EXAMPLES OF RESEARCH PROJECTS
The Role of RUNX3 in leukaemogenesis in human haematopoietic cells (8/26 week or PhD)
Dr Alex Tonks
The Role of RUNX3 knock-in on RUNX1-ETO expressing cells (8/26 week or PhD)
Dr Alex Tonks
The nature of Natural Killer T-cell antigen recognition at the atomic level (26 week)
Dr David Cole
The ‘COAGULABILITY’ of endothelial-derived microparticles (8/26 week)
Dr Phil James
The effect of inorganic nitrate on generation of pro-thrombotic and pro-coagulant microvesicle
populations by vascular cells (8/26 week)
Dr Phil James
Do exosomes interfere with tumour antigen cross-presentation from irradiated prostate
cancer cells? (26 week)
Dr Zsuzsanna Tabi
microRNAs in Kidney Disease (26 week)
Dr Tim Bowen & Dr Donald Fraser
Calcium signalling in cardiac physiology and disease (26 week)
Dr Spyros Zissimopoulos
Exploring neurodevelopment in children with Copy Number Variants (CNVs) (26 week)
Dr Marianne van den Bree
Analysing the mechanism of action of a novel viral immune evasion gene (26 week)
Dr Richard Stanton
Cognitive Impairment in the Older Surgical Patient; a literature review (8 week*)
Dr Jonathan Hewitt
Frailty in the Older Surgical Patient; a literature review (8 week)
Dr Jonathan Hewitt
Characterisation of tissue resident memory T cells in mucosal tissues (26 week)
Dr Ian Humphreys
Evaluating the capacity of soluble TLR2 and HMGB1 to act as biomarkers to discriminate
between infectious and non-infectious acute inflammatory conditions (8 week)
Dr M. O. Labéta
Hepatitis C virus evasion of Natural Killer cells (26 week)
Prof A Gallimore & Dr A Godkin
Role of mc026 in pleiotropic effects induced by Molluscum Congiosum Virus in human epidermal
keratinocytes (26 week)
Dr J J Bugert
Development of PET imaging probes for cancer (26 week)
Dr Stephen Paisey, Dr Richard Clarkson
Can alterations in cytokine signalling predict the course of inflammatory arthritis? (26 week)
Prof Simon A Jones & Dr Gareth W Jones
Targeted inhibition of Interleukin-6 trans-signalling prevents early bone damage during
inflammatory arthritis (8 week with possibility of being followed by a 26 week)
Dr. Anwen S Williams
Analysis of factors influencing optimal function of chimeric antigen receptors for adoptive cell
therapy of cancer (26 week)
Dr John S Bridgeman
Delirium in the Older Surgical Patient (26 week)
Dr Jonathan Hewitt
The role of RNA binding protein Sam68 in ADAM15 alternative splicing (26 week)
Dr Zara Poghosyan
Manipulating T lymphocyte homing for tumour immunotherapy (26 week)
Dr Ann Ager (agera@cardiff.ac.uk)
The role of inflammation in Huntington’s disease (8/26 week)
Dr. Ann Ager (agera@cardiff.ac.uk) and Professor Lesley Jones (jonesL1@cardiff.ac.uk)
The impact of neurodegeneration on the blood brain barrier (8/26 week)
Dr Ann Ager (agera@cardiff.ac.uk) and Dr Caroline Tinsley
Project Length: Short or long project
Editing the genome of human T-cells with CRISPR/Cas9 to improve cancer cellular therapies (26
week)
Dr Bruno Laugel (LaugelBF@cardiff.ac.uk) & Prof Andrew Sewell (SewellAK@cardiff.ac.uk)
Behavioural profile of a genetic mouse model for schizophrenia (8 week)
Dr. Anthony Isles (IslesAR1@cardiff.ac.uk)
Evaluation of community-based infant CPR performance (8/26 weeks)
Dr P Theobald (ENGIN), Prof A Kemp (MEDIC)
Functional analysis of genes implicated in late-onset Alzheimer’s disease (26 week possibly 8
week)
Dr Amy Gerrish, Prof Lesley Jones, Prof Julie Williams
Investigating differences in the cellular structure of immortalised embryonic cell lines carrying
mutant huntingtin (26 week)
Prof L Jones
Investigating RNA toxicity as a pathogenic process in Huntington’s disease (26 week)
Dr Alis Hughes and Prof Lesley Jones
Investigating the translation of novel splice variants in Huntington’s disease (26 week)
Dr Alis Hughes and Prof Lesley Jones
Validating the interaction between Huntingtin and the Tap protein in Huntington’s disease (26
week)
Dr Alis Hughes and Prof Lesley Jones
Validating the specificity of Huntingtin antibodies for immunofluorescence microscopy in
Huntington’s disease (8/26 weeks >1 student as an 8 week project)
Dr Alis Hughes and Prof Lesley Jones
Age of onset and progression in Huntington’s disease (8/26 weeks)
Prof L Jones and Prof P Holmans
Analysis of age of onset and progression of Huntington’s disease in genome-wide
association data from the Registry study (8/26 weeks)
Prof L Jones and Prof P Holmans
Role of Hepatocyte Growth factor (HGF) in Mediating Oral Mucosal Fibroblast Wound Healing
Responses and Resistance to TGF- -Driven Differentiation (26 weeks)
Dr. Bob Steadman (MEDIC) and Dr Ryan Moseley (DENTL)
Cancer Exosomes bind Hyaluronic Acid (8 weeks)
Dr Jason P Webber, Dr Aled Clayton, Dr Robert Steadman
The role of oestrogen in the pathogenesis of osteonecrosis in childhood acute lymphoblastic
leukaemia (8 weeks)
Dr Bronwen Evans (evansba@cardiff.ac.uk)
Bone cell-cell communication via microvesicles (26 week)
Dr Bronwen Evans; evansba@cardiff.ac.uk
Assessing the roles of TRPV1 and TRAP-A1 in cellular responses to gastric constituents (8 weeks)
Dr Amanda J Tonks
Understanding molecular mechanisms involved in Ca2+ signalling
(More specific title will be discussed and agreed with potential students) (8/26 weeks)
Professor Tony Lai (lait@cf.ac.uk) incl. Drs S. Zissimopoulos, S. Patel, M. Nomikos
Stimulatory Effects of Pharmaceutical Agents, EBC-46 and EBC-211, on the Wound Healing
Responses of Primary Dermal Keratinocytes in Vitro. (26 week)
Dr Ryan Moseley (DENTL), Dr. Bob Steadman (MEDIC) and Dr. Paul Reddell (Qbiotics Ltd., Australia).
Effects of Novel Tigliane Compounds on the Wound Healing Responses of Dermal Fibroblasts and
Primary Dermal Keratinocytes in Vitro. (26 week)
Dr Ryan Moseley (DENTL), Dr. Bob Steadman (MEDIC) and Dr. Paul Reddell (Qbiotics Ltd., Australia).
Mechanisms underlying the effect of estrogen on deficient healing in aged cells. (8 week)
Dr Robert Steadman