INTERNATIONAL CENTER FOR BIOMEDICINE
PRESENTS
THE CONFERENCE & SYMPOSIUM
“CURRENT HYPOTHESES ON ALZHEIMER´S DISEASE
November 22 - 25, 2007
CONFERENCE TOWN, REÑACA
Chairman: Dr. Ricardo B. Maccioni (U Chile & International Center Biomedicine, ICC)
Co-Chair: Dr. Patricio Fuentes (Faculty of Medicine, U Chile)
SPONSORS:
PROGRAMA BICENTENARIO DE CIENCIA Y TECNOLOGIA, CONICYT
INTERNATIONAL CENTER FOR BIOMEDICINE (ICC)
IBERO-AMERICAN MOLECULAR BIOLOGY ORGANIZATION (IMBO)
MEDICHI-FACULTY OF MEDICINE, UNIVERSIDAD DE CHILE
INTERNATIONAL BRAIN RESEARCH ORGANIZATION (IBRO)
CONTRIBUTORS:
NEUROINNOVATION LTD.
LUNDBECK
PHARMA VITA
SCIENTIFIC PROGRAM
Thursday Nov. 22,
16:00-16:15 h Opening Ceremony and Conference Remarks
16:15-16:30
16:30-16:50
Ricardo B. Maccioni
Director International Center for Biomedicine (ICC)
Ivan N. Saavedra President of the ICC
Coffe break (Meeting together)

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SESION1. CHAIRPERSON: Dr. LESTER I. BINDER
16:50-17:40 PLENARY LECTURE 1: "INFLAMMATORY PROCESSES
EXACERBATE DEGENERATIVE NEUROLOGICAL DISORDERS"
17:40-17:50
17:50-18:40
Patrick McGeer (U British Columbia, Vancouver, Canada)
Discussion
LECTURE 2: “TRANSMISSIBILITY OF ALZHEIMER'S DISEASE
BY A PRION-LIKE MECHANISM"
Claudio Soto (U. Texas, Galveston, U.S.A.)
18:40-18:50
19:30
Discussion
WELCOME RECEPTION (Social)
Friday Nov. 23,
SESION II. CHAIRPERSON Dr. RODRIGO. O. KULJIS
9:00-9:50 LECTURE 3: “ GENETIC ANALYSIS POINTS TO UNDERLYING
SIMILARITIES IN THE MECHANISMS OF PATHOGENESIS OF
NEURODEGENERATIVE DISEASES”
John Hardy (NIA-NIH, Bethesda, U.S.A. & Institute of Neurology,
UCL, London, UK)
9:50- 10:00
10:00-10:50
Discussion
10:50-11:00
11:00-11:30
11:30-12:20
LECTURE 4: “WHAT HAVE WE LEARNED FROM THE
PERSPECTIVE OF THE TAU HYPOTHESIS?”
Ricardo B. Maccioni (ICC, Chile)
Discussion
Coffee Break
LECTURE 5: “ UNRAVELING THE NEUROFIBRILLARY
TANGLE”
Lester Binder (Northwestern U, Chicago, U.S.A.)
12.20-12:30 Discussion
13:00-14:30 LUNCH
SESION III. CHAIRPERSON: Dr. GEORGE PERRY
15:00- 15:50 LECTURE 6: “THE OXIDATIVE HYPOTHESIS OF
ALZHEIMER´S DISEASE”
George Perry (U Texas, San Antonio, U.S.A.)
15:50-16:00 Discussion

