Online Appendix for the following August 21 JACC article
TITLE: Characteristics, Treatments, and Outcomes of Patients With Preserved
Systolic Function Hospitalized for Heart Failure: A Report From the OPTIMIZE-HF
Registry
AUTHORS: Gregg C. Fonarow, MD, FACC, Wendy Gattis Stough, PharmD,
William
Mihai
T.
Abraham,
Gheorghiade,
MD,
MD,
FACC,
FACC,
Nancy
Barry
H.
M.
Albert,
Greenberg,
PHD,
MD,
RN,
FACC,
Christopher M. O’Connor, MD, FACC, Jie Lena Sun, MS, Clyde W. Yancy, MD,
FACC, James B. Young, MD, FACC, for the OPTIMIZE-HF Investigators and
Hospitals
APPENDIX
Variables Used in the Models
In-Hospital Mortality Model
(With EF)
(19 total)
60-Day
Mortality Model
(12 total)
60–90-Day Mortality or
Rehospitalization
(14 total)
Admission serum creatinine
Admission SBP
Admission serum creatinine
Admission SBP
Admission serum creatinine
SBP
Age
Age
Admission hemoglobin
Admission heart rate
Pulmonary - reactive airway
Pulmonary - COPD
disease
Admission serum sodium
Discharge medication - lipidWeight
lowering agent
HF as primary cause of
admission
Lower extremity edema
>0 HF hospitalizations in past 6
months (yes/no)
Liver disease
Discharge medication - lipid
lowering
Coronary angiography performed
CVA/TIA (prior)
during hospitalization
Admission sodium
Admission hemoglobin
Admission medication - nitrates
Depression
Peripheral vascular disease
Mechanical ventilation performed
Discharge SBP
Hyperlipidemia
during hospitalization
Discharge serum creatinine
No known HF prior to this
Admission medication - digoxin
admission
Liver disease
Admission medication - diuretic
Race (white vs other)
CVA/TIA (prior)
EF
ICD placed during hospitalization
Pulmonary - COPD
Liver disease
Rales
Admission DBP
Admission ACE inhibitor
Admission β-blocker
ACE = angiotensin-converting enzyme; COPD = chronic obstructive pulmonary
disease; CVA/TIA = cerebral vascular accident/transient ischemic attack; DBP =
diastolic blood pressure; EF = ejection fraction; HF = heart failure; ICD = implantable
cardioverter-defibrillator; SBP = systolic blood pressure.
Linear Spline Transformations for Continuous Variables
In-Hospital Mortality Model
EF: linear up to 38%, no association above 38%
Admission heart rate: linear above 65, no association below 65
Admission SBP: linear up to 160, no association above 160
Admission DBP: linear up to 100, no association above 100
Admission serum sodium: 2 slopes, linear up to 140, linear with different slope above 140
Admission serum creatinine: linear up to 3.5, no association above 3.5
Post Discharge Mortality Model
Admission SBP: 2 slopes, line up to 140, linear with different slope above 140
Admission serum creatinine: linear up to 4.0, no association above 4.0
Admission sodium: linear below 140, no association above 140
Discharge SBP: linear up to 130, no association above 130
Discharge serum creatinine: linear up to 3.0, no association above 3.0
Post Discharge Death or Rehospitalization Model
Admission hemoglobin: linear above 11, no association below 11
Admission serum creatinine: 2 slopes, linear up to 3.8, linear with different slope
above 3.8