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Revised July, 2008
Description of Department, Graduate Program & Faculty . 3
Student Learning Outcomes 5
Student Assessment 6
Required and Recommended Courses 10
Graduate Program Requirements 12
Academic Policies 16
Tropical Medicine Course Descriptions 16
Useful Links 19
UH Manoa Campus Map 20
Map to John A. Burns School of Medicine (Kaka`ako Campus) 22
Graduate Faculty Description & Contact Information 23
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Revised July, 2008
Tropical Medicine is the study of diseases that occur more commonly in the tropical regions of the world. However, in today’s era of globalization and modern transportation, diseases that were once confined to the tropics have spread geographically and now play a significant role in the 20 th century global resurgence of infectious diseases. As such, research in the area of tropical medicine and medical microbiology has greatly increased in importance in the past 20 years.
The Department of Tropical Medicine, Medical Microbiology, and
Pharmacology, at the John A. Burns School of Medicine, University of Hawaii at Manoa
(UHM) offers graduate programs leading to the MS and PhD in Biomedical Sciences
(Tropical Medicine). A major goal of the department is to provide Asian and Pacific countries the expertise needed to conduct tropical infectious diseases research. Tropical medicine faculty conduct studies on infectious organisms and the diseases they cause, including dengue, West Nile, AIDS, hepatitis, viral and bacterial encephalitis, malaria, tuberculosis and Kawasaki disease. The faculty employs a multidisciplinary approach, including immunology, pathogenesis, epidemiology, pharmacology, diagnosis, prevention, control, treatment, socio-ecological systems, human ecology, microbial and vector ecology, environmental change, and participatory action research to answer fundamental questions associated with the transmission dynamics and pathogenesis of these diseases. These studies can be laboratory-based, field-based, clinic-based, or include a combination of all three.
The field of tropical medicine requires knowledge of virology, bacteriology, parasitology, entomology, immunology, cell and molecular biology, epidemiology, ecology, behavioral science and clinical medicine. In this respect, the tropical medicine program at UHM provides learning opportunities in a range of biological disciplines available in few other university departments. Students also receive vigorous training in scientific methodology. The department has active research programs with several community hospitals and collaborates closely with the State of Hawai`i Department of
Health, providing instruction and expertise in bioterrorism preparedness and diagnosis of infectious diseases using the latest technology. In addition to local collaborations, department faculty have partnered with several international institutions in Southeast
Asia and Africa specializing in infectious disease research.
Faculty
*Graduate Faculty
*D. J. Gubler, ScD (Chair)—arboviruses and vector-borne disease, epidemiology and control
*S. N. Bennett, PhD—molecular evolution and epidemiology of emerging infectious
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Revised July, 2008 diseases
*S. P. Chang, PhD—immunology, molecular biology, malaria vaccine development
A. Collier, PhD – pharmacology, pharmacokinetics, reproductive pharmacology
C. B. Cropp, MS—arbovirology
*A. R. Diwan, PhD—medical virology, chemotherapy, vaccines (retired)
*E. Furusawa, MD, PhD—viral chemotherapy (retired)
L. Gollin, PhD—medical anthropology and ethnobotany
*W. L. Gosnell, PhD—host parasite interactions, malaria, immunology
*G. S. N. Hui, PhD—parasitology, immunology, cell biology
P. H. Kaufusi - pathogenesis of West Nile virus
*K. J. Kramer, PhD—parasitology, epidemiology, leptospirosis, HIV serodiagnosis
H. Luo, PhD – pathogenesis of arboviruses and polyomaviruses
*F. D. Miller, PhD—epidemiology of infectious diseases
*V. R. Nerurkar, PhD—pathogenesis of infectious diseases, delineating cellular and molecular mechanisms underlying microbe-host interaction
*D. W. Taylor, Ph.D. - malaria immunology, maternal and child health
*S. Verma, PhD—molecular, biochemical aspects of viral diseases
G. Watt, MD—zoonotic infectious diseases
*B. A. Wilcox, PhD—ecology of infectious diseases, integrative health research, community medicine
*S. Verma, PhD—diagnosis of Kawasaki syndrome, effect of selenium deficiency on
RNA virus mutations
*K. Yamaga, PhD—immunological mechanisms of diseases
Cooperating Graduate Faculty
J. M. Berestecky, PhD—enteric bacteria
G. Erdem, MD—molecular epidemiology of group A streptococcal and staphylococcal infections; complications of strep infections like acute rheumatic fever
A. Imrie, PhD—cytotoxic T-cells & HIV
J. H. Kim, MD—HIV viral neutralization, cytokine gene therapy in HIV specific T-cells,
HTLV-I and-II mechanisms of Rex protein function
S. R. Kim, PhD—basic immunology of HIV-1 infection
Y. Lu, PhD – gene transfer and gene therapy in HIV-infection, diagnostic virology
M. E. Melish, MD—staphylococcal infection and toxins, clinical infectious disease,
Kawasaki syndrome
F. D. Pien, MD—clinical microbiology, diagnostic bacteriology and parasitology, efficacy of antimicrobial agents
R. C. Rudoy, MD—clinical aspects of viral and bacterial diseases
B. Shiramizu, MD—pathobiology of HIV-associated disorders
E. K. Tam, MD—inflammation, immunologic mechanisms of pulmonary diseases, genetic and environmental determinants of asthma
R. Yanagihara, MD—emerging and re-emerging infectious diseases
Q. Yu, MD,PhD – HIV-1 vaccines and memory CTL responses
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Revised July, 2008
Affiliate Graduate Faculty
F. Mercier, PhD – neurovirology
C. F. T. Uyehara, PhD—developmental and cardiovascular pharmacology
Administrative Staff
Sheila Kawamoto, Administrative & Fiscal Support Specialist
Karen Amii, Clerk Stenographer
Tropical Medicine Graduate Program Student Learning Outcomes
1.
Demonstrate a fundamental knowledge base in the major subdisciples of the field of Tropical Medicine: bacteriology, virology, mycology, parasitology, immunology, molecular epidemiology, and infectious disease ecology.
2.
Demonstrate a mastery of technical and experimental methodologies required to conduct research in the field of Tropical Medicine.
3.
Demonstrate the ability to plan, execute, interpret, and evaluate experimental studies in Tropical Medicine.
4.
Demonstrate skills required for instruction, assessment and mentoring of undergraduate and MS level students.
5.
Demonstrate proficiency in written and verbal communication skills in classroom lectures and other teaching formats and in professional seminars and presentations.
6.
Demonstrate sufficient mastery and scientific maturity to assess the work of peers in related fields.
1.
Demonstrate an advanced knowledge base in the major subdisciples of the field of Tropical Medicine: bacteriology, virology, mycology, parasitology, immunology, molecular epidemiology, and infectious disease ecology.
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Revised July, 2008
2.
Demonstrate a mastery of technical and experimental methodologies required to conduct research in the field of Tropical Medicine.
3.
Demonstrate the ability to plan, execute, interpret, and evaluate experimental studies in Tropical Medicine.
4.
Demonstrate skills for instruction, assessment and mentoring of undergraduate, MS and PhD level students.
5.
Demonstrate skills to verbally communicate scientific concepts and results in classroom lectures and other teaching formats and in professional seminars and presentations.
6.
Demonstrate written communication skills as required in various professional duties including manuscript preparation for scientific publication, preparation of research grant applications, preparation of lecture notes, development of introductory and advanced courses in related disciplines.
7.
Demonstrate sufficient mastery and scientific maturity to assess the work of peers in related fields.
8.
Develop administrative skills to manage a research laboratory, supervise technical and professional staff, and assume responsibilities and provide leadership as a faculty member.
Tropical Medicine Graduate Program Student Assessment
A.
Master of Science Degree
1.
Course evaluations a.
Core courses: written examinations at regular intervals (midterm exams) as well as a final examination at the end of the course b.
Advanced courses: written exams may be substituted by term papers or oral presentations on a subject selected by student and the faculty instructor c.
Course examinations, papers and presentations are evaluated by the faculty instructor
2.
Diagnostic evaluation a.
First or second semester of residence b.
Written exam to evaluate background in infectious disease microbiology & immunology c.
Used to advise on course of study
3.
Master's Plan A (Thesis)
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Revised July, 2008 a.
Thesis proposal is evaluated and subject to approval by thesis advisory committee b.
General (Qualifying) Examination

