Sunday, Sept. 25
14:00-17:00 Registration
18:00 Arrival coffee
19:00 – 19:05 Welcome: Madalena Tarsounas
19:05 – 19:55 Keynote lecture: Elizabeth Blackburn, Telomeres and
telomerase regulation in humans under adverse conditions.
19:55-20:45 Session 1 - Telomere structure and function, Chair: Thanos
Halazonetis
Eric Gilson: How telomere topology determines chromosome stability
and replicative senescence?
Peter Baumann: Telomerase RNA Biogenesis.
20:45 Dinner
Monday, Sept. 26
9:00-10:35 Session 2 – Cellular responses to dysfunctional telomeres,
Chair: E. Blackburn
Frank Buchholz: Harnessing high throughput biology for novel insights
into DNA repair and telomere length regulation
Sandy Chang: Single strand telomere binding protein Pot1b is essential
for hematopoietic stem cell survival and function
Short talks - Madalena Tarsounas: Checkpoint responses emanating from
uncapped telomeres
Jacqueline Jacobs: A functional genetic screen identifies factors
critical for DNA damage response signaling and repair activities at
uncapped telomeres.
Sara Sandin - Structure of active, dimeric human telomerase in
complex with telomeric DNA
10:35-11:15 Coffee break
11:15-12:45 Session 3 - Mechanisms and regulation of DSB repair and
DSB signaling, Chair: Tony Carr
The Gray Institute Lecture, Daniel Durocher: Orchestration of DNA
damage signaling by regulatory ubiquitylation
Yoshi Shiloh: The ATM-mediated DNA damage response: from specific
pathways to system – and back
George Iliakis: The role of DNA ligase III in DNA replication and DNA
double strand break repair
Short talk - Vassilis Gorgoulis: ATM downregulates oncogene-induced ARF
expression through a Protein Phosphatase 1–mediated pathway
13:00-15:00 Lunch
15:00-17:00 Poster session (posters no. 1-30)
17:00-17:45 Coffee
17:45-19:30 Session 4 - Chromatin structure and DNA repair, Chair: Daniel
Durocher
Dimitris Thanos: Stochastic inter-chromosomal interactions coordinate
the antiviral transcriptional program
Tim Richmond: Structure and mechanism of the chromatin remodeling
factor ISW1a
Anna Friedl: Double-strand break-induced transcriptional silencing
Short talks Steve Jackson: Assembly and disassembly of proteins at
sites of DNA damage
Batsheva Kerem: Failure of origin activation in response to fork
stalling leads to chromosomal instability at fragile sites.
19:30-21:00 Dinner
21:00-21:55 Outdoors session – DNA damage repair and ageing, Chair:
Vassilis Gorgoulis
Jan Hoeijmakers: Genome maintenance: impact on aging and disease
Short talks – Paula Martinez: In vivo synthetic lethality of 53BP1 and TRF1
deficiencies.
Douglas Oliveira: FACT-dependent recruitment of RNF20 during
DNA repair.
Tuesday, Sept. 27
9:00-10:30 Session 5 - Responses to replicative stress 1, Chair: Oskar
Fernandez-Capetillo
Tony Carr: Replication forks restarted by homologous recombination
display a high frequency of errors at inverted repeats
Philippe Pasero: Spontaneous replication stress regulates replication
timing in budding yeast
Vincenzo Costanzo: Understanding the role of DNA repair and
chromatin remodelling factors in vertebrate DNA replication
Short talk Thanos Halazonetis: DNA replication stress in human
cancers
10:30-11:10 Coffee break
11:10-12:55 Session 6 - Responses to replicative stress 2, Chair: Kim
Nasmyth
John Tainer: FEN1 and the MRN complex at the replication-repair
interface
Sarantis Gagos: Chromosome instability in replication stress and
telomere dysfunction
Camilla Sjogren: Replication-induced topological tension and the
Smc5/6 complex
Short talks Jo Murray: Smc5/6 regulates recombination and
chromosome segregation.
Bekker-Jensen Simon: Rapid deubiquitylation of p15(PAF) in
cellular responses to replication stress
13:00-15:00 Lunch
15:30-17:00 Session 7 - Chromosomal alignment and segregation, Chair:
Steve Jackson
The KuDOS Lecture, Kim Nasmyth: Running rings around
chromosomes
Andrea Musacchio: Dissecting mitotic progression with small molecule
inhibitors
Steve Doxsey: Cilia assembly machinery is required for chromosome
alignment and spindle orientation
Short talks - Joanna Morris: The 19S proteasomal de-ubiquitinating enzyme
POH1 co-ordinates the mammalian DNA damage response.
17:00-17:40 Coffee
17:45 Trip to Sounio (sunset 19:14)
20:00 Dinner with poster viewing (posters no. 31-65)
Wednesday, Sept. 28
9:00-10:30 Session 8 - The DNA damage response in tumorigenesis and
cancer therapy, Chair: Sandy Chang
Ruth Muschel: Strategies for radiosensitization of tumours: implications for
therapy
Jiri Bartek: DNA damage response: Mechanistic insights and impact on
cancer treatment
Gillies McKenna: High-throughput screening for genes determining
radiosensitivity
Short talk - Dimitris Kletsas: DNA damage, cellular senescence and role in
tissue homeostasis
10:30-11:10 Coffee break
11:10-12:25 Session 9 - Mouse models for genome instability, Chair: Jos
Jonkers
The MicroLeman Lecture, Andre Nussenzweig: Functional connection
between FA, NHEJ and HR in repair of DNA interstrand crosslinks.
Jos Jonkers: Studying therapy response and resistance in genetically
engineered mouse models of BRCA-associated breast cancer
EMBO YIP Lecture, Oskar Fernandez Capetillo: Exploiting oncogeneinduced replicative stress for cancer therapy
12:30-14:00 Lunch and airport departure
End of the meeting