Winning Essays Sixteenth Annual High School Essay Contest "Why Are Animals Used in Biomedical Research?" 2007 Pennsylvania Society for Biomedical Research Post Office Box 1163 Camp Hill, Pennsylvania 17001-1163 www.psbr.org High School Essay Contest Winners The Pennsylvania Society for Biomedical Research is pleased to announce the winners in its sixteenth annual essay contest for high school students. A total of 442 students from 48 different schools wrote on the topic question, “Why Are Animals Used in Biomedical Research?” Winners were selected after three rounds of judging by PSBR members and friends. PSBR congratulates the winners and applauds the efforts of all the students, teachers, and judges who took the time to help make this contest a great success. Grand Essayists Awards 10th Grade Student Council Rock High School North Newtown, PA Is biomedical research inhumane, or does the inhumanity lay in allowing vital information with the capability to save millions of lives, animal and human alike, to slip through our fingers? Many believe that testing cures and remedies on animals is cruel and inhumane, although this research is imperative to medical progress. Animal testing not only advances the scientific knowledge of medicine used to treat humans but to treat animals as well. Protected by restrictive laws to ensure proper treatment, animals provide critical information for medical progress. In order to uncover the mysteries of the human body, cure diseases, and discover new methods of surgery and treatment, scientists must study a model similar to that of the human body. Scientists use biomedical research "to assess human biologic reactions and responses" ("Animal"). Animals are used in biomedical research because they are structured similarly to the human body. Although advances in technology have enabled scientists to use cell and tissue samples to conduct research, many processes can only be accurately studied through the use of mammals, because of their similarity to humans. Emulating the body's complex processes is essential to biomedical research in order to study how diseases and possible treatments affect the body. Animals are vital components to advancements in medicine: "Animal studies have provided the scientific knowledge that allows health care providers to improve the quality of life for humans and animals by preventing and treating diseases and disorders, and by easing pain and suffering" ("Animal"). This information is obtained through careful animal testing, regulated by multiple laws within the United States to ensure the safety of the animals. Animals are protected by the Animal Welfare Act which guarantees that animals receive proper housing, food, exercise, and living environment. Scientists are also required to present a research proposal to an institutional animal care and use committee to receive permission before beginning research. In addition, research conducted involves experiments that do not harm the animals, or drugs are administered to the animal prior to the experiment in order to ease the pain. Biomedical research is conducted safely in order to ensure the proper treatment of the animals and is imperative to scientific progress. Medical advancements through biomedical research are extremely beneficial to humans. Without the inclusion of animal testing in biomedical research, the scientific discoveries made throughout the years concerning medical treatments and cures would not have progressed to the advanced knowledge society possesses today: "Animal research has played a vital role in virtually every major medical advance of the last century-for both human and animal health" ("Proud"). Through biomedical research, scientists have been able to develop vaccines against polio, measles, smallpox, tetanus, and rubella. Animal testing also contributed to the development of antibiotics to fight bacterial infection, treatments for cancer, insulin to aid diabetes patients, kidney dialysis, and the use of penicillin. Many more discoveries have been made over the past century, enabling many diseases, which were once life threatening, to be treated. Scientists have also been able to study cancer, AIDS, openheart surgery, artificial joints, Alzheimer's disease, organ transplants, and blood transfusions by being able to study these diseases and procedures through animal testing. Over time, humans have benefited immensely from the medical advancements made possible through animal testing-an important process in obtaining research that has increased human life span and greatly improved the lives of human beings. Many believe that animal testing benefits only humans, when in fact this research provides vital medical information that can be beneficial to animals as well. Through biomedical research, scientists have been able to find cures and treatments for diseases that affect animals. Animal research has lead to the development of the vaccines against rabies, feline leukemia, anthrax and tetanus. Many studies conducted have also lead to discoveries of treatments for cancer in animals, treatment of arthritis, controlling tuberculosis, and controlling heartworm infection. In addition, many of the treatments found to work on humans are later altered in order to treat animals. There are many diseases that can be cured or treated in order to improve the life of humans, as well as animals: "[...] both humans and animals suffer from diseases that cause years or even a lifetime of pain" ("Use"). Biomedical research is imperative for medical advancements for both human beings and animals. There are many factors that contribute to the ongoing argument