St. Vincent’s University Hospital Department of Clinical Neurology Neurology Handbook Professor Michael Hutchinson Professor. Niall Tubridy Dr. Christopher McGuigan Dr. Sean O’Riordan The Students Spr 2 Bleep 260 xxxxxxx SpR 1 Bleep 117 Intern Bleep 246 SHO Bleep 485 2010 Neurology Undergraduate Teaching and Learning PART 1 Log on to ucd.ie for access to video on how to do a neurological examination Page PART 1 Appendices: 3-7 1. Examination of the nervous system 2. Small group information 8 3. Aid to the examination of motor function 9 4. Student rota for attendance 10 5. Review of Progress and end-of-rotation grades and marks 11 6. Marking scheme and Performance Descriptors 12 7. Example of scenario sign-up 13 8. Summary of clinical skills to be acquired 14 9. Weekly neurology timetable 15 10. Introductions to web-based clinical scenarios 2 16-19 Appendix 1 EXAMINATION OF THE NERVOUS SYSTEM INTRODUCTION The following guidance on examination of the nervous system. The objective is to inform teachers and students of the core methods for performing a basic examination of the nervous system. These should enable the student to detect and record the physical signs of common and important disorders of the nervous system. The student should understand the principle behind each test and what it is designed to detect. It may be necessary to modify and extend the basic examination to deal with individual clinical problems. In practice individual neurologists use a wide range of techniques for examining the nervous system. ORDER OF EXAMINATION The conventional order for describing the examination is: General appearance Stance and gait Higher functions Cranial nerves Motor system Sensory system In individual cases it may be better to focus the examination first on the affected part. It is often convenient to examine stance and gait before examining the patient on the couch. Stance and Gait Ask the patient to rise from a chair without using their hands and stand still with their feet together. Ask the patient to stand on their toes and then their heels, steadying the patient by gently holding their hands. Watch the patient walk across the room turn round and come back to you looking for: Whether the gait is normal or abnormal Painful gait Unsteadiness Foot drop Hemiparetic gait Spastic gait Stooped posture, slowness and loss of arm swinging Others: marche á petit pas, Waddling gait If, and only if, the patient is steady, test heel-toe walking HIGHER FUNCTIONS Ask if the patient is left or right handed. Establish if the patient is alert and able to give a clear history. If relevant, test for dysphasia, examine the mental state and perform the Mini Mental State Examination. CRANIAL NERVES Cranial Nerve I – Olfactory nerve: (need containers with coffee or peppermint) Ask if the patient can appreciate taste and smell. Further testing is not necessary unless the patient complains of abnormal taste or smell or there is a special reason to test olfaction. If testing is needed check that the airway is clear and test each nostril with a basic smell, such as peppermint or coffee. Cranial Nerve II - Optic nerve: (need 3- or 6-metre Snellen chart and pinhole) 3 Visual acuity Ask patient if they are aware of reduced vision in either eye. Test visual acuity wearing distance glasses, if worn, in each eye separately with Snellen chart. Use 3-metre chart at 3 metres or 6-metre chart at 6 metres, which produce equivalent results. If visual acuity less than 6/6 use a pinhole. Record visual acuity right (VAR) X/60 with/without aid of pinhole/glasses and visual acuity left (VAL) Y/60 with/without aid of pinhole/glasses. Visual fields (need 7 mm red pin) Ask patient if they are aware of a field defect in either eye. Establish that the small red pin target (7 mm) is visible with each eye. Test extent of visual field by testing each eye from each quadrant asking the patient to state as soon as they can see the pinhead at all (regardless of colour). Fundoscopy (need ophthalmoscope and darkened room) Use the ophthalmoscope to examine the fundus of each eye separately with the other eye fixating in the distance. Hold ophthalmoscope correctly (examining right eye with ophthalmoscope in right hand and using right eye and examining left eye with ophthalmoscope in left hand and using left eye unless good reason not to be able to do so). The index finger should be on the focussing wheel. Assess red reflex for presence of media opacities. View fundus at an appropriate distance from the patient and focus the ophthalmoscope. Cranial nerves III, IV and VI – Oculomotor, trochlear and abducent nerves: (need torch) Inspect for ptosis (drooping eyelid), pupil size, strabismus (squint), proptosis. Test for pupil light reaction and accommodation in each eye separately. Look for nystagmus within a 30o range. Cranial