2015-16 RESEARCH ELECTIVES – Faculty Participants Dr. Ellen Andrews (Anatomy) Plasticity & functional recovery after CNS injury Dr. Bjork (Biochemistry) Developmental and molecular characterization of the transcription factor Prdm16 during mouse embryonic craniofacial development. Identification of novel gene mutations that affect craniofacial development. Dr. Nalini Chandar (Biochemistry) The p53 gene in cancer Dr. Mae Ciancio (Biomedical Sciences) The role of heat shock protein 70 in preventing gastrointestinal and urogenital pathogens. Dr. Kirk Dineley (Pharmacology) and Dr. Latha Malaiyandi (Anatomy) Metal biology in steroidogenic human adrenocortical carcinoma cells Dr. Joshua Edwards (Pharmacology) The effects of metal exposure on insulin release and other pancreatic islet functions Dr. Chris Evans (PT), Dr. Ciancio (BMS) Dr. LePard (Physiology) Exercise prevents diet-induced obesity: the role of the gut flora and heat shock protein 70 Dr. Michael Fay (Pharmacology) Expression and function of the putative tumor suppressor gene product Cullin-5 in cancer Michele Fornaro, Ph.D. (Anatomy) Neuronal plasticity in the PNS during development and adulthood. Dr. Joshua Gasiorowski (Biomedical Sciences) Gene therapy enhancements and biomaterial development for tissue engineering projects www.midwestern.edu/joshuagasiorowski.html Annette Gilchrist (Pharmaceutical Sciences) Assessing dual CCR1/CCR5 antagonists for use in multiple myeloma. Dr. Joanna Goral (Anatomy) Effects of ethanol exposure on immune response Dr. David Green (Anatomy) Comparative anatomy and functional morphology of the primate shoulder Dr. Jacalyn Green (Biochemistry) Folic acid metabolism in Escherichia coli Role of the abg operon in wildtype and pathogenic bacteria Folate transport protein expression in human tissue samples Dr. Anil Gulati (Pharmaceutical Sciences) Resuscitation of hypovolemic shock Endothelin, stroke and neurodegenerative diseases Melphine Harriott (Microbiology and Immunology) Development of a chronic in vivo wound model to evaluate polymicrobial biofilms Dr. Kyle K. Henderson (Physiology) Thyroid hormone deiodinases in the pathogenesis and treatment for heart failure Cranial OMT (entrainment, proof-of-principle: mechanical, surgical, video) Lymphatic OMT and cranial O2 saturation Dr. Sandra Inouye (Anatomy) Growth, function, and evolution of the human and non-human primate skeleton; including comparative anatomical orthopaedic studies Dr Medha Joshi (Pharmaceutical Sciences) Nanoparticles for targeted delivery of pharmaceuticals Dr. Phillip Kopf (Pharmacology) Pharmacology of steroidogenic eicosanoids and endocrine disruptors Vascular activity of endocrine disruptors in resistance vessels Dr. Kolla Kristjansdottir (Biomedical Sciences) Identification of proteins important for the high-risk form of Neuroblastoma, a pediatric cancer Dr. Sophie La Salle (Biochemistry) Meiosis and fertility: characterizing the role of new genes during germ cell development Dr. Kathy LePard (Physiology) Effect of diabetes on pancreatic morphology and gastrointestinal function Dr. Erin Leslie (Anatomy) Growth, function, and evolution of the human and non-human primate skeleton; including comparative anatomical studies using two-dimensional radiographic images Dr. Sean Lynch (Biochemistry) Thiocyanate and myeloperoxidase involvement in the oxidation of human high-density lipoprotein Dr. Latha Malaiyandi (Anatomy) and Kirk Dineley (Pharmacology) Metal biology in steroidogenic human adrenocortical carcinoma cells Dr. Alejandro Mayer (Pharmacology) Pharmacology and toxicology of marine natural products Dr. Paul McCulloch (Physiology) Brainstem cardiorespiratory control mechanisms Dr. Rafael Mejía-Alvarez (Physiology) Biophysical properties of SR Cl- channels from neonate heart Postnatal development of excitation-contraction coupling in heart Dr. Ashlesh Murthy (Pathology) Mechanisms of protective immunity and immunopathogenesis following bacterial mucosal infections Vaccine development against mucosal bacterial pathogens Dr. Glenn Nordehn (Clinical Medicine) Human heart sound analysis and classification - Artificial intelligence in auscultation systems Dr. Jacob Peuler (Pharmacology) Effects of drugs on contractile properties of smooth muscle Dr. Balbina Plotkin (Microbiology and Immunology) Effect of stress hormones on microbial pathogenesis and antibiotic resistance Dr. Maura Porta (Physiology) Electrophysiology of the heart: modulation of ryanodine receptors by endogenous and exogenous agents. Dr. Walt Prozialeck (Pharmacology) Cadmium toxicity Dr. Kyle Ramsey (Microbiology and Immunology) Plasmid-mediate virulence and immunity in chlamydial infections “Genomic variation and its effects on immunity and virulence in chlamydial infection” Dr. Ira Sigar (Microbiology and Immunology) Comparison of in vitro Chlamydial infection under aerobic and anaerobic conditions Graviola extract efficacy on oral microbes Dr. Michelle Singleton (Anatomy) Investigation of primate cranial evolution and development using 3D morphometric analysis and computer simulation Dr. Michelle Swanson-Mungerson (Microbiology and Immunology) Effects of Epstein-Barr virus latency on B cell function and tumor development Dr. Vaibhav Tiwari (Department of Microbiology and Immunology) Viral entry into the cell Dr. Lon J. Van Winkle (Biochemistry) Amino acid transport regulation of preimplantation embryo development, implantation and embryonic stem cell differentiation. Dr. Natarajan Venkatesan (Venkat) (Pharmaceutical Sciences) Formulation of poorly soluble/absorbable drugs for improved bioavailability. Dr. Susan Viselli (Biochemistry) Androgens and environmental anti-androgens in the development of autoimmune diseases Dr. Michael Volin (Microbiology and Immunology) Inflammatory mediators in the pathogenesis of anterior uveitis and rheumatoid arthritis Dr. Robin Zavod (Pharmaceutical Sciences) Benign by design drug discovery methods Practical application of medicinal chemistry Pharmacy student self-efficacy (confidence) evaluation Pharmaceutical and personal care products in the environment Rev 2/15