about the morality of using animals for biomedical research. When formulating an opinion about animal testing and its justification, it is important to consider the benefits of the information obtained. The research conducted has been essential to the medical advancements made over the years that are responsible for saving millions of lives daily. Through animal testing, scientists have also been able to discover new cures and treatments for diseases prevalent in animals as well as humans. Research facilities are also required to ensure the safety and proper treatment of the animals, in accordance with multiple laws passed in the United States to prevent the maltreatment of animals. When all the facts are considered, it is the lack of compassion for those suffering with life altering diseases, not the use of animals to improve and save the lives of millions, which is inhumane. Works Consulted "Animal Research and Human Health." Pennsylvania Society for Biomedical Research. 1992. "The Proud Achievements of Animal Research." Foundation for Biomedical Research. 2003. "Questions People Ask About Animals in Research." The American Physiological Society. 2001. "Use of Animals in Biomedical Research: Understanding the Issues." American Association for Laboratory Animal Science. November 2003. 12th Grade Student Trinity High School Camp Hill, PA It seemed as if a million molecules of formaldehyde were waging simultaneous attacks on my nostrils as the wide, heavy door was pulled open; the air inside was thick with the odor, and it choked me and burned my eyes. Goosebumps found their way to the surface of my arms and cheeks, and chills from the cold room danced up and down my spine. They were multiplied exponentially as I approached the two cadavers, their eyes covered with gauze, looking so lonely and damaged on the cold steel lab tables. I closed my eyes as our guide, a typical "mad scientist"-looking character, began to speak. The initial impressions I had of the gross anatomy lab's atmosphere reflected my original biased view of the process, something I viewed as necessary but somehow sinister-a frozen tomb encapsulating only dead bodies and pungent vapors. However, my views were quickly changed when I heard our lecturer and his students speak. I was amazed at the immense and genuine respect they had for the individuals who had donated their bodies to science, respect that translated into every interaction they had with the cadavers. It became clear to me that my aversion to the gross anatomy lab sprung from that very concern, the fear that those participating in the research (medical students in particular) did not appreciate the sacrifice that the donors had made and might not treat their bodies respectfully. It seems to me that many people who denounce the use of animals in research subscribe to the same fears as I did, thinking that researchers inflict undue pain and even death without regard to the lives of the animals. After seeing the care and diligence that was put forth when researching on cadavers (which cannot even feel pain or die as a result of the experimenters' actions), I can hardly conceive of any sane and stable human needlessly harming an animal in the pursuit of research. With legislation like the Animal Welfare Act, routine inspections of laboratories, rigorous pre-funding reviews of proposed experiments, and general professional procedures, such an atrocity should never be allowed to happen. Of course, the issue of animal experimentation will always generate mixed opinions; it is simply an inevitable fact due to the polarizing nature of the argument. But the ethical dilemmas that arise from the nonuse of animals in the lab, in my opinion, outweigh their counterparts. Animals are not used in the lab to be tortured. They are meant to help find solutions to problems that plague humans and animals alike, and they do a fantastic job. If it weren't for lab animals, we might not have insulin for diabetics, vaccines for diphtheria, whooping cough, canine distemper, feline leukemia, polio, German measles, hepatitis, or meningitis, and we wouldn't be en route to finding one for malaria. We are in debt to lab animals for helping to create drugs that greatly increase survival rates in certain cancers as well as those that battle HIV and depression.1 Can we in good conscience halt research that could ameliorate the suffering of so many people? Some argue that certain uses of animals in the lab-such as testing for cleaning products and beauty supplies-are frivolous and cruel. However, these uses account for only about 3% of animal testing2 and are still extremely important, despite the fact that they may not directly save lives. Safety testing is imperative to ensure that products are as safe as possible for both humans and animals, and there is no feasible alternative (such as a computer program or statistical model) that can simulate these tests. However, these alternative measures can be viable in some instances, and should be utilized whenever possible-this illustrates the theory of replacement, one of the three "Rs" that most scientists subscribe to when it comes to animal usage in the lab. The other two are refinement of experiments to reduce animal stress and discomfort and reduction of the amount of animals used in studies.3 Nearly everyone likes and is sensitive toward animals and interested in promoting their welfare, which is an extremely laudable goal and one that should be a top priority for researchers. However, it is easy to be swayed by the fanatical rantings of extremist animal rights groups, who capitalize on the good will, love, and empathy of the