Nerve V – Trigeminal Nerve: (need cotton wool, pin or neurotip, tendon hammer) Ask if the patient has any numbness or altered sensation in the face. Test light touch in each of the three divisions. If an abnormality is found determine its extent with a pin. Test the corneal reflex with a wisp of cotton wool, touching cornea not sclera. Avoid touching eyelashes and eliciting a ‘threat’ reaction. Cranial Nerve VII – Facial nerve: Test frontalis – wrinkle the forehead. Test orbicularis oculi – burying of the eyelashes should be looked for. Test orbicularis oris – the patient is asked to show their teeth. Ask about taste. Cranial Nerve VIII – Auditory and vestibular nerves: (need 256 or 512 Hz tuning fork and auroscope) Ask if the patient has a problem with their hearing. Test by first speaking and then whispering numbers at three feet with masking of the non-tested ear using a piece of paper held over the non-test ear and scratching it when speaking or whispering. If hearing loss is reported (history or examination) first perform the Weber test. Strike a 256 or 512 Hz tuning fork on your knee and apply it firmly to the patient’s forehead. Ask whether they hear it more on one side or the other or equally. The tuning fork lateralises to the side of greater conductive loss or the side with the better cochlea in sensori-neural hearing loss. Then perform the Rinne test with the same tuning fork. First apply the tuning fork firmly to the mastoid process and then hold it in front of the external auditory meatus. Ask the patient which is louder. Patients with normal middle ear function hear better by air than bone conduction. Examine the external auditory meatus and tympanic membrane with an auroscope. Examination of the vestibular nerve includes testing stance and gait, see below, and for nystagmus, see above. 4 Cranial Nerve IX – Glossopharyngeal nerve: Not necessary. Cranial Nerve X – Vagus nerve: (need torch, tongue depressor) Ask about difficulty swallowing. Test articulation (for dysarthria), coughing and elevation of the soft palate on saying Aah! If any of these are abnormal test gag reflex by touching the posterior pharyngeal wall on each side with an orange stick and comparing the responses. Cranial Nerve XI – Spinal- Accessory nerve: Test sternocleidomastoid examined with the head tilted to the opposite side and with resistance against the tester’s hand placed at the angle of the jaw. The muscle belly is visible and may be palpated. Neck flexion is a useful screening test but not sufficient. Test trapezius by asking the patient to shrug the shoulders and palpating the muscles, with shoulders elevated. Cranial Nerve XII – Hypoglossal nerve: (need torch) Observe the tongue rest in the floor of the mouth for wasting and fasciculation. Observe protrusion of the tongue and note deviation. Observe tongue movements for slowness seen in UMN lesions. MOTOR SYSTEM UPPER LIMBS The patient should be seated with the upper limbs exposed to show the shoulders and their arms outstretched and the hands supinated and then pronated. Observation Look for: Any obvious abnormality Skin changes (including scars, ulcers, café au lait patches, neurofibromas) Deformity (including joint swelling, asymmetry) Wasting (especially first dorsal interosseous, abductor pollicis brevis, shoulder muscles) Involuntary movements (fasciculation, tremor, dystonia, chorea, myoclonus). Tone Test wrist pronation-supination for a pronator catch in spasticity. Test for rigidity by slow rotation of the stabilised wrist. 5 Power Test the following muscle groups in order, comparing each side as you progress. Each movement should be tested in isolation: thus to test elbow flexion you must fix the upper arm with your free hand. Movement Shoulder abduction Elbow flexion Elbow extension Wrist extension Extensor digitorum communis Grip First dorsal interosseous Abductor pollicis brevis Starting position 900 abduction 900 flexion 900 flexion Full extension Full extension Note Apply pressure over PIP joints Open patient’s grip Test in isolation in a plane at right angles to the palm Full abduction Full abduction Reflexes Test biceps, supinator (= brachioradialis) and triceps. If the reflexes are absent use reinforcement. Co-ordination Ask the patient to touch the tip of your stationary finger, at full stretch, accurately and gently, and then the tip of their own nose with first one and then the other index finger. Bradykinesia Test fine finger movements to detect bradykinesia if parkinsonism is suspected. LOWER LIMB Then ask the patient to recline on a couch undressed to shorts Observation Look for: Any obvious abnormality Skin changes (including hair loss, ulcers) Deformity (including joint swelling, pes cavus, claw toes) Wasting (especially quadriceps and tibialis anterior (when the tibia stands out like a keel) Involuntary movements (fasciculation, tremor). Tone Check that the patient does not have pain in their limbs. Roll the leg on the couch and then quickly flex the knee to detect a quadriceps catch (present in spasticity). Test for ankle clonus. 