UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
Chlorotrifluoroethylene
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Purpose
Chlorotrifluoroethylene (CTFE) is a chlorofluorocarbon with chemical formula CF2CClF. It is commonly
used as a refrigerant in cryogenic applications. CTFE has a carbon-carbon double bond and so can be
polymerized to form polychlorotrifluoroethylene (PCTFE) or copolymerized to produce the plastic ECTFE.
PCTFE has the trade name Neoflon PCTFE from Daikin Industries in Japan, and used to be produced under the
trade name Kel-F from 3M Corporation in Minnesota.
It is also used as an intermediate/monomer for CTFE resins, in telomerization with carbon tetrachloride or
chloroform for use as inert fluids, hydraulic fluids, or lubricants, and an intermediate in the production of the
inhalation anesthetic halothane. An inhibitor is added to stabilize this material.
Synonyms: CTFE, Trfluorochloroethylene, stabilized (DOT), and Trifluorovinyl chloride.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 79-38-9
Class: Highly toxic, Highly Flammable
Molecular Formula: C2ClF3
Chlorotrifluoroethylene
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Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Form (physical state): gas
Color: colorless
Boiling point: -28.4°C (-19.4°F)
Potential Hazards/Toxicity
Flash Point: -27.8°C (-18°F)
Chlorotrifluoroethylene(CTFE) mixes well with air, explosive mixtures are formed easily. On combustion,
CTFE forms toxic and corrosive gases including: hydrogen chloride and hydrogen fluoride. It ships as a
USDOT Zone C Poison Inhalation Hazard (UN1082).
Acute toxicity
Oral LD50
LD50 Oral - mouse - 268 mg/kg
Inhalation LC50
LC50 Inhalation - rat - 4 h - 1000 ppm
Remarks: Lungs, Thorax, or Respiration:Other changes. Gastrointestinal:Other changes.
Potential health effects
Inhalation Toxic if inhaled. May cause respiratory tract irritation.
Ingestion Toxic if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
Pulmonary edema. Effects may be delayed., Dizziness, Nausea, Vomiting, renal failure, Cardiac arrhythmias,
Asphyxia,
Symptoms of renal malfunction may be delayed., Liver injury may occur., Kidney injury may occur.
Engineering Controls
Work with this chemical in a certified ducted fume hood. Facilities storing or utilizing this material should be
equipped with an eyewash facility and a safety shower.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by
EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)
Hand Protection
Handle with insulated PVC/butyl gloves. Gloves must be inspected prior to use. Use proper glove removal
technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and
dry hands.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are
compatible with Chlorotrifluoroethylene-gas.
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
Chlorotrifluoroethylene
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Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
ANSI approved properly fitting safety glasses or chemical splash goggles. Face shield is also recommended.
Skin and Body Protection
Flame resistant/cotton lab coats should be worn. These laboratory coats must be appropriately sized for the
individual and be buttoned to their full length. Laboratory coat sleeves must be of a sufficient length to
prevent skin exposure while wearing gloves. Full length pants and close-toed shoes must be worn at all times
by all individuals that are occupying the laboratory area. The area of skin between the shoe and ankle should
not be exposed.
Hygiene Measures
Wash thoroughly and immediately after handling. Remove any contaminated clothing and wash before reuse.
First Aid Procedures
If inhaled
Move into the fresh air immediately and give oxygen. If not breathing give artificial respiration. Seek medical
attention immediately.
In case of skin contact
Immediately flush skin with plenty of water for at least 15 minutes. If contact with liquid form, treat like
frostbite and do not remove any clothing. Seek medical attention immediately. Wash any contaminated
clothing before reuse. Thoroughly clean shoes before reuse.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes. If possible, check for and remove any contact
lenses and consult a physician.
If swallowed
Do NOT induce vomiting unless directed by medical personnel. Never give anything by mouth to an
unconscious person. Seek medical attention immediately.
Special Handling and Storage Requirements
Precautions for safe handling: Avoid contact with skin and eyes and inhalation. Do not breathe gas. Avoid of
vapors, mist, or gas. Use only with adequate ventilation or respiratory protection. Keep sparks, flames, and
other sources of ignition away.
Materials to avoid:
Strong oxidizing agents, Strong bases, Strong oxidizing agents, Reacts violently with water.
Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated fire-proof place
away from incompatible materials and conditions. Store in original container.
Chlorotrifluoroethylene
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Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area.
Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent
material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal
protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear
plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency
shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no
further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-4761300 during work hours, or 9-911 during non-working hours and weekends.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for
15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency
Department. If no further discomfort is experienced, have the SDS ready and contact Poison
Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct
supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working
hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-8857580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday
7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the
affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane
exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick
nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Chlorotrifluoroethylene
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Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as
hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html
Protocol/Procedure
Quantities covered by this SOP:
______ (g , ml) to _______ (g, ml)
Temperature range covered by this SOP:
__ °C – __ °C
General Overview and Purpose:
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Procedure:
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NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
Chlorotrifluoroethylene
5
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)