masses in order to promote their radical and often illegal agendas. In the United Kingdom, scientists have been intimidated, harassed, and even physically harmed by members of extremist groups like the Animal Liberation Front, and research has been slowed.4 The United States has its share of radical groups as well, such as People for the Ethical Treatment of Animals (PETA), whose president Ingrid Newkirk claimed that "A rat is a pig is a dog is a boy," a sentiment that few would agree with. Animals are the most valuable resource in biomedical research, and the positive effects of their use are immeasurable-they have saved lives, reduced suffering, and contributed to nearly every advance in medicine. The appropriate and responsible use of animals in a laboratory setting is imperative in the quest for knowledge about our world and the ways that we can better it. We should praise research animals for the sacrifice they make to save others, and allow them to continue to do so; in that way we will be able to appreciate their immense contribution to society rather than focus on distasteful and demeaning renditions of their lives. 1 Research Defence Society, http://www.rds-online.org.uk-Medical Benefits Timeline Research Defence Society, http://www.rds-online.org.uk- Areas of Research 3 Americans for Medical Progress, http://www.amprogress.org - Animals in Research 4 BBC Hot Topics-Animal Experiments, http://www.bbc.co.uk/science/hottopics/animalexperiments/protests.shtml 2 Finalists 10th Grade Student Council Rock High School North Newtown, PA To Whom It May Concern, By outlawing biomedical testing, you may think that you are saving innocent animals, but the truth is that you are putting the lives of many at risk. The argument that animal testing for medical research is inhumane and immoral is completely misguided. There are laws in place so animals cannot be treated heartlessly or unkindly and the information obtained through biomedical testing is very often beneficial to the health of animals as well as to that of humans. While animal testing may not exactly sound ethical, analyzing it further can aid in a better understanding of why biomedical testing is so imperative to the health of our world. Practically every "major medical advance of the last century - for both human and animal health" is owed to biomedical testing (Proud). It is agreed throughout the scientific and medical communities that animal testing is an irreplaceable research option. Without it, advances in medicine would be extremely complicated and it would be almost impossible for doctors to accurately predict what effects different treatments, surgeries or vaccines may have on people. Arguments against animal testing claim that computer-generated experiments can obtain the same information as animal testing. This is just not the case. Computers - a lifeless piece of technology can only do so much to predict; while animals, being biologically similar to humans, can give much better insight as to how new medical procedures will work when put to use in a real life medical scenario. The animals used for biomedical testing are a necessity to the medical world. So, of course, tests are done on healthy, happy animals, not frightened, hungry ones; the happier and healthier the animals, the more accurate the prediction following the testing. This is why scientists keep the animals well-fed and care especially for their well-being. They are not kept in horrendous caging; they are not starving; and they are not crying out for help. The animals are specially bred for testing and are not anyone's lost house pet or wild animal being denied freedom. These animals are created to serve a purpose and their purpose is vital to our modern society. "Treatment of 100 kinds of cancer costs our nation an estimated $107 billion a year" (Questions). Almost ten million Americans are alive today, after being cured of cancer. This scary disease affects millions, all over the world, gradually killing them by overwhelming their bodies through uncontrollable cell growth. Today, due to animal testing, "almost half the people diagnosed with cancer will live at least five years, and some will never have a recurrence of their disease" (Questions). This is compared to the one in five ratio of people who survived cancer in 1930. Chemotherapy drugs, radiation therapy and surgical techniques have made huge strides in the treatment of cancer in both humans and animals, and all of these discoveries were first developed using biomedical research. Animal testing for medical research has also uncovered treatment options for heart disease - the number one killer of men, women and children in the United States. Techniques to diagnose and cure many conditions of the heart have saved millions of lives thanks to biomedical research. HIV/AIDS is another disease affecting almost one million Americans. Although scientists have not yet found a cure, animal testing has led to a better understanding of how the disease affects the body and what steps researchers can take to find a cure. Penicillin and other antibiotics were discovered to cure bacterial infections using animal testing as well. Bacterial infections were once horrifying because doctors did not know how to stop bacterial organisms from infecting the body. Due to the discovery of drugs like penicillin, common infections can now be treated easily with a prescription. Sparing the lives of a few, over saving the lives of millions is, in fact, the heartless idea. By outlawing biomedical testing, you are consequently putting all medical research at a standstill. Where would medicine be if it weren't for all of the treatments discovered by animal testing? Whether it comes to saving a mother, a father or a child, the advances that biomedical testing promises are vital to medicine and cannot be outlawed. Sincerely, A Tenth Grade Student Works Consulted "Frequently Asked Questions About Animal Research." Foundation for Biomedical Research. "The Proud Achievements of Animal Research." Foundation for Biomedical Research 2003. "Questions People Ask About Animals in Research." The American Physiological Society. 