Supplementary Material
Acute Lymphoblastic Leukaemia and Hypereosinophilic Syndrome: Cases reports in the English
literature 1973-2007.
Michael Lonergan
1. Spitzer G, Garson OM. Lymphoblastic leukemia with marked eosinophilia: a report of two cases. Blood
1973; 42: 377-384.
2. Blatt PM, Rothstein G, Miller HL, Cathey WJ. Loffler's endomyocardial fibrosis with eosinophilia in
association with acute lymphoblastic leukemia. Blood 1974; 44: 489-393.
3. Nelken RP, Stockman JA, 3rd. The hypereosinophilic syndrome in association with acute lymphoblastic
leukemia. J Pediatr 1976; 89: 771-773.
4. Pereira F, Moreno H, Crist W, Ermocilla R. Loffler's endomyocardial fibrosis, eosinophilia, and acute
lymphoblastic leukemia. Pediatrics 1977; 59: 950-951.
5. Geltner D, Friedman G, Naparstek E, Granot H, Polliack A. Acute lymphoblastic leukemia. Its occurrence
with hypereosinophilic syndrome' and bilateral spontaneous pneumothorax. Arch Intern Med 1978; 138: 292
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6. Wimmer RS, Raney RB Jr, Naiman JL. Hypereosinophilia with acute lymphocytic and acute myelocytic
leukemia in childhood. J Pediatr 1978; 92: 244-246.
7. Parker D, Graham-Pole J, Malpas JS, Paxton A. Acute lymphoblastic leukemia with eosinophilia and
basophilia. Am J Pediatr Hematol Oncol 1979; 1: 195-199.
8. Catovsky D, Bernasconi C, Verdonck PJ, Postma A, Hows J, van der Does-van den Berg A, et al. The
association of eosinophilia with lymphoblastic leukaemia or lymphoma: a study of seven patients. Br J
Haematol 1980; 45: 523-534.
9. Bachhuber R, Fitchen JH, Harty-Golder B. Rash and eosinophilia in a 23-year-old man. West J Med 1982;
137: 221-227.
10. Bottone E, Macchia P, Consolini R. Acute lymphoblastic leukemia first appearing as hypereosinophilia.
Eur J Pediatr 1982;138: 85-88.
11. Chilcote RR, Pergament E, Kretschmer R, Mikuta JC. The hypereosinophilic syndrome and
lymphoblastic leukemia with extra C-group chromosome and q14+ marker. J Pediatr 1982; 101: 57-60.
12. Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, et al. Hypereosinophilic syndrome in
acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]. Med Pediatr Oncol 1984; 12: 3337.
13. Troxell ML, Mills GM, Allen RC. The hypereosinophilic syndrome in acute lymphocytic leukemia. Cancer
1984; 54: 1058-1061.
14. de Korte D, Haverkort WA, Behrendt H, Roos D, van Gennip AH. Abnormal nucleotide pattern in the
eosinophils of a patient with acute lymphoblastic leukemia associated with eosinophilia. Leuk Res 1986; 10:
1419-1424.
14. Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL. Acute lymphoblastic leukemia with
chromosomal 5;14 translocation and hypereosinophilia: case report and literature review. J Clin Oncol 1987;
5: 382 – 390.
15. Keene P, Mendelow B, Pinto MR, Bezwoda W, MacDougall L, Falkson G, et al. Abnormalities of
chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association. Br J Haematol
1987; 67: 25-31.
16.Tan AM, Downie PJ, Ekert H. Hypereosinophilia syndrome with pneumonia in acute lymphoblastic
leukaemia. Aust Paediatr J 1987; 23: 359-361.
17. Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, et al. Callapositive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity? Acta Haematol
1989; 82: 85-90.
18. Grimaldi JC, Meeker TC. The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia
joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Blood 1989; 73: 208-2085.
19. Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG. Acute lymphoblastic leukemia with
eosinophilia. Medicine (Baltimore) 1990; 69: 232-243.
20. Meeker TC, Hardy D, Willman C, Hogan T, Abrams J. Activation of the interleukin-3 gene by
chromosome translocation in acute lymphocytic leukemia with eosinophilia. Blood 1990; 76: 285-289.
21. Rios-Herranz E, Fores-Cachon R, Diez-Martin SL, Fernandez MN. Hypereosinophilia and acute
lymphocytic leukemia. Postgrad Med J 1991; 67: 702-703.
22. Blatt J, Proujansky R, Horn M, Phebus C, Longworth D, Penchansky L. Idiopathic hypereosinophilic
syndrome terminating in acute lymphoblastic leukemia. Pediatr Hematol Oncol 1992; 9: 151-155.
23. Schiff DE, Ortega JA. Chorea, eosinophilia, and lupus anticoagulant associated with acute lymphoblastic
leukemia. Pediatr Neurol 1992; 8: 466 – 468.
