WebQuest:
Introduction to Respiration
Name ______________________
A. http://www.phschool.com/science/biology_place/labbench/lab5/intro.html
1. Cellular respiration occurs in most cells of both plants and animals. It takes place in the
___________________, where energy from nutrients converts _______ to _______.
2. ATP is used for all cellular activities that require _______________.
3. Go to the next screen and write a word equation for respiration:
4. Go to the next screen - Grasshopper “closer look” - describe what is happening when the
grasshopper respires.
B.
http://dwb.unl.edu/Teacher/NSF/C11/C11Links/www.harcourtcollege.com/chem/biochem/GarrettGri
sham/HardToGrasp/Redox/Redox.html
1. How OIL RIG is going to help you remember the definitions of Oxidation and Reduction.
C. http://www2.wwnorton.com/college/biology/discoverbio3/full/content/ch8/animations.asp
1. Click on 8.1a: View the animation and sketch a picture that depicts the process of
photosynthesis.
2. Click on 8.2a: View the animation of Glycolysis.
 Where does Glycolysis occur in cells? _________________
 Electrons are donated to ___ molecules of NAD+, generating 2 molecules of
___________.
 In glycolysis, there is a net energy yield of ___ ATP and ___ NADH molecules.
 How many ATP molecules are needed for glycolysis to happen?
 How many ATP molecules are made by glycolysis?
3. Click on 8.2b: View the animation of Krebs Cycle (Citric Acid Cycle).
 Before the Krebs Cycle, the pyruvate molecule is split into ___________ (released) and
________________ (the high energy molecule that enters the Krebs Cycle).
 How many carbons does pyruvate have? ____
 How many carbons does Acetyl CoA have? ____
 Where does the Kreb Cycle occur in cells? ______________________
 In the Krebs Cylce (Citric Acid Cycle) a 4-Carbon compound called _____________ is
combined the 2-C compound called ________________ to make a 6-C compound called
________________.
 During the Krebs Cycle, __ CO2 are released. How many carbons is that? ___
 All of the carbons in the pyruvate (3-C compound) are released as _________.
3. Click on 8.2c: View the animation of Oxidative Phosphorylation.
 Where does Oxidative Phosphorylation occur in cells? _____________________
 Donated ________________ move through the ____________________________ that
occurs through several different protein channels. What is this type of transport called
(using protein channels)? ______________________________.
 Electrons are donated to __________________ (the final electron acceptor) that has
entered the mitochondrial matrix through the process of ____________________.
Oxygen then combines with protons (H+) to form _______________.
 Draw a picture of frame 6, labeling all of the parts shown in the picture
D.
http://www.sp.uconn.edu/~terry/Common/respiration.html
1. Where does respiration occur in prokaryotes (bacteria)?
2. Click go, then animate – Food is the electron _________________ and Oxygen is the
electron _______________.
3. During respiration the disposal product of food (glucose) is ________________.
4. During respiration the disposal product of water is _____________________.
E. http://www.bbc.co.uk/schools/gcsebitesize/teachers/biology/activities.shtml
Click on “Chemical Reactions during Respiration”
1. Write the equation for Respiration
2. Describe in words what happens to the glucose molecule.
F. http://www.phschool.com/science/biology_place/biocoach/cellresp/overview.html
1. Glycolysis occurs in the _____________________.
2. The Krebs cycle takes place in the __________________ of the
________________________.
3. Oxidative phosphorylation via the electon transport chain is carried out on the
_____________________________.
4. Fill in the words for A-H in the following diagram.
5. Fill in what the result of Glycolysis is (at the end of the arrows).
6. Fill in what the result of Krebs Cycle is (at the end of the arrows)
G.
http://staff.jccc.net/pdecell/cellresp/respintro.html
1. Fill in the number of ATP, NADH, FADH2 and CO2 in the diagram below
H. http://www.biosci.uga.edu/metabolism/overview1.html - Watch the Animations
Glycolysis
1. Glycolysis means _________________________.
2. During Glycolysis enzymes break a 6-carbon ______________ into _______ 3-carbon
_________________.
3. What 3 things go into Glycolysis? ____________________________________
4. What are the 3 products of Glycolysis? _________________________________
5. Does Glycolysis require oxygen? ______________________________________
6. What must be present for glycolysis to begin? ______________________________
7. What does NADH do?
Click on Krebs Cycle
1. The Krebs cycle takes materials made during glycolysis and turns them into
______________ and ________________, which contain the ________________ used to
fuel the last phase of metabolism in which large amounts of ATP are produced.
2. Why are mitochondria so important to a cell? ______________________________