A general examination (written and oral) will be required before a student is advanced to candidacy for a Master of
Science degree.

The examination will be given during the third or fourth semester of residence. The questions will be composed by the graduate faculty and will be designed to adequately test the student's basic knowledge of the fields of biomedical

 sciences and Tropical Medicine.
The results of the oral/written examination will be used to evaluate the student's progress and to advise him/her on a course of study to correct any weakness.
A student who passes the examination may be recommended for advancement to candidacy for the
 master's degree.
A student who fails the general examination may repeat it once within six months following the date of the first examination. The exact time of examination will be determined by mutual agreement between the student and examination committee.

The student will not be considered for candidacy again should he/she fail the general examination a second time. c.
Final Examination

A final oral examination, covering the thesis and related areas, is required. It will be held at least three weeks before the end of the term during which the degree is conferred.

The student will be expected to present the work covered in his/her thesis, giving the purpose, methodology, results, and meaning of the work in a clear, orderly manner.

He/she will be expected to discuss questions regarding the thesis and demonstrate a sufficient background in related areas.

The final examination will be conducted by the thesis
 committee and may be open to all graduate faculty
Should the student fail the final examination, he/she may repeat it only once at the discretion of the thesis committee.

A student who fails the examination a second time is dismissed from the program.
4.
Master's Plan B (Non-thesis) a.
Research project proposal is evaluated and subject to approval by the advisory committee.
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Revised July, 2008 b.
General (Qualifying) Examinatiom

A general examination (oral or written) will be required before a student is advanced to candidacy for a Master of
Science degree.