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16:00-16:50 LECTURE 7: "TRANSGENIC MODELS OF TAU PATHOLOGY
FOR DEVELOPMENT OF THERAPEUTICS"
Hanno Roder (Mayo Clinic, Jacksonville, FL, U.S.A.)
16:50-17:00 Discussion
17:00-17:30
17:30-18:30
Cofee Break
LECTURE 8: “ TAU AS A SENSOR OF THE PROCESSES THAT
CAUSE ALZHEIMER´S DISEASE”
Peter Davies (Albert Einstein Coll Med, NY, U.S.A.)
Discussion 18:30-18-40
18:40- 19:25 Lecture 9: “DEREGULATION OF CDK5 ACTIVITY AND
HYPERPHOSPHORYLATION OF NEURONAL CYTOSKELETAL
PROTEINS IS INHIBITED BY PEPTIDES DERIVED FROM ITS
ACTIVATOR P35”. Harish C. Pant (NINDS/NIH , Bethesda, USA)
CHAIRPERSONS: Drs. PATRICIO FUENTES & JORGE POSTERS
FARIAS
20:00- 22:00 Posters Presentations (these should be presented at the indicated time intervals and shown during the entire event)
Saturday Nov. 24
MINISYMPOSIUM ON AD PATHOGENESIS
CHAIRPERSON: Dr. LEONEL ROJO
9:00- 9:15 “
. Teresa
Carthery-Goulart (U Sao Paulo, Brazil and Cambridge UK)
9:15-9:20
9:20-9:35
Discussion
“WHAT CAN NEUROPSYCHOLOGY TEACH US ABOUT THE
ETIOPATHOGENESIS OF ALZHEIMER’S DISEASE? Andrea
Slachevsky (U Chile, Chile)
9:35-9:40
9:40-9:55
Discussion
“GLIAL CELLS AND THE PATHOGENESIS OF AD:
UNDERSTANDING THE SIGNAL TRANSDUCTION PATHWAYS
INVOLVED IN NEUROINFLAMMATION” Rommy von Bernhardi
(Catholic University, Chile)
9:55-10:00
10:00-10:15
Discussion
“BIOCHEMICAL DETECTION OF MISFOLDED AMYLOID-BETA
OLIGOMERS FOR SENSITIVE DIAGNOSIS OF ALZHEIMER’S

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DISEASE” Lisbell D. Estrada (U Texas Medical Branch, Galveston,
TX, U.S.A.)
10:15-10:20
10:20-10:40
10:40-10:55
Discussion
Coffee Break
“ACUTE AND DELAYED EFFECTS of Abeta ON SYNAPTIC
TRANSMISSION ON HIPPOCAMPAL NEURONS". Luis Aguayo,
(Universidad de Concepción, Chile)
10:55-11:00
11:00-11:15
Discussion
“NUTRITIONAL INTERVENTIONS IN AGING AND
NEURODEGENERATIVE DISEASE: EFFECTS ON ADULT STEM
CELLS”. Paula C. Bickford (James A Haley VAMC & USF Health,
Fl, U.S.A.)
11:15-11:20
11:20-11:35
Discussion
“CHOLESTEROL AND INFLAMMATORY PROCESSES:
CONTRIBUTIONS TO AD PATHOGENESIS”. Leonel Rojo (ICC &
Universidad Arturo Prat, Chile)
11:35- 11:40 “CURRENT ANTIDEMENTIA DRUGS: HYPOTHESIS AND
CLINICAL BENEFITS” Patricio Fuentes (U Chile and ICC, Chile)
11:40-16:30
SESION IV.
16:30-17:20
Free time to enjoy Reñaca
CHAIRPERSON Dr. ROMMY VON BERNHARDI
LECTURE 9: “THE HEART-BRAIN VASCULAR CONNECTION IN
ALZHEIMER´S DISEASE: AN OLD PATHWAY TO A NEW
MIND SHIFT”. Jack de la Torre (Case Western U., Ohio, U.S.A.)
17:20-17:30
17.30-19:20
Discussion
LECTURE 10: "FACTORING IN THE SELECTIVE REGIONAL,
LAMINAR, MODULAR AND CELLULAR CORTICAL
VULNERABILITY IN THE FORMULATION OF ALZHEIMER
DISEASE HYPOTHESES" Rodrigo Kuljis (U Miami, FL, U.S.A.)
19:20-19:30
19:30-19:45
20:30 -
Discussion
Closing Remarks
Dinner Party
Information: International Center for Biomedicine (ICC).
Phones: 562 978 7228 (M. J. Riquelme) and 274 1560 Ext. 742
E-mail: cbb@uchile.cl