CURRICULUM VITAE DATE: 4/17/2020 NAME: James M. Stark, M.D., Ph.D. PRESENT TITLE: Visiting Professor of Pediatrics Division Chief, Pediatric Pulmonary Medicine, Allergy/Immunology & Rheumatology Program Director, Pediatric Pulmonary Medicine Fellowship Training Program ADDRESS: 6431 Fannin MSB 3.228 Houston, Texas 77030-1503 BIRTHDATE: 10/09/1953 CITIZENSHIP: USA UNDERGRADUATE EDUCATION: 1972-1976 The Cleveland State University Cleveland, Ohio B.S., Biology (Summa Cum Laude) GRADUATE EDUCATION: 1976-1982 Case Western Reserve University Ph.D. in Microbiology and Molecular Biology School of Medicine, Cleveland, Ohio Thesis Advisor, Charles W. Shuster, Ph.D. 1976-1983 Case Western Reserve University M.D. School of Medicine, Cleveland, Ohio POSTGRADUATE TRAINING: Post-Doctoral 1983-1986 Department of Pediatrics Rainbow Babies and Children's Hospital University Hospitals of Cleveland Cleveland, Ohio 1986-1989 Department of Pediatrics Case Western School of Medicine University Hospitals of Cleveland Cleveland, Ohio MILITARY SERVICE (IF APPLICABLE): Residency in Pediatrics (William T. Speck, Chairman, Department of Pediatrics) Fellowship in Pediatric Pulmonology (Pamela B. Davis, M.D., Ph.D., Program Director) none ACADEMIC APPOINTMENTS: Assistant Professor 07/01/89-02/28/93 Department of Pediatrics Division of Pediatric Pulmonology University of Wisconsin Children's Hospital Research Assistant Professor 03/01/93-09/30/98 Department of Pediatrics, Division of Pulmonary Medicine Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio Research Associate Professor 09/01/98-09/30/99 Department of Pediatrics, Division of Pulmonary Medicine Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio Associate Director, Division of Pulmonary Medicine, CHMC, Cincinnati, 03/01/93-09/30/99 OH Pediatric Pulmonary Fellowship Training Director, CHMC, Cincinnati, 01/01/96-12/31/98 OH Assistant Professor, Department of Molecular Microbiology and 10/01/99-03/31/03 Immunology University of Missouri-Columbia, Columbia, MO Associate Professor, Department of Pediatrics, University of Texas 04/01/03-06/15/06 Health Sciences Center at Houston Associate Professor, Department of Pediatrics, Wright State 06/17/06-06/30/11 University, Dayton Ohio Professor, Department of Pediatrics, Wright State 07/1/11-08/31/11 University, Dayton Ohio Visiting Professor, Department of Pediatrics, University of Texas Health 09/1/11-present Sciences Center at Houston HOSPITAL APPOINTMENTS: 07/01/89-02/28/93 Attending Staff University of Wisconsin Children's Hospital University of Wisconsin, Madison Wisconsin 03/01/93-09/30/99 Attending Staff Children's Hospital Medical Center 10/99-3/31/03 Attending Staff University Hospital and Clinics- University of Missouri-Columbia 08/01/04-06/15/06 Attending Physician, Memorial Herman Children’s Hospital 08/01/03-06/15/06 Active Medical Staff, Harris County Hospital District/LBJ Hospital 08/15/04-06/15/06 Medical Staff, HealthBridge Children’s Hospital 06/17/06-08/31/11 Attending Physician, Dayton Children’s Medical Center 09/28/11-present Harris County Hospital District/LBJ General Hospital 09/01/11-present Temporary Privileges, Memorial Hermann Hospital LICENSURE: Medicine State of Texas State of Ohio CERTIFICATION: 1987 Diplomate, American Board of Pediatrics 1992 Diplomate, American Board of Pediatrics Sub-Board of Pediatric Pulmonology Certificate Number 35922 Certificate Number 362 Recertified 2006-2013 PROFESSIONAL ORGANIZATIONS (AND COMMITTEES OF THESE): LOCAL: REGIONAL: NATIONAL: American Society for Microbiology, 1986-present American Thoracic Society, 1989-present American Thoracic Society, Program Committee, Allergy, Immunology and Inflammation Assembly, ALA/ATS National Meeting, 1993-1996 Pediatric Assembly, ALA/ATS International Meeting, 1997-2001 Elected to Society for Pediatric Research, 12/96 Pediatric Pulmonary Training Directors Association (PEPTDA) 19961998 HONORS AND AWARDS: 1991-1994 Harry S. Shwachman Cystic Fibrosis Clinical Investigator Award Cystic Fibrosis Foundation 1991-1996 Clinical Investigator Award (K08) National Institutes of Health 1986-1989 Parker B. Francis Post-doctoral Research Fellowship Parker B. Francis Foundation 1976-1978 National Research Service Award 1981-1982 Department of Health, Education, and Welfare, National Institutes of Health Predoctoral Fellowship, Medical Scientists Training Program Case Western Reserve University, Cleveland, Ohio 1979-1981 National Research Service Award National Heart, Lung, and Blood Institute, National Institutes of Health Predoctoral Fellowship Case Western Reserve University Cleveland, Ohio EDITORIAL POSITIONS: SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES: British Columbia Lung Association, May 1996 National Institutes of Health, National Institute of Allergy and Infectious DiseasesRFA AI95-11 Mucosal and Synovial Gene Transfer, April 11, 1996 VA Medical Center, Merit Award, March 1997 National Institutes of Health, National Heart Lung and Blood Institute, SCOR in Neurobiology of sleep and sleep apnea, airway biology and pathogenesis of Cystic Fibrosis, and Acute Lung Injury, SCOR in Airway biology and pathogenesis of Cystic Fibrosis. RFA HL-96-14. 1/11/98-1/12/98 British Columbia Lung Association, May 1998 The Wellcome Trust, June 1999 Michael Smith Foundation for Health Research, July 2001 National Institutes of Health, National Heart Lung and Blood Institute, SCOR in Neurobiology of sleep and Sleep Apnea and Airway Biology and Pathogenesis of Cystic Fibrosis. RFA HL-02-13. 3/12/03-3/13/03 National Institues of Health, Special Emphasis Panel/Initial Review Group 2005/01 LCMI (1) 10/13/2004-10/14/2004 National Institutes of Health. Heart, Lung, and Blood Special Review Committee. PPG Review: 1 P01 HL083069-01. 