The examination will be given during the third semester of residence.

The questions will be composed by the graduate faculty and
 will be designed to adequately test the student's general knowledge of the biomedical sciences and Tropical
Medicine.
The results of the oral examination will be used to evaluate the student's progress and to advise him/her on a course of study to correct any weakness.


A student who passes the examination may be recommended for advancement to candidacy for the master's degree.
A student who fails the general examination may repeat it once within six months following the date of the first examination. The exact time of examination within that six months may vary and will be determined by mutual agreement between the student and examination committee.

A student who fails the examination a second time is dismissed from the program. c.
Final Examination

A comprehensive written and oral examination is required and will be conducted by the candidate's advisory committee.

The final examination will be given at least three weeks before the end of the term during which the degree is conferred.

The student will be required to demonstrate a basic knowledge of the various fields encompassed by Tropical


Medicine.
Should the student fail the final examination, he/she may be permitted to repeat it only once at the discretion of his/her advisory committee.
A student who fails the examination a second time is irrevocably dropped from the program.
B.
Ph.D. Degree
1.
General diagnostic examination
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Revised July, 2008 a.
conducted by an advisory committee representative of the general field of infectious diseases before the end of the first semester b.
evaluates the student's general knowledge of the field of tropical medicine and used to outline a course of study to correct any deficiencies.
2.
Qualifying Examination a.
Usually administered after the first year of study b.
Examination Committee consists of graduate faculty representative of the general field of infectious diseases and will prepare and evaluate the results of the exam. c.
Examination committee determines whether the student has passed or failed the exam, note any academic weaknesses and recommend an appropriate course of study. d.
The qualifying exam may be repeated once e.
This examination is also used to determine whether to encourage a student to proceed in a doctoral program or end with a terminal
MS degree.
3.
Comprehensive Examination a.
The Tropical Medicine PhD Comprehensive Examination will consist of the preparation and defense of a research proposal based on the student’s dissertation research project. b.
This examination should be administered by the end of the second year of PhD training by members of the student’s dissertation committee. c.
The exact format of the proposal is to be specified by the dissertation committee; however it should generally follow the format of a grant proposal to a major funding agency such as the
National Institutes of Health or the National Science Foundation. d.
The proposal should be prepared in consultation with the student’s research advisor but should include at least one innovative objective that is not included as part of an existing grant or a proposal developed by the advisor. e.
An oral examination based on the written proposal will be carried out by the dissertation committee. The content of this oral examination may include fundamental concepts underlying the hypotheses addressed in the proposal, technical or experimental design issues, and any other topics which the committee feels are pertinent to the student’s understanding of his/her research area. f.
A majority of the committee must vote to pass the student in order for student to pass the exam. g.
The exam may be repeated once.
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Revised July, 2008 h.
Failure to pass the comprehensive exam after two attempts will result in dismissal from the graduate program.
4.
Final Examination and Dissertation Defense a.
Administered upon completion of the dissertation research in the form of a seminar presentation, defense and oral examination b.
The examination and dissertation committee will consist of faculty within the graduate program with expertise in the various programmatic disciplines as well as an external member representing the UHM academic community at large c.
Committee evaluation is based on the following criteria: i.
Student’s proficiency in the area of specialization within the field of Tropical Medicine as commensurate with the expectations of the specific degree ii.
Whether or not the student has produced a body of work which is on par with program expectations for the specific degree iii.
Whether or not the student has effectively communicated and defended this body of work d.
A majority of the committee must vote to pass the student in order for student to pass the exam. e.
The exam may be repeated once. f.
Failure to pass the final examination after two attempts will result in dismissal from the graduate program.
Required and Recommended Courses
The required and/or recommended courses are divided into three groups.
GROUP I - Core Courses: All students are required to have a background of undergraduate courses in medical microbiology, organic chemistry and biochemistry, physics, and mathematics. An introductory course in Immunology (e.g. MICR 461) will be required of students who do not have an adequate background in immunology.
All students are required to take:
TRMD 604
TRMD 605
TRMD 606
CMB 621
CMB 622
CMB 626 or
MICR 614
Infectious Disease Micro I
Infectious Disease Micro II
Tropical Medicine Research Rotations
Molecular Biology of Cell I (MS and PhD)
Molecular Biology of Cell II (PhD only)
Research Ethics
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Revised July, 2008
TRMD 690 Tropical Medicine Seminar (each semester)
GROUP II - Tropical Medicine elective courses to be selected by the student and his/her graduate committee according to the student's interests and needs.
TRMD 607 Neurovirology
TRMD 609
TRMD 650
TRMD 652
Advances in Medical Immunology
Advanced Ecology of Infectious Diseases
Advanced Genetics & Evolution of Infectious
TRMD 653
TRMD 671
TRMD 672
TRMD 673
TRMD 695
Diseases
Bioinformatics for Infectious Diseases
Advanced Medical Parasitology
Advanced Medical Virology
Advanced Medical Bacteriology
Plan B Master’s Project
TRMD 699
TRMD 700
TRMD 705
TRMD 800
Directed Reading/Research
Thesis Research
Special Topics in Tropical Medicine
Dissertation Research
GROUP III - Courses available in related fields: Elective courses available in related fields of study include:
Asian Studies 600
Biochemistry 441
643
644
Cell & Molecular Biology
625
680
650
654
671
Entomology* 486
661
671
675
686
Asian Studies Seminar
Basic Biochemistry
Bioenergetics & Carbohydrates
Metabolic Biochemistry
Advanced Topics in Genetics
Molecular Genetics
Population Genetics
Genetics Seminar
Techniques in Genetics
Insect-Microbe Interactions
Medical and Veterinary Entomology
Insect Ecology
Biological Control of Pests
Insect Transmission of Plant Pathogens
*Plant & Environmental Protection Sciences
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Revised July, 2008
Geography 410
411
488
654
665
Interdisciplinary Studies
650
651L
Microbiology 461
463
470
490
625
630
632
655
661
680
681
685
Pharmacology 601
602
Public Health 655
656
658
661
663
664
666
Zoology 621
631
632
652
Human Role in Environmental Change
Human Dimensions of Global
Environmental Change
Geographic Information Systems
Seminar in Geography of S.E. Asia
Seminar in Geography of the Pacific
Principles of Applied Evolutionary
Ecology
Laboratory in Applied Evolutionary
Ecology
Immunology
Microbiology of Pathogens
Microbial Pathogenesis
Animal Virology
Advanced Immunology
Microbial Genome
Advanced Microbial Physiology
Advanced Virology
Bioinformatics & Comparative Genomics
Advances in Microbial Ecology
Host-Parasite Relationships
Molecular and Cellular Bacterial
Pathogenesis
General Pharmacology
Systematic Pharmacology
Biostatistics I
Biostatistics II
Computer Applications in Public Health
Epidemiological Study Design Critique
Principles of Epidemiology I
Principles of Epidemiology II
Seminar in Infectious Disease Control
Evolutionary Ecology
Biometry
Advanced Biometry
Population Biology
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Revised July, 2008
690 Conservation Biology
Tropical Medicine Graduate Program Requirements
Master’s Plan A (Thesis)
1) Preliminary Conference with graduate program chair


