Wen-Sheng Wu,
Associated professor, Department of Laboratory Medicine and Biotechnology,
College of Medicine, Hualein, Taiwan
Email：wuws@mail.tcu.edu.tw
PhD. Program:
Institute of Biochemistry, school of medicine, Taiwan university
Research and Teaching Career
Post-doctor :
1.Department of Medical research and education, verterian general hospital,
Taipei, Taiwan
2.Department of Medical research, Kaoshiung Medical university, Kaoshiung.
Taiwan
Teaching:
1. Department of Medical technology, Central Taiwan University of Science
and Technology, Taichung, Taiwan
2. Department of Laboratory Medicine and Biotechnology, College of
Medicine, Tzu Chi University, Hualein, Taiwan
Research background:
Molecular and Cellular Biology, Oncology, Molecular Medicine, Gene Theray
Current project:
1. Signal mechanism for HGF-induced tumor progression of hepatocellular
carcinoma
2. Preclinical trial of target therapy for prevention of metastasis of
hepatocellular carcinoma
3. Transcriptional upregulation of MMP9 by Snail for tumor invasion
4. Signal mechanisms for dengue non-structure protein-1 (NS1) Ab
triggered pathological effect on endothelial cell
Recent Publications (2006-2013)
1. Wu W-S*. Protein kinas C  trigger Ras and Raf-independent MEK/ERK
activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
Cancer Lett. 2006；239(1)：27-35.
2. *Wu W-S. The signaling mechanism of ROS in tumor progression. Cancer
Metastasis Rev. 2006, 25:695-705. SCI
3. Wu W-S*. Rong Kung Tsai, Chung Hsing Chang, Sindy Wang, Jia-Ru Wu, and
Yu-Xun Chang. Reactive oxygen species mediated sustained activation of
protein kinase C  and ERK for migration of human hepatoma cell HepG2. Mol
cancer Res. 2006；4(10)：747-758
4. Hu CT, Wu JR, Chang TY, Cheng CC, Wu WS*. The transcriptional factor Snail
simultaneously triggers cell cycle arrest and migration of human hepatoma
HepG2. J Biomed Sci. 2008, 15:343–355. SCI
5. Wu WS*, Wu JR, Hu CT. Signal cross talks for sustained MAPK activation and
cell migration: the potential role of reactive oxygen species. Cancer Metastasis
Rev. 2008, 27:303–314. SCI (IF:9.345)
6. Tsai RK, Chang CH, Hseu CM, Chang SM, Wu JR, Wang HZ, Wu WC, Wu
WS* Ethambutol induces PKC-dependent cytotoxic and antiproliferative
effects on human retinal pigment cells. Exp Eye Res. 2008 Dec;87(6):594-603.
7.Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu,
Ming-Che Li1 and Wen-Sheng Wu*
Snail associates with EGR-1 and SP-1
to upregulate transcriptional activation of p15INK4b. FEBS Journal 2010,
277: 1202–1218 (IF:3.042)
8. Rong Kung Tsai, Ming Shan He, Zih-Yao Chen, Wen Chen Wu and Wen Sheng
Wu* PKC-dependent signaling mediates ethambutol-induced toxic effects on
human retinal pigment cells. Mol Vis. 2011;17:1564-76.
9. Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Sindy Wang, Hsiao-Ting Wang,
Ming-Che Lee, Ling-Jung Wang, Siou-Mei Pan, Tsu-Yao Chang, Wen-Sheng
Wu*. Reactive oxygen species-mediated PKC and integrin signaling promotes
tumor progression of human hepatoma HepG2. Clin Exp Metastasis. 2011
28(8):851-63.
10. Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS*. Enhanced PKCδ and
ERK signaling mediate cell migration of retinal pigment epithelial cells
synergistically induced by HGF and EGF. PLoS One. 2012;7(9):e44937.
11.Hu CT, Cheng CC, Pan SM, Wu JR, Wu WS*. PKC mediates fluctuant
ERK-paxillin signaling for hepatocyte growth factor-induced migration of
hepatoma cell HepG2. Cell Signal. 2013;25(6):1457-67.
12. Hu CT, Wu JR, Wu WS*. The role of endosomal signaling triggered by
metastatic growth factors in tumor progression. Cell Signal. 2013
l;25(7):1539-45.
* corresponding author