QJM MS. Num. QJM-D-06-00193R1: supplementary material 26/01/2007 Page 1
Supplement 1: Distribution of coronary risk factors and conditions of elevated h-FABP levels in presenting patients
Risk factor/condition
Total (n=280)
STEMI (n=73
NSTEMI (n=36)
UA (n=31)
No ACS (n=140)
History of CAD
114 (41%)
22 (30%)
12 (33%)
24 (77%)
56 (40%)
Family history of CAD
125 (45%)
34 (47%)
14 (39%)
17 (53%)
60 (43%)
Smoker
139 (50%)
50 (68%)
17 (47%)
13 (42%)
59 (42%)
Hypertension
183 (65%)
42 (57%)
23 (4%)
25 (81%)
93 (66%)
Hypercholesterolaemia
156 (56%)
35 (49%)
23 (63%)
21 (69%)
77 (55%)
Stroke
18 (6%)
6 (8%)
1 (3%)
2 (6%)
8 (6%)
AOD
31 (11%)
8 (11%)
1 (3%)
5 (16%)
17 (12%)
Diabetes
45 (16%)
10 (14%)
3 (8%)
6 (19%)
26 (19%)
Sedentary lifestyle
134 (48%)
31 (43%)
20 (56%)
19 (60%)
64 (46%)
Potentially interfering conditions
Renal failure
14 (5%)
4 (5%)
0 (0%)
3 (10%)
7 (5%)
Excessive exercise
18 (6%)
5 (7%)
4 (11%)
0 (0%)
9 (6%)
Data are numbers (%).STEMI, ST-segment elevation myocardial infarction; NSTEMI, non ST-segment elevation
myocardial infarction; UA, unstable angina; ACS, acute coronary syndrome; CAD, coronary artery disease; AOD, arterial
occlusive disease.
QJM MS. Num. QJM-D-06-00193R1: supplementary material 26/01/2007 Page 2
Supplement 2: Subgroup analysis of all patients presenting to hospital for the secondary endpoint ACS
n
ACS
Sensitivity
Specificity
LR (+)
LR (–)
prevalence (%)
Overall
280
50%
58.6 (49.9–66.8)
72.9 (64.7–80.0)
2.16 (1.59–2.93)
0.569 (0.456–0.712)
<2 h
107
58%
56.5 (43.3–69.0)
75.6 (60.5–87.1)
2.31 (1.32–4.04)
0.576 (0.415–0.801)
2–6 h
105
48%
50.0 (35.5–64.5)
70.9 (57.1–82.4)
1.72 (1.05–2.83)
0.705 (0.510–0.976)
>6 h
68
41%
78.6 (59.0–91.7)
72.5 (56.1–85.4)
2.86 (1.67–4.90)
0.296 (0.142–0.616)
≥55 years
164
56%
65.2 (54.6–74.9)
58.3 46.1–69.8)
1.57 (1.15–2.14)
0.596 (0.424–0.839)
<55 years
116
41%
45.8 (31.4–60.8)
88.2 (78.1–94.8)
3.90 (1.90–8.00
0.614 (0.467–0.808)
Female
67
36%
58.3 (36.6–77.9)
65.1 (49.1–79.0)
1.67 (0.984–2.84)
0.640 (0.380–1.08)
Male
213
54%
58.6 (49.1–67.7)
76.3 (66.6–84.3)
2.47 (1.68–3.65)
0.542 (0.425–0.692)
No
254
50%
57.5 (48.4–66.2)
75.6 (67.2–82.8)
2.35 (1.68–3.31)
0.563 (0.449–0.704)
Yes
26
50%
69.2 (38.6–90.9)
46.2 (19.2–74.9)
1.29 (0.692–2.39)
0.667 (0.244–1.82)
No
262
50%
58.0 (49.1–66.6)
71.8 (63.2–79.3)
2.05 (1.51–2.80)
0.585 (0.466–0.735)
Yes
18
50%
66.7 (29.9–92.5)
88.9 (51.8–99.7)
6.00 (0.893–40.3)
0.375 (0.145–0.972)
Symptom start
Age
Gender
CRF
Exercise
Risk stratification*
<4 risk factors
200
51%
60.8 (50.6–70.3)
74.5 (64.7–82.8)
2.38 (1.64–3.46)
0.526 (0.403–0.688)
≥4 risk factors
80
48%
52.6 (35.8–69.0)
69.0 (52.9–82.0)
1.70 (0.988–2.93)
0.686 (0.464–1.01)
Data are numbers, percentages, or means (95%CI), as appropriate. LR, likelihood ratio. ACS, acute coronary syndrome;
CRF, chronic renal failure. *High risk group: patients were considered to be at high risk when presenting with ≥4 of the
QJM MS. Num. QJM-D-06-00193R1: supplementary material 26/01/2007 Page 3
following risk factors: Past medical history of CAD, family history of CAD, smoker, hypertension, diabetes,
hypercholesterolaemia
QJM MS. Num. QJM-D-06-00193R1: supplementary material 26/01/2007 Page 4
Supplement 3: Cross table of h-FABP test results vs. diagnosis for the secondary endpoint ACS
h-FABP (+)
h-FABP (–)
Inconclusive
Missing
Total
ACS present
69
47
24 (13+/11–)
0
140
ACS absent
30
95
15 (8+/7–)
0
140
Total
99
142
39 (21+/18–)
0
280
At presentation
Four hours after presentation
ACS present
97
25
16 (6+/10–)
2
140
ACS absent
25
95
17 (9+/8–)
3
140
Total
122
120
33 (15+/18–)
5
280
ACS, acute coronary syndrome.