 appointment of interim advisor diagnostic evaluation with entire faculty
Complete relevant sections of Pre-Candidacy Progress Form I

Preliminary Conference

Transfer of credits (if applicable)

Identification and remediation plan for deficiencies (if applicable)
2) General (Qualifying) Examination
 second semester of residence
 written/oral exam with questions composed by advisory committee (3
3)




 members: advisor + 2 other T3M faculty) test general knowledge of biomedical sciences used to evaluate, advise on course of study to correct weaknesses may be repeated once pass: advancement to candidacy
Completion and submission of Pre-Candidacy Progress Form I to
Graduate Division
Coursework requirements

30 credit hours

18 hrs approved course work excluding 699 and thesis 700
 at least 12 hrs in courses numbered 600-798
 participation in TM690, Journal Club (TM699-1 cr) every semester
 registration in thesis 700 during last semester; at least 9 cr. hrs of thesis 700
4)
5)
Master’s Thesis Committee

Selection of permanent advisor by end of first year (chair of thesis committee)

Appointment of two other members of T3M faculty to committee
Thesis proposal

Submission of research topic and thesis proposal to committee by end of

 third semester
− Thesis proposal should be presented as a departmental seminar
Approval of thesis topic by committee
Obtain certification, approvals and guidance as needed:

Committee on Human Studies www.hawaii.edu/irb/ ; 539-3955

Environmental Health & Safety Office www.hawaii.edu/ehso/ ; 956-8660
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Revised July, 2008
6)



Institutional Animal Care and Use Committee www.hawaii.edu/ansc/IACUC/ ; 956-4446
Advancement to thesis stage
Submission of Advance to Candidacy Form II to Graduate Division (must be submitted prior to registering for Thesis 700)
Final Examination

Research seminar and oral examination covering thesis research and
7)
 related areas
Conducted by thesis committee; open to all graduate faculty
Judgement of Thesis

Evaluation of final oral exam and written thesis by thesis committee

Submission of Master’s Thesis Evaluation Form III to Graduate Division
Master’s Plan B (Non-thesis)
1)
2)
3)
Preliminary Conference with graduate program chair
 appointment of interim advisor
 diagnostic evaluation with entire faculty

Complete relevant sections of Pre-Candidacy Progress Form I

Preliminary Conference

Transfer of credits (if applicable)

Identification and remediation plan for deficiencies (if applicable)
General (Qualifying) Examination
 second semester of residence
 questions composed by advisory committee
 test general knowledge of biomedical sciences
 used to evaluate, advise on course of study to correct weaknesses
 may be repeated once
 pass: advancement to candidacy

Completion and internal filing of Pre-Candidacy Progress Form I
Coursework requirements

