Contact Information: Laura A. Kresty Assistant Professor Cancer Chemoprevention Program Division of Hematology & Oncology Department of Internal Medicine 302B CCC Building 410 W 12TH AVE Columbus, OH 43210 Office Phone: 614-688-7787 Cell Phone: 614-202-0521 FAX: 614-293-4072 E-mail: firstname.lastname@example.org Research Interests: The focus of my research is cancer chemoprevention of aerodigestive tract lesions. It has been estimated that 35% of cancer deaths could be prevented through dietary modifications. This in turn has sparked interest in assessing the role of both specific foods and food-based bioactive components as cancer chemopreventive agents. My interests are in identifying and evaluating potential inhibitors utilizing in vitro assays, employing clinically relevant in vivo models to study carcinogenesis, and translating the evaluation of promising agents into phase I and phase II trials in high risk human cohorts. Currently we are evaluating both natural and some synthetically produced agents including: freeze-dried black raspberries in Barrett’s esophagus patients; cranberry proanthocyanidins, strawberry and black raspberry extracts, a licorice extract, isothiocyanates, and a number of histone deacetylase inhibitors utilizing in vitro assays; and we are working in a hamster respiratory tract model to evaluate the chemopreventive potential of indole 3-carbinol, anethole dithiolethione, and the polyamine difluoromethylornithine. We are also working on novel imaging technologies to detect early epithelial and sub-epithelial changes for more rapid evaluation of chemopreventive agents. Lastly, we are interested in investigating the link between obesity and cancer, specifically esophageal adenocarcinoma.