Charles C. Reed, Ph.D. 187 Montgomery Drive Harleysville, PA 19438 Home: 215-513-2242 Cell: 267-994-7272 Email: creed_phd@earthlink.net PUBLICATIONS Goldoni, S., Iozzo, R.A., Kay, P., Campbell, S., McQuillan, A., Agnew, C., Zhu, J.X., Keene, D.R., Reed, C.C., and Iozzo, R.V. (2007) A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity, Oncogene, 26:368-81. Zhu, J.X., Goldoni, S., Bix, G., Owens, R.T., McQuillan, D.J., Reed, C.C., and Iozzo, R.V. (2005) Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis, J. Biol. Chem., 280:32468-32479. Weis, S.M., Zimmerman, S.D., Shah, M., Covell, J.W., Omens, J.H., Ross, J. Jr,, Dalton, N., Jones, Y., Reed, C.C., Iozzo, R.V., McCulloch, A.D. (2005) A role for decorin in the remodeling of myocardial infarction, Matrix Biol. 24:313-24. Gonzalez, E.M.*, Reed, C.C.*, Bix, G., Fu, J., Yue Zhang, Y., Gopalakrishnan, B., Greenspan, D.S., and Iozzo, R.V. (2004) BMP-1/tolloidlike metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan, J. Biol. Chem., 280:7080-7. *co-first authors Reed, C.C., Waterhouse, A., Kirby, S., Kay, P., Owens, R.T., McQuillan, D.J., and Iozzo, R.V. (2004) Decorin prevents metastatic spread of breast cancer, Oncogene, 24:1104–1110. Bix, G., Fu J, Gonzalez, E.M., Macro, L., Barker, A., Campbell, S., Zutter, M.M., Santoro, S.A., Kim, J.K., Hook, M., Reed, C.C., and Iozzo, R.V. (2004), Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol., 166:97-109. Reed, C.C., and Iozzo, R.V. (2003), The Role of decorin in collagen fibrillogenesis and skin homeostasis, Glycoconjugate Journal, 19:249255. Santra, M., Reed. C.C., and Iozzo, R.V. (2002) Decorin binds to a narrow region of the EGF receptor, partially overlapping with, but distinct from, the EGF-binding epitope, Journal of Biological Chemistry, 277:35671-35681. Reed, C.C., Gauldie, J., and Iozzo, R.V. (2002) Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin, Oncogene 21:3688-3695. Byrne, B., Rollag, M.D., Hanifin, J.P., Reed, C.C., and Brainard, G.C. (2000) Bright light imagery does not suppress melatonin. Journal of Pineal Research 29:62-64. Csordas, G., Santra, M., Reed, C.C., Eichstetter, I., McQuillan, D.J., Gross, D., Nugent M.A., Hajnoczky, G., and Iozzo, R.V. (2000) Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo. Journal of Biological Chemistry 275:32879-32887. Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.-F., Harrison, R.W., and Weber, I.T. (1999) Structural and kinetic analysis of drug resistant mutants of HIV-1 protease. European Journal of Biochemistry, 263:238-45. Reed, C.C., Fu, Z.-Q., Wu, J., Xue, Y.-N., Harrison, R.W., Chen, M.-J. and Weber, I.T. (1997) Crystal Structure of TNF-a mutant R31D with greater affinity for receptor R1 compared to R2. Protein Engineering, 10:1101-1107. Harrison, R.W., Reed, C.C., and Weber, I.T. (1997) Analysis of comparative modeling predictions for CASP targets 1, 3, 9, and 17. Proteins Structure, Function, and Genetics, Supplement 1: 68-73. Fu, Z.-Q., Harrison, R.W., Reed, C.C., Wu, J., Xue, Y.-N., Chen, M.-J. and Weber, I.T. (1995) Model of TNF receptor 2 (P75) and complexes of TNF-a with receptors R1 and R2. Protein Engineering 8: 1233-1241. POSTERS AND ABSTRACTS Gonzalez, E.M.*, Reed, C.C.