Animal Administration Standard
Operating Procedure (SOP) for
Agents With The GHS Signal word
Danger
Chemical Name
GHS Classification: Signal Word: DANGER
Pictograms:
Additional Classifications:
Purpose: According to the Safety Data Sheet (SDS) special precautions must be
taken when working with the chemical described below. The following information
includes animal administration, chemical characteristics, followed by
recommendations for handling prior to administration, and any paperwork
needed in order to use the chemical in the laboratory. This Standard Operating
Procedure will be followed along with the requirements of the Chemical Hygiene
Plan.
Brief description of agent use:
Section 1: Brief Safety Overview
● The Principal Investigator is responsible for training employees using the
material on site. The training should include a discussion of the known
and potential hazards; an explanation of the relevant policies, techniques
and procedures including the proper use of personal protective equipment,
emergency/spill procedures and containment equipment (engineering
controls).
● Limit access to authorized users.
● Minimize the possibility of inadvertent ingestion, inhalation and direct skin
or eye contact with the substance.
● Chemical has been entered in the Chemical Inventory (EHS Assistant)
● Require annual training.
 Records of usage will be recorded for all DEA controlled substances.
Non-controlled substances do not require specific records to be kept of
their usage.
 Controlled substances require special precautions for use and disposal
outlined in The Ohio State University Individual Investigator Use of
Controlled Substances in Research. Review the controlled substances
policy if in use in your laboratory.
Created: January 2014
Revised: xxxx Page 1
Section 2: Animal Administration

Route of Administration (Injection*, inhalant, topical, or oral):
* For injections: Syringes will be used to measure and dispense injectables. Re-capping is
typically not performed and syringes will be disposed into an appropriate sharps container after
one use. If re-capping is necessary, a one-handed re-capping process should be used. For
additional information on the handling of syringes please contact your EHS representative.


Agent Administration Location (Injection site, area agent applied to,
etc):
Dosage given to animals:

Laboratory location where agent is being administered to animals:
Section 3: Research Laboratory Procedures

Handling: Brief description of handling procedures prior to animal
administration (mixing procedures*/ dilutions*/vehicles etc):
* If agents have been mixed or diluted the agents must clearly labeled with the correct chemical
name and date of preparation.

Storage: When not in use, agents will be stored in room ROOM #,
BUILDING at the appropriate temperature, either -80˚C, -20˚C, 4˚C or
room temperature. Agents should be checked to verify that the agent is
not past the expiration date. Controlled substances will be secured in an
appropriate lock box
Location – Engineering controls
Ventilation (example: Fume Hood, Canopy Hoods, etc):
Designated area (specify):
Bio-Safety Cabinet
PPE required:
Skin/Body Protection (example: Lab Coat)
Eye protection
Face shield
Respirator (example: N95):
Hand protection (example: Nitrile gloves):
Created: January 2014
Revised: xxxx Page 2

Cleanup/Decontamination procedures for work area after use:

Disposal Procedures
Section 4: Occupational Exposures

Routes of Exposure
Skin Inhalation IngestionInjection-

Toxicological Effects
Acute Effects/ Precautionary Safety Measures:
Chronic Effects/ Precautionary Safety Measures:

Occupation Exposure Response and First Aid Measures
Skin Eyes Inhalation Ingestion -

Emergency Procedure for Chemical Spills and Accidental Releases
Created: January 2014
Revised: xxxx Page 3
This Standard Operating Procedure must be placed in the Chemical Hygiene Plan and the SDS
must be accessible. Also, all laboratory personnel must be familiar with safe handling practices
(i.e., training with documentation of training) when working with these chemicals. This must be
incorporated into the comprehensive chemical hygiene plan of the laboratory. If you have any
questions regarding a comprehensive mandatory laboratory chemical hygiene plan please
contact your Representative at Environmental Health and Safety (292-1284).For any other
questions or concerns, please contact:
PI contact information
Name:
Primary Contact Number:
Emergency Contact Number:
P.I. Signature _________________
Created: January 2014
Revised: xxxx Page 4