13 May 2005 SERVICE ON THE UNIVERSITY OF TEXAS-HOUSTON HEALTH SCIENCE CENTER COMMITTEES: SERVICE ON THE UNIVERSITY OF TEXAS-HOUSTON MEDICAL SCHOOL COMMITTEES: Graduate Education Committee member 9/1/2004- 2006 Fellowship Training Director Pediatric Pulmonology 2011- present SERVICE ON GRADUATE SCHOOL COMMITTEES: SERVICE ON UT-HMS AFFILIATED HOSPITAL COMMITTEES: SERVICE TO THE COMMUNITY: Committee Member, BSA Troop 464, Pearland, TX Coach, Science Olympiad Northmont High School, Dayton Ohio 2004-2006 2007-2009 SPONSORSHIP OF CANDIDATES FOR POSTGRADUATE DEGREE : (include names and years) Advisory Committee and Examination Committee, Rebecca R. Corrigan, 2004 SPONSORSHIP OF POSTDOCTORAL FELLOWS: (include names and years) CURRENT TEACHING RESPONSIBILITIES: Medical School: MSIII Lectures- Pediatrics Rotation Ad hoc teaching of students on rotation Supervision of Residents during Pediatric Pulmonology rotations (1-3/month) Ad hoc teaching of residents (Pediatrics, Transitional, Med-Peds) on misc. Pediatrics rotations Supervision of Pediatric Pulmonology fellows during clinical rotations and Teaching in core research and clinical curriculum. CURRENT GRANT SUPPORT: amount) (include project title, P.I., funding agency, award period and None PAST GRANT SUPPORT: (include project title, P.I., funding agency, award period and amount) Cystic Fibrosis Foundation 1990-1992 New Investigator Award Cell Biology of Parainfluenza virus Type 2 Direct Costs (annual): $32,000 Total Costs (project): $64,800 1991-1994 Cystic Fibrosis Foundation Harry S. Shwachman Clinical Investigator Award Respiratory Virus Infection and Airway Inflammation Direct Costs (annual): $15,700 Total Costs (project): $52,155 1991-1996 National Institutes of Health Clinical Investigator Award Respiratory Virus Infection and Airway Inflammation Direct Costs (annual): $80,730 Total Costs (project): $340,416 1991-1992 Fisons Pharmaceuticals Effects of Nedocromil Sodium on Neutrophil Adhesion to Airway Epithelial Cells Direct Costs (annual): $5,760 Total Costs (project): $5,760 1994-1996 Cystic Fibrosis Foundation Adenovirus Infection and Airway Inflammation Direct Costs (annual): $30,000 Total Costs (project): $64,800 1993-1994 Cystic Fibrosis Foundation Adenovirus Infection and Airway Inflammation Part of CFF RDP PI: Jeffrey A. Whitsett, M.D. Direct Costs (annual): $40,000 Total Costs (project): $40,000 1996-1998 Board of Trustees, Children's Hospital Medical Center Role of ICAM-1 in RSV-Induced Pulmonary Inflammation PI: James M. Stark, M.D., Ph.D. Direct Costs (annual): $40,000 Total Costs (project): $40,000 1997-1999 Cystic Fibrosis Foundation IL-1 and Adenovirus vector-induced Airway Inflammation Direct Costs (annual): $30,000 Total Costs (project): $64,800 1997-1999 American Lung Association Mechanisms of RSV-Induced Airway Inflammation Direct Costs (annual) $25,000 Total Costs (project) 1998-1999 NIH: Center for Environmental Genetics PI: G. Grabowski Subcontract (Pilot project): PI: J. M. Stark Genetic Analysis of RSV Infection in a Mouse Model Direct Costs (annual) $20,000 Total Costs (project) $50,000 $20,000 2001-2002 Children's Miracle Network Research Grant (PI: JM Stark) RSV increases susceptibility to bacterial pneumonia Direct Costs (annual) $10,000 Total Costs (project) $10,000 2001-2004 Cystic Fibrosis Foundation Research Grant (PI: JM Stark) RSV Enhances Susceptibility to P. aeruginosa Pneumonia Direct Costs (annual) $ 60,000 Total Costs (project) $129,600 04/01/01-03/31/04 2001-2005 National Institutes of Health (NIAID) 1R01 AI46556-01A1 (PI: JM Stark) Genetic Determinants of RSV susceptibility in mice Direct Costs (year 1) $225,000 Total Costs (project) 9/1/01-6/30/05 2004-2006 $1,208,017 National Institutes of Health, NIEHS R21 ES012927-01 (PI: Colasurdo GN) SP-A Signaling and Age-Dependent Vulnerability to PM $275,000 The major goals of this project are to define the cellular regulation of SP-A and its role in enhanced susceptibility to PM in developing mice. Role: co-investigator 4/1/2004-3/31/2006 PENDING GRANT APPLICATIONS (include project title, P.I., funding agency, award period and amount) PUBLICATIONS: A. Abstracts 1. Stark JM, O'Neil J, Nisimune T, Shuster CW. Analysis of multiple antibiotic resistant strain of Enterobacter agglomerans. Abstracts of the Annual Meeting of the American Society for Microbiology, 1978. 2. Shuster CW, Stark JM, O'Neil J. Properties of an ampicillin resistance plasmid from Enterobacter agglomerans. Abstracts of the Annual Meeting of the American Society for Microbiology, 1978. 3. Stark JM, Shuster CW. Mapping of the genes for alpha hemolysin production by Tn5 mutagenesis in Escherichia coli. Abstracts of the Annual Meeting of the American Society for Microbiology, 1981. 4. Stark JM, Shuster CW. Structure of the hemolysin portion of pHly185. Abstracts of the Annual Meeting of the American Society for Microbiology, 1982. 5. Stark JM, Brooks LJ. Differences between slow and fast vital capacities in patients with cystic fibrosis. Abstracts of the North American CF Conference, 1988. 6. Stark JM, Huang YT, Davis PB. Parainfluenza and respiratory syncytial virus infection of cultured human airway epithelial cells- A possible model for lower respiratory tract disease. Am Rev Respir Dis 139:A318. 1989. 7. Stark JM, Huang YT, Davis PB. Parainfluenza and respiratory syncytial virus infection of an immortalized human tracheal epithelial cell line, 9HTEo-. Pediatric Pulmonol Suppl 4, 134, 1989. 8. Stark JM, Kercsmar C, Tosi M. Enhanced neutrophil adherence to cultured tracheal epithelial cells infected with human parainfluenza virus type 2. Am Rev Respir Dis 139:A691, 1990. 9. Tosi MF, Stark JM, Hamedani A, Smith CW, Gruenert DC, and Huang YT. Increased adhesion to human tracheal epithelial cells infected with parainfluenza virus type 2: Role of epithelial ICAM-1 and neutrophil CD11/CD18 Adhesins. Society for Pediatric Research, 1991 Annual Meeting. 10. Stark JM, Tosi MF. Use of a microtiter assay to demonstrate enhanced neutrophil adhesion to human airway epithelial cells. Am Rev Respir Dis 143:A43, 1991. 11. Stark JM, Carabell SK. Detection of enhanced neutrophil adhesion to parainfluenza-infected airway epithelial cells using a modified myeloperoxidase assay in microtiter format. Pediatric Pulmonol suppl 6: 301. 1991. 