas A&M University, Department of Pathobiology
2009 Jan; Invited Speaker
Piedrahita J
Triangle Reproductive Biology Symposium, NIEHS
2009 Jan; Invited Speaker
Piedrahita J
Sigma Xi Lunch Seminar Series, RTP
2009 Mar; Invited Speaker
Piedrahita J
Molecular Reproduction and Development, Brown University, Rhode Island
2009 Mar; Invited Speaker
Piedrahita J
Reproductive Technologies Symposium, University of Maryland
2009 Mar; Keynote Speaker
Piedrahita J
VIII International Conference in Pig Reproduction, Banff, Canada
2009 Jun; Invited Speaker
Piedrahita J
Transgenic animals in agriculture.
Bi- Annual Meeting, Tahoe, CA
2009 Aug; Invited Speaker
58
Posner LP
Analgesia for declaw pain.
NAVC Magazine
In press
Posner LP
Introduction: pain and distress in fish: a review of the evidence
North American Veterinary Conference: Orlando Florida
Anesthetic complications
Pain Scoring/ welfare symposium
Analgesia for emergencies
Dexmedetomidine
Treatment of Chronic Pain
2010 Jan; Invited CE Lectures
ILAR J
2009; 50(4):327-328
Posner LP
Introduction: pain and distress in fish: a review of the evidence
Western Veterinary Conference
Anesthetic complications
Analgesia for emergencies
2010 Feb; Invited CE Lectures
ILAR J
2009; 50(4):327-328
Rodriguez-Puebla M
Cell cycle, CDKs and carcinogenesis.
Institute “Cesar Milstein, Foundation Cassara”, Buenos Aires, Republic Argentina
2009 Nov; Invited Speaker
Rodriguez-Puebla M
Cell-cycle regulation and cancer stem cells.
Institute “Luis F Leloir”, Buenos Aires, Republic Argentina
2009 Nov; Invited Speaker
Saker KE
Nutrition and the cancer patient: where to start.
Veterinary Cancer Society Newsletter
2009; 33(1):9-10
Saker KE
Stone-walled by uroliths.
Proceedings, Annual NCVMA Conference
2009 Nov
Seiler G
Animal models in veterinary medicine.
UNC-CH Intramural Medical and Biomedical Ultrasonic Imaging Symposium.
2009-2010; Invited Lecture
Seiler G
Veterinary radiology.
RadVets Club Meeting, North Carolina State University
2009-2010; Lecture
59
Seiler G
Introduction and patient preparation
CT of the spine
CT of the lungs and airways
CT of the pleural space and mediastinum
Wetlabs on CT Interpretation
TC International Workshop, Cremona, Italy
2009-2010
Sherry B
Straight from the heart: the cardiac response to viral infection.
University of Maryland, Department of Veterinary Medicine, College Park, MD
2009 Oct 15
Sherry B
Straight from the heart: the cardiac response to viral infection.
Montana State University, Department. of Veterinary Molecular Biology, Bozeman, MT
2009 Nov 10
Sherry B
Modulation of the interferon response and myocarditis.
Triangle Virology Association, Research Triangle Park, NC
2009 Dec 11
Sherry B
Straight from the heart: the cardiac response to viral infection.
Research Triangle Institute, Research Triangle Park, NC
2010 Mar 23
Sherry B
Straight from the heart: the cardiac response to viral infection.
Cornell University, Ithaca, NY
2010 Apr 16
Swanson C
Risk assessment and anesthesia for patients with cardiac disease.
Boehringer-Ingelheim sponsored continuing education seminar, Durham, NC
2009 Oct 13
Thomas R
Microarray-based cytogenetic profiling of feline injection-site sarcomas.
North Carolina State University College of Veterinary Medicine, Research in Progress seminar, Raleigh, NC
2010 Mar
Thomas R, Duke SE, Wang HJ, Breen TE, Higgins RJ, Linder KE, Ellis P, Langford CF, Dickinson PJ, Olby NJ.
Breen M
Putting our heads together’ on brain tumors: microarray-based comparative genomic hybridization analysis of 60
canine intracranial tumors provides insights into conservation of cytogenetic profiles with their human counterparts.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
Thrall DE
Bowel obstruction: surgical vs. non-surgical apparance.
97th Purdue Annual Veterinary Conference, W. Lafayette, IN
2009; Sept 23-25
Thrall DE
Making sense of lung patterns.
97th Purdue Annual Veterinary Conference, W. Lafayette, IN
2009 Sept 23-25
60
Thrall DE, Widmer WR
Case-based image interpretation.
97th Purdue Annual Veterinary Conference, W. Lafayette, IN
2009 Sept 23-25
Tsai P-C, Breen TE, Lana SE, Nielsen D, Motsinger-Reif AA, Breen M
Canine lymphoma - the prognostic significance of cytogenetic changes.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
Woolard K, Totonchy M, Thomas R, Breen M, Son MJ, Beederman M, Clark E, Simpson M, Lee J, Fine H
Canine gliomas are driven by tumor stem cells, which share significant similarities to their human counterparts.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
Yoder JA
The recent and rapid evolution of novel immune-type receptor genes in bony fish.
Eastern Carolina University, Greenville, NC
2009; Invited Talk
Yoder JA
Zebrafish larvae as a whole-organism model for identifying novel innate immune response genes.
American Society for Microbiology – General Meeting, Philadelphia, PA
2009; Invited Talk
Yoder JA
The form, function and phylogenetics of NITRs in bony fish.