2001. "Use of Animals in Biomedical Research: Understanding the Issues." American Association for Laboratory Animal Science. November 2003. 12th Grade Student Lower Moreland High School Huntingdon Valley, PA "Why Are Animals Used in Biomedical Research?" Since Science News and Scientific American are two of my favorite magazines, I often find myself reading articles about medical research based on information obtained from experiments with animals. I distinctly remember reading one such article for my AP Biology class about stem cell research. The article included a scanned image of a mouse whose damaged heart had been treated with injected stem cells. I was surprised to see the differences and obvious signs of improvement in the 'after' picture compared with the 'before' picture. The researchers pointed out that a significant amount of the mouse's tissue had regenerated, and that because this tissue had come from stem cells, it was a perfect genetic copy of the existing heart tissue. One of the challenges scientists face in working with stem cells is the problem of controlling exactly what kind of tissue these omnipotent cells will develop. In a petri dish, it is relatively easy to manipulate the stem cell culture, but it is nearly impossible to predict how the stem cells would behave in a living system. Although there are still risks in stem cell treatments, the mouse that participated in the study showed that under the right circumstances, stem cells could have healing properties. I realized that research animals, such as the mouse in this study, provide scientists with invaluable information that cannot be learned through any other form of experimentation. Biomedical researchers have a wide variety of research tools available to them, including molecular and cellular models, and in vitro experimentation. However, testing with animals remains the most comprehensive method for determining the full effect of a new substance, drug, pathogen, or surgical procedure on a living organism similar to a human. New drugs are developed using animal research, and also must be tested on animals for safety before they can be tested on humans and approved by the FDA. Animal testing allows researchers to monitor an entire living system for side effects or other problems that could not have been predicted through only tissue studies. Through animal research, scientists have developed vaccines for smallpox, anthrax, rabies, tetanus, polio, and rubella. Through studies of pigeons, scientists have been able to better understand the malarial life cycle, an ancient disease that continues to affect millions of people. Using animals such as dogs, sheep, cows, and pigs, scientists have studied organ transplantation techniques and learned about immune system responses. It is almost unthinkable to imagine the modern world without these medical advancements. Of course, if animals are to be used in medical research, they must be treated with compassion. Animal welfare organizations, as well as both state and national laws, ensure that the animals that are helping us to develop the medical advancements that will someday change the world are handled with care and respect. Researchers' efforts to treat animals as humanely as possible can be summarized in the 3R's: reducing, refining, and replacing. Scientists always try to reduce the number of animals needed in an experiment. For example, one group of scientists used multiple brain slices from a single rat in a series of experiments to study epilepsy. Also, experiments are refined, possibly through anesthesia, to minimize any pain or discomfort experienced by the animals. Whenever possible, scientists try to replace an animal experiment with other methods, like cell or tissue cultures. As biomedical science is improving, these research techniques appear to be successful. Even though the number of research facilities has increased, the numbers of almost all species of animals used in research have decreased. About 90% of all research animals are specially bred rodents (rats and mice), and the numbers of dogs, cats, and non-human primates combined add up to less than one half of one percent of all animals used in research. Additionally, the number of dogs and cats used in research has declined by 67 percent since 1979. Fortunately, as medical techniques and technologies progress, the benefits of animal research will continue to far outweigh the inevitable sacrifices. Someday it may even be possible to eliminate the need for animals in research. But as Nobel laureate Sir Peter Medawar stated, "Nothing but research on animals will provide us with the knowledge that will make it possible for us, one day, to dispense with the use of them altogether." Animals are used in biomedical research because of the life-saving applications of this research in both human medicine and veterinary science. Many of the most important medical breakthroughs of the twentieth century can be attributed to animal research, and the medical advancements of the near future, maybe even including the development of stem cell treatments, will almost certainly rely on animal research. Bibliography of sources not provided by the Pennsylvania Society for Biomedical Research Rosenthal, Nadia; Lanza, Robert. "The Stem Cell Challenge." Scientific American. June 2004. Vol. 290, Issue 6, p. 92. 