12. Tosi MF, Stark JM, Hamedani A, Smith CW, Gruenert DC, Huang YT. Neutrophil adhesion to human airway epithelium: Role of epithelial ICAM-1 in cells infected with respiratory viruses or treated with IL-1 or TNF. Pediatric Pulmonol suppl 6: 301, 1991. 13. Doran O, Shinners P, Chen, M, Stark J, Graziano FM. Isolation and characterization of guinea pig (Gp) epithelial cells (Ec). J. Allergy Clin Immunol 89:145. 1992. 14. Stark JM, Tosi MF. A soluble factor in supernates from parainfluenza-infected cells increased ICAM-1 expression by airway epithelial cells but does not significantly enhance neutrophil adhesion. Pediatric Pulmonol suppl 8:315, 1992. 15. Stark JM, van Egmond AWA, Keller SA. The de-adhesion of neutrophils from parainfluenza virus-infected A549 airway epithelial cells results from a change in neutrophil function over time. Pediatric Pulmonol suppl 8:281, 1992. 16. Stark JM, van Egmond AWA, Keller SA. Neutrophil adherence to A549 airway epithelial cells is energy-dependent, reversible, and transient. Pediatric Pulmonol suppl 8:281, 1992. 17. Graziano FM, Cook E, Stark JM. Evaluation of viral infection of guinea pig (GP) tracheal epithelial cells. J Allergy Clin Immunol. 91:160, 1993. 18. Cook E, Stahl J, Stark JM, Graziano FM. Adhesion of guinea pig inflammatory cells to guinea pig tracheal epithelial cells (GPTE) and a human epithelial cell line. J Allergy Clin Immunol 91:161, 1993. 19. Stark JM, Godding V, Keller S, Sedgwick J. Tumor Necrosis Factor (TNF) enhances eosinophil adhesion to cultured airway epithelial cells. J Allergy Clin Immunol 91:254, 1993. 20. Stark JM, Godding V, Sorkness RL, Nagata M, Sedgwick JB. The method of cell isolation alters eosinophil adhesion to airway epithelial cells and eosinophil superoxide generation. Am Rev Respir Dis 147:A817, 1993. 21. van Egmond A, Keller SA, Stark JM. Neutrophil adhesion to parainfluenza virusinfected airway epithelial cells is reversible and energy-dependent, and deadhesion results from "changes" in the neutrophil. Am Rev Respir Dis 147:A474, 1993. 22. Stark JM, Amin R, Warner B, Trapnell B. Exposure of cultured airway epithelial cells to a replication-deficient adenovirus vector increases expression of IL-8 and ICAM-1, and enhances neutrophil adhesion to the AEC monolayers. Pediatric Pulmonol 17:64, 1994. 23. van Egmond AWA, Stark JM. Neutrophil adhesion to parainfluenza type-2 virus infected airway epithelial cells results in priming of superoxide generation. Pediatric Pulmonol, suppl 9:289, 1993. 24. Godding V, Sedgwick JB, Stark JM. Respiratory virus infection enhances eosinophil (EOS) Adhesion to airway epithelial cells (AEC): Role of EOS CD18 and AEC ICAM-1. Pediatric Pulmonol, suppl 9:289-290, 1993. 25. Amin RS, Wilmott R, Trapnell B, Stark JM. The effect of exposure of airway epithelial cells to a replication-deficient adenovirus vector on the expression of IL-8 and ICAM-1 and the down regulation of IL-8 by dexamethasone. Am J Respir Crit Care Med 149:A33, 1994. 26. Zhou S, Stark JM, Leikauf, GD. Human airway epithelial cell-neutrophil interactions increase leukotriene B4 formation. Am J Respir Crit Care Med 149:A831, 1994. 27. Stark JM, Godding, V, Sedgwick, J.B. Eosinophil (EOS) adhesion to airway epithelial cells (AEC): The roles of EOS b2 integrins and AEC ICAM-1. Am J Respir Crit Care Med 149:A835, 1994. 28. Stark JM, Amin R, Trapnell B. Dexamethasone treatment significantly suppresses ICAM-1 expression induced in airway epithelial cells following exposure to a replication-deficient adenovirus vector: Cell line differences. Pediatric Pulmonol, suppl 10:284, 1994. 29. Schwarz YA, Amin RS, Stark JM, Trapnell B, and Wilmott RW. Exposure of airway epithelial cell cultures to a replication-deficient recombinant adenovirus vector results in IL-8 production secondary to IL-1 expression: Evidence for autocrine or paracrine cytokine regulation. Pediatric Pulmonol, suppl 10:233, 1994. 30. Fiedler MA, Dollries KW, Stark JM, Wilmott RW. Direct effects of interleukin-8 (IL8) on mouse lung epithelial cell proliferation and function. Pediatric Pulmonol, suppl 10:287-288, 1994. 31. Amin RS, Wilmott RW, Baughman R, Trapnell B, Stark JM. Replication deficient adenovirus induces IL-8 production by alveolar macrophages in vitro. Pediatric Pulmonol, suppl 10:224, 1994. 32. Fiedler MA, Wernke-Dollries,K, Stark JM. Early release of interleukin-8 (IL-8) by respiratory syncytial virus (RSV) infected airway epithelial cells (AEC). Am J Respir Crit Care Med 151:A13, 1995. 33. Evans DA, Hopkins T, Stark JM. A soluble factor produced by RSV-infected cells induces ICAM-1 expression and enhances PMN adhesion. Am J Respir Crit Care Med 151:A603, 1995. 34. Fiedler M, Wernke-Dollries K,Stark JM. Respiratory syncytial virus (RSV) increases interleukin-8 (IL-8) gene transcription via NF-kappa-B activation in A549 cells. Pediatric Pulmonol, suppl 12: 275,1995. 35. van Egmond AWA., Hopkins TM, Stark JM. Neutrophils utilize different ligands for adhesion to respiratory epithelial cells infected with Respiratory Syncytial Virus or Parainfluenza virus: Role of viral hemagglutinins. Pediatric Pulmonol, suppl 12: 276, 1995. 36. Evans DA, Fiedler MA, Milligan L, Stark JM. RSV-Infected respiratory epithelial cells produce IL1-a that results in ICAM-1. Pediatric Pulmonol, suppl 12:275, 1995. 37. Amin RS, Stark JM, Kitzmiller J, Wilmott R. Transcriptional and posttranscriptional regulation of IL-8 mRNA by IL-1 and TNF in lung epithelial cells. Pediatric Pulmonol, suppl 12: 271, 1995. 38. Amin RS, Wilmott R, Trapnell B, Kitzmiller J, Stark JM. Mechanism of increase gene expression of IL-8 and ICAM-1 by lung epithelial cells transfected with replication-deficient adenovirus and the effect of dexamethasone. Pediatric Pulmonol, suppl 12:228, 1995. 39. Fiedler MA, Wernke-Dollries K, Stark JM. Effects of N-acetyl cysteine on RSVinduced IL-8 gene expression and NF-kB activation in A549 cells. Am J Respir Crit Care Med 153: A18, 1996 40. LeVine AM, Evans D, Stanley S, Stark JM. RANTES, IL-8 and IL-11 in children with respiratory syncytial virus (RSV). Am J Respir Crit Care Med 153: A597, 1996. 