Questions Q1. The graphs show the effect of three different antibiotics on bacterial growth. (i) Which of these is most effective at reducing the number of bacteria? Put a cross ( ) in the box next to your answer. (1) A antibiotic A B antibiotic B C antibiotic C D no antibiotic (ii) Explain how chemical defence mechanisms in the body reduce the chance of infection. (3) .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. Q2. Athlete's foot fungus is a pathogen. (i) Describe how athlete's foot fungus is spread. (1) .............................................................................................................................................. .............................................................................................................................................. (ii) State the type of medication that can be used to treat this pathogen. (1) .............................................................................................................................................. Q3. Controlling infections (a) Athlete's foot fungus is a pathogen. (i) Describe how athlete's foot fungus is spread. (1) .............................................................................................................................................. .............................................................................................................................................. (ii) State the type of medication that can be used to treat this pathogen. (1) .............................................................................................................................................. (b) The graphs show the effect of three different antibiotics on bacterial growth. (i) Which of these is most effective at reducing the number of bacteria? Put a cross ( ) in the box next to your answer. (1) A antibiotic A B antibiotic B C antibiotic C D no antibiotic (ii) Explain how chemical defence mechanisms in the body reduce the chance of infection. (3) .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. *(c) MRSA is a bacterial infection. The graph shows the number of cases of hospital patients with MRSA infections from 1993 to 2005. Explain the trend in the graph, even though the patients were treated with antibiotics. 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Q4. * Describe how different pathogens are spread within human populations. 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Q5. The spread of disease Pathogens are microorganisms that cause disease. (a) Draw one straight line from each disease to the type of pathogen that causes the disease. (2) (b) Some diseases can be treated with antibacterial drugs. Explain how an antibacterial drug may become ineffective over time. (3) .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. .............................................................................................................................................. (c) Complete the sentence by putting a cross (img) in the box next to your answer. Chemicals may prevent the entry of pathogens. One chemical that prevents the entry of pathogens is (1) A cilia B lysozyme C mucus D skin *(d) Describe how different pathogens are spread within human populations. 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Mark Scheme Q1. Answer (i) (ii) C antibiotic C An explanation including 3 of the following points: lysozymes / enzymes (1) found in tears (1) hydrochloric acid (1) in the stomach (1) (chemical defence) destroy bacteria / pathogens (1) Acceptable answers Mark (1) accept lungs/saliva for tears stomach acid (1) accept viruses for pathogens Ignore references to mucus (3) Q2. Answer (i) (ii) (direct) contact (with fungus) / touch / through the skin /surfaces antifungal Acceptable answers Mark (1) fungicide / antibiotics/ nystatin / terbinafine / itraconazole (1) Q3. Answer (a)(i) (a)(ii) (b)(i) (b)(ii) QWC Acceptable answers (direct) contact (with fungus) / touch / through the skin /surfaces antifungal C antibiotic C An explanation including 3 of the following points: lysozymes / enzymes (1) found in tears (1) hydrochloric acid (1) in the stomach (1) (chemical defence) destroy bacteria / pathogens (1) * (c) Mark (1) fungicide / antibiotics/ nystatin / terbinafine / itraconazole (1) (1) accept lungs/saliva for tears stomach acid (1) accept viruses for pathogens Ignore references to mucus (3) Indicative Content An explanation of how MRSA has increased since 1993 also using the evaluation of data from the graph the number of patients suffering from MRSA has increased / more cases of MRSA by over 366 000 since 1993 data quoted from the graph ref to poor hygiene in hospitals MRSA is a bacterium that is resistant to antibiotics individual bacteria show variation when a bacterial infection is treated with antibiotics those bacteria with low resistance are Mark (6) Level 1 0 1-2 destroyed first the more resistant bacteria survive if a patient stops taking the antibiotics then the resistant bacteria will live to reproduce the new bacteria will also be resistant to antibiotics these bacteria will not be able to be treated with antibiotics so the number of cases continue to rise No rewardable content a limited description of the graph only or the increase in bacteria only the answer communicates ideas using simple language and uses limited scientific terminology spelling, punctuation and grammar are used with limited accuracy 2 3-4 a simple description of the graph with a limited explanation of how bacteria continued to increase the answer communicates ideas showing some evidence of clarity and organisation and uses scientific terminology appropriately spelling, punctuation and grammar are used with some accuracy 3 5-6 a detailed explanation (with data) using the graph of the emergence of resistant bacteria which then reproduce, linked to antibiotic treatment most of the steps are identified and are in a logical order the answer communicates ideas clearly and coherently uses a range of scientific terminology accurately spelling, punctuation and grammar are used with few errors Q4. Question Number QWC Indicative Content * Level 1 0 1-2 2 3-4 3 5-6 Mark A description of how pathogens are spread and how they enter the human body in a logical order • cholera bacteria ingested through the drinking of ‘dirty’ water • Salmonella bacteria ingested through contaminated food products / spread by direct contact • influenza virus spread through droplet inhalation/airborne process • athlete’s foot fungus spread by contact with fungal spores • HIV spread by exchange of contaminated body fluids • dysentery infection / bacteria spread through housefly vector • malaria protozoa spread by the Anopheles mosquito (6) No rewardable content • few examples of pathogens are given and/or wrongly linked to their sources of infection or method of transmission • the answer communicates ideas using simple language and uses limited scientific terminology • spelling, punctuation and grammar are used with limited accuracy • there are several examples of pathogens mentioned linked to their source of infection • there is a link to the method of transmission for each of the pathogen • the answer communicates ideas showing some evidence of clarity and organisation and uses scientific terminology appropriately • spelling, punctuation and grammar are used with some accuracy • the majority of the pathogens are mentioned and linked to their source of infection • the method of transmission is described accurately for each of the pathogens • the answer communicates ideas clearly and coherently uses a range of scientific terminology accurately • spelling, punctuation and grammar are used with few errors Q5. Question Number (a) Question Number (b) Answer both lines needed for 2 (2) marks Answer Acceptable answers Mark An explanation linking three of the following points • to treat bacterial infection, antibiotics / antibacterial drug are used (1) • antibacterial drug / antibiotics may be overused / misused (1) • some bacteria resistant to the antibacterial drug may survive (1) • these resistant bacteria will produce resistant offspring (1) (3) Question Number (c) QWC Mark Answer Acceptable answers (1) B Question Number *(d) Mark Indicative Content A description of how pathogens are spread and how they enter the human body in a logical order • cholera bacteria ingested through the drinking of ‘dirty’ water • Salmonella bacteria ingested through contaminated food products / spread by direct contact • influenza virus spread through Mark (6) Level 1 0 1-2 2 3-4 3 5-6 droplet inhalation/airborne process • athlete’s foot fungus spread by contact with fungal spores • HIV spread by exchange of contaminated body fluids • dysentery infection / bacteria spread through housefly vector • malaria protozoa spread by the Anopheles mosquito No rewardable content • few examples of pathogens are given and/or wrongly linked to their sources of infection or method of transmission • the answer communicates ideas using simple language and uses limited scientific terminology • spelling, punctuation and grammar are used with limited accuracy • there are several examples of pathogens mentioned linked to their source of infection • there is a link to the method of transmission for each of the pathogen • the answer communicates ideas showing some evidence of clarity and organisation and uses scientific terminology appropriately • spelling, punctuation and grammar are used with some accuracy • the majority of the pathogens are mentioned and linked to their source of infection • the method of transmission is described accurately for each of the pathogens • the answer communicates ideas clearly and coherently uses a range of scientific terminology accurately • spelling, punctuation and grammar are used with few errors