6 Power Test the following muscle groups in order, comparing each side as you progress: Movement Hip flexion Hip extension Knee flexion Knee extension Ankle dorsiflexion Ankle plantar flexion Extensor hallucis longus Starting position Max voluntary flexion Lying flat 900 flexion 900 flexion Full dorsiflexion Full plantar flexion Full dorsiflexion Note Knee straight Hand under knee Test for L5 root lesion or peripheral neuropathy Co-ordination Ask the patient to lift the heel high and then carefully place it on the knee of the other limb and run it down the shin once. This test is difficult to interpret if hip flexion is weak. Reflexes Examine the knee and ankle reflexes (with the joints at 900) and (with an orange stick) the plantar responses. If the reflexes are absent, use reinforcement. SENSATION Ask if the patient has noted altered sensation in any part of their body. If the answer is negative, show the patient what each of the following feel like with their eyes open and them check that they can appreciate them on the distal phalanx of the index finger and hallux with their eyes closed: Light touch with your finger tip Vibration with a 128 Hz tuning fork Joint position sense Pinprick with a neurotip or tooth pick with the patient’s eyes open asking whether they can feel that it is sharp and hurts like a pin. If the patient reports an abnormality map out its extent with light touch or pinprick testing or compare the two sides and draw it on a body chart. 7 Appendix 2 Small group information Your tutor is: Dr Niall Tubridy Email: n.tubridy@svuh.ie The sessions will take place at: Monday 2pm (Spr Bleep 117) Tuesday 2pm (Consultant- arrange in OPD) Wednesday 2pm (SHO- Bleep 485) Friday 12 noon (Intern Bleep 246) The venue will be: St. Vincent’s Ward, 3rd Floor If you have any problems contacting your associate tutor, then please contact Dr. Niall Tubridy. The students in your group are: Name E mail (a) (b) (c) (d) (e) (f) Physiotherapy and neurology nurse teaching at SVUH Your group may arrange to have one hour’s teaching during the 13-week rotation with a physiotherapist and neurology nurse specialist. Physiotherapy If your group is interested in arranging a physiotherapy teaching session, please contact the Clinical Lead of NeuroRehabiliation Neurology nursing Your neurology nurse specialists are Marguerite Duggan, Clinical MS Nurse Specialist. She can be contacted on Bleep 591 And Heather Kevlighan, Parkinson’s Nurse Specialist (contact on ext 4146) Neurophysiology You are encouraged to sign up for one day in the neurophysiology department. Please report to the Neurophysiology Reception, Ground Floor and ask for Dr. John McHugh. You will need to wear your white coat and ID badge. We suggest that you locate the department before your allocated day. Neuroradiology You are also encouraged to sign up for one half-day in the neuroimaging department. On your allocated day, please report to the Neuroimaging Reception, 3rd Floor. On call You are encouraged to sign up for one night on call. 8 Appendix 3 Aid to examination of motor function MOVEMENT MUSCLE UMN Shoulder Abd. deltoid Elbow Flex biceps C5/6 + musculo-cutaneous Brachio-radialis C6 + radial Elbow Ext. triceps + C7 + radial Radial Wrist Ext. ECRL + C6 Finger Ext. EDC + C7 (+) PIN Finger Flex FPL + FDP index C8 + AIN ++ ROOT REFLEX C5 axillary radial FDP ring + little Finger Abd. 1st DI ++ APB ++ NERVE ulnar T1 ulnar T1 median L1/2 femoral Hip Flex. iliopsoas Hip Add. adductors L2/3 Hip Ext. gluteus max. L5/S1 sciatic Knee Flex. hamstrings S1 sciatic Knee Ext. quadriceps Ankle dorsiflex. tib. ant. Ankle eversion + + L3/4 ++ ++ obturator femoral L4 deep peroneal peroneii L5/S1 sup.peroneal Ankle plantarflex. gastroc./soleus S1/S2 Big toe ext. EHL L5 ++ tibial deep peroneal 9 Appendix 4 Students must attend and contribute actively to ALL rounds and clinics during the Rotation. Students should present at least two cases at rounds in each rotation. The tutor in charge of the student rounds will award a mark based on these two presentations (or on the best two if more than two cases are presented). Tutors may take into account the complexity of the case presented. Tutors will award a mark for the student’s overall attendance and participation in all rounds in the Rotation. It is the student’s responsibility to ensure that the tutor is fully aware of their attendance and participation in rounds. Students should consider the following criteria carefully when preparing a presentation Tutors may refer to these criteria in awarding marks 1 Presentation skills including