Anatomy Chapter 3 -Histology Upon completion of this chapter, you should know the following: -The four types of tissues in the body -General characteristics of Epithelial tissue -Epithelial membranes (mucous, serous, cutaneous) and location of each -Specific types of “covering & lining” epithelium in the body, including how they derive their name, physical characteristics, locations, basic functions Simple squamous Simple cuboidal Simple columnar Stratified squamous (keratinized (dry)/non-keratinized (moist)) Stratified cuboidal Stratified columnar Pseudostratified ciliated columnar (PSCC) Transitional -Exocrine vs. endocrine glands -Mode of secretion of exocrine glands (merocrine, apocrine, holocrine), types of secretions, basic structure of glands -General characteristics of Connective tissue including cell types, fiber types, ground substance -Specific characteristics, locations & functions of the following connective tissues: A. Embryonic CT’s – comprised of mesenchymal cells 1. Mesenchyme B. CT “Proper” – comprised of fibroblasts primarily (with one exception) in syrupy ground substance containing hyaluronic acid 1. Loose CT’s a. Areolar b. Adipose c. Reticular 2. Dense CT’s a. Dense regular (collagenous) b. Dense irregular c. Elastic C. Supporting CT’s 1. Cartilage – comprised of chondrocytes in lacunae, in thick ground substance containing chondroitin sulfate a. Hyaline b. Fibrocartilage c. Elastic 2. Bone (osseous) tissue – comprised of osteocytes in lacunae, in calcified matrix a. Compact (dense) b. Cancellous (spongy) - Characteristics of muscle tissue - Functions of muscle tissue -Types of muscle tissue (skeletal, cardiac, smooth/visceral) – location, functions & histological characteristics of each -General characteristics of neural tissue – neurons and neuroglia Summary of Epithelial & Connective Tissues Tissue Type Epithelial tissues Simple squamous Simple cuboidal Simple columnar Stratified squamous Transitional Pseudostratified ciliated columnar (PSCC) Connective tissues Mesenchyme Areolar CT Adipose Tissue Reticular CT Dense regular CT Dense irregular CT Elastic CT Description Location Function One layer of flat epithelial cells bound to CT Lines heart (endocardium) & blood vessels (endothelium), alveoli of lungs, lines body cavities (pleura, pericardium, peritoneum Kidney tubules, thyroid gland, pancreas, salivary glands Lines GI tract from stomach to rectum, gallbladder, fallopian tubes (ciliated) Diffusion, osmosis, filtration, absorption, reduce friction through serous secretion Secretion, absorption One layer of relatively “cube” shaped epithelial cells bound to CT One layer of tall, “column”- like cells bound to CT; may be modified with microvilli, goblet cells &/or cilia Multilayered epithelial tissue with the apical cells flattened, only basal cells in direct contact with basement membrane Multilayered epithelial tissue with the apical cells varying in their shape from flat to rounded or cuboidal, depending on amount of distension on tissue One layer of different sized columnar cells that appear to be stratified, all cells contact basement membrane, apical surface is ciliated “non-keratinized” – lines mouth, tongue, esophagus, vagina “keratinized” – surface of skin Mesenchymal cells in a thick fluid ground substance with some collagen & reticular fibers Loosely woven arrangement of fibers (collagen, elastic & reticular) embedded in a “syrupy” ground substance of hyaluronic acid, surrounding fibroblasts, macrophages, WBC’s & some adipocytes; highly vascularized Modified areolar tissue comprised primarily of adipocytes with little surrounding matrix Scattered fibroblasts with interconnecting short reticular fibers creating a loose “meshwork” to support cells within organs Densely packed collagen fibers arranged in parallel bundles, few fibroblasts, little ground substance, not well vascularized Densely packed collagen fibers randomly arranged in various directions, few fibroblasts & ground substance Densely packed elastic fibers Secretion, absorption, protection, transport of ova & sperm (ciliated) Protection Lines urinary bladder , ureters Allows for organ distension Lines most of respiratory tract, portions of male reproductive tract Movement of