Disease Modelling in Zebrafish: Cancer and Immune Responses, Spoleto, Italy
2009; Invited Talk
Yoder JA
The form, function and phylogenetics of NITRs in bony fish.
Memorial University of Newfoundland, Department of Biochemistry, Newfoundland and Labrador, Canada
2009; Invited Talk
Young AC, Thomas R, Tsai P-C, Kisseberth WC, Motsinger-Reif A, Guillermo Couto C, Subramanian S, Nielsen
DM, Modiano JF, Breen M
Heritable and breed specific genetic abnormalities in canine osteosarcoma.
Genes, Dogs, Cancer –V, Orlando, Florida
2009 Feb; Invited Presentation - Trainee
8.
Works prepared for presentation and distribution through electronic media, including CD-ROMS, audio
and video disks and tapes, computer-generated presentations, broadcast videos, etc.
Brown J
Established the NCSURadiology YouTube channel to serve as a library of ultrasound videos for use in teaching and
presentations by NCSU faculty.
Saker K
Web-based CE modules for IAMS Proctor Gamble education division:
Canine Obesity Management
Feline Obesity Management
Two feature stories for AAVN quarterly newsletter (Obesity; Pancreatitis)
Veterinary Cancer Society Newsletter
2009; 33(1):9-10, Invited Article
Swanson C
Intravenous Catheteriazation in Small Animals - Multimedia digital presentation authored in Adobe Flash
http://courses.ncsu.edu/vmb977/common/media/catheterization.swf
61
9.
Titles of continuing education presentations/papers/proceedings where the primary audience was not
professionals (livestock producers, dog breeders, horse owners, etc.)
Campbell N
Common misconceptions in veterinary anesthesia [VET214 Veterinary Clinical Practices III (Small Animal)].
Anesthesia for Caesarean Section [VET214 Veterinary Clinical Practices III (Small Animal)].
Central Carolina Community College, Sanford, NC
2009 Apr
Robertson ID
Overview of veterinary imaging with emphasis on MRI.
AnimalScan Marketing Seminar, 14 hours, Raleigh, NC
2009 Nov
Saker K
Honey I’m killing the pets.
Seminar (8 hr) focused on small animal nutrition for pet owners, CSU-CE sponsored
2009 Apr
10.
Copyrighted software and other copyrighted scholarly material.
Saker K
Nutrition Support for Cardiac Disease Patient
Developed for new NCSU-CVM cardiology web-site
62
Appendix VI
Other Professional Achievements
APPOINTMENT OR ELECTION TO RESEARCH STUDY SECTIONS AND NATIONAL ADVISORY COUNCILS
Adler K
NIH Special Review Committee Study Sections
Chair, California Tobacco-Related Diseases Pulmonary Research Study Section, March 2009
Nebraska DOH Respiratory Review Panel, April 2009
Chair, Flight Attendants’ Medical Research Institute Study Section, October 2009
Other Reviews, Florida Biomedical Research Program
Arasu P
USDA International Science and Education Grant Review Panel, March/April 2010
Breen M
NCI Site Visit Team, Evaluating the Activities of the Laboratory of Genome Diversity
Scientific Advisory Board (new), The Oatmeal Group, commenced 2009
Morris Animal Foundation Scientific Advisory Board (continuation), 2005-2009
Reviewer, Cancer Research UK (continuation), Ad hoc
Grant Reviewer, AKC Canine Health Foundation (continuation), Ad hoc
Grant Reviewer, Wellcome Trust UK (continuation), Ad hoc
Grant Reviewer, BBSRC (continuation), Ad hoc
Reviewer, Cancer Research UK (continuation), Ad hoc
Netherlands Organization for Scientific Research (new), Ad hoc
Brody A
Invited Participant, NIEHS Workshop, a Science-Based Examination of the Mode of Action of Asbestos and Related
Mineral Fibers
Dean G
NIH/NCRR ZRR1-CM-4
NIH/NIDCR ZRR1-CM-4
NIH/CSR ZDE1 JH 27
Invited Participant, ACC&D Vaccine Think Tank, Sponsored by the Alliance for Contraception in Cats and Dogs,
Roanoke, VA, November 19-21, 2009
McGahan MC
Appointed, National Advisory Eye Council, Term 2007-2010
Nascone-Yoder N
Ad hoc Grant Reviewer, NSF
Nordone S
Grant Review Panel & Scientific Consultant, Winn Feline Foundation, 2010-2013
Piedrahita J
NIH SBRI, April 2006
Ad hoc Reviewer, Maryland Agricultural Research Station Research Program, 2008
Ad hoc Reviewer, Danish Research Council
Ad hoc Reviewer, AKC foundation
63
Rodriguez M
Ad hoc Member, NIH/NCI Study Section, Tumor Progression and Metastasis
Saker K
Appointed, Advisory Council for Industry, Nestle Purina
Appointed, Advisory Council for Industry, Mark Morris Educational Council
Sannes P
National Institutes of Health
Special Emphasis Panel, National Institute for Environmental Health Sciences, Superfund
Special Emphasis Panel, National Institute for Environmental Health Sciences, Manufactured Nanoparticles
Reviewer, NANO Materials Study Section, National Institutes of Health
Special Emphasis Panel, National Heart, Lung, and Blood Institute, Study Section Member Conflict Review
Thrall D
Editor-In-Chief, Veterinary Radiology & Ultrasound, Official Journal of the American College of Veterinary Radiology,
the European College of Veterinary Radiology, the European Association of Veterinary Diagnostic Imaging and
the International Veterinary Radiology Association
Yoder J
Ad hoc Grant Reviewer, National Science Foundation, Integrative Organismal Systems, September 2009
