2007-october Admission Exams

Structural and Functional Genomics Entrance Exams
October 2007
1) Dynamical model of metabolic pathways: describe in some detail a possible approach by
means of an example
2) Using microarray analysis to find the targets of a drug treatment
3) Time series analysis and modeling
4) What are the noncoding RNAs?
5) Describe how you would identify differences in gene expression between two tissues
6) Describe the different components of the mammalian transcriptome
7) Eucaryotic transposable elements
8) Regulation of eucaryotic RNA polymerases
9) miRNAs: how are they synthesized and what do they do
10) Technologies useful for conditional mutagenesis
11) Genes patterning the drosophila embryo
12) Epigenetics
13) Is the “ from DNA to RNA to Protein” biological dogma still valid?
14) How many proteins a single gene can code for?
15) Describe examples of how chromatin structure can influence gene expression
16) Describe what type of intermolecular interactions are responsible for the formation of (1)
protein aggregates (2) the DNA double strand.
17) Describe a major experimental technique to solve the structure of membrane proteins
18) Structure and function of G-protein coupled receptors
19) The sequence of a new protein has just been determined in your lab. Can you obtain any
structural and functional information from it?
20) Beta-strands are secondary structure elements much more common in cytoplasmatic
proteins than membrane proteins. Why?
21) Provide an example of the usefulness of molecular simulation approaches for structural
22) Describe some physical process playing a major role in biological functions
23) Describe optical tools for visualizing cells at the micro and nano-scale.
24) Discuss how and why nanotechnology can help understanding biological problems.