41. Rey-Rosa A, Evans D, Roberts N, Tomasi A, Reising S, Stark JM, Bernstein D, Christie C. Complicated pneumococcal pneumonias, pleural empyemas and lung abscesses linked to influenza A infections in healthy children. Interscience conference on Antimicrobial Agents and Chemotherapy , New Orleans La . Abstract K8. 1996. 42. Chini B, Milligan L, Fiedler MA, Hopkins T, Stark JM. ICAM-1 upregulation in RSV-infected cells. Pediatric Pulmonol, suppl 13: 329, 1996. 43. Fiedler MA, Wernke-Dollries K, Stark JM. Inhibition of viral replication reverses RSV-induced NF-kB activation and IL-8 gene expression. Pediatric Pulmonol, suppl 13: 330, 1996. 44. Fiedler MA, Chini B, Milligan L, Wernke-Dollries K. Mort-Hopkins T, Stark JM. Mechanisms of RSV-induced airway inflammation. Symposium, RSV after 40 years, an Anniversary Symposium. Kiawah Island, Nov 9-12, 1996. Invited participant 45. Stark JM, Milligan L, Fiedler MA, Mort-Hopkins T. RSV infection causes transcriptional upregulation of RANTES expression in A549 cells. Am J Respir Crit Care Med 155: A465, 1997. 46. Chini B, Miligan L, Fiedler MA, Hopkins T, Stark JM. RSV-induced activation and ICAM-1 gene expression. Am J Respir Crit Care Med 155, A468, 1997. 47. Kitzmiller JA, Stark JM, Wilmott RW. Reduced neutrophil response to the effects of intratracheal murine IL-1a in a transgenic mouse with airway epithelial cell expression of the human interleukin-1 receptor antagonist (HIL-1Ra). Am J Respir Crit Care Med 155: A470, 1997. 48. Fiedler MA, Wernke-Dollries K, Chini BA, Stark JM. IkB degradation in the airway epithelial cell-mediated inflammation. Pediatr Pulmonol, suppl. 14:315, 1997. 49. Ayad O, Stark JM, Wong HR. The Heat Shock Response inhibits Rantes Gene Expression. Society of Critical Care Medicine Educational and Scientific symposium. 1997. 50. Wernke-Dollries K, Stark JM, Fiedler M. Alteration of IkB levels in RSV-infected A549 cells affects NF-kB activation. Am J Respir Crit Care Med 157: A739, 1998. 51. McDowell SA, Fiedler MA, Milligan L, Hopkins TM, Stark JM. Transcriptional regulation of RANTES expression in respiratory epithelial cells (REC) following Respiratory Syncytial Virus (RSV) infection. Am J Respir Crit Care Med 157: A605, 1998. 52. Levine AM, Koeningsknecht V, Stark JM. Decreased pulmonary clearance of Streptococcus pneumoniae following non-lethal Influenza A infection in mice. Am J Respir Crit Care Med 159:A107, 1999. 53. Levine AM, Gwozdz J, Stark JM, Bruno M, Whitsett J, Korfhagen T. Surfactant protein A enhances clearance of respiratory syncytial virus in vivo. Am J Respir Crit Care Med 159:A18, 1999. 54. D. O'Donnell D, Milligan L, Stark JM. Induction of CD95 (Fas) and Apoptosis in Respiratory Epithelial Cell Cultures Following Respiratory Syncytial Virus Infection. Am J Respir Crit Care Med 159: A105, 1999. 55. Pallone MN, Stark JM, Harris,C. Role of bronchoscopy in pediatric stem cell transplant. Am J Respir Crit Care Med 159:A431, 1999. 56. Fiedler MA, Holbrook A, Stark JM. The Effects of Antibodies Targeted at The RSV Fusion Protein on Cytokine Production. Am J Respir Crit Care Med 161:A702, 2000. 57. Cohn G, Shanley T, Fiedler M, Stark JM. The effect of heat shock on human intercellular adhesion molecule-1 (ICAM-1) expression by A549 cells. Am J Respir Crit Care Med 161:A155, 2000. 58. Stark JM, McDowell SA, Koeningsknecht V, Prows DR, Leikauf JE, LeVine AM, Leikauf,GD. Genetic susceptibility to Respiratory Syncytial Virus in inbred mice. Am J Respir Crit Care Med 163:A52, 2001. 59. Shan-Ze Wang, Cynthia L. Rosenberger, James M. Stark, Barney S. Graham, and Kevin S. Harrod. Clara Cell Secretory Protein Modulates Lung Inflammation and Airway Reactivity in Respiratory Syncytial Virus Infection. Am J Respir Crit Care Med 165: A459, 2002. 60. Stark JM, LeVine AM. Respiratory syncytial virus (RSV) infection decreases bacterial clearance and increases lung inflammation in the mouse: effect of virus dose and mouse genetic background. NACF meeting 2002, New Orleans, LA. 61. Stark JM, Turner-Dickson AM. Sequential pulmonary infection (Respiraory Syncytial virus-Pseudomonas aeruginosa) decreases bacterial clearance- role of the pulmonary macrophage. Am J Respir Crit Care Med 167:A723, 2003. 62. Graff GR, Schnitzer PB, Stark JM, Smith AL. Outcome of Multi-Resistant Pseudomonas aeruginosa (MRPA) infection in Cystic Fibrosis. Am J Respir Crit Care Med 167: A914, 2003. 63. Berkenbosch JW, Graff GR, Stark JM. Safety and efficacy of ketamine for infant flexible fiberoptic bronchoscopy. Pediatr Res 2003:53 part 2: 574A. 64. Spivey, JF, Berkenbosch JW, Graff GR, Stark JM. Safety and efficacy of ketamine sedation for infant flexible fiberoptic bronchoscopy. Pediatr Crit Care Med 2003;4 (Suppl): A159 (ThP16). Presented at the 4th World Congress on Pediatric Intensive Care, Boston, USA, June 2003. 65. Graff GR. Kreiswirth BN, Martinez J, Saiman L, Stark J, Smith A. Molecular typing of MRSA in CF subjects from a single CF Center. Pediatri Pulmonol. 2003; 36 (S25:)308 66. Stark JM and Colasurdo GN. Early alterations in innate cellular lung defenses following RSV lung infection: effects on the alveolar macrophage. RSV 2003, Atlanta GA Nov 8-11. 67. Stark JM, Alcorn JL, Chiappetta CL, Jenkins G, Piedra P, and Colasurdo GN. Surfactant protein A (SP-A) production by primary cultures of human type II pneumocytes following RSV infection. RSV 2003, Atlanta GA Nov 8-11. 68. Colasurdo GN, Khan AM, Chiappetta CL, Xue H, Stark JM. RSV produces persistent airway dysfunction after infection in early life in an murine model. RSV 2003, Atlanta GA Nov 8-11. 69. Wang SZ, Bao YX, Rosenberger CL, Stark JM, Harrod KS. IL-12 modulates lung inflammatory and immune responses to RSV infection. RSV 2003, Atlanta GA Nov 8-11. 70. Berkenbosch JW, Ner Z, Stark JM, Graff GR. Remifentanil-Propofol Sedation for Flexible Fiberoptic Bronchoscopy in Older Children. 2004. Society of Critical Care Medicine Annual Meeting. 