clarity, conciseness, and use of visual aids or handouts (relevant papers) 2 Description of clinical features 3 Use of relevant tests and investigations 4 Assessment of principal clinical problems and differential diagnosis 5 Development of management plan 6 Evaluation of associated problems (e.g. ethical or public health issues) 7 Use of clinical sciences and literature review to illustrate case 8 Handling of questions and discussion Marking scheme Excellent Good Competent Not competent Not done Date 9 – 10 7–8 5–6 1–4 0 Neurology case presentation Attendance and participation in ALL rounds during this Rotation OVERALL MARK /20 I have witnessed this student display a level of competence appropriate to their year Signed (Neurology): Name (Print) Date 10 Mark /10 Appendix 5 Academic Clinical and Professional Development Based on attendance, performance and participation in firm activities, courtesy to staff and patients, punctuality, acceptance of advice and feedback, confidentiality Review of Progress: Satisfactory Unsatisfactory (if so, why) Comment on strengths and areas for improvement * I have no concerns about this student's fitness to practise * I have the following concerns about this student's fitness to practise and I have referred this student to Student Advisor Consultant Name …………………………………..…… Signature ……..…………………………………………. Date ………………… End-of-rotation Review of Progress: Unsatisfactory (if so, why) Satisfactory Comment on strengths and areas for improvement * I have no concerns about this student's fitness to practise * I have the following concerns about this student's fitness to practise and I have referred this student to Student Adviser Using the Performance Descriptors given in section 9 of the Logbook, the consultants shall award the end-of-rotation grades and marks Neurology grade Neurology mark Excellent, good, competent, not competent (0 – 100) Consultant Name …………………………………..…… Signature ……..…………………………………………. 11 Date ………………… Appendix 6 MARKING SCHEME AND PERFORMANCE DESCRIPTORS For use when awarding marks for in-course assessment Descriptors History Taking (including communication skills) Clinical Examination (including mental state examination) Clinical knowledge (including clinical reasoning) Professional development (including contribution to the Firm) 85 – 100 Excellent history taking with some aspects demonstrated to a very high level of expertise and no flaws at all Thorough, accurate and comprehensive clinical examination demonstrating excellent skills throughout Comprehensive and detailed knowledge in most topics with no gaps Highest standards of conduct at all times; highly organized; excellent attendance and enthusiastic member of firm 70 – 84 Well structured, methodical and sensitive history taking at all times; no errors or omissions Thorough and detailed examination with no significant errors or omissions Good knowledge of most topics with depth in some areas, and no significant gaps 50 – 69 Adequately structured, methodical, sensitive; no important omissions Able to perform examination covering all the essential aspects of case Satisfactory knowledge with few gaps 40 – 49 Barely adequate in structure, but without major oversights 30 – 39 Poor and badly structured < 30 Very poor and incomplete Mark range Excellent Good Competent Not competent Unsatisfactory examination, with some errors or omissions Inadequate examination, with significant errors or omissions Rudimentary examination with serious errors or omissions Unsatisfactory level of knowledge, with several errors or omissions Inadequate knowledge, with several significant errors or omissions Rudimentary knowledge with many serious errors or omissions High standards of conduct and organization most of the time; full attendance and good contribution to firm Maintains appropriate standards of conduct, attendance and organization at all times Occasional lapses in conduct or organization that must be improved Clearly below the required standards of professional conduct and behaviour Displays serious lack of professional standards (e.g. rude, disorganized) In an average firm of 4 students, a firm head would normally expect to award no more than one student marks in the “Excellent” range and two students marks in the “Good” range per rotation. The majority of students should be rated as “Competent”. Only a small minority of students (fewer than one per rotation) are likely to be found “Not competent” and these should be reported directly to the Student Advisor 12 Appendix 7 Scenario Sign-up Students should attend all Scenario teaching sessions. Tutors will mark the student’s performance in Scenario teaching (attendance, contribution, knowledge & enthusiasm) as below. The rating will be reviewed by the Tutor when considering the end-of-rotation assessment. It is the student’s