SPONSORED PROJECT ADMINISTRATION BURLINGTON, VT 05405 February 21, 2013 Dear Dr. Verschraegen, If you and/or your colleagues are interested in working on a coordinated submission for this competition please let Dr. Ira Bernstein know. Only one application per institution is allowed. The National Cancer Institute (NCI) has recently announced NCI Experimental Therapeutics-Clinical Trials Network with Phase 1 Emphasis (ET-CTN) (UM1), a limited competition (see the description at http://www.grants.nih.gov/grants/guide/rfa-files/RFA-CA-13-006.html) with a requested Letter of Intent deadline of March 23, 2013 and a Full Application deadline of August 23, 2013. The purpose of this Funding Opportunity Announcement (FOA) is to support an experimental therapeutics clinical trials program through the creation of a consolidated, integrated NCI Experimental Therapeutics-Clinical Trials Network (ET-CTN). This FOA solicits UM1 cooperative agreement applications for multidisciplinary groups that will conduct early phase experimental therapeutics clinical trials. Members of the ET-CTN will work on investigational agent-specific trans-network project teams to define the drug development plan, and to conduct experimental therapeutic clinical trials filed to the Investigational New Drug (IND) applications by NCI’s Division of Cancer Treatment and Diagnosis (DCTD), Cancer Therapy Evaluation Program (CTEP). You may direct questions concerning this announcement to Dr. Bernstein or Hilda Alajajian. Sincerely, Hilda Alajajian Grant Resources Specialist, SPA Office of the Associate Vice President for Research 340 Waterman Building Phone 802- 656-3360 Fax 802-656-8604 Sponsored Project Administration 217 Waterman Building Phone 802-656-3360 Fax 802-656-8604