_______________________________________________________________________
3. click on “Evolution of Mitochondria” – where do scientists think mitochondria came
from?
4. What evidence do scientists have to prove that?
5. The Krebs Cycle turns ___ times for each glucose molecule that goes through
respiration.
6. The main role of the Krebs Cycle is to produce __________ and ______________, the
high energy molecules that carry the electrons which will be used to make ATP.
7. For every molecule of glucose that enters the Krebs Cycle, what is produced?
Click on Electron Transport (Oxidative Phosphorylation)
1. The two main parts are the:
 Electron Transport Chain which produces ______________
 Chemiosmosis which produces ____________________
2. The two “taxicabs” are _________ and __________ which take their “passengers” the
________________ to _____________________________________________. The
passengers jump from cab to cab to get to their destination, the final electron carrier:
___________.
3. What is the importance of breathing in the process of respiration?
4. During the Electron Transport Chain, H+ went from __________________ to
_________________________ and build up like a dam. ________________ is the name
of the enzyme that acts like a “turbine” to get H+ rapidly into the inner membrane of the
mitochondria, which creates energy to change ADP + P to ____________________.
5. Summary of Electron Transport Phosphorylation
Inputs
Outputs
6. The Electron Transport System is located where? _________________________
7. The final electron receptor for cellular respiration is _______________________
8. What is the direct source of ATP generation during the Electron Transport
Phosphorylation?________________________________________________________
____
I. ATP synthase turbine - http://www.sp.uconn.edu/~terry/Common/respiration.html
1. For every ____H+ that get pushed through the cell membrane ____ ATPs are produced.
J.
http://www.sp.uconn.edu/~terry/images/anim/ETS.html
Great animation of Electron Transport Chain (Oxidative Phosphorylation)
Best for Class LCD
Start with this
http://www.qcc.cuny.edu/BiologicalSciences/Faculty/DMeyer/respiration.html
Oxidation - Reduction
http://dwb.unl.edu/Teacher/NSF/C11/C11Links/www.harcourtcollege.com/chem/biochem/Garr
ettGrisham/HardToGrasp/Redox/Redox.html
http://www.wiley.com/legacy/college/boyer/0470003790/animations/animations.htm
What the molecules look like for all 3 steps:
http://www.johnkyrk.com/indexkaleido7x7.eng.swf John Kyrk
Reducing/Oxidizing
ETC – step by step animation
http://science.nhmccd.edu/biol/etc/respirat.html
Aerobic AND Anaerobic
Diagram
http://www.emc.maricopa.edu/faculty/farabee/BIOBK/energpath1.gif
Glycolysis Aerobic AND ANEAROBIC
Use this for anaerobic
http://www.sp.uconn.edu/~terry/Common/respiration.html
Aerobic and anaerobic respiration animations:
http://www.sp.uconn.edu/~terry/Common/respiration.html
http://instruct1.cit.cornell.edu/Courses/biomi290/MOVIES/GLYCOLYSIS.HTML
http://www.sp.uconn.edu/~terry/images/anim/ETS_slow.html
http://fig.cox.miami.edu/~cmallery/150/metab/c9x6cell-respiration.jpg
Glycolysis
There are 4 important stages in glycolysis:
• Activation of glucose by ATP
• Splitting of glucose into two roughly equivalent phosphorylated halves
• Reduction of NAD+ to NADH
• Phosphorylation of ADP
1. Whole Process and Enzymes
2. Overall Reaction Dr. Meyer at CUNY
3. Metabolic Pathways Wisconsin Online
4. Cellular Respiration Thomas M. Terry at Univ. of Conn.
5. Enzyme Tutorial from Northland Community and Technical College
6. Enzyme Pathways McGraw-Hill
7. Enzyme Activity Lew-Ports Biology Place
8. Enzymologie by Laurent Martorell Académie de Créteil
9. Enzyme Reaction - Simulation BBCi
10.Enzyme Kinetics Wiley
11.Enzyme Inhibition Wiley
12.Glycolysis
13.Gylcolysis by Sue Merkel, Cornell Univ (BEST)
14.Glycolysis by RM Chute
15.Glycolysis by John Kyrk
16.Anaerobic Respiration-Glycolysis and Fermentation by Sue Merkel, Cornell Univ
17.Glycolysis Animation from Northland Community and Technical College
18.Glycolysis Donald Nicholson
19.Acetyl CoA and Krebs (TCA)(Citric Acid) Cycle
20.Virtual Cell's Educational Animations MCBE
21.TCA (Citric Acid) Cycle by Rodney F. Boyer
22.Citric Acid Cycle Purdue University
23.Fatty Acid Respiration Campbell Interactive Chemistry
24.The Pruvate Dehydrogenase Complex Campbell Interactive Chemistry
25.Acetyl CoA and Krebs Cycle by June B. Steinberg
26.Oxidative Phosphorylation
27.ATP Synthase Gradient: The Movie Virtual Cell
28.ATP Synthase Movie Thomas M. Terry at Univ. of Conn.
29.ATP Synthesis (ATPase) Flash Animation Carnegie Mellon
30.Production of ATP by Oxidative Phosphorylation
31.Electron Transport by June B. Steinberg
32.Oxidative Phosphorylation Campbell Interactive Chemistry
33.Oxidative Phosphorlyation (advanced) Nature Reviews Molecular Cell Biology
34.Electron Transport McGraw-Hill
35.Electron Transport by Rodney F. Boyer
36.Oxidative Phosphorylation Purdue University
37.