mucus by ciliary action, secretion Only found in developing embryo Precursor to all connective tissues Widely distributed throughout body surrounding organs, BV’s, nerves, joints; found in upper part of dermis of the skin Support, strength, elasticity, cushioning Subcutaneous layer of skin, around kidneys, behind eyeballs in orbit, marrow of long bones Lymph nodes, spleen, liver, kidney, bone marrow Cushioning, protection, energy reserve, insulation Creates supportive “stroma” (framework) within organs Tendons, ligaments Attachment Lower (deeper) layer of dermis, periosteum, perichondrium, joint capsule, surrounding skeletal muscles, capsules around come organs Within wall of aorta & other large Protection, attachment, support, reduce friction between muscles Allows for elasticity & interspersed with some collagen fibers, few fibroblasts arteries, within some spinal ligaments (ligamentum flavum & ligamentum nuchae, underlying transitional epithelium Ends of long bones (articular cartilage), rib (costal) cartilage, larynx, trachea, bronchi, embryonic skeleton Support, some flexibility, provides smooth movement at joints Pubic symphysis, intervertebral disc, menisci of knees Support, fusion, shock absorption External ear, epiglottis, Eustachian tubes Flexible support, maintains shape At epiphyses of long bones, in short bones, flat bones & irregular bones to varying degrees Support, protection, mineral storage Osteocytes within lacunae in calcified matrix; surrounded by periosteum; matrix arranged in Osteons/Haversian systems comprised of concentric lamellae of matrix which surround central canals, osteocytes located within lacunae in lamellae & are interconnected through canaliculi At diaphysis of long bones, surrounding spongy bone in short, flat & irregular bones Support, protection, mineral storage Elongated, cylindrical cells that lie adjacent to each other, striated in appearance, multinucleate Combined with connective tissues & neural tissue in skeletal muscles Short, branched cells, striated, single nucleus, cells are interconnected by intercalated discs Myocardium of heart wall Smooth (visceral) muscle tissue Short, spindle-shaped cells, nonstriated, single nucleus Within walls of blood vessels and organs of digestive, respiratory, urinary & reproductive systems Neural (nervous) Tissue Comprised of neurons (larger, more obvious) with their cell body and processes (axons/dendrites) extending from them; and the more numerous, smaller neuroglia (glial cells) Primarily in brain and spinal cord Movement of skeleton, support, protection, generation of heat; voluntary contraction Create force to propel blood; involuntary contraction Moves (through involuntary contraction) food, urine, & reproductive tract secretions, regulates diameter of airways & blood vessels Neurons – transmit, process, and store “information”; neuroglia provide support & protection Hyaline cartilage Fibrocartilage Elastic cartilage Spongy (cancellous) bone tissue Compact (dense) bone tissue Muscle Tissue Skeletal muscle tissue Cardiac muscle tissue Chondrocytes within lacunae in a firm ground substance of chondroitin sulfate; no visible fibers apparent in glossy looking matrix; most locations surrounded by perichondrium Chondrocytes in lacuae surrounded by dense bundles of collagenous fibers with little ground substance, has no perichondrium Chondrocytes in lacunae surrounded by a network of elastic fibers & moderate ground substance, has perichondrium Osteocytes within lacunae in a calcified matrix (“osteoid” + Ca+2 salts); matrix arranged in trabeculae pattern with marrow cavites between recoil while still being supportive Epithelial Tissue Simple Stratified Pseudostratified S. Squamous epith. Str. Squamous (dry) Keratinized epith. Pseudostratified Ciliated Columnar (PSCC) epith. S. Cuboidal epith. Str. Squamous (wet) Non-Keratinized epith. S. Columnar epith. Transitional epithelium Connective Tissue CT “Proper” Embryonic Mesenchyme Cartilage Bone Loose Dense Hyaline cartilage Compact (Dense) bone Areolar CT Dense Regular CT (Collagenous) Elastic cartilage Spongy bone (Cancellous) Adipose CT Elastic CT Fibrocartilage Reticular CT Dense Irregular CT Muscle Tissue Skeletal Cardiac Smooth Neural Tissue