71. Khan AM, Stark JM Chiappetta CL Colasurdo GN. Post-Natal Exposures to RSV and Airborne Particulate Matter Protect Against the Development of Allergic Responses Pediatr Res, 55:335A, 2004. 72. Colasurdo GN, Khan AM, Chiappetta CL and Stark JM. RSV produces persistent airway dysfunction in BALB/c mice following infection in early life. Am J Respir Crit Care Med 2004; 169: A501. 73. Stark JM, Chiappetta CL, Alcorn JL, Colasurdo GN. Early alterations in innate cellular lung defenses following RSV lung infection. Am J Respir Crit Care Med 2004; 169: A715. 74. Stark JM, Khan AM, Stark MA, Chiappetta CL, Greene TN, Colasurdo GN. RSV infection in the CFTR knockout mouse increase susceptibility to superinfection with Pseudomonas aeruginosa. Pediatri Pulmonol. 2004; 38(S27): A257, p276 75. Fullmer JJ, Elidemir O, Khan AM, Colasurdo GN, Stark JM. Aberrant response to RSV in a murine model of Cystic Fibrosis- is Nitric Oxide responsible for the increased susceptibility to respiratory pathogens? Pediatri Pulmonol. 2004; 38 (S27): A269, p280 76. Lawson JK, Khan Am, Atkins CL, Stark JM, Colasurdo GN, Fullmer J. Timing of Exposure to Endotoxin Determines the Protecting or Exacerbating Effect on Allergic Response. Proc Am Thoracic Soc 2005; 2:A694 77. Stark JM, Larsen GL, Khan AM, Atkins CL, Xue H, Colasurdo GN. Pattern of Airway and Immune Response to a Primary Respiratory Syncytial Virus Infection in Inbred Mouse Pups with Different Genetic Susceptibility: Lack of Altered Th1/Th2 Balance. Proc Am Thoracic Soc 2005; 2:A602 78. Colasurdo GN, Khan AM, Atkins CL, Xue H, Stark MA, Stark JM. Age-Specific Effects of RSV Infection on Airway Function, Viral Clearance and NO production in Mice: Significant Differences in Very Young and Elderly Mice. Proc Am Thoracic Soc 2005; 2:A603 79. Khan AM, Atkins CL, Xue H, Holian A, Stark JM , Colasurdo GN. The role of SP-A in particulate matter induced changes in airway responsiveness and inflammation in mice. Society for Pediatric Research, Washington DC, May 2005. 80. Jon CK, Stark JM, Khan AM, Alcorn JL, Atkins BS, Xue H, Schecter MG, Larsen GL, Colasurdo GN. Genetic susceptibility to RSV Infection in Inbred Mouse Pups: Important role of SP-A. Proc Am Thoracic Soc 2006; 3: A411. 81. Lawson JK, Colasurdo GN, Atkins CL, Khan AM, Schecter MG, Stark JM. Exposure of Newborn Mice to LPS Protects from Allergen (Ovalbumin)-Induced airway Hyperresponsiveness and Airway Remodeling Independent ot Th1/Th2 Pathways. Proc Am Thoracic Soc 2006; 3: A153. 82. Stark JM, Jon CK, Khan AM, Atkins BS, Stark MA, Xue H, Larsen GL, Colasurdo GN. Effect of Genetic Background and Age on Airway Responsiveness Following RSV Infection in Inbred Mouse Pups. Proc Am Thoracic Soc 2006; 3:412. 83. Schecter MG, Morandi M, Holian A, Khan AM, Atkins CL, Jon CK, Stark JM, Colasurdo GN. Functional an Cellular Response to Lipopolysaccharide and Particulate Matter (PM-1648 and PM-Hou) in Developing Mice. Proc Am Thoracic Soc 2006; 3: A 553. 84. Shah BS, Khan AM, Atkins CL, Schecter MG, Jon CK, Colasurdo GN and Stark JM. Age-Dependent differences in Disease Severity and Inflammatory Responses to RSV Infection in Young and Aged Mice. Proc Am Thoracic Soc 2006; 3:781. 85. Enrique H Rios, James M. Stark, Gaye N. Jenkins, Joseph L. Alcorn. The presence of an amino or carboxy-terminal FLAG-tag has no effect on biosynthesis, oligomerization and secretion of surfactant protein-A (SP-A). PAS meeting 2007, Toronto, Canada. 86. Stark JM, Prows DR, Leikauf GD. Genetic Determinants of Respiratory syncytial virus (RSV) susceptibility in inbred mice. Am J Respir Crit Care Med 2007; 175:A760. 87. Alcorn JL, Atkins CL, Khan AM, Stark JM, Colasurdo GN. Regulation of surfactant protein-A (SP-A) protein in human lung epithelial cells after infection by respiratory syncytial virus (RSV). Am J Respir Crit Care Med 2007; 175:A889. 88. Reverdin AK, Khan AM, Dsa S, Atkins CL, Jon CK, Colasurdo GN, Alcorn JL, Stark JM. Determinant of disease severity after RSV infection in young and aged mice. Am J Respir Crit Care Med 2007; 175:A760. 89. Reverdin AK, Stark JM, Khan AM, Atkins CL, Jon CK, Larsen GL and Colasurdo GN. Susceptibility to RSV infection and persistent airway dysfunction in inbred mouse pups: influence of genetic background and host response. Am J Respir Crit Care Med 2007; 175:A697. 90. Jon CK, Stark JM, Khan AM, Alcorn JL, Atkins CL, Schecter MG, Reverdin AK and Colasurdo GN. Genetic susceptibility to RSV in inbred mouse pups: role of leukotriene signaling. Am J Respir Crit Care Med 2007; 175:A919. 91. Stark JM, Leikauf GD, Prows DR. Candidate genes for Respiratory Syncytial Virus susceptibility in mice, American Society for Microbiology International Meeting, Boston, MA June 1-5 2008. 92. Stark JM, Leikauf GD, Prows DR. Role of CFTR in RSV susceptibility: an inbred mouse model. Pediatr Pulmonol 2008; 322:Abstr 340. B. Refereed Original Articles in Journals 1. Stark JM. Studies on plasmid-coded hemolytic determinants of Escherichia coli. Doctoral dissertation, Department of Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio. 1982. 2. Stark JM, Shuster CW. Analysis of hemolytic determinants of plasmid pHly185 by TN5 mutagenesis. J Bacteriol 152:963-967, 1992 3. Stark JM, Shuster CW. The structure of cloned hemolysin DNA from plasmid pHLY185. Plasmid 10:45-54, 1983. 4. Stark JM, Fatemi H, Amini SB, Huang, YT. Occurrence of respiratory syncytial virus subtypes isolated from hospitalized children in Cleveland, Ohio from 19851988. Pediatr Pulmonol 11:98-102, 1991. 5. Stark JM, Huang YT, Carl J, Davis PB. Infection of cultured human tracheal epithelial cells by human parainfluenza viruses types 2 and 3. J Virol Methods 31:31-46, 1991. 6. Tosi M, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: Effects on neutrophil-epithelial cell adhesion. Am J Respir Cell Mol Biol 7:214221,1992. 7. Tosi MF, Stark JM, Hamedani A, Smith CW, Gruenert DC, Huang YT. ICAM-1 dependent and ICAM-1-independent adhesive interactions between PMN and human airway epithelial cells infected with parainfluenza virus type 2. J Immunol 149:3345-3349, 1992. 