ab includes a worksheet.
Back to the top
Links








Aerobic and anaerobic respiration animations:
http://www.sp.uconn.edu/~terry/Common/respiration.html
Aerobic respiration tutorial: http://www2.nl.edu/jste/aerobic_respiration.htm
ATP and biological energy tutorial:
http://www.estrellamountain.edu/faculty/farabee/biobk/BioBookATP.html
ATP to ADP animation: http://www.biologyinmotion.com/atp/index.html
Respiration and photosynthesis animations:
http://www.science.smith.edu/departments/Biology/Bio231/
Cellular metabolism and fermentation:
http://www.estrellamountain.edu/faculty/farabee/biobk/BioBookGlyc.html
Good photosynthesis animation:
http://www.web.virginia.edu/gg_demo/movies/figure18_12b.html
Glycolysis animations: http://science.nhmccd.edu/biol/glylysis/glylysis.html










Celluar respiration animation:
http://instruct1.cit.cornell.edu/courses/biomi290/ASM/glycolysis.dcr
Good narrated animation of photosynthesis:
http://www.fw.vt.edu/dendro/forestbiology/photosynthesis.swf
Photosynthesis animation:
http://www2.kumc.edu/netlearning/examples/flash/photosyn2.html
Production of ATP by oxidative phosphorylation animations:
http://science.nhmccd.edu/biol/etc/respirat.html
Fermentation animation:
http://instruct1.cit.cornell.edu/Courses/biomi290/MOVIES/GLYCOLYSIS.HTML
Good outline of cellular respiration and photosynthesis from Kim Rebello.
The structure of mitochondria vs chloroplasts:
http://w3.dwm.ks.edu.tw/bio/activelearner/08/ch8c1.html
PowerPoint presentation on photosynthesis:
http://sun.sunyrockland.edu/~kbaker/photo.ppt
Another good photosynthesis animation: http://www.johnkyrk.com/photosynthesis.html
Good photosynthesis animations with audio: http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter10/animations.html#
PS Workbook/ Tutorial http://www.nclark.net/photosynthesis.pdf
Activities at this website: http://www.nclark.net/PhotoRespiration