responsibility to ensure the tutor is aware of his or her attendance and performance. No Title of scenario Date completed 1 2 3 4 5 6 7 Overall performance including attendance and active participation (circle and/or delete as appropriate): Excellent Good Satisfactory Unsatisfactory attendance Unsatisfactory participation I have witnessed this student display a level of competence appropriate to Phase 3 Signed (Neurology): Name (Print) Date 13 Tutor’s initials Appendix 8 SUMMARY OF CLINICAL SKILLS TO BE ACQUIRED IN NEUROLOGY ROTATION There are 16 clinical skills which you are required to perform to a satisfactory level in order to progress. Each of these skills has an accompanying set of performance criteria, similar to that used in the OSCE assessments. You should be observed performing the task in a clinical environment or in the Clinical Skills Centre, by an appropriate practitioner. The skills are assessed as being either carried out competently or not. There is no grading system for performance. If you do not perform adequately on the first attempt, you may have another attempt later. You should liaise with your skills assessor as to when it will be possible for you to present yourself for assessment. At the end of the rotation this form will be checked by the firm head and the record sent to the Registry for recording and filing. You must demonstrate your competence in the skills listed below. Skills checklists are given in detail on the subsequent pages, each of which must be signed as competent. Basic adult neurology, ophthalmology Take a history from a patient with a neurological complaint Examine gait and co-ordination Examine the sensory and motor system in the upper limb Examine the sensory and motor system in the lower limb Take a history from a patient with an eye complaint Examine the eye including use of ophthalmoscope Perform a mental state examination Assess memory and cognitive state Choose and interpret tests and investigations in the adult neurological patient Observed clinical case (complete history and examination of a neurology patient) Date completed Appendix 9 Weekly Neurology timetable for Clinical Apprenticeship students Clinical Apprenticeship Mon AM Neurology: 8.00-8.30 am Radiology 8.30 OPD Team Meeting 9.00-12.30 Consultant Ward Round Tues 8.30 am General Neurology Review Clinic Thurs Fri 8am Medical Grand Rounds 8am Beaumont Hospital Neurology Grand Round 9am Consultant Ward Round Or Parkinson’s Clinic 11am Consultant Ward Round 2pm Consultant Teaching 2pm Neurology: 2pm Registrar Teaching St. Vincent’s Ward 2pm Intern Teaching 9am General Neurology Review Clinic (Professor Hutchinson) 2pm SHO Teaching Or Or Or 3pm Students to clerk patient for next ward round 1.30 pm General Neurology New Patient Clinic (Professor Hutchinson) 1.30pm General Neurology New Patient Clinic (Dr. Tubridy) 1.30pm Dystonia Clinic (Dr. Tubridy) Or Multiple Sclerosis Clinic with Consultant PM Weds 8am Neurology Journal Club (ERC) 12noon Clerk Patients for Monday Round Observe Procedures in Neurology OPD Or Observe LP in OPD You have small group neurology learning most afternoons. You should usually spend the equivalent of about ½ day working independently or in pairs on clerking neurology patients, and reading in preparation for your small group neurology teaching. If you cannot find patients to clerk, we suggest you contact your associate tutor in advance and ask him/her to recommend patients that you can clerk, and present to your tutor. Appendix 10 Introductions to web-based clinical scenarios Mr Thomas’ Falls Mr William Thomas, a 59 year old gentleman, presented to hospital on a summers day in 2004 complaining of lethargy, difficulty in getting around and 3 falls recently. He was seen in the Accident and Emergency Department, where he was found to be stiff, tremulous and quite agitated and had to be given “calming down” pills. When he had become a more rested, Mr Thomas said that he had become progressively more and more stiff and slow in the last 8-10 years. His problems had started approximately ten years back. At this stage he worked as an asbestos removal specialist and had noticed that his left hand had become increasingly clumsy and difficult to use. There was also the development of occasional involuntary shaking of this hand which at times, he was unable to control. The shaking would get worse when he was tense or anxious and he had also noticed that his writing had been affected. He was lefthanded. Over the next ten years, the stiffness and the shaking has developed to involve his right side as well and occasionally his neck and his legs. He would spill cups of water or tea when he attempted to carry them because of tremor. He has increasing difficulty in walking, turning, sleeping at night particularly turning in bed. He has also experienced