30 credit hours

18 hrs approved course work excluding 699 and thesis 700
 at least 18 hrs in courses numbered 600-798
 participation in seminar (TM690), Journal Club (TM699-1 cr) every
4)
5)
 semester at least 1 semester 699 research but no more than 9 cr of TM699
Master’s Committee
 permanent advisor; selected by end of first year
 two other members of T3M faculty
Study Program and Research Project proposal
 meet with committee to decide on study program before end of second semester
 additional courses
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Revised July, 2008
6)

 research project proposal
Obtain certification, approvals and guidance as needed:

Committee on Human Studies www.hawaii.edu/irb/ ; 539-3955

Environmental Health & Safety Office www.hawaii.edu/ehso/ ; 956-8660

Institutional Animal Care and Use Committee
 www.hawaii.edu/ansc/IACUC/ ; 956-4446
Completion and internal filing of modified Advance to Candidacy Form
II
Final examination

Comprehensive written and oral examination; demonstrate basic knowledge of the various fields encompassed by Tropical Medicine


To be conducted by candidate’s advisory committee
To be given at least three weeks before the end of the term in which the degree is conferred


Presentation of research seminar and written paper covering research project
Completion and internal filing of modified Progress Report Form III
Doctor of Philosophy
1) Preliminary Conference with graduate program chair


 appointment of interim advisor remedy all undergraduate deficiencies completion of relevant sections of Pre-Candidacy Progress Form I
2) General (Qualifying) Examination
 end of second semester of residence
 written exam, approx. 3-4 hours covering tropical medicine & medical microbiology, molecular and cell biology
 questions composed by examination committee appointed by graduate program chair; should be more detailed, challenging than MS general exam


 determine whether to encourage student to proceed to Ph.D. used to evaluate, advise on course of study to correct weaknesses pass: advancement to candidacy, submission of Pre-Candidacy Progress
3)
Form I to Graduate Division
Coursework requirements

No specific course credit requirements except that candidates who have not had equivalent courses should take the core courses: TRMD 605 and
606, and CMB 621 and 622 in order to pass the qualifying examination and a Research Ethics course
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Revised July, 2008
4)
5)
6)
7)
8)


Candidates will be required to enroll in courses which, in the opinion of their advisors, are essential for a comprehensive background in Tropical
Medicine and to prepare them for a research career
Candidates must gain teaching experience by assisting in one course for two or more semesters
Doctoral Committee

4 members of graduate faculty representing various infectious disease


 subdisciplines, and
1 outside member: one faculty from another field of study and from outside department’s graduate faculty selected after candidate passes general exam & admitted to candidacy meeting of student with doctoral committee at least once per semester to assess progress
Dissertation
 independent research, original contribution to Tropical Medicine
 preparation, approval, etc. to follow Graduate Division guidelines
 approval of research topic by committee before end of third semester
Comprehensive Examination
 preparation and defense of a written research proposal in grant proposal format

 conducted by student’s doctoral committee tests broad knowledge and basic understanding of Tropical Medicine and chosen minor fields; also evaluates ability to use knowledge to develop a


