UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
1-Hydroxyanthraquinone
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Purpose
1-Hydroxyanthraquinone can be used as an intermediate in the production of dyes and drugs. A general
method for synthesis of anthraquinones, including 1-hydroxy-anthraquinone, has been developed. The
anthraquinones were obtained under mild conditions from ortho-dicarboxylic acid chlorides and suitable
aromatic substrates via a FriedelCrafts process.
Synonyms: 1-Hydroxy-9,10-anthraquinone and 1-Hydroxy-9,10-anthracenedione.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 129-43-1
Class: Carcinogen, Irritant
Molecular Formula: C3H4O2 / CH2=CHCOOH
Form (physical state): Solid – Needle/crystals
Color: Orange-Red
Boiling point: 198°C (388.4°F) melting point
1-Hydroxyanthraquinone
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Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Potential Hazards/Toxicity
Solubility: ethanol, benzene, ethyl ether, and oxygenated solvents.
Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury
or death. Irritating to eyes and skin on contact. Prolonged exposure may cause nausea/headache/dizziness.
When heated to decomposition it emits acrid smoke and fumes.
Chronic Toxic Effects
Oral TDLo
TDLo Oral - rat - 288 gm/kg/68 weeks continuous.
TOXIC effects:
Tumorigenic – carcinogenic by RTECS criteria
Gastrointestinal – Tumors
Liver – Tumors.
Potential health effects
Inhalation - Inhalation causes irritation of the lungs and respiratory system.
Ingestion - Harmful if ingested. Severe overexposure can result in injury or death.
Skin - Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.
Eyes - Inflammation of the eye is characterized by redness, watering, and itching.
Engineering Controls
Chemical fume hood with adequate exhaust and capture filtration to minimize airborne contaminates.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by
EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)
Hand Protection
Handle with nitrile or neoprene gloves. Gloves must be inspected prior to use. Use proper glove removal
technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves as hazardous waste. Wash and dry hands.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are
compatible with 1-Hydroxyanthraquinone
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
Tightly fitting safety goggles should be used at a minimum. Faceshield (8-inch minimum) as necessary. Use
equipment for eye protection tested and approved under appropriate government standards such as NIOSH
(US) or EN 166(EU).
1-Hydroxyanthraquinone
2
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Skin and Body Protection
Lab coats should be worn. These laboratory coats must be appropriately sized for the individual and be
buttoned to their full length. Laboratory coat sleeves must be of a sufficient length to prevent skin exposure
while wearing gloves. Personnel should also wear full length pants, or equivalent, and close-toed shoes at all
times by all individuals that are occupying the laboratory area. The area of skin between the shoe and ankle
should not be exposed
Hygiene Measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the
product.
First Aid Procedures
If inhaled
Move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Consult a physician.
In case of skin contact
If no burns have occurred, wash off with soap and plenty of water. Consult a physician. Remove contaminated
clothing prior to re-use.
In case of eye contact
Check for and remove any contact lenses. Rinse eye thoroughly with plenty of water for at least 15 minutes
and consult a physician.
If swallowed
Induce vomiting. Lower the head so the vomit will not reenter the mouth and throat. Never give anything by
mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Special Handling and Storage Requirements
Avoid contact with skin and eyes. Avoid inhalation of dust. Minimize exposure to this material. Keep away
from sources of ignition - No smoking. Take measures to prevent the buildup of electrostatic charge. Keep
container tightly closed in a cool, dry and well-ventilated place. Containers which are opened must be
carefully resealed and kept upright to prevent leakage. Always store away from incompatible compounds
such as oxidizing materials.
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area.
Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent
material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal
protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear
plastic bags, label and take to the next chemical waste pick-up.
1-Hydroxyanthraquinone
3
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency
shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no
further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-4761300 during work hours, or 9-911 during non-working hours and weekends.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for
15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency
Department. If no further discomfort is experienced, have the SDS ready and contact Poison
Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct
supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working
hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-8857580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday
7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the
affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane
exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick
nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as
hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html
Protocol/Procedure
Quantities covered by this SOP:
______ (g , ml) to _______ (g, ml)
Temperature range covered by this SOP:
1-Hydroxyanthraquinone
4
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
__ °C – __ °C
General Overview and Purpose:
Enter the experimental purpose
Procedure:
Enter experimental procedure. You can copy procedure from your lab notebook or from literature.
NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
1-Hydroxyanthraquinone
5
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)