8. Stark JM, van Egmond AWA, Zimmerman JJ, Carabell SK, Tosi MF. Detection of enhanced neutrophil adhesion to parainfluenza-infected airway epithelial cells using a modified myeloperoxidase assay in a microtiter format. J Virol Methods 40:225-242, 1992. 9. Stark JM, Smith CW, Gruenert DC, Tosi MF. Neutrophil adhesion to parainfluenza virus-infected airway epithelial cells: Possible contributions of ICAM-1 dependent and ICAM-1 independent mechanisms. Chest 101:405-406, 1992. 10. Amin RS, Wilmott RW, Trapnell B, Stark JM. Replication deficient adenovirus induces expression of interleukin-8 by airway epithelial cells in vitro. Hum. Gene Ther. 6:145-153, 1995. 11. Zhou S, Stark JM, Leikauff GD. Human airway epithelial cell-neutrophil interactions increase Leukotriene B4 formation. Journal of Applied Physiology 78: 1396-1403, 1995. 12. Godding V, Stark JM, Sedgwick JB, Busse WW. Adhesion of activated eosinophils to respiratory epithelial cells (REC) is enhanced by tumor necrosis factor alpha and interleukin-1 beta. Am J Respir Cell Mol Biol, 13:555-562, 1995. 13. Fiedler MA, Wernke-Dollries K, Stark JM. Respiratory syncytial virus increases IL-8 gene expression and protein release in A549 cells. Am J. Physiol 269 (Lung Cell Mol.Biol 13): L865-L872, 1995. 14. Stark JM, Godding V, Sedgwick JB, Busse WW. Respiratory syncytial virus infection enhances eosinophil (EOS) adhesion to airway epithelial cells (AEC): Role of EOS CD18 and AEC ICAM-1. J Immunol. 156:4774-4782, 1996. 15. Stark JM, Amin RS, Trapnell BC. Infection of A549 Cells with a Recombinant Adenovirus Vector Induces ICAM-1 Expression and Increased CD-18-Dependent Adhesion of Activated Neutrophils. Human Gene Therapy 7:1669-1681, 1996. 16. Fiedler MA, Wernke-Dollries K, Stark JM. Inhibition of viral replication reverses respiratory syncytial virus-induced NF-k-B activation and IL-8 expression in A549 cells. J Virol. 70:9089-9092, 1996. 17. Fiedler MA, Wernke-Dollries K, Stark JM. Mechanism of RSV-induced IL-8 gene expression in A549 cells prior to viral replication. Am J. Physiol 271(Lung Cell Mol Biol) 15: L963-L971, 1996. 18. Wilmott RW, Kitzmiller JA, Fiedler MA, Stark JM. Generation of a transgenic mouse with lung-specific over-expression of the human interleukin-1 receptor antagonist protein. Am J Respir Cell Mol Biol. 18:429-434, 1998. 19. Chini B., Fiedler MA, Mort-Hopkins T, Milligan L, Stark JM. Mechanisms of RSVinduced ICAM-1 expression. J. Virol. 72:1623-26, 1998. 20. Fiedler MA, Wernke-Dollries K, and Stark JM. Inhibition of TNFa-induced NF-kB activation and IL-8 release in A549 cells using the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol. 19:259-268, 1998. 21. LeVine AM, Kurak KE, Bruno MD, Stark JM, Whitsett JA, Korfhagen TR. Surfactant Protein-A deficient mice are susceptible to Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol. 19:700-708, 1998. 22. Ayad O, Stark JM, Menendez IY, Ryan MA, Wong HR. The heat shock response inhibits RANTES gene expression in cultured human lung epithelium. J Immunol. 161: 2594-2599, 1998. 23. D. O'Donnell D, Milligan L, Stark JM. Induction of CD95 (Fas) and Apoptosis in Respiratory Epithelial Cell Cultures Following Respiratory Syncytial Virus Infection. Virology 257:198-207, 1999. 24. LeVine AM, Gwozdz J, Stark JM, Bruno M, Whitsett J, Korfhagen T. Surfactant protein A enhances clearance of respiratory syncytial virus in vivo. J Clin Invest. 103: 1015-1021, 1999. 25. Schwarz, Y, Amin RS, Stark JM, Trapnell BC, Wilmott RW. IL-1 receptor antagonist (IRAP) inhibits IL-8 expression in respiratory epithelial (A549) cells infected in vitro with a replication-deficient recombinant adenovirus vector. Am J Respir Cell Mol Biol. 21: 388-394, 1999. 26. Zimmerman N, Daugherty BL, Stark JM, Rothenberg ME. Induction of functional CC chemokine receptor-3 in the eosinophilic cell line AML 14.3D10. J Imunol. 164:1055-1064, 2000. 27. LeVine AM, Koenigknecht V, Stark JM. Decreased Pulmonary Clearance of S. pneumoniae following influenza A infection in mice. J Virol Methods 94: 173-186, 2001. 28. Kohn G, Wong HR, Bsesh K, Zhao B, Vasi N, Denenberg A, Morris C, Stark JM, Shanley TP. Heat Shock inhibits TNF-induced ICAM-1 expression in human endothelial cells via I kappa kinase (IKK) inhibition. Shock.17:91-7, 2002. 29. Stark JM, McDowell SA, Prows DR, LeVine AM, Leikauf GD. Genetic susceptibility to respiratory syncytial virus infection in mice. J Med Virol 67:92-100, 2002. 30. Wang SZ, Rosenberger CL, Bao YX, Stark JM, Harrod KS. Clara Cell Secretory Protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 2003; 171: 1051-1060. 31. Wang SZ, Bao YX, Rosenberger CL, Tesfaigzi Y, Stark JM, Harrod KS. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 2004; 173:4040-9. 32. Fullmer JJ, Khan AM, Elidemir O, Chiappetta C, Stark JM, Colasurdo GN. Role of Cysteinyl Leukotrienes in Airway Inflammation and Responsiveness Following RSV Infection in BALB/c Mice, Pediatr allergy Immunol 2005;16: 593-601. 33. Stark JM, Khan AM, Chiappetta C, Xue H, Patel T, Colasurdo GN. Immune and Functional Role of Nitric Oxide in a Mouse Model of RSV Infection. J Infect Dis 2005. 191:287-395 34. Fullmer JJ, Khan AM, Elidemir O, Chiappetta C, Stark JM, Colasurdo GN. Role of Cysteinyl Leukotrienes in Airway Inflammation and Responsiveness Following RSV Infection in BALB/c Mice, Pediatr allergy Immunol 2005;16: 593-601. 35. Alcorn JL, Stark JM, Chiappetta CL, Jenkins G, Colasurdo GN. Effects of RSV infection on Pulmonary Surfactant Protein in Cultured Human Type II Cells: Contrasting Consequences on SP-A mRNA and Proteins. Am J Physiol Lung cel Mol Physiol 2005; 289: L1113-1122. 36. Stark JM, Stark MA, Colasurdo GN, LeVine AM. Decreased Pulmonary Clearance of Streptococcus pneumoniae Following Respiratory Syncytial Virus Infection in Mice. J Med Virol 2006; 78: 827-838 37. Colasurdo GN, Fullmer JJ, Elidemir O, Atkins C, Khan AM, Stark JM. Respiratory syncytial virus infection in a murine model of cystic fibrosis. J Med Virol. 2006; 78:651-8. 