Ad hoc Grant Reviewer, Netherlands Genomics Initiative, The Hague, Netherlands, January 2010
APPOINTMENT TO EDITORIAL BOARDS
Adler KB
Editor, American Journal of Respiratory Cellular and Molecular Biology, 2008 Editor, Journal of Organ Dysfunction, 2005 Associate Editor, Respiratory Research, 2004 Editorial Board, American Journal of Physiology, Lung Cellular & Molecular Physiology
Editorial Board, International Journal of Biochemistry and Cell Biology
Editorial Board, Expert Review of Respiratory Medicine
International Advisory Board, Aspen Lung Conference, 1999 Breen M
Chromosome Research
Veterinary and Comparative Oncology
Brody A
American Journal of Pathology
American Journal of Physiology; Lung, Cellular, and Molecular Physiology
American Journal of Respiratory, Cell, and Molecular Biology
Current Respiratory Medicine Reviews
Journal of Environmental Pathology, Toxicology, and Oncology
Journal of Inflammopharmacology
Journal of Organ Dysfunction
Section Editor, Pathology, Journal of Lipid Mediators and Cell Signaling
Dean G
Journal of Veterinary Clinical Pathology
64
Gadsby J
Domestic Animal Endocrinology, August 2006 - present
Horowitz J
Biochemical Journal
McGahan MC
Experimental Eye Research
Ocular Pharmacology & Therapeutics
Papich M
Editorial Review Board, Veterinární Medicína Vet Med, Czech, 2007 - present
Appointed as Editor, Review Manuscripts, Journal of Veterinary Pharmacology and Therapeutics, 2005 - present
Editorial Review Board, Journal of Veterinary Pharmacology and Therapeutics, 1988 - present
Editorial Review Board, Journal of the American Animal Hospital Association, 1985 - present
Editorial Review Board, Journal of Feline Medicine and Surgery, 2003 - present
Piedrahita JA
Journal of Biomedicine and Biotechnology
Sannes P
Board of Review, The Anatomical Record
Editorial Board, Journal of Organ Dysfunction
Editorial Board, American Journal of Respiratory Cell and Molecular Biology
Sherry B
Associate Editor, PLoS Pathogens, 2008 - present
Editor, Virology, 2005 - present
Editorial Board, Virology, 2004 - present
AD HOC MANUSCRIPTS REVIEWS
Adler KB
AmerJ Physiol, Lung Cellular and Molecular Physiology
Amer J Resp Cell Molec Biology
Amer J Resp Crit Care Med
Cancer
Cell Biology International
Current Signal Transduction Therapy
Cytokine
Experimental Lung Research
Inflammation Research
Internat J Biochem Cell Biol
J Cell Molec Medicine
J Immunology
J Pharmacol Exper Therap
Molecular & Cellular Biology
Pharmacological Research
Physiological Genomics
Regulatory Peptides
Respiratory Physiology & Neurobiology
Respir Res
65
Breen M
Chromosome Research
Cytogenetic and Genome Research
Genome Research
Genomics
Journal of Animal Breeding and Genetics
Journal of Heredity
Journal of the American Veterinary Medical Association
Journal of Veterinary Internal Medicine
Mammalian Genome
Nature Genetics
Veterinary and Comparative Oncology
Brody A
American Journal of Respiratory and Critical Care Medicine
Chemico-Biological Interactions
Environmental Health Perspectives
Environmental Research
FASEB Journal
Journal of Cellular Physiology
Journal of Clinical Investigation
Journal of Immunology
Journal of the American Physiological Society
Laboratory Investigation
Chest
Brown J
Veterinary Radiology and Ultrasound
Journal of Avian Medicine and Surgery
Campbell N
Journal of the American Veterinary Medical Association
Journal of Equine Veterinary Science
Dean G
Virology
Retrovirology
Veterinary Immunology and Immunopathology
Proceeding of the National Academy of Sciences
Journal of Veterinary Clinical Pathology
Gadsby J
Biology of Reproduction
Reproduction
Domestic Animal Endocrinology
Journal of Veterinary Pharmacology and Therapeutics
Journal of Endocrinology
Endocrinology
Reproduction in Domestic Animals
66
Ghashghaei T
Nature Neuroscience
Neuron, Cell Stem Cell
Journal of Neuroscience
Development
Cerebral Cortex
BMC Neuroscience
Journal of Biomedicine and Biotechnology
Horowitz J
Biochemical Journal
International Journal of Cancer
Hudson L
J Vet Med C (Anatomia, Histologica, Embryologica)
McGahan MC
Experimental Eye Research
Investigative Ophthalmology and Visual Science
Molecular Vision
Biochemical Journal
Nascone-Yoder N
Evolution and Development
Nordone S
Journal of Leukocyte Biology
Infection and Immunity
Papich M
American Journal of Veterinary Research
Antimicrobial Agents and Chemotherapy
Chemotherapy
Equine Veterinary Journal
Journal of Pharmaceutical Sciences
Journal of the American Veterinary Medical Association
Journal of Antimicrobial Chemotherapy
Journal of Veterinary Internal Medicine
Research in Veterinary Science
The Veterinary Journal, Australia
Veterinary Dermatology
Veterinary Therapeutics
Piedrahita J
Ad hoc Reviewer, Biology of Reproduction
Ad hoc Reviewer, Nature Genetics
Ad hoc Reviewer, Nature Biotechnology
Ad hoc Reviewer, Nucleic Acid Research
Ad hoc Reviewer, Proceedings National Academy of Sciences
Ad hoc Reviewer, Mammalian Genome
Ad hoc Reviewer, Animal Genetics
Ad hoc Reviewer, Theriogenology
67
Posner L
JAA for Laboratory Animal Science