Do this "Investigating Photosynthesis and Respiration through Kinesthetics and
Inquiry" activity.
Use this "Photosynthesis / Cell Respiration / Enzymes / Light" Jeopardy Game
with
instructions.
Try this Flinn "Respiration versus Photosynthesis" activity.
Have students do this "Energy in a Cell" crossword puzzle.
Or do this "Energy in a Cell" wordsearch puzzle with answers .
"The Demise of the Halloween Pumpkin" would be a great activity to start around
Halloween. This is an ongoing activity that will last aproximately 3 months. The activity
measures energy use, but teaches about setting up controlled experiments and about the
decomposing activity of microorganisms.
Use this "Photosynthesis" tutorial with questions for students to answer.
Using the Cells Alive website, Maria Ferraro contributed this "The Cell Cycle and
Animal Cell Mitosis" worksheet.
Play the "Come On Down (The Electron Transport Chain)" song performed by Sam
Reid. (To save the song you can right-click on the link and select "Save Target As.")



Use this "Jeopardy PowerPoint: Photosynthesis / Cell Respiration / Enzymes / Light" to
review for quizes.
Play this Quia battleship "Glycolysis" game.
"The Effects of Light Intensity and Wavelength on the Rate of Photosynthesis" is an
activity that uses this photosynthesis animation.
Back to the top
Labs













The "Burning Peanuts Laboratory" reveals the energy stored in food and includes a
student guide .
The "Effects of a Closed Environment on Living Things" lab demonstrates how plants
use carbon dioxide and produce carbon and how animals use oxygen and produce carbon
dioxide.
This "Do Plants Consume or Release CO2? Or Both?" lab demonstrates how plants carry
on both photosynthesis and respiration.
The "Rate of Photosynthesis" lab explores just that.
Do the "Leaf Pigment Chromatography" lab .
This lab compares the production of starch in leaves kept in the light and those in the
dark.
This "Fermentation by Yeast" lab can be used in this unit or with the study of
microorganisms. This is an image of the lab report for this lab done by one student
group.
"Photosynthesis: A Controlled Experiment" illustrates the effect of differing amounts of
carbon dioxide on photosynthesis in geranium plants. Coleus or other similar plants
could just as easily be used.
"The Energy Content of Food Laboratory" is another activity for determining the
calories in food and includes a teacher's guide .
In "The Heat is On - The Energy Stored in Food" students will burn several types of nuts
and snack foods in order to determine their heat content per gram.
In Kim Rebello's "Every Breath You Take" lab students investigate whether animals
and plants carry on respiration.
Make a homemade calorimeter to determine "The Energy in Food" .
This "Waterweed Simulation" is a worksheet to acompany "The Waterweed
Simulator." Students count the bubbles released by Elodea to determine which color of
light is more effective for photosynthesis. (Since Elodea is hard to come by these days,
this is a good alternative.)

This "Plant Respiration" lab uses seedlings and a bromothymol blue
solution to demonstrate that plants give off CO2 during respiration.

In "Studying the Effect of Photosynthesis and Respiration on Aquatic
Chemistry" students use microcosms and RUSS data to investigate changes in oxygen
concentrations that result from photosynthesis and respiration. The lab includes a
worksheet.
Back to the top
Links


