38. Stark JM, Barmada MM, Winterberg AV, Majumber N, Gibbins WJ Jr., Stark MA, Sartor MA, Medvedovic M, Kolls J, Bein, K, Maalaparambil B, Krueger M, Heinzmann A, Leikauf GD, Prows DR. Genomewide association analysis of severe respiratory syncytial virus infection. J Virology 2010, 2009; 84: 2257-2269 Clinical 1. Weatherly MR, Stark JM, Rao PS, Askin F, Gilbert-Barness E. Pathological case of the month. Am J Dis Child. 146:427-428, 1992. 2. Graff GR, Stark JM, Berkenbosch JW, Holcomb GW III, Garola RE. Chronic Lung Disease After Activated Charcoal Aspiration. Pediatrics 109:959-961, 2002. 3. Berkenbosch JW, Graff GR, Stark JM. Safety and efficacy of ketamine sedation for infant flexible fiberoptic bronchoscopy.Chest. 2004;125:1132-7 4. Berkenbosch JW, Graff GR, Stark JM, Ner Z, Tobias JD. Use of a remifentanilpropofol mixture for pediatric flexible fiberoptic bronchoscopy sedation. Paediatr Anaesth. 2004;14:941-6. 5. Graff GR, Stark JM, Grueber R. Nebulized Fentanyl for end of life care in Cystic Fibrosis. Respiration 2004; 71:646-649. C. Invited Articles (Reviews, Editorials, etc.) in Journals 1) Stark JM, Busse WW. Respiratory virus infection and airway hyperreactivity in children. Pediatric Allergy Immunol 2:95-110, 1991. 2) Stark JM. Lung infections in children. Curr Opin Pediatr 5:273-280, 1993. 3) Acton JD, Stark JM. Management of Acute Exacerbations of Cystic Fibrosis Lung Disease. Clinical Pulmonary Medicine 6: 153-164, 1999. 4) Wilmott RW, Khurana-Hershey G, and Stark J.M. Current Concepts on Pulmonary Host Defense Mechanisms in Children. Curr Opin Pediatr. 12: 187193, 2000. 5) Stark JM. Models for the study of respiratory syncytial virus infection and disease. Drug Discovery Today: Disease Models 2006; 3:63-68 (epub). D. Chapters 1) Cypcar D, Stark JM, Lemanske RF. Impact of respiratory infections on asthma. Pediatr Clin North Am 39:1259-1276, 1992. 2) Stark JM. Adhesion molecules and airway inflammation. In: Adkinson N.F., ed. Allergy: Principles & Practice, Update Number 13. St. Louis: Mosby, pp 117, 1992. 3) Busse WW, Lemanske RF Jr, Stark JM, Calhoun WJ. Role of respiratory infections. In Holgate ST, Austen KF, Lichtenstein LM, Kay AB, eds. Asthma: Physiology, Immunopharmacology, and Treatment. Boston, MA: Academic Press, pp 345-355, 1993. 4) Stark JM and Graziano FM. Lower airway response to virus. In: Busse WW, Holgate S, eds. Asthma and Rhinitis. Cambridge, MA: Blackwell Scientific Publications, Inc., Chapter 93, pp 1229-1243, 1995. 5) Wilmott RW, Fiedler MA, Stark JM. Host Defense Mechanisms. In: Chernick V and Boat TF, Eds. Disorders of the Respiratory Tract in Children, 6th Edition. WB Saunders Co. Philadelphia, PA. Chapter 12, pp 238-264, 1997. 6) Schroth MK, Stark JM, Sedgwick JB, Busse WW. Eosinophil-Epithelial interactions and transepithelial migration, In: Bochner BS ed. Adhesion Molecules in Allergic Disease, Marcel Dekker, Inc. NY, NY. Chapter 11, 201226, 1997. 7) Fiedler MA, Stark JM. Viral Pneumonia and Antiviral Therapy, in: Wilmott RW ed. The Pediatric Lung, Birkhauser Publishing Ltd. Basel, Switzerland. Chapter 4, pp 83-112, 1997. 8) Stark JM. The induction of chemokines by viruses in allergic states, in: Rothenberg ME ed. Chemokines and Allergic Disease. Marcel Dekker, Inc., New York, NY. Chapter 13, pp 263-287, 2000. 9) Stark JM. Leukocyte-Endothelial Adhesion. In: Busse WW, Holgate S, eds. Asthma and Rhinitis. Second Edition. Cambridge, MA: Blackwell Scientific Publications, Inc. Chapter 46, pp 702-720, 2000. 10) Stark JM and Colasurdo GN. Lung Defenses. In: Chernick V, Boat TF, Wilmott WW, Bush A, Eds. Disorders of the Respiratory Tract in Children, 7th Edition. WB Saunders Co. Philadelphia, PA. 2006. Chapter 12, pp205-223. 11) Stark JM. Pulmonary Manifestations of Immunosuppressive Diseases Other Than Human Immunodeficiency Virus (HIV) Infection. In: Turcios NL and Fink RJ Eds. Pulmonary Manifestations of Pediatric Systemic Diseases Saunders Elsevier Inc. Philadelphia PA 2009, Chapter 3, pp49-78. 12) Stark JM, Mueller G. Lung Defenses. In: Chernick V,Boat TF, Wilmott WW, Bush A, Eds. Disorders of the Respiratory Tract in Children, 8th Edition. WB Saunders Co. Philadelphia, PA. 2011, pp89-109. E. Books F. Other Professional Communications Presentations 5/12-5/15/91 Roundtable discussion leader: "Respiratory Syncytial Virus Vaccine Development" Annual Meeting of the American Thoracic Society, Anaheim, CA Invited Speaker, Aspen Lung Conference, entitled: "Neutrophil adhesion to 6/5-6/8/91 parainfluenza virus-infected human airway epithelial cells: Possible contributions of ICAM-1 dependent and ICAM-1 independent mechanisms." Invited Speaker, "Infections" , presented as part of: Update in Allergy and Clinical 10/1-10/2/92 Immunology, University of Wisconsin, Madison, WI 10/15/- 10/18/92 Sixth Annual North American Cystic Fibrosis Conference Speaker, Workshop session: "Neutrophil Adherence to Parainfluenza virus-infected A549 Airway Epithelial Cells is Energy-dependent, Reversible, and Transient. Sixth Annual North American Cystic Fibrosis Conference Speaker, Workshop session: "A soluble factor in supernates from parainfluenzainfected cells increases ICAM-1 expression by airway epithelial cells but does not significantly enhance neutrophil adhesion." 