some falls and in particular increasing forgetfulness. He has developed some stiffness around the shoulder region particularly the left upper limb. This initially was thought to be due to “frozen shoulder”. Weakness in the right arm James Clark is a 69 year-old right handed man. He has recently retired from his lifelong office job as a pension’s advisor. He is in the local A&E department having been brought in by London Ambulance Service. He presents with a 2-hour history of right-sided arm and leg weakness and difficulty expressing himself. His wife comments that the right side of his face has drooped. She has had to give the history because of his speech difficulty. He is examined on a trolley in the ‘majors’ part of the Accident and Emergency Department. Numbness in the toes Mrs A. a 46 year old typist, went to her GP because she had experienced some pain in the right wrist. She said it would wake her at night and that her hand felt dead. Her GP elicited the further history that for about 6 months she had had some intermittent numbness in her toes and sometimes felt as if she were walking on hard stony ground. The numbness had now become continuous and had spread up to her ankles. A child with fever and headache You are working at a district hospital. One evening a GP phones that she has just visited a 4year child at home. His mother called the doctor because her son had been unwell over the previous 24 hours with fever and increasing headache. In the past few hours he had become irritable and drowsy and had refused his supper. His younger sister is recovering from chicken pox. The GP found him febrile, restless, pale and sick looking and was very sore all over to touch. There was a faint flea bite type rash on the trunk which blanched on applying the glass test. The GP was concerned there was neck stiffness and asks your advice re urgent admission and acute management. Headache Mr. K is a 37 year old man who has experienced a constant background headache for the past 18 months. The pain is in both temples and radiate to his neck. He described this pain is a tight squeezing sensation which tends to be worse in the evening but does not stop him from performing his normal activities. There are no exacerbating features to this pain and no real alleviations either. Having a good night sleep usually helps but most painkillers will only “take the edge off”. In the last 3 years, he also experienced a different type of headache. These attacks are episodic, initially coming on once every 2-3 months but in the last 6 months, the frequency has increased to 2-3 times a week. The attacks can come on anytime but more commonly during the weekend and last for one day. These more severe headaches start with stiffness and discomfort in the neck that become progressively worse and the pain will then spread to one eye. He is nauseated and may vomit with these attacks. He will have to go to bed or sit in a dark quiet room with this headache. This morning, Mr. K made an urgent appointment to see his GP because he developed another severe episode of headache yesterday afternoon. He went to bed after taking some pain killers but this morning he was alarmed to wake up with drooping of his right eyelid and double vision. His GP sent him to the hospital and you were asked to see him. Epilepsy and blackouts Scenario 1 A 45-year-old man felt tingling in his right hand followed by unilateral stiffness then jerking of the arm which spread to the face; within 30 seconds he had lost consciousness. According to witnesses, he then collapsed and convulsed for 3 minutes. When the jerking subsided, he lay still for 5 minutes and was placed in the recovery position. He gradually came round and the paramedics walked him to the ambulance. When questioned in the Emergency Room, he remembered coming round only when already in hospital. He had bitten his tongue, wet himself and ached all over. He also reported having had brief and transient tingling/stiffness in the right arm over the last two months, more intensely and more frequently in the last week. Scenario 2 A 20-year-old continues to suffer from blackouts despite trying 4 anti-epileptic drugs over the last four years. He tends to collapse when exercising heavily. His mother is very worried about him. He has a brief warning of feeling faint; he then goes ‘sheet-white’ and falls limply to the ground, where he twitches, irregularly, for no more than thirty seconds. He does not usually bite his tongue or wet himself, although he has injured himself. As soon as he comes round he is upset that he has blacked out, yet again, despite taking his medicine. His physical examination (CVS and CNS) has always been normal. There is no family history of epilepsy on his mother’s side. His father had left his mother when he was a toddler, but she thinks he died in