Aerobic and anaerobic respiration animations:
http://www.sp.uconn.edu/~terry/Common/respiration.html
Aerobic respiration tutorial: http://www2.nl.edu/jste/aerobic_respiration.htm
ATP and biological energy tutorial:
http://www.estrellamountain.edu/faculty/farabee/biobk/BioBookATP.html
ATP to ADP animation: http://www.biologyinmotion.com/atp/index.html
Respiration and photosynthesis animations:
http://www.science.smith.edu/departments/Biology/Bio231/
Cellular metabolism and fermentation:
http://www.estrellamountain.edu/faculty/farabee/biobk/BioBookGlyc.html
Good photosynthesis animation:
http://www.web.virginia.edu/gg_demo/movies/figure18_12b.html
Glycolysis animations: http://science.nhmccd.edu/biol/glylysis/glylysis.html
Celluar respiration animation:
http://instruct1.cit.cornell.edu/courses/biomi290/ASM/glycolysis.dcr
Good narrated animation of photosynthesis:
http://www.fw.vt.edu/dendro/forestbiology/photosynthesis.swf
Photosynthesis animation:
http://www2.kumc.edu/netlearning/examples/flash/photosyn2.html
Production of ATP by oxidative phosphorylation animations:
http://science.nhmccd.edu/biol/etc/respirat.html
Fermentation animation:
http://instruct1.cit.cornell.edu/Courses/biomi290/MOVIES/GLYCOLYSIS.HTML
Good outline of cellular respiration and photosynthesis from Kim Rebello.
The structure of mitochondria vs chloroplasts:
http://w3.dwm.ks.edu.tw/bio/activelearner/08/ch8c1.html
PowerPoint presentation on photosynthesis:
http://sun.sunyrockland.edu/~kbaker/photo.ppt
Another good photosynthesis animation: http://www.johnkyrk.com/photosynthesis.html
Good photosynthesis animations with audio: http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter10/animations.html#
Great timing! I just had a test on cellular respiration... Here are a few good web sites...
http://www.sp.uconn.edu/~terry/images/anim/ATPmito.html
Animations of ATP production in the mitochondria. Thomas Terry of the University of
Connecticut has created excellent animations of electron transport and the ATP synthease
enzyme. These animations help to explain how electron transport generates an electrical
gradient that provides the energy necessary to produce ATP. Click on the various links for
different animations.
http://www.sp.uconn.edu/~terry/images/anim/ETS.html
Animations of electron transport in the mitochondria. You may reach this animation using links
from the first address, since this is another animation produced by Thomas Terry.
http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookGlyc.html
Cellular metabolism and fermentation. This chapter of M.J. Farabee’s excellent online textbook
will help you learn about both aerobic and anaerobic respiration.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellularRespiration.html
A summary of the process of cellular respiration.
http://www2.nl.edu/jste/electron_transport_system.htm
Electron transport system. Hit the play buttons at the corners of the diagrams to view some nice
animations. This is a really good visual representation of electron transport and chemiosmosis.
http://www.bact.wisc.edu/microtextbook/Metabolism/Fermfoods.html
Fermentations of Importance to Humans. Examples of, and a brief discussion of how to make,
some of the products of fermentation.
http://www.goaskalice.columbia.edu/0818.html
Muscle soreness and weightlifting. Alice explains why your muscles produce lactic acid and
how you can avoid lactic acid production when weightlifting.
http://www.stolaf.edu/people/giannini/flashanimat/metabolism/mido%20e%20transport.swf
Another animation of electron transport. I can’t get enough of these. I am including so many
illustrations of this concept because it is very important. Plus, these are neat to watch. Hit the
GO button in the lower left corner to start the show.
http://www.jonmaber.demon.co.uk/glyintro/
Introduction to glycolysis. Go to the questions at the bottom and click on each one. You can use
the arrows at the top of each question page to proceed. Lots of information here if you can work
your way through the site. I found that the Quicktime animations worked better on my
computer.
http://www.ruf.rice.edu/~bioslabs/studies/mitochondria/mitopoisons.html
Use of metabolic poisons to study mitochondrial function. A brief list of poisons that inhibit
mitochondrial functioning.
http://www.gwu.edu/~mpb/
Metabolic pathways of biochemistry. While in more detail than your text, this site presents you
with excellent three-dimensional rotatable images of carbohydrate metabolism (glycolysis,
Krebs cycle…), lipid metabolism, protein metabolism, and chemiosmosis (oxidative
phosphorylation). I had some trouble connecting to the 3-D plug-ins.
http://old.jccc.net/~pdecell/cellresp/respoverview.html
Overview of cellular respiration. You can click on various regions of the map for a more
detailed explanation of that component of cellular respiration.
http://instruct1.cit.cornell.edu/Courses/biomi290/MOVIES/GLYCOLYSIS.HTML
The miracle of fermentation. You will need Macromedia’s Shockwave player to view this
animation on lactate (lactic acid) fermentation.