Supplement Table 1: Summary and comparison of behavioral effects of
ERK1 ablation and psychostimulants
Test/paradigm
Activity in novel
environment
Immobility in the forced
swim test
Open-arm activity in the
elevated plus maze
Voluntary wheel
running
Psychostimulantinduced psychomotor
activity
Conditioned place
preference
Psychomotor
sensitization
Response of
hyperactivity to
antimanic treatment
Psychostimulants
Increased by amphetamine (1)
Reduced by amphetamine (2)
ERK1 deletion
Increased (Fig. 4 & 6
and supplement Fig 1)
Reduced (Fig. 3)
Increased or decreased by different
doses of amphetamine (3)
Increased or decreased by different
doses of amphetamine (4) or cocaine
(5)
Cross substitutable with cocaine (6)
or amphetamine (7) in reward- or
drug addition-related tests
Common neurochemical changes for
dynorphin (8) and deltaFosB (9)
Inducer
Increased (Fig. 2)
Inducer
Enhanced (10)
Inducer
Enhanced (11)
Yes (1)
Yes (Fig. 7-9)
Increased running
(Fig. 5)
Enhanced (Fig. 6 and
Supplement Fig. 1)
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