Module for Academic Year 2011/2012
Semester 1
Part A: *1
1.
Module Code and Title:
2.
Rationale for introducing this module:
3.
Brief Module Description:
The teaching and learning objectives.
The major topics covered.
4.
5.
Cross Listing (if applicable):
Pre-requisites/Co-requisites (if applicable):
6.
7.
Preclusions (if applicable):
Workload:
(The weekly workload for a 4-MC module must add
up to 10 hours. e.g. 2 hours lecture; 1 hour tutorial; 7
hours preparatory work.)
8.
9.
Modular Credits [MC]:
To be offered with effect from:
Part B:
1.
Aims and objectives: *5
(Elaboration of teaching and learning objectives.)
2.
Maximum Class Size:
BL5223 – Advanced Molecular Genetics
Molecular Genetics is an important area of study and research in
basic biology. The Advanced Molecular Genetics module aims to
provide graduate students an in-depth knowledge about the
importance of and advances in this field. This module is designed to
help them to understand the important questions in biology
particularly in disease and development that have been addressed as
a result of molecular genetics based approaches.
The lectures and subsequent tutorials and/or discussions will allow
in-depth survey and critical analysis of molecular genetics,
beginning with basic principles and extending to modern approaches
and special topics. The module will draw on examples from various
systems such as Drosophila, C. elegans, yeasts, human, plants and
bacteria. The module encompasses advanced treatment of the Central
Dogma of molecular biology and covers recent developments in the
molecular understanding of genetic information transfer from DNA
to RNA to protein, using current examples. Building upon this
platform, the module will then proceed to special topics such as
Prions, epigenetics, modular signaling cascades, ion channels,
membrane dynamics and cellular energetics.
It will also provide a broad overview of Protein folding and function.
Intended primarily for new graduate students familiar with basic
molecular biology and genetics
Nil
Students should have basic knowledge in molecular biology and
genetics
Nil
(i)
Lecture hours per week:
3
(ii)
Tutorial hours per week:
(iii) Laboratory hours per week:
(iv) Number of hours per week for projects, fieldwork,
assignments, etc. :
(v)
Number of hours per week for preparatory work
*3:
Total hours per week:
4MC
Semester 1 of AY2004-5 *
3
0
0
4
10
To provide background knowledge as well as cover recent and
significant advances in the field of molecular genetics
To inculcate the importance of molecular genetics and stimulate
research interest therein
To allow first year graduate students to interact with experts in
the field of molecular genetics
To provide a platform for interaction between graduate students
interested in molecular biology and/or genetics
50
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3.
Syllabus:
(Elaboration of major topics covered.)
4.
Assessment:
(Please indicate the % breakdown for each continuous
assessment [CA] component and the % for the Final
Examination.)
DNA Replication
Transcriptional regulation
Translational regulation
Prions and function
Metabolomics
Cellular Energetics
Membranes and Ion channels
Signal Transduction in bacteria
Chromatin structure and Function
Epigenetics
Protein Folds & Function
Signal Cascades
Recombination in Yeast
Mating Type switching in Yeast
CA Components:
(a) Tutorials:
(b) Laboratories:
(c) Tests:
(d) Others: (participation in lecture discussion)
Total for CA Components:
Total for Final Examinations:
Total Assessment:
5.
6.
7.
Module Lecturer/s: *6
(Name/s and Department/s.)
Modes of Teaching and Learning:
(Lectures, regular tests, Q & A, IVLE, problem-based
learning.)
Illustrative Basic Reading List:
(a)
Compulsory reading:
(b)
Supplementary reading:
35%
%
%
5%
%
40%
60%
100%
Mohan Balasubramanian (TLL; DBSNUS)
Sanjay Swarup (DBS-NUS)
Chan Woon Khiong (DBS-NUS)
Ng Huck Hui (GIS; DBS-NUS)
Uttam Surana (IMCB)
Zhang Lian Hui (IMCB; DBS-NUS)
Invited guest lecturers
(local and
international)
(i) Principle
lecturer/s:
(ii) Alternative
lecturer/s:
Lectures
Regular Discussions and/or tutorials
To be Recommended by the respective tutors
(handouts or lecture notes or recommended reading material will
be provided a week in advance)
To be Recommended by the respective tutors
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