 research plan and solve problems in a logical manner pass: advancement to candidacy for Ph.D. degree submission of Advance to Candidacy Form II to Graduate Division
Helpful resources for preparation of research proposal
NIH: http://deainfo.nci.nih.gov/extra/extdocs/gntapp.htm
NIH: http://www.niaid.nih.gov/ncn/grants/app/default.htm
NIH: http://www2.hawaii.edu/~sandrac/TRMD_Comprehensive_Exam_Propos al_Guidelines.doc
https://laulima.hawaii.edu/access/content/user/sandrac/TRMD%2
0Comprehensive%20Exam%20Proposal%20Guidelines.doc
NSF: http://www.cs.cmu.edu/~sfinger/advice/advice.html
General: http://www.learnerassociates.net/proposal/
Final Examination
 defense of the research dissertation, related subjects
 conducted by student’s doctoral committee
 taken at least 6 wks before end of semester in which degree granted
Judgement of Dissertation
 review of written dissertation by doctoral committee
 submission of Dissertation Evaluation Form III to Graduate Division
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Revised July, 2008
MS/PhD Student Progress Forms:
I. Preliminary Conference, General/Qualifying Exam, Pre-Candidacy Progress
II. Formation of Master’s Committee/Dissertation Committee, Approval of
Thesis/Dissertation Topic, Results of Comprehensive Exam (PhD only),
Advancement to Candidacy
III. Final Oral Examination/Defense of Thesis/Dissertation, Judgment of
Thesis/Dissertation
Academic Policies
Undergraduate and graduate students in the School of Medicine must adhere to the academic policies of UH Manoa. A summary description of these policies may be found in the online catalog: http://www.catalog.hawaii.edu/about-uh/campuspolicies/campus-policies.htm
.
Tropical Medicine and Medical Microbiology (TRMD) Course Descriptions
TRMD 499 Reading and Research (V) Directed reading and research in laboratory; diagnostic aspects of bacterial, parasitic, and viral infections. Pre: consent.
TRMD 500 Master’s Plan B/C Studies (1) Enrollment for degree completion. Pre: master’s Plan B or C candidate and consent.
TRMD 512 Unit II Concurrent Elective (1) Elective course for first-year medical students. CR/NC only. Pre: BIOM 551 and consent.
TRMD 513 Unit III Concurrent Elective (1) Elective course for first-year medical students. CR/NC only. Pre: BIOM 551 and consent.
TRMD 514 Unit IV Concurrent Elective (1) Elective course for second-year medical students. CR/NC only. Pre: BIOM 551 and consent.
TRMD 515 Unit V Concurrent Elective (1) Elective course for second-year medical students. CR/NC only. Pre: BIOM 551 and consent.
TRMD 525 Unit V Block Elective (1) Required elective for second-year medical students; objectives to be determined by contract. One option is a review of USMLE step. CR/NC only. Pre: BIOM 551.
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Revised July, 2008
TRMD 545 Topics in Tropical Medicine (V) Elective for fourth-year medical students for advanced study of selected topics within the field of tropical medicine and medical microbiology. Pre: fourth-year standing.
medical students; (B) infectious diseases; (C) parasitology; (D) epidemiology; (E) immunology. MD majors only. CR/NC only. Pre: MDED 554 or consent. Fall only.
Research elective for medical students; (B) infectious diseases; (C) parasitology;
(D) epidemiology; (E) immunology. MD majors only. CR/NC only. Pre: MDED
554 or consent. Fall only.
TRMD 604 Infectious Disease Micro I (3) Pathogenesis, epidemiology, immunobiology of infectious diseases caused by bacterial and fungal pathogens; principles of hostpathogen interactions; public health aspects of infectious diseases. Repeatable one time.
A-F only. Pre: MICR 351 or consent. (Cross-listed as PH 665)
TRMD 605 Infectious Disease Micro II (3) Pathogenesis, epidemiology, immunobiology of infectious diseases caused by viruses and parasites; principles of host-pathogen interactions; public health aspects of infectious diseases. Repeatable one time. A-F only. Pre: MICR 351 and TRMD 604; or consent. (Cross-listed as PH 667)
use of equipment and procedures in infectious disease and immunology research; introduction to research in tropical medicine. Repeatable unlimited times. Pre: 604 (or concurrent), or consent. (Cross-listed as PH 668)
TRMD 607 Neurovirology (1) Seminar course on neuroinvasive viruses giving basics of viruses causing nervous system diseases and discussing recent advances in the research field of neurovirology. Pre: MICR 351 or equivalent; or consent. Fall only.
TRMD 609 Advances In Medical Immunology (3) Presentations/discussions of current literature concerning recent advances in immunology relevant to disease and to disease processes. Pre: consent. (Alt. years: spring)
Applications of population biology, pathogen/host life history, and population genetics to infectious disease epidemiology, including micro- and macroparasites, and implications to disease control and prevention of strategies.
18

Revised July, 2008
A-F only. Pre: 604 (or concurrent) and 605 (or concurrent), or consent. (Alt. years: spring)
evolutionary perspective to examine the interactive responses between infectious agents and the immune system. Topics will include natural selection, life history evolution, population genetics of pathogens and hosts, and anti-microbial resistance. A-F only. Pre: 604 (or concurrent) and 605 (or concurrent), or consent.
(Alt. years: spring)
TRMD 653 Bioinformatics for Infectious Diseases (1) Combined lecture/computer lab course on bioinformatic tools used in genomics, including sequence assembly, search algorithms, alignment, phylogenetics, and molecular evolution/epidemiology. Focus will be on infectious disease examples. Open to nonmajors. A-F only. Pre: 604 (or concurrent) and 605 (or concurrent) or consent. Fall only.
TRMD 671 Advanced Medical Parasitology (2) Consideration of ultrastructure, physiology, biochemistry, in-vitro cultivation and host-parasite relationship of parasites of medical importance. A-F only. Pre: consent. (Alt. years: fall)
TRMD 672 Advanced Medical Virology (2) In-depth study of the major groups of viruses pathogenic for human; virus replication, host range, pathogenesis, immunology, and epidemiology. Pre: 605 or equivalent, or consent. (Alt. years: fall)
TRMD 673 Advanced Medical Bacteriology (2) Role of bacteria in infectious diseases, with emphasis on clinical aspects and identification of etiological agents. Pre: 605 or equivalent, or consent.
TRMD 690 Seminar in Tropical Medicine and Public Health (1) Weekly discussion and reports on current advances in tropical medicine and public health. (Cross-listed as
PH 755)
TRMD 695 Plan B Master’s Project (3) Independent study for students working on a
Plan B Master’s project. A grade of Satisfactory (S) is assigned when the project is satisfactorily completed. Pre: graduate standing in TRMD.
TRMD 699 Directed Research (V) Directed research in medical microbiology
(bacteriology, parasitology, virology). Pre: consent.
TRMD 700 Thesis Research (V) Research for master’s thesis. Approval of department faculty required.
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Revised July, 2008
TRMD 705 Special Topics in Tropical Medicine (1) Advanced instruction in frontiers of tropical medicine and public health. Repeatable. (Cross-listed as PH 756)
TRMD 800 Dissertation Research (V) Research for doctoral thesis. Approval of department faculty is required.
Useful Links
Asia-Pacific Institute of Tropical Medicine & Infectious Diseases: http://apitmid.hawaii.edu/
Graduate Division: http://www.hawaii.edu/graduate/
Graduate Division forms and manuals: http://www.hawaii.edu/graduate/download/list.htm#master
UH Manoa online catalog: http://www.catalog.hawaii.edu/
Get a UH username: https://sunsys.its.hawaii.edu/acctmgmt/
Course Registration: http://www.hawaii.edu/myuh/manoa/
International Student Services: http://www.hawaii.edu/issmanoa/
Graduate Student Organization: http://gso.hawaii.edu/
JABSOM: http://jabsom.hawaii.edu/jabsom/
JABSOM Health Sciences library: http://www.hawaii.edu/hslib
JABSOM 2004-2005 Bulletin (catalog): http://hawaiimed.hawaii.edu/medical_ed/0405bltn.pdf
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651 Ilalo St., Honolulu, HI 96813 http://jabsom.hawaii.edu/jabsom/about/map.php
Revised July, 2008
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Revised July, 2008
23