AJVR
JAAHA
Veterinary Anesthesia and Analgesia
JAVMA
Robertson I
Veterinary Radiology and Ultrasound
Rodriguez M
Carcinogenesis
Molecular Carcinogenesis
Cancer Research
Oncogene
Saker K
Journal of Lipids
Journal Veterinary Internal Medicine
Journal American Veterinary Medical Association: Timely Topics in Nutrition
Journal of Dairy Science
Veterinary Radiology and Ultrasound
Sannes PL
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory and Critical Care Medicine
American Journal of Physiology, Lung Cell and Molecular Biology
Seiler G
Veterinary Radiology & Ultrasound
Journal of the American Veterinary Medical Association
Journal of Veterinary Internal Medicine
Veterinary Ophtalmology
Sherry B
Journal of Virology
Smallwood J
Veterinary Radiology and Ultrasound
Journal of Veterinary Medical Education
Swanson C
Veterinary Anesthesia and Analgesia
Thomas R
Veterinary Pathology
Thrall D
International Journal of Hyperthermia
68
Yoder J
Disease Models & Mechanisms, July 2009
Future Microbiology, Jan 2010
Genome Biology, July 2009
Journal of Immunology
Molecular Biology and Evolution, June 2009
MBS DEPARTMENTAL COMMITTEES
Adler K
Executive Committee
Breen M
Committee for Review of Tenured Faculty
Ad hoc Committee for the Review of Teaching Track Faculty
Executive Committee
Campbell N
Executive Committee
Dean G
Committee for Review of Tenured Faculty
Gadsby J
Committee for Review of Tenured Faculty
Ad hoc Committee for the Review of Teaching Track Faculty
Horowitz J
Executive Committee
Committee for Review of Tenured Faculty
Hudson L
Executive Committee
Nascone-Yoder N
Executive Committee
Posner L
Executive Committee
Rodriguez M
Organization of Research in Progress Seminar Series
Sannes PL
Committee for Review of Tenured Faculty
Sherry B
Executive Committee, 2006 - present
Swanson C
Executive Committee
69
Thrall D
Clinical Track Faculty Review Committee
Yoder J
Executive Committee, 2006 Committee for Review of Clinical Track Faculty, 2010
CVM COMMITTEES
Arasu P
International Programs
Barnes J
Diversity Committee
Co-Chair, Course Coordinators Group
Curriculum Committee
Admissions Committee
Breen M
Co-Coordinator, Molecular Medicine Course Initiative
Curriculum and Course Evaluation
Ad hoc Dept Head Review, Dr. MC McGahan
Brody A
Compact Planning
Library Committee
Research Committee
Campbell N
Admissions Committee
Service Chief, Anesthesia and Radiology, NCSU-CVM Hospital Board
Search Committee, Assistant Professor of Soft Tissue Surgery, 2010
Dean G
DVM/PhD Admissions Committee
Chair, CCMTR Executive Committee
Chair, Comparative Medicine and Translational Research Training Program, Executive Committee
Chair, CCMTR Symposium Organizing Committee
Outpatient Center Planning Committee
Fleisher L
Non-Voting Member, Faculty Committee on Curriculum and Course Evaluation
Non-Voting Member, CBS Graduate Studies Committee
Course Director, CVM Curriculum Revision Committee
Search Committee, Director of Operations, CVM Laboratory Animal Research Facility
Gadsby J
DVM-Course Coordinators Group, Spring 2010
Horowitz J
Web Site Design Committee
Information Technology Committee
70
Hudson L
Safety
Ad hoc Bylaws
Chair, Academic Performance
Ad hoc Dept Head Review, Dr. MC McGahan
Ad hoc Office Space
Nascone-Yoder
Research Committee
Papich M
Pharmacy and Central Supply Committee, VTH Standing Committee
Chairman, Infectious Disease Control Committee, VTH Standing Committee
Curriculum Committee, Faculty Committee on College Curriculum Evaluation, 2007 - present
Search Committee, Assistant/Associate Professor of Bacteriology, PHP Department, 2009-2010
Piedrahita J
Cell Biology Focus Area Leader, Executive Committee, CBS program, 2008 - present
Posner L
IACUC Ad-Hoc Veterinary Reviews, 2009-2010
Outpatient Center Steering Committee, 2009-2010
FCHOP Committee, 2009-2010
Ad hoc Dept Head Review, Dr. MC McGahan, 2010
VTH Case Review, 2009-2010
Rodriguez M
Research Committee, January 2008 Saker K
Admissions Committee
EPA/SPA Awards Committee
Sannes
Admissions Committee, DVM Program
Chair, Mentorship Committee, CCMTR
Reappointment, Promotion and Tenure Committee
Core Leader, Mucosal Pathophysiology, Center for Comparative Molecular Medicine and Translational Research
Executive Committee, CCMTR
Seiler G
Faculty Committee on House Officer Programs, FCHOP
Sherry B
Chair, Reappointment, Promotion and Tenure Committee, 8/06 – present
Swanson C
Awards Committee
DVM Curriculum Revision Task Force
71
Thrall D
Building Committee, Randall Terry Veterinary Medical Center
Chair, Ad hoc Dept Head Review, Dr. MC McGahan, 2010
Yoder J
Research Committee, 2006-2009
Comparative Biomedical Sciences Graduate Program Committee, 2008 - present
Comparative Biomedical Sciences Graduate Program DVM/PhD Admissions Committee, 2010 - present
UNIVERSITY COMMITTEES
Adler K
Postdoctoral Advisory Committee
Implementation Team for the NC State Response to the UNC Vision for Technology Transfer
Arasu P
International Operations Council
MBA Biosciences/ Industry Advisory Board
Research Operations Council
Graduate Operations Council