10th Grade Student Council Rock High School North Newtown, PA "Few tragedies can be more extensive than the stunting of life, few injustices deeper than the denial of an opportunity to strive or even to hope, by a limit imposed from without, but falsely identified as lying within." - Stephen Jay Gould, Biologist From the time I was a child, I have always been taught to treat animals with kindness. For many years I believed this meant that every animal should be free of anguish - that every man, creature, or being deserves the opportunity to strive for a better life. However, as I grew older, I realized that it is impossible to completely eliminate suffering. There exists a valid need for some animals to be sacrificed to science for the greater benefit of all forms of life. Some critics would ban the use of any animals for research to benefit mankind. They create the false perception that we value life less through our use of animals for research - that animal research is cruel and heartless. Should we allow this limit to be imposed? The use of animals in biomedical research is not only regulated and humane, but it is also essential to medical progress. The foremost claim of the critics of animal research is that the practice is harmful to the animals involved, but this is far from the truth. The scientific community strongly supports animal welfare, and ensures the well-being of all the animals they use for testing. Proper care of these animals is of the utmost importance for both humanitarian and scientific reasons. Analgesic or anesthetic drugs are often used to ease the pain of animals in tests, and often these tests do not involve pain at all. In addition, animal research is strictly regulated and controlled by multiple federal acts and organizations. Even the most specific details of animal testing are regulated by legislation: "Federal laws, the Animal Welfare Act and the Public Health Service Act, regulate the alleviation and the elimination of pain, as well as such aspects of animal care such as caging, feeding, exercise of dogs and the psychological well-being of primates" ("Frequently"). These stringent controls have been guaranteeing the well-being of animals for decades. The Animal Welfare Act, in particular, has been in place for over forty years. This combination of scientific support for the well-being of animals with federal regulations and organizations has resulted in a reasonable and humane method of animal research. Through this method, incredible progress in the field of medicine and scientific research has been made that has benefited both humans and animals. Animal research has played a major role in a surge of new treatments for harmful diseases. Directly evolving from the availability of these new medications is the increase of the life expectancy in the United States, which "has dramatically improved from an average of 49 years in 1900 to 67.6 years in 2001" ("Use"). This increase in life expectancy is at least partially because of the revolution in heart treatments brought on by tests on canines. The use of dogs in biomedical research has led to invaluable developments such as heart transplants, open-heart surgery, and pacemakers. Studies on dogs have also resulted in the creation of an insulin pump to treat diabetics. Other debilitating diseases eliminated with the help of animal research include polio, typhus, diphtheria, tetanus, and smallpox. Our pets are also benefiting from the results. Thanks to animal testing, vaccines now exist for feline immunodeficiency virus and canine parvovirus. The tremendous successes of animal testing have been invaluable to the improvement of both human and animal lives. Even with all the advancements made to date, there is still a hope and a need for future achievements. Many fatal ailments still afflict mankind. Namely, the development of cures for many infectious diseases relies heavily on the continuation of animal research: More than 800 million people worldwide suffer from the debilitating and often fatal diseases schistosomiasis, malaria, leprosy, leishmaniasis, and trypanosomiasis. Animals are essential to developing ways to prevent and treat such diseases because they allow researchers to measure the host response to disease-causing agents, as well as the effectiveness and short and long-term side effects. ("Animal") Measurements of certain parameters of treatment for these diseases, including side effects, are only valid when tested on animals. This is primarily because many animals have short life spans, which allows for timely measurements, and many are similar to humans, which causes them to undergo comparable symptoms. The same qualities that make animal testing ideal for use in the development of cures for infectious diseases would also aid research on cancer and Alzheimer' s disease. Should we impose a limit on this method of research, which could ultimately lead to the discovery of a cure for cancer? The "stunting of life" is indeed a terrible tragedy. However, this tragedy does not occur because of the use of individual animals in biomedical research. Rather, it is the abolishment of animal testing that could stunt the lives of vast numbers of humans and animals. The limitations on the hope for a world without human and animal suffering truly are imposed from without the laboratory, not from within it. We must renounce the presumption that animal testing is wrong or cruel. Otherwise, we are all denying ourselves an opportunity - the opportunity for a world where disease no longer threatens the lives of men and animals alike. Works Consulted "Animal Research & Human Health." Foundation for Biomedical Research. 