School), acollier@hawaii.edu
GRADUATE FACULTY IN THE DEPARTMENT OF TROPICAL MEDICINE
Name
Shannon N. Bennett, Ph.D. (Univ. of British
Colombia, Canada), sbennett@hawaii.edu
Sandra Perreira Chang, Ph.D. (Oregon Health
Sciences University), sandrac@hawaii.edu
Abbie Collier, Ph.D. (Univ. of Auckland Medical
Rank and Department
Assistant Professor
Tropical Medicine
Professor
Tropical Medicine
Assistant Professor
Pharmacology
Arwind R. Diwan, Ph.D. (Univ. of London, School of Hygiene & Tropical Medicine), arwind@hawaii.edu
Professor
Tropical Medicine (retired)
Eiichi Furusawa, M.D., Ph.D. (Osaka, Japan), 956-
3168
Professor
Pharmacology (retired)
William L. Gosnell, Ph.D. (Univ. of Hawaii), gosnell@hawaii.edu
Duane Gubler, ScD. (Johns Hopkins Bloomberg
School of Public Health) dgubler@hawaii.edu
Junior Researcher
Tropical Medicine
Professor & Chairperson
Tropical Medicine
George S.N. Hui, Ph.D. (Univ. of Hawaii), ghui@hawaii.edu
Kenton J. Kramer, Ph.D. (Univ. of Hawaii),
Kramer@hawaii.edu
Researcher
Tropical Medicine
Associate Professor
Tropical Medicine
Research Interests
Dengue virus molecular epidemiology and evolution, parasitic nematodes of marine fishes
Malaria immunity & vaccine development, biomarkers of severe dengue virus infection, immunology of latent M. tuberculosis infection, molecular biology of M. tuberculosis drug resistance
Pharmacokinetics, pharmacodynamics, molecular studies of drug metabolism, reproductive pharmacology and teratogenesis
Chemotherapy of viral diseases; viral vaccines; oncogenic viruses; slow virus infections; hepatitis; AIDS
Pharmacology of natural products, viral and cancer chemotherapy
Host parasite interactions, malaria, TB immunology
Vector-borne diseases including dengue and West Nile virus
Immunology of parasitic infections, immunomodulators for parasite vaccines, cell biology of protozoan parasites
Parasitic diseases of the Pacific; amebic infections in Hawaii;
Community Medicine Program for Health Promotion; epidemiologic/immunologic methods of malaria control
Infectious disease epidemiology F. DeWolfe Miller, Ph.D. (Univ. of Michigan), dewolfe@hawaii.edu
Vivek R. Nerurkar, Ph.D. (Univ. of Bombay,
India), nerurkar@hawaii.edu
Professor
Tropical Medicine
Professor
Tropical Medicine
Pathogenesis of infectious diseases; cellular & molecular mechanisms underlying microbe-host interaction.
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Revised July, 2008
Leslie Q. Tam, Ph.D. (Univ. of Hawaii), taml@hawaii.edu
Diane Wallace Taylor, Ph.D. (University of
Hawaii), taylordw@georgetown.edu
Professor, Tropical Medicine
(emeritus)
Adjunct Professor
Tropical Medicine
P. falciparum merozoite surface & rhoptry antigens; bacterial cell wall adjuvants
Maternal and neonatal immunity to malaria
Saguna Verma, Ph.D. (Devi Ahilya University,
India), saguna@pbrc.hawaii.edu
Bruce Wilcox, Ph.D. (Univ. of California San
Diego), bwilcox@hawaii.edu
Karen M. Yamaga, Ph.D. (Univ. of Hawaii), yamaga@hawaii.edu
Assistant Researcher
Tropical Medicine
Diagnosis of Kawasaki syndrome, effect of selenium deficiency on RNA virus mutations,
Professor
Tropical Medicine
Population biology; human-ecosystem interaction; ecological and human health linkages
Professor
Tropical Medicine
Immunological mechanisms of diseases; pathogenesis of rheumatoid arthritis
COOPERATING GRADUATE FACULTY
John Berestecky, Ph.D. (Univ. of Hawaii), johnb@hawaii.edu
Mona Bomgaars, MD mbomgaars@hawaii.rr.com
Associate Professor
Kapiolani Community
College
Hansen’s Disease Branch
State Dept. of Health
(retired)
Frederick M. Burkle, Jr., M.D., M.P.H. (University of Vermont College of Medicine, Univ. California
Berkeley)