India Working Group
Africa Working Group
Breen M
Steering Committee, CCMTR Clinical Studies Core
Director, CCMTR, Clinical Studies Core
Leader, Clinical Genomics Core, CCMTR
CVM Representative, NCSU Hearings Committee
CVM Representative, Unified Communications Committee
Dean G
GAANN Fellowship Executive Committee
Biotechnology Training Grant Executive Committee
Center for Quantitative Sciences in Biomedicine, Executive Committee
Technology Transfer Advisory Board
Health and Well Being Advisory Board
Participant, Research Administration Retreat
Fleisher L
Chair, Institutional Animal Care and Use Committee
CVM Representative, Administrative Board of the Graduate School
CVM Representative, Faculty Senate
Faculty Senate Resources and Environment Committee
University Registration, Records and Calendar Committee
University Campus Safety and Emergency Planning Committee
Emergency Planning Committee
University O. Max Gardner Award Committee
Faculty Well Being Advisory Committee
Gadsby J
NCSU Physiology Program Graduate Student Admissions Committee, August 2008 - present
72
Ghashghaei
CVM Representative, Biosafety Committee
Horowitz J
DVM/PhD Program Admissions Committee
Pre-proposal Selection Committee for Packard Foundation Fellowships
Pre-proposal Selection Committee for Beckman and Pew Foundations Fellowships
Genomic Sciences Graduate Program, Admissions Committee
Center for Comparative Medicine and Translational Research Executive Committee
Center for Comparative Medicine and Translational Research Oncology Core leader
University Grievance Panel
Genetics Graduate Program Review Committee
McGahan MC
Strategic Rapid Response Team
Chairperson, Steering Committee for Streamlining the EPA Hiring Process
Piedrahita J
CVM Representative, Intellectual Property Committee
Director, Clinical Genomics Core, CCMTR, Executive Committee
Functional Genomics Admission Committee, 2006 - present
IMSD Executive Committee
Posner L
Faculty Wellbeing Committee, 2009-2010
Robertson I
Radiation Safety Committee
Sannes
Committee on Evaluation of Teaching
Committee on Reappointment, Promotion, and Tenure
Sherry B
Graduate School Thesis and Dissertation Award Committee, July 2009 – August 2009
Chair, Misconduct Investigation Committee, June 2008 – July 2009
Vice Chair, University Research Committee, August 2007 – present
GAANN Training Grant Executive Committee, November 2002 - present
Co-Director, Biotechnology Training Program, January 1999 – present
Expanding Your Horizons Organizational Committee, July 1998 - present
Awards Committee, GAANN Fellowships, August 1994 - present
Thrall
Radiation Safety Committee
OTHER COMMITTEES
Adler K
Triangle Visiting Pulmonary Scholar Committee
73
Arasu P
International Affairs Committee (IAC), American Association of Veterinary Medical Colleges
Committee on International Affairs (CIVA), as AAVMC Representative to American Association of Veterinary
Medicine (AVMA)
Triangle Global Health Consortium
Asakawa M
Japanese Veterinary Pain Management
Barnes J
Vice President, Psi Chapter of Phi Zeta
Chair, Awareness Committee, American Association of Veterinary Anatomists
Breen M
Board of Directors and Treasurer, Canine Comparative Oncology and Genomics Consortium (CCOGC), Inc
Steering Committee, CCOGC Inc
CCOGC Biospecimen Committee
CCOGC PR Subcommittee
American Kennel Club Canine Health Foundation, President’s Council
American College of Veterinary Pathology Oncology Subcommittee on Myeloid Neoplasms
American College of Veterinary Pathology Oncology Subcommittee on Lymphoma
Morris Animal Foundation, Scientific Advisory Board, to June 2009
Oatmeal Group, Scientific Advisory Board
NCI Site Visit Team, Evaluating the Activities of the Laboratory of Genome Diversity
Primary Organizer, International Scientific Conference, Genes, Dogs and Cancer – V, Orlando, Florida
Brody A
American Thoracic Society, Program Committee, 2008, 2009 and 2010 Annual Meetings
Brown J
Residency Standards and Evaluation Committee, American College of Veterinary Radiology
Dean G
Speaker, NC State Graduate Student Orientation
Session Chair and Invited Speaker, National Veterinary Scholars Symposium
Invited Speaker, Burrows-Wellcome, Short Course: Becoming Faculty
Chair, Triangle Immunology Interest Group, Steering Committee
Chair, International Feline Retrovirus Research Symposium Organizing Committee
One Health Intellectual Exchange Group, Steering Committee
Gadsby J
Society for the Study of Reproduction Nominating Committee, 2008 - 2009
Chair/Primary Organizer, 2010 Triangle Consortium for Reproductive Biology (TCRB) Annual Conference
Hudson L
Ad hoc AAVA Bylaws
McGahan MC
Secretary, Department of Health and Human Services, National Advisory Eye Council, Appointed by Michael Leavitt,
December 2006 – December 2010
Secretary, International Society for Eye Research, http://iser.org/governance.html, 2008 - 2011
74
Papich M
Advisory Boards:
Pfizer Pharmaceuticals, Expert Advisory Panel for Antimicrobial Drugs
Boehringer-Ingelheim, Pain Medication Advisory Board
Bayer Animal Health, Consulting activity.