*, Bix, G., Fu, J., Yue Zhang, Y., Gopalakrishnan, B., Greenspan, D.S., and Iozzo, R.V. (2004) BMP-1/tolloidlike metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. American Society of Matrix Biology 2nd Annual Meeting, San Diego, CA. *co-first authors Reed, C.C., Waterhouse, A., Kirby, S., Owens, R.T., McQuillan, D.J., and Iozzo, R.V. (2004), Decorin prevents metastatic spread of breast cancer. Society of Matrix Biology 2nd Annual Meeting, San Diego, CA. Charles C. Reed. Ph.D. Reed, C.C., Gauldie, J., and Iozzo, R.V. (2002) Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Gordon Research Conference, Andover, NH. Reed, C.C., Wu, J., Harrison, R.W., Louis, J.M., and Weber, I.T. (1997) Structure and analysis of HIV-1 protease mutant with MVT-101: Structure determination and refinement in a monoclinic space group. Protein Society Eleventh Annual Symposium, Boston, MA. Kurinov, I., Harrison, R.W., Reed, C.C., and Weber, I.T. (1997) Crystal structures and kinetic analysis of RSV protease mutants. Protein Society Eleventh Annual Symposium, Boston, MA. Reed, C.C., Wu, J., Harrison, R.W., Louis, J.M., and Weber, I.T. (1997) Refined crystal structure and analysis of HIV-1 protease mutant with inhibitor MVT-101: A new crystal form. Sigma Xi Student Research Day,Thomas Jefferson University, PA. Reed, C.C., Fu, Z.-Q., Harrison,R.W., Xue, Y.-N., Wu,J., Chen, M.-J. and Weber, I.T. (1996) Crystal structure of TNF-a and TNF mutant R31D. International Union of Crystallography 17th Congress, Seattle, WA. Reed, C.C., Fu, Z.-Q., Harrison,R.W., Xue, Y.-N., Wu,J., Chen, M.-J. and Weber, I.T. (1996) TNF-a mutant discrimination between receptors R1 and R2: Predictions from homology models. Mid-Atlantic Protein Crystallography Workshop, Frederick, MD. Reed, C.C., Fu, Z.-Q., Harrison,R.W., Xue, Y.-N., Wu,J., Chen, M.-J. and Weber, I.T. (1996) TNF-a mutant discrimination between receptors R1 and R2: Predictions from homology models. Thomas Jefferson University, Philadelphia, PA. Brainard, G. C., Reinecke, R., Hanifan, J., Pettingill, P., Reed, C.C., Ruberg, R., Sanford, B., and Rollag, M. (1996) Melatonin regulation in humans with color vision deficits: Are photometric measures appropriate for quantifying light used to induce biological and therapeutic effects? The Society for Light Treatment and Biological Rhythms Seventh Annual Meeting. Reed, C.C., Fu, Z.-Q., Xue, Y.-N., Hu, B.-C., Wu,J., Harrison,R.W., Chen, M.-J. and Weber, I.T. (1995) Crystal Structures of wild type TNF-a and TNF Mutant R31D: Implications for Differential Receptor Binding. Thomas Jefferson University, Philadelphia, PA. Brainard, G. C., Pratap, V., Reed, C.C., Levitt, B., and Hanifin, J. P. (1995) Plasma Cortisol Reduction in Healthy Volunteers Following a Single Session of Yoga Postures. The Endocrine Society 77th Annual Meeting. Byrne, B., Hanifin, J. P., Reed, C.C., Rollag, M. D., and Brainard, G. C. (1994) Are Melatonin Responses to Bright Light a Placebo-Resistant Biological Marker for Light Therapy Studies? The Society for Light Treatment and Biological Rhythms Sixth Annual Meeting. CONTRIBUTIONS TO PEER-REVIEWED RESEARCH PUBLICATIONS, PARTICIPATION CITED BUT NOT BY AUTHORSHIP Weber, I.T., Harrison, R.W., and Iozzo, R.V. (1996) Model structure of decorin and implications for fibrillogenesis. Journal of Biological Chemistry 271: 31767-31770. Iozzo, R.V., ed. (2001) Proteoglycan Protocols, Methods in Molecular Biology: Volume 71, Humana Press. Iozzo, R.V. (2001) Heparan sulfate proteoglycans: intricate molecules with intriguing functions. Journal of Clinical Investigation, 108: 165-7. Goldoni, S., Owens, R.T., McQuillan, D.J., Shriver, Z., Sasisekharan, R., Birk, D.E., Campbell, S., and Iozzo, R.V. (2004) Biologically active decorin is a monomer in solution. J. Biol. Chem. 279: 6606 – 6612. 2