Dr Xuebo Hu
Professor in Medicinal Plants/Protein engineering
Expertise Statement
Teaching Duties

Protein engineering, antibody engineering, cell molecular biology
Research Interests

Protein engineering

Discovery of active compounds from Chinese traditional medicine

Nutritional estimation of Chinese traditional medicine
Professional Memberships

Member of American Association for the Advancement of Science

Member of American Protein Society

Member of Chinese Microbiology Society
Other Roles
Education & Working Experience
EDUCATION

Doctoral degree of Philosophy, Plant Pathology, 2006. Zhejiang University, Hangzhou,
China

Bachelor of Biology; Major: Plant protection, 1997
Huazhong (Central China) Agricultural University, Wuhan, China
WORK EXPERIENCE
09/2012-present, Professor, Huazhong (Central China) Agricultural University, Wuhan,
China
12/2009-08/2012, Research Associate, Department of Biomedical Engineering, Cornell
University
11/2006-11/2009, Postdoctoral Associate, Department of Biomedical Engineering, Cornell
University
08/2004-10/2006, Research assistant, Institute for Microbiology, Chinese Academy of
Science, Beijing, China
09/1997-08/1999, Research fellow, Division of plant disease control, Institute of
Agricultural Science of Wenzhou municipal, Zhejiang, China
Publications
1. Xuebo Hu, P. Saha, Xiaoyue Chen, Dogeun Kim, Mahesh Devarasetty,
Raghavan Varadarajan, Moonsoo Jin. Cell Surface Assembly of HIV gp41
Six-Helix Bundles for Facile, Quantitative Measurements of
Hetero-oligomeric Interactions. J. Am. Chem. Soc. 2012,
134:14642-14645.
2. Novel strategy for selection of monoclonal antibodies against highly
conserved antigens: phage library panning against ephrin-B2 displayed on
yeast. Gu X, Vedvyas Y, Chen X, Kaushik T, Hwang CI, Hu X, Nikitin AY,
Jin MM. PLoS One. 2012;7:e30680.
3. Wong R, Chen X, Wang Y, Hu X, Jin MM. Visualizing and quantifying
acute inflammation using ICAM-1 specific nanoparticles and MRI
quantitative susceptibility mapping. Ann Biomed Eng. 2012:132813-38.
4. Jacque M Tremblay, Chueh-Ling Kuo, Claudia Abeijon, Jorge Sepulveda,
George Oyler, Xuebo Hu, Moonsoo M Jin, Charles B Shoemaker.
Camelid single domain antibodies (VHHs) as neuronal cell intrabody
binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT)
proteases. Toxicon, 2010,56:990-998.
5. Xuebo Hu, Sungkwon Kang, Craig Lefort, Minsoo Kim, Moonsoo Jin.
Combinatorial libraries against libraries for selecting neoepitope
activation-specific antibodies. Proc. Natl. Acad. Sci. U. S. A. 2010,107:
6252-6257.
6. Xuebo Hu, Sungkwon Kang, Xiaoyue Chen, Shoemaker CB, Moonsoo Jin.
Yeast surface two-hybrid for quantitative in vivo detection of
protein-protein interactions via the secretory pathway. J Biol Chem. 2009
12;284(24):16369-76.
7. Xuebo Hu, Huijuan Zhang, Guojun Li, Yuxia Yang, Zhong Zheng,
Fengming Song. Ectopic expression of a rice protein phosphatase 2C gene
OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009,
28(6):985-95.
8. Chaozheng Zhang , Yueyong Liu , Liyue Liu , Zhiyong Lou, Hongyan
Zhang, Hongqin Miao, Xuebo Hu, Yanping Pang, Bingsheng Qiu. Rice
black streaked dwarf virus P9-1, an alpha-helical protein, self-interacts and
forms viroplasms in vivo. J Gen Virol. 2008 89:1770-1776.
9. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular characterization and
expression analysis of a rice protein phosphatase 2C gene, OsBIPP2C1,
and overexpression in transgenic tobacco conferred enhanced disease
resistance and abiotic tolerance. Physiol Plant. 2006,127: 225-236.
10. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F.
Gao, Bingsheng Qiu, Zihe Rao, Po Tien. Structural characterization of
Mumps virus fusion protein core. Biochem. Biophys. Res. Commun. 2006,
348:916-922.
11. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular cloning and
expression of rice OsTVLP1, encoding a protecin with similarity to
TGF-belta
receptor
interacting
proteins
and
vacuolar
assembly
Vam6p/Vps39p proteins. DNA Seq. 2006 17(2):152-158.
12. Yong Li, Mingyu Wu, Houhui Song, Xuebo Hu, Bingsheng Qiu.
Identification of a tobacco protein interacting with tomato mosaic virus
coat protein and facilitating long-distance movement of virus. Arch Virol
2005, 150:1993-2008.
13. Yueyong Liu, Yong Li, Liyue Liu, Xuebo Hu, Bingsheng Qiu. Design of
vectors for efficient integration and transformation in Hansenula
polymorpha. Biotech Lett. 2005, 27(19):1529-1534.
14. Unlisted 8 other papers in Chinese journals for plant science.
PATENT
1
“A Yeast Surface Two-Hybrid System for Quantitative Detection of
Protein-Protein Interactions”, Pending. Second petitioner.
2
“The esterase of chrysanthemic acid, its encoding gene, engineered
expressing strains and their applications”. Chinese Patent No. CN1766097,
2006. Third petitioner.
Contact details
Phone & Fax：027-8664-3277
Cell phone: 18971339266
Email：xuebohu@mail.hzau.edu.cn
Address: Room 101 East Wing of Main Hall,
1 Shizishan, Hongshan,Wuhan, Hubei, China 430070