Putney Pharmaceuticals, Consultant and advisory panel
Vet Med Labs, Advisory Panel
Central Life Sciences (formerly Farnam Inc.), Consulting Activity for Animal Drugs
National and International Committees:
Vice Chair and Member, Subcommittee on Veterinary Antimicrobial Susceptibility Testing (VAST), National
Committee for Clinical and Laboratory Standards Institute (CLSI) (formerly the Clinical Laboratory
Standards, NCCLS, 2001 – present, appointed to Vice-Chair in 2008
United States Pharmacopeia Convention (USP), Rockville, Maryland
USP Council of Experts, 2005 - 2010
USP Chairman, Expert Panel on Veterinary Drugs, 2005 - 2010
Panel Member, USP Expert Panel on Veterinary Drug Information, 2005 - 2010
Robertson I
Chair, ACVR Exam Committee
ACVR, Digital Imaging Standards Committee
Saker K
President, The American Academy of Veterinary Nutrition (AAVN)
Chair, Education Committee for the American College of Veterinary Nutrition (ACVN)
Development Committee for the ACVN
Sannes P
External Advisory Committee, Program Project Grant, University of California at Davis
Sherry B
Panelist, NCSU Postdoctoral Professional Development, April 2009
Judge, NCSU Graduate Student Research Symposium, March 2010
Smallwood J
National Secretary-Treasurer, Society of Phi Zeta, Honor Society of Veterinary Medicine
Director, CVM Alumni Affairs
Swanson C
Chairman, American College of Veterinary Anesthesiologists, Appeals Committee
Thrall D
Duke University Comprehensive Cancer Center
Yoder J
External Graduate Student Examiner, Department of Biochemistry, Memorial University of Newfoundland, St.
John’s, Canada, November 2009
CCMTR, Clinical Studies Core Steering Committee, 2008 Coordinator, Triangle Zebrafish Group, 2006 -
75
Appendix VII
Research Grants
Granting
Agency
PI
NIH
Adler K
Sepracor
Adler K (<2%)
Waterman J
(50%)
EPA
Adler K (20%)
NIH
Adler K` (35%)
Sannes P (10%),
Shea D (5%)
Horowitz (10%)
USDA
Arasu P (5%)
Broad Institute
Breen M (15%)
Broad Inst
(MIT/NHGRI)
NIH/NCI
Breen M (15-25%)
AKC Canine
Hlth Fdn
Breen M (3% c/s)
AKC Canine
Hlth Fdn
AKC Canine
Hlth Fdn
AKC Canine
Hlth Fdn
Morris An Fdn
Breen M (5% c/s)
UNC-LCCC
Co-I(s)
Fellner V (5%),
Gimeno I (1%),
Correa M (1%),
Sharma R (1%)
Breen M (22%)
Breen M (5% c/s)
Breen, M
(5% c/s)
Breen, M
(5% c/s)
Breen, M
(10%)
NIH
Brody A
NIH/NICDR
ARRA
supp
NIH-NIAID
Admin supp
Dean G
Dean G
Suter S,
Motsinger-Reif A
Title
Date of
award
NIH 15th Int’l Colloquium on Pulmonary &
Airway Fibrosis (travel award)
Differential effects of albuterol and
formoterol isomers on transcription factor
activation in human airway epithelium
Cooperative training in environmental
sciences research
Mechanism of oxidant-induced respiratory
mucin secretion
Sustainable livestock production practices,
biofuels and health: lessons with India
6/15/086/14/09
6/1/075/31/09
Molecular cytogenetic anchoring of
vertebrate genomes
Molecular cytogenetic anchoring of
vertebrate genomes
Spontaneous canine tumors as models for
gene discovery
Cellular genomics – a molecular
cytogenetic investigation of canine soft
tissue sarcoma
Canine lymphoma – the prognostic
significance of chromosome aneuploidy
Heritable and spontaneous genetic lesions
in canine lymphoma
Heritable and sporadic genetic lesions in
canine osteosarcoma
Comparative Molecular Cytogenetics of the
Canidae
Integrated molecular characterization of
naturally occurring B-cell lymphomas in
dogs for use as a relevant large animal
model of human DLBCL
TNF-Alpha to TGF-Beta signal
transduction
Recombinanat lactobacillus as an oral
mucosal vaccine against HIV-1.