Clinical Professor, Dept. of
Surgery
Adjunct Tropical Medicine
Guliz Erdem, M.D. (Hacettepe University Faculty of Medicine, Turkey), guliz@hawaii.edu
Assistant Professor
Dept. of Pediatrics
Allison Imrie, Ph.D. (Univ. of New South Wales,
Sydney, Australia), imrie@pbrc.hawaii.edu
Epidemiology & pathogenesis of Campylobacter enteritis, immune response of Hawaiian Green Turtles, identification of plant pathogens using monoclonal antibodies
Hansen’s disease and international health
International emergency and disaster medicine
Assistant Professor, Dept. of
Public Health Sciences
Molecular epidemiology of group A streptococcal & staphylococcal infections; complications of strep infections like acute rheumatic fever.
HIV-1and dengue virus pathogenesis; evaluation of antiretroviral drugs on host metabolism; effects of HIV-1 infection on the neurological system
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Revised July, 2008
Claude Jourdan-Le Saux, Ph.D. (Universite d’Aix-
Marseille, France), claude@pbrc.hawaii.edu
Jerome H. Kim, M.D. (Yale University School of
Medicine) jkim@hivresearch.org
(on leave)
Yuanan (Ron) Lu, Ph.D. (Univ. of Hawaii), ylu@pbrc.hawaii.edu
Assistant Researcher, Dept. of Cell and Molecular
Biology
Clinical Associate Professor,
Dept. of Medicine
Marian E. Melish, M.D. (Univ. of Rochester), marianm@kapiolani.org
Frederic Mercier, Ph.D. (University of
Montpellier II, France) fmercier@hawaii.edu
Francis D. Pien, M.D. (Univ. of Chicago)
Silvia Ratto Kim, Ph.D. (University of Genoa,
Italy) silviak@hawaii.edu
City)
(on leave)
Peru), rrudoy@hawaii.edu
Richard Yanagihara, M.D. (Univ. of Cincinnati), yanagiha@pbrc.hawaii.edu
Bruce Shiramizu, M.D. (Univ. of Utah, Salt Lake
Raul C. Rudoy, M.D. (Cayetano Heredia Univ.,
Elizabeth K. Tam, M.D. (Univ. of California, San
Francisco), tameliza@hawaii.edu
Human genetic disorders, asthma, interleukins and pulmonary function.
HIV viral neutralization, Cytokine gene therapy in HIV specific
T-cells, Molecular mechanisms of apoptosis in HIV infection,
HTLV-I and -II mechanisms of Rex protein function, tuberculosis
(clinical syndromes)
Professor, Dept. of Public
Health Sciences
Gene therapy for HIV-1 infection, gene transfer approaches for neuroAIDS, immunodiagnosis of herpesvirus infection of green turtles, aquaculture virology
Professor, Dept. of Pediatrics Staphylococcal infection and toxins; clinical infectious disease;
Kawasaki's syndrome
Assistant Researcher,
Tropical Medicine
Neurovirology, neurogenesis and neural stem cellsBrain anatomy and cytoarchitecture
Associate Professor
Dept. of Medicine
Clinical microbiology with special reference to diagnostic bacteriology & parasitology; evaluation of antimicrobial agents
Associate Researcher, Hawaii
AIDS Clinical Research
Program
Basic immunology of HIV-1 infection
Professor, Depts. of Medicine and Pediatrics
Pathobiology of HIV-associated disorders
Professor, Dept. of Pediatrics Clinical aspects of viral and bacterial disease in pediatrics
Professor
Dept. of Medicine
Genetic & environmental determinants of respiratory disease
(eg. asthma); volcanic air pollution & modulators of respiratory health;genetics & tobacco smoke in lung disease.
Professor, Dept. of Pediatrics Transdisciplinary investigations of emerging & re-emerging infectious diseases; use of infectious agents to trace ancient & recent movements of human populations.
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Revised July, 2008
Qigui Yu, M.D., PhD (Wuannan Medical School,
Fourth Military Medical University)
Assistant Professor, Dept. of
Medicine
HIV-1 Vaccines, HIV-1 specific CTL memory responses
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