1992. "Frequently Asked Questions About Animal Research." Foundation for Biomedical Research. 2003. "Use of Animals in Biomedical Research: Understanding the Issues." American Association for Laboratory Animal Science. November 2003. Creative Category Winner 10th Grade Student Council Rock High School North Newtown, PA J. Quackenbocker: Animal Activist Jannik Quackenbocker, a 35-year-old painter, was sitting on scaffolding on the side of a building, catching his breath after painting a slogan under a mural of the Peaceable Kingdom: Stop Animal Cruelty. Ban Biomedical Testing. He felt unusually tired. Suddenly, passers by screamed in horror as they saw a man fall off of the scaffolding onto the busy streets of New York City. An ambulance arrived and rushed him to the nearest hospital. When Jannik Quackenbocker awoke, he was in a hospital bed, hooked up to machines that made various beeping noises. His right leg was in a full cast, and he could not move his neck. When the doctor came in, Jannik asked, "What happened to me? One minute, I was putting away my paintbrush, and now I'm trussed up in a hospital bed!" The doctor replied, "Mr. Quackenbocker, you just survived a heart attack. We have concluded that you have a severe form of heart disease. You probably need to change your eating habits, take a few medications, and develop an exercise routine in order to return your body to a healthier state." "How can you tell what is wrong with me? You don't have superhuman vision," said Jannik. "Well, Mr. Quackenbocker, in order to arrive at a diagnosis, we used special equipment and techniques that helped us look into your heart. We conducted electrocardiography, and inserted a cardiac catheter into your heart through one of your veins. These studies suggested that you have one severely blocked artery and we can fix it by performing a coronary angioplasty. You are also suffering from arrhythmia, so we will need to implant a pacemaker close to your heart.” "Wait a second, you must have tested these procedures on animals first. Didn't you?" "Yes, Mr. Quackenbocker, we did. Why do you ask? Do you oppose the use of animals in scientific research?" "Of course I do! I am an animal rights activist! Do you expect me to just sit here while you are mistreating little animals in your labs right now? I demand to be let out of this sickening establishment this very instant!" Jannik Quackenbocker attempted to lift himself off of the hospital bed, but to no avail. The doctor sat down and waited for Jannik to calm down. "Mr. Quackenbocker, since you are in no condition to move right now, let me explain to you some of the reasons why animals are used in biomedical research: Medical researchers need to understand health problems before they can develop ways to treat them. Some diseases and health problems involve processes that can only be studied in a living organism. Animals are necessary to medical research when it is impractical or unethical to use humans. ("Questions") If we do not conduct our research on animals prior to treating humans, we could potentially harm many human lives: 'Due to medical research, life expectancy in the United States has dramatically improved from an average of 49 years in 1900 to 67 years in 2001' ("Use"). This is why animal testing is essential.” "Though that may be true, you medical people poke and prod around the insides of these poor, defenseless creatures, which is a form of cruelty! I would like to hear you explain yourself out of that hole," said Jannik. "Though we perform various tests and procedures on our lab animals, we treat them with the utmost care. We feed them very well, and try and make sure that they are as healthy and comfortable as possible. Would you rather have us practice a new operating procedure on animals first, or would you volunteer to let us experiment on your first-born child, before we treat another human being? These are life-changing surgeries that we practice on the animals - the ones that could determine if one lives or dies. These surgeries and treatments not only benefit humans, but they also benefit the animals on which they are performed." "Really? I didn't know that. I never looked at it that way. What other procedures have these animals martyred themselves for?" "Well, I will begin with the benefits of animal research on human health. We have developed 'cognitive enhancing drugs' that slow down the progression of Alzheimer's disease ("Proud"). We have also managed to eradicate smallpox, and we have been able to create certain drugs that can shrink the size of cancerous tumors. In addition, we have developed vaccines to fight HIV and AIDS. In animals, we have been able to perform heart transplants for animals with heart problems, and develop drugs that can treat arthritis in dogs. I see you are getting tired. You need to get some rest. " The doctor left the hospital room. Three months later, the painter returned to his mural and painted these words over his slogan: "The use of animals in biomedical research, not the prevention of it, is the key to improving the health of society." Works Consulted "The Proud Achievements of Animal Research." Foundation for Biomedical Research. "Questions People Ask About Animals in Research." The American Physiological Society 2001. "Use of Animals in Biomedical Research: Understanding the Issues." American Association for Laboratory Animal Science. November 2003.