Basis and modulation of the innate
immune defect in FIV
Total Costs for
Total Grant
Period
15,000
Total DC for
Total Grant
Period
15,000
Total costs for
Current Year
Award
15,000
Total DC for
Current Year
Award
15,000
110,000
73,852
9/1/068/31/11
3/1/092/28/14
7/20086/30/12
3,380,480
3,186,481
232,540
216,580
1,929,115
1,296,160
385,823
259,232
100,000
80,000
25,000
20,000
7/1/096/30/10
5/1/076/30/09
10/1/077/31/12
10/1/079/30/09
119,200
80,000
119,200
80,000
545,705
392,359
356,187
249,950
1,423,625
987,130
283,547
197,426
135,963
125,892
68,409
63,342
8/1/087/31/10
8/1/087/31/10
8/1/087/31/10
1/1/0912/31/10
1/1/0906/30/10
113,929
106,342
56,398
52,220
149,369
139,157
75,389
69,805
147,912
136,956
75,147
69,581
79,176
73,311
39,048
36,155
289,134
289,134
144,567
144,567
9/1/067/31/10
9/22/098/31/10
882,533
443,724
no cost ext
no cost ext
207,368
156,570
207,368
156,570
9/1/096/30/10
61,329
41,160
61,329
41,160
Granting
Agency
PI
Co-I(s)
Title
Date of
award
NIH/NIAID
Dean G (20%)
NIH-NIAID
Dean G (25%)
Optimizing immunogenicity of lactobacillus
as a mucosal vaccine against HIV-1
Basis and modulation of the innate
immune defect in FIV
2/15/087/31/10
7/1/076/30/11
NIH/NAID
Dean G (30%)
Klaenhamer T
(5%)
Nordone S
(25%), Tompkins
MB (5%)
Klaenhammer T
(5%), Nordone S
(50%), Howard K
(75%)
Recombinanat lactobacillus as an oral
mucosal vaccine against HIV-1
NIH-NIAID/NCI/
NHLBI
Winn
Foundation
Dean G (5%)
NIH
Ghashghaei T (10%)
UNC-CH/NIHNIMH
Hudson L (5%)
Tompkins MB
(5%)
10th International Feline Retrovirus
Research Symposium
Ability of a novel probiotic lactobacillus
acidophilus NCK2025 to colonize and
stimulate mucosal IL-10 synthesis in
healthy and immunosuppressed cats
Transcriptional regulation of aging in the
adult neural stem cell niche
Choroid plexus macrophages in FIV
neuropathogenesis
NIH
Hudson L 5%
NIH
McGahan C (40%)
Sherman B 5%
Gruen M 5%
Meeker R 5%
Goralska M
(100%)
NIH
McGahan
NSF
Nascone-Yoder N
(22%)
Morris An Fdn
Nordone S (40%)
Bayer Health
Care
Papich M
Pfizer Animal
Health
Triangle
Community
Papich M
Dean G (5%)
Papich M
Birkenheuer A
(10%), Yoder J
(2%), Wood M
(2%)
Quantifying cognitive-motor decline in FIVinfected cats
Trace element dynamics in the vertebrate
eye
Trace element dynamics in the vertebrate
eye (suppl)
Mechanisms of vertebrate gut
morphogenesis
Evaluation of TREM-1 as a specific
biological marker for sepsis in dogs
Distribution of enrofloxacin, and it’s active
metabolite, using an in-vivo ultrafiltration
sampling technique after the injection of
enrofloxacin to pigs.
Retrospective analysis of convenia- a
review of clinical case utilization
George H. Hitchings New Investigator
Award in Health Research
Total Costs for
Total Grant
Period
408,375
Total DC for
Total Grant
Period
275,000
Total costs for
Current Year
Award
222,750
Total DC for
Current Year
Award
150,000
1,316,374
884,968
325,592
218,815
3/20/081/31/13
1,825,000
1,250,000
345,263
232,500
4/15/103/31/11
4/1/103/31/11
27,000
27,000
27,000
27,000
15,000
15,000
15,000
15,000
1/18/1011/30-13
3/1/062/28/10
(no cost ext
to 2/28/11)
9/30/097/31/11
1,290,394
854,258
322,745
218,750
464,907
321,184
124,304
85,142
412,760
281,231
222,889
153,130
7/1/066/30/11
7/1/096/30/10
4/1/073/31/10
(no cost ext
to 3/31/11)
9/1/088/31/11
1,238,072
851,302
248,091
169,925
368,875
368,875
368,875
368,875
410,247
(includes 4
supplemental
awards)
224,078
292,622
120,000
84,707
207,481
70,683
65,447
12/1/096/30/10
26,567
17,8300
26,567
17,830
7/1/096/30/10
5/7/109/1/10
7,450
5,000
7,450
5,000
5,000
5,000
5,000
5,000
77
Granting
Agency
PI
Co-I(s)
Title
Olby N (5%)
USDA
Piedrahita J
(5%)
Piedrahita J (10%)
Development of canine induced pluripotent
stem cells
Association of imprinted genes with
reproductive efficiency in swine
NIHNCHHD
Piedrahita J (20%)
Imprinted genes and placental function
NIH/NHLBI
Piedrahita J (25%)
Gene targeting and xenotransplantation
NIH-AR
Piedrahita J (8%)
NIH/NCI
Rodriguez-Puebla M
Development of a swine model of marfan
syndrome
Roles of Cyclin D3 (Supplement)
NIH/NCI
Rodriguez-Puebla M
(35%)
Saker K 75%)
Roles of cyclin D3 in neoplastic
proliferation
Frozen Dog Treat Evaluation
AAVN and
Waltham Res
Saker K (8%)
NIH
Sannes P (10%)
NIH
Sannes P (35%)
Immuno
Biosciences
Sherry B (2%)
NIH (NIAID)
Sherry B (30%)
NIH (NIAID)
Sherry B (50%)
Morris An Fdn
Thomas R (25%)
Duke/NIH
Thrall D (29%)
Evaluation of small intestinal epithelial tight
junction complex proteins in canine and
feline inflammatory bowel disease
Differentiation of Alveolar Epithelium in
Pulmonary Fibrosis.