his late 30’s of a ‘heart attack’. Scenario 3 A previously well 6-year-old girl is no longer attentive at school. She seems to stop what she is doing for a couple of seconds and stares ahead. She then picks up where she left off. She may have more than 20 such blank spells a day. Scenario 4 An 18-year-old has had epilepsy from infancy after meningitis that left him with physical and mental handicap. He has many types of seizures, atypical absences, partial seizures, myoclonic jerks, tonic seizures and convulsions. Normally, his convulsions last less than five minutes, usually stopping after 2 minutes without intervention. He was on 4 anti-epileptic drugs, but recently one of his medications was withdrawn to reduce side-effects. Today he started convulsing, but this time the fit did not stop by itself as per usual and he is still fitting. Scenario 5 A 17-year-old has had what she calls, ‘twitches’ in the morning for the last two years. Her arms would jump and she may drop what she is holding. She also noticed that she felt uncomfortable with flashing lights. After a late night and a few drinks too many, she got up earlier than usual in the morning and was rushing. She suddenly collapsed and was seen to convulse for two minutes. She bit her tongue badly. She was confused on coming round. Her mother had a history of childhood absence epilepsy but is now fine. Scenario 6 An 18-year-old has had episodes of feeling unwell for two years. Initially, he would feel a churning in his stomach then a deja-vu feeling for a few seconds. Sometimes he would have a run of these. For a year, the feeling has been followed by loss of awareness for about a minute. During the blank spell, witnesses say that he would be briefly blank without any movement or, in more prolonged attacks, his left arm might be stiff and flexed at the elbow. His right arm would fiddle with his clothes and he would smack his lips and swallow. Recovery would take about thirty seconds, although on one occasion he went on to convulse. Scenario 7 A previously fit 20-year-old university student starts experiencing up to fifteen ‘turns’ a day. Sometimes she lies still for half an hour with no movement and no response and, sometimes, her limbs shake irregularly and her head moves from side to side. Occasionally she arches her back. Her colour is normal and she does not bite her tongue. When the attacks are over, she recovers immediately and is alert with no deficit. She is concerned that these attacks may interfere with her final exams. She is on her third AED without benefit so far. Years ago she had had similar episodes for about six months at the age of 13. Scenario 8 A previously fit 24-year-old successful shop manager has a headache and a temperature for a few days. She wakes up confused one morning and has a blank spell followed by a convulsion. Her speech is no longer fluent and she has word-finding difficulty. She is also forgetful. She has further fits over the next 24 hours and is admitted. CT scan shows no masses but lumbar puncture reveals lymphocytic CSF with normal protein and glucose concentration. Scenario 9 A teenage girl is at a party. She has not eaten or drunk much that day. There are many people around. She is in a tight space and feels hot. She is standing in a corner with little room for movement. Her vision darkens and she feels dizzy and nauseated. She needs some fresh air and wishes she could lie down. She tries to get out of the room, but blacks out and falls to the ground. Witnesses say that she slumps and jerks a few times and then comes around, within less than a minute, looking embarrassed. She is clammy and pale. This had happened before at school assembly when she had period pains and was standing for too long. Scenario 10 A 25-year-old falls asleep rather too easily while watching television, in company, at work and even while eating. He sleeps well at night and wakes up refreshed. His girlfriend says he does not snore. Sometimes he wakes up and is unable to move, just for a few seconds. He used to panic with this; sometimes he has vivid dreams which seem so real. Worst of all, if he laughs too much he becomes floppy and falls. He is lucky as his friends do not pull his leg too often. Mrs S has difficulty walking Mrs S, a 30 year old police officer presents complaining of difficulty walking which she first noticed a week ago and has since gradually become worse. She also now describes: Stiffness and weakness particularly affecting her right leg and to a lesser extent her right arm Pins and needles that have gradually spread up from her toes to involve her hands particularly on the left, but spare her face A funny feeling down her body when she bends her neck Frequently having to pass urine with urgency but without pain. She has been incontinent of urine on a couple of occasions.