5/16-5/19/1993 American Thoracic Society, American Lung Association 1993 International Conference Chairman, Mini-Symposium entitled "Airway Eosinophil Recruitment", and, Featured Speaker, "Recruitment and Activation of Airway Eosinophils" 10/13-10/16/93 Seventh Annual North American Cystic Fibrosis Conference Invited Discussion Leader and Speaker, Rise'N Shine Roundtable: "Pathogenic Role of Virus Infections in CF", presented 10/14 and 10/15/94. Speaker, Symposium Session "Late-Breaking Science", entitled, "Exposure of cultured airway epithelial cells to a replication-deficient adenovirus vector increases expression of IL-8 and ICAM-1, and enhances neutrophil adhesion to the AEC monolayers" American Thoracic Society/American Lung Association International 5/21-5/35/94 Conference. Chairman and Facilitator , Poster Session, entitled: "Therapeutic Modulation of Allergic Inflammation" Invited Speaker, American Thoracic Society/American Lung Association 5/21/94 International Conference Postgraduate Course Entitled: "Development of Mouse Models for Lung Injury and Inflammation Using Molecular biology Techniques". American Thoracic Society/American Lung Association International 5/21/94 Conference Course Organizer, Postgraduate Course Entitled: "Development of Mouse Models for Lung Injury and Inflammation Using Molecular Biology Techniques". (Organized the course content and invited speakers, developed printed teaching materials (syllabus) for this course. Invited Participant, "Workshop on Tuberculosis in Children", CDC, Atlanta, GA. 8/1-8/3/94 Invited Speaker, Pulmonary Research Conference, Rainbow Babies and Children's 8/4/94 Hospital, Cleveland, Ohio, talk entitled "Adenovirus Gene Vectors and Inflammation in vitro in cultured human airway epithelial cells." Invited Speaker, Section of Allergy and Immunology, University of Wisconsin9/16/94 Madison, entitled, "Adenovirus gene vectors and pulmonary inflammation." 10/20-10/23/94 Eighth Annual North American Cystic Fibrosis Conference Invited Discussion Leader and Speaker, Rise'N Shine Roundtable: "Pathogenic Role of Virus Infections in CF", Presented 10/21 and 10/22/94 Speaker, "Dexamethasone Treatment Significantly Suppresses ICAM-1 Expression Following Exposure to a Replication-Deficient Adenovirus Vector: Cell Line Differences Exist". Invited speaker, Symposium on Nursing Management of Pediatric Respiratory 12/5/94 Disease, entitled "Pediatric Tuberculosis", Children's Hospital Medical Center, Cincinnati, OH, USA Chairman and invited speaker: Transgenic mouse models as tools for studying 5/11/96 lung inflammation, fibrosis and development. Postgraduate Course, ATS international conference, New Orleans, LA Invited speaker, Allergy Conference: Role of the respiratory epithelium in 10/9/97 modulating airway inflammation following viral lower respiratory tract infections. Divisions of Pulmonary and Critical Care Medicine, and Allergy and Immunology, Washington University School of Medicine, St. Louis, MO Moderator and invited speaker: Respiratory syncytial virus infection in patients 10/25/97 with cystic fibrosis. Workshop, 1997 International Cystic Fibrosis Meeting, Nashville, TN. Invited Speaker: The RSV Virus and issues in Vaccine Development. Midwest 1/23/98 Critical Care Symposium in Neonatology. 1/22-1/23 1998. Chicago, IL. Chairman and Speaker: Models for Pulmonary Development and Differentiation: 4/24/98 Introduction and Overview. Postgraduate Course, 1998 ALA/ATS International Conference, Chicago, IL. Invited Speaker: Virus-induced Airway Inflammation: Respiratory Syncytial Virus. 4/27/98 Symposium, 1998 ALA/ATS International Conference. Chicago, IL. Invited Speaker: Responses to viral infection. Cystic Fibrosis Foundation. 1998 6/1/98 Williamsburg Conference, May 31-Jun5, 1998, Williamsburg, VA. Roundtable moderator and speaker: Contribution of viral infection to CF lung 10/17/98 disease. 1998 International Cystic Fibrosis Foundation Meeting, Montreal, Quebec, Canada Chairman, Poster Discussion Session: Virus-induced airway inflammation. 1999 4/25/99 ALA/ATS International Conference, San Diego, California Invited Speaker: Clinical Year in Review-Pediatric Pulmonary Infections. 1999 4/27/99 ALA/ATS International Conference, San Diego, California. Symposium Chairman : Respiratory virus infections in Asthma. Speaker: 4/28/99 Epithelial responses in virus-induced airway inflammation. 1999 ALA/ATS 11/6/99 11/10/99 05/08/00 05/09/00 5/18/01 5/23/01 5/21/02 10/5/02 5/25/04 10/14/04 05/07 10/08 09/09 02/12 04/13 International Conference, San Diego, California Invited Speaker: RSV and Chronic Lung Disease.1999. 3rd Annual Midwest Critical Care Symposium for Neonatology, Cincinnati, Ohio Invited Speaker: The Cellular Biology of RSV. 1999. RSV after 43 Years. Stuart, Florida. Symposium Chairman: Genetic Determinants of Lung Disease. Speaker: Overview. 2000 ALA/ATS international conference, Toronto, Ontario, Canada Symposium Chairman: RSV Infection and Airway Inflammation. Invited speaker: ALA/ATS international conference, Toronto, Ontario, Canada Cellular Responses of Respiratory Epithelial Cells to RSV Infection. 2000 Postgraduate Course Chairman and Invited Speaker: Genetic Analysis of Lung development and Injury using Mouse Models: Background: ALA/ATS International Conference, San Francisco, California, USA 2001 Invited Speaker: Antiviral agents for Lung infections in children. Symposium, 2001 ALA/ATS International Conference, San Francisco, California, USA. Chairman and Invited Speaker, Pathogenesis of RSV bronchiolitis Minisymposium, 2002 ALA/ATS International Conference, Atlanta, GA, USA. Invited Speaker: Respiratory Syncytial Virus (RSV) infection decreases bacterial clearance and increases lung inflammation in the mouse: effect of virus dose and mouse genetic background. Workshop 22: Update on Pathogenesis of P. aeruginosa. North American Cystic Fibrosis Conference, New Orleans, LA, USA. MiniSymposium, Abstract: RSV Produces Persistent Airway Dysfunction in BALB/c Mice Following Infection in Early Life. 2004 ALA/ATS International conference, Orlando, FL, USA. Workshop: RSV Infection in the CFTR knockout mouse increases susceptibility to superinfection with Pseudomonas aeruginosa. 2004 North American Cystic Fibrosis Conference, St. Louis, MO, USA. Genetic Determinants of Respiratory Syncytial Virus (RSV) susceptibility in inbred mice. ATS International Meeting in San Francisco CA. Role of CFTR in RSV susceptibility in mice: an inbred mouse model. North American Cystic Fibrosis Conference, Orlando FL Asthma Overview: The Problem of Asthma and Asthma Pathophysiology, American Lung Association Asthma Educator Institute, Mason Ohio Grand Rounds, “Bronchiolitis 2012”, UTHealth, Pediatric Department, Houston TX Grand Rounds, “Lung Defenses”, UTHealth, Pediatric Department, Houston TX 2. Non-refereed publications 3. Letters to the Editor 4. Scientific Exhibits 5. Videos 6. Other G. Visiting Professorships