Alveolar basement membrane/cell
interactions in the lung
Continued development and application of
immune complex vaccine (ICV) technology
to mammalian systems
Reovirus modulation of the cardiac innate
response: type I interferon and Hsp25
The cardiac interferon response to reovirus
infection
Cytogenetic profiling – an aid to
subclassification of feline abdominal
lymphoma
Hyperthermia and perfusion effects in
cancer therapy
NIH
Yoder J (25%)
Foundation
AKC
Hunter Farms
Posner L (5%)
Horowitz J (15%)
Hauck M (9%),
Pruitt A (5%)
Williams L (4%),
Linder K (2%),
Case B (85%)
Whole organism transcriptional profiling of
innate immune response
Date of
award
Total Costs for
Total Grant
Period
Total DC for
Total Grant
Period
Total costs for
Current Year
Award
Total DC for
Current Year
Award
1/1/102/31/12
1/1/0512/31/08
(no cost ext
to 12/31/09)
3/20062/28/11
4/1/103/31/14
9/1/078/31/10
9/15/082/28/11
4/1/062/28/11
6/1/098/31/09
6/20086/2010
82,610
76,500
41,310
38,250
719,257
575,406
no cost
no cost
1,529,463
1,047,577
290,299
221,086
1,511,050
1,087,200
386,950
271,800
347,688
233,920
188,050
126,420
113,230
76,086
27,666
18,630
1,135,037
780,218
226,471
155,117
16,612
14,445
9,736
9,736
9,736
9,736
148,959
100,000
74,500
50,000
1,856,250
1,250,000
371,250
250,000
530,400
363,288
116,800
80,000
358,752
248,008
358,752
248,008
1,403,322
987,081
No cost
No cost
91,721
84,927
46,368
42,933
7/1/056/30/10
2,527,508
1,731,170
461,649
316,198
6/15/085/31/10
390,407
275,000
245,070
175,000
07/01/0906/30/11
4/1/093/31/14
2/1/071/31/13
9/2/09 –
8/31/10
5/15/044/30/10
12/1/0811/31/10
78
Granting
Agency
PI
Co-I(s)
NIH/USF
subcontract
NIH (sub from
Dieters/NCSU
Chem)
Yoder J (5%)
Morris An Fdn
Brainard B (Univ GA)
Papich M (2%),
V Foundation
for Cancer
Research
Cavanagh J
Horowitz J
NIH
Deiters A (NCSU
Chemistry)
NC Biotech
Franzen S (10%)
PHS/NIH
Hawkridge A (80%)
NCSU/ CVM
Law J
ACVIM
Research
Foundation
NSF
Mariani C
Title
Date of
award
Total Costs for
Total Grant
Period
291,600
Total DC for
Total Grant
Period
199,726
Total costs for
Current Year
Award
65,000
Total DC for
Current Year
Award
44,521
609,856
422,840
117,950
80,000
Novel innate immune receptors in
zebrafish
Switchable systems for spatio-temporal
control of gene expression in zebrafish
12/15/0411/30/10
8/1/077/31/12
The effect of aspirin and clopidogrel on
equine platelet function and serotonin
release
Jimmy V/NCSU Cancer Therapeutics
Training Program
2009-2010
48,484
9/1/088/31/12
1,000,000
1,000,000
250,000
250,000
Yoder J (20%)
Switchable systems for spatio-temporal
control of gene expression in zebrafish
8/1/077/31/12
Dean G (5%),
Hauck M (10%),
Lommel S (5%)
Horowitz J (comentor – 5%)
Yoder J (3%)
Novel translational methods: determining
the biodistribution of targeted therapeutics
8/1/087/31/10
1,437,561
(609,856 to
Yoder)
239,426
1,000,000
(422,840 to
Yoder)
239,426
288,794
(117,950 to
Yoder)
239,426
200,000
(80,000 to
Yoder)
239,426
7/1/076/30/12
7/1/086/30/09
09-10
888,000
600,000
177,600
120,000
7,500
7,500
7,500
7,500
Musulin S,
Papich M
Comparative proteomics applied to the
avaian model of ovarian cancer.
Determining the barrier function of the
chorion in the fish embryo
Diazepam pharmacokinetics with nasal
drop and atomized nasal administration.
McMillan W
Breen M
(and others)
Acquisition of massively deep-read
sequencing technology at NCSU
9/1/09
452,502
452,502
452,502
452,502
AKC Canine
Hlth Fdn
AKC Canine
Hlth Fdn
Olby N
Breen M (1% c/s)
07-09
54,810
50,750
Olby N
Breen M (1% c/s)
07-09
64,800
60,000
Morris An Fdn
Pratt S
3/1/087/31/10
64,022
59,280
NIH-NIAID
Tompkins W (25%)
Saker K (10%), ,
Siciliano PD,
Eisemann J
Dean GA (10%),
Tompkins MB
(20%)
Gene discovery in hereditary cerebellar
abiotrophy of Scottish Terriers
Identificaton of mutations causing
hereditary cerebellar cortical degeneration
in american staffordshire terriers and old
english sheepdogs
Changes in insulin sensitivity with body
composition in the horse
CD4+CD25+T cells: a reservoir of
productive FIV infection
9/1/048/31/09
1,289,260
884,685
404,550
225,000
Yoder J (5%)
7,849
79