24. Kita R, Enokihara H, Nagashima S, Tsunogake S, Yamato H, Saito K, et al. GM-CSF and eosinophil
chemotactic factors in an acute lymphoblastic leukemia patient with eosinophilia. Acta Haematol 1993; 90:
144-147.
25. Knuutila S, Alitalo R, Ruutu T. Power of the MAC (morphology-antibody-chromosomes) method in
distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and
t(5;14). Genes Chromosomes Cancer 1993; 8: 219-223.
26. Follows GA, Owen RG, Ashcroft AJ, Parapia LA. Eosinophilic myelodysplasia transforming to acute
lymphoblastic leukaemia. J Clin Pathol 1999; 52: 388-389.
27. Ghosh K, Hiwase D, Muirhead D. Intense eosinophilia with abnormal ultrastructure as presenting
manifestation of acute lymphoblastic leukemia. Haematologia (Budap) 2000; 30: 137 – 141.
28. Jain P, Kumar R, Gujral S, Kumar A, Singh A, Jain Y, et al. Granular acute lymphoblastic leukemia with
hypereosinophilic syndrome. Ann Hematol 2000; 79: 272-274.
29. Narayanan G, Hussain BM, Chandralekha B, Sivasankar C, Nair MK. Hypereosinophilic syndrome in
acute lymphoblastic leukaemia--case report and literature review. Acta Oncol 2000; 39: 241-243.
30. Eapen RS, Lemler MS, Ramaciotti C. Serial echocardiographic changes in a child with hypereosinophilia
syndrome. Pediatr Cardiol 2001; 22: 426.
31. Bjerregaard LL, Rosthooj S. Vertebral compression and eosinophilia in a child with acute lymphatic
leukemia. J Pediatr Hematol Oncol 2002; 24: 313-315.
32. Bernasconi C. Hypereosinophilia in acute lymphoblastic leukemia: an association to be remembered.
Haematologica 2001; 86: 893.
33. Nunez CA, Zipf TF, Roberts WM, Medeiros LJ, Hayes K, Bueso-Ramos CE. Molecular monitoring of
cerebrospinal fluid can predict clinical relapse in acute lymphoblastic leukemia with eosinophilia. Arch
Pathol Lab Med 2003; 127: 601-605.
34. Fasipe F, Bestak M, Green NS. Recurrent central nervous system acute lymphoblastic leukemia
associated with cerebrospinal fluid eosinophilia and basophilia: a proposed cytokine-mediated
mechanism. Pediatr Hematol Oncol 2003; 20: 31-37.
35. Hill A, Metry D. Urticarial lesions in a child with acute lymphoblastic leukemia and eosinophilia. Pediatr
Dermatol 2003; 20: 502-505.
36. Wynn TT, Heerema NA, Hammond S, Ranalli M, Kahwash SB. Acute Lymphoblastic Leukemia with
Hypereosinophilia: Report of a Case with 5q Deletion and Review of the Literature. Pediatr Dev Pathol 2003;
6: 558-563.
37. Chien AJ, Argenyi ZB, Colven RM, Kirby P. Acute lymphoblastic leukemia presenting with urticarial
plaques and hypereosinophilia in a child. J Am Acad Dermatol 2004; 51: S151-S155.
38. Huang MS, Hasserjian RP. Case records of the Massachusetts General Hospital. Weekly
clinicopathological exercises. Case 19-2004. A 12-year-old boy with fatigue and eosinophilia. N Engl J Med
2004; 350: 2604- 2612.
39. Robyn J, Noel P, Wlodarska I, Choksi M, O'Neal P, Arthur D, et al. Imatinib-responsive hypereosinophilia
in a patient with B cell ALL. Leuk Lymphoma 2004; 45: 2497-2501.
40. Koenig CS, Zhao W, Reyes MR, DeMuth KA, Irani A, Schwartz LB. Development of B cell acute
lymphoblastic leukemia in a 12 year old girl with hypereosinophilic syndrome (HES). J Allergy Clin Immunol
2005; 115: S194.
41. Wilson F, Tefferi A. Acute lymphocytic leukemia with eosinophilia: Two case reports and a literature
review. Leuk Lymphoma 2005; 46: 1045-1050.
42. Hagler KT, Zori RT, Yuan CM, Gray BA, Moreb JS. Diagnosis of an early precursor-B-ALL presenting
with hypereosinophilia using FISH on immunomagnetically selected CD19+ cells. Clin Adv Hematol Oncol
2005; 3: 62-64.
43. Rezk S, Wheelock L, Fletcher JA, Oliveira AM, Keuker CP, Newburger PE, et al. Acute lymphocytic
leukemia with eosinophilia and unusual karyotype. Leuk Lymphoma 2006; 47: 1176-1179.
44. Bae SY, Yoon SY, Huh JH, Sung HJ, Choi IK. Hypereosinophilia in biphenotypic (B-cell/T-cell) acute
lymphoblastic leukemia. Leuk Lymphoma 2007; 48: 1417-1419.
We acknowledge Nerida Hackenberg for updating this search and inclusion of the final 3 references.