Anatomical Pathology

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American Society for Clinical Pathology

2004 Resident In-Service Examination

Item Descriptors

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Anatomical Pathology

Cytopathology

1. Desmoid-type fibromatosis; no metastatic potential

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Hodgkin's disease; fine-needle aspirate neck

Mesothelial cell; staining pattern

Papillary carcinoma; aspirate thyroid nodule

Chromagranin; fine-needle aspiration liver

Mesothelial cells; effusions

Fine-needle aspiration biopsy; nodular fasciitis

Carcinoma of breast; intracytoplasmic lumens

Radiation effect; Pap smear

Cervical smears; tissue sections

High grade squamous intraepithelial lesion; Pap smear

Atypical squamous cells of undetermined significance; reporting definition

Carcinoma; fine-needle aspiration of breast mass

Subareolar abscess of the breast; ruptured epidermal inclusion cyst

Meningioma; fine-needle aspiration of a scalp lesion

Adenocarcinoma in situ; Pap smear

Colloid carcinoma; fine-needle aspirate breast

Bilateral mass; fine-needle aspirate breast

Reserve cells; small cell undifferentiated carcinoma

Bronchioalveolar carcinoma; fine-needle aspiration lung

Follicle center lymphoma; fine-needle aspiration lymph nodes

Aspirate of solitary thyroid nodule; lesion excised

Busulfan; mimic cancer

Course of acyclovir; Pap smear

Cryptococcus neoformans; fluid aspirated thigh abscess

Warthin's tumor; bilateral parotid tumor

Gleason pattern3+4; prostatic adenocarcinoma

Contamination; urine cytology specimen

Sarcomatoid renal carcinoma; any histologic type

Chromophobe renal carcinoma; outcome

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Renal carcinoma; t(X;1) (p11.2;q21) chromosome translocation

Endometrial cells; Bethesda

Intractable gastric ulcers duodenal wall mass; peripancreatic lymph node

Benign mixed tumor; fine-needle aspiration jaw

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Warthin tumor; fine-needle aspiration parotid

Small cell carcinoma; sputum

Forensic Pathology

37. Hypothermia; Anatomic findings

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Stomach contents; cocaine toxicity

Incised wound; laceration

Designer drugs; modifying the structure

Gunshot wound; exit

Postmortem change; lesions

Atlantooccipital dislocation; vehicle accident death

Vitreous fluid; hyperglycemia

Drowning; other causes of death

Ateriosclerotic heart disease; sudden and unexpected death

Postmortem interval; > 16 hours

Temporal and frontal lobe contusions; fall on the back of the head

Gunshot wound; high velocity military rifle

Injury on the arm; bite mark impression

Sudden infant death syndrome; heart

Man without a spleen; Gram stain of meninges

Manual strangulation; fracture of the hyoid bone

Homicide; manner of death

Mechanism of death; septicemia

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Surgical Pathology

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Paget’s disease; regional carcinoma

57. Thyroid cancer; age

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Breast neoplasms; worst prognosis

Intramuscular myxoma; gelatinous tumor of the thigh

Gynecomastia; Ultrastructural features

Intratubular germ cell neoplasia; placental alkaline phosphatase

Anogenital verrucous carcinoma; description

Renomedullary interstitial cell tumor

Renal artery; Fibromuscular dysplasia

Adenocarcinoma of the urinary bladder; enteric carcinomas

Erythema nodosum; characterization

Contact allergy; Lichenoid interface dermatitis

Progressive multifocal leukoencephalopathy; characteristics

Fibroadenoma of the breast; greatest incidence

Mulitcystic renal dysplasia; renal mass, primitive ducts

Dermatofibrosarcoma protuberans; CD34 positive

Subacute sclerosing panencephalitis; slowly progressive neurodegenerative disease

Osteoblastoma; flat bones

Dermatitis herpetiformis; gluten-sensitive enteropathy

Colon biopsy; labeling of collagen

Pulmonary lesion; lumen of a large airway

Seminoma

Cervical tunnel clusters; dilated endocervical glands

Testicular tumor; 1-year-old

Solitary fibrous tumor of pleura; increased recurrence

Familial adenomatous polyposis syndrome; genetic abnormality

Ground glass hepatocytes; Hepatitis B

Malakoplakia; Escherichia coli

Primary sclerosing cholangitis; primary biliary cirrhosis

Metastatic papillary cancer; good prognosis

Hashimoto's thyroiditis; thyromegaly

Giant cell (temporal) arthritis; Associated findings

Pure hepatic canalicular cholestasis; sepsis

Adenomatoid tumor

Cerebral hematoma metastatic tumor; beta HCG

Kaposi's sarcoma; multiple organs

Biopsy from the great toe; polarized light

Cervical lymph node biopsy; Epstein Barr-virus testing

Enchondroma; low grade central chondrosarcoma

Gastrectomy specimen; ascites and bilateral ovarian masses

Osteoarthritis; femoral head

Yelloe fever; necrosis

Small intestinal tumor; interstitial cells of Cajal

Low grade sil; eventual regression

Gastrointestinal tract dysplasia; unequivocally neoplastic epithelium

Gallbladder; stones

Adenocarcinoma of the lung; predictor of survival

Invasive mammary carcinoma; appearance

Liposarcomas; prognostic indicator

Thymoma; myasthenia gravis

Polymorphous low-grade adenocarcinoma of minor salivary gland; oral cavity

Lobular carcinoma of the breast; Classic-type invasive

Pseudoangiomatous change; breast

Inflammatory breast cancer; dermal lymphatic invasion

Osteoid osteoma; osteoblastoma

Common primary malignant neoplasm; malignant fibrous histiocytoma

Nodular fasciitis; characteristics

Epithelioid sarcoma; positive for cytokeratins

Esophagitis; mid-esophagus biopsy

Crohn's disease; a gastric biopsy

Anti-gliadin antibodies; lymphocytic colitis

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Peutz-Jehger's polyposis; small bowel

Jejuno-ileal carcinoid tumors; fibroblastic reaction

Ulcerative colitis; biopsies

Colon biopsies; H&E and trichrome-stained

Focal nodular hyperplasia; young women

Genetic hemochromatosis; stainable iron

Primary sclerosing cholangitis; cholangiocarcinoma

Esophageal adenocarcinoma; gastroesophageal reflux

Helicobacter pylori gastritis; atrophic gastritis

Gastric adenocarcinoma; atrophic gastritis

Gastric stromal tumors; c-kit gene

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Clinical Pathology

Clinical Chemistry

128 Major intracellular cation; K+

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Prostate specific antigen; monitoring

Serum osmolality; calculation

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Transthyretin; nutritional status

Distal renal tubular acidosis; normal anion gap

Loop diuretics; mechanism

Methanol ingestion; serum osmole gap

LDL cholesterol levels; 160 mg/dL

LDL subclasses; Higher risk

PKU; screening tests

Pituitary gland; prolactin secreting tumor

Method comparison; precision

Fetal fibronectin; negative

Diabetes Mellitus; Fructosamine

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Acute leukemia; elevated potassium

Sensitivity of MCV; screen iron deficiency

Distribution of the values: 25th percentile

NT-proBNP: description

Linearity; regression

Cholesterol; maximum bias

CML in blast crisis; glucose

Fasting hypoglycemia; C-peptide

Blunt head trauma; distinguishing fluids

Canavan disease; mutation in aspartoacylase

Fetal fibronectin; preterm labor

Nitric oxide; peroxynitric acid

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BNP; congestive heart failure

Drugs of abuse; metabolite of crack cocaine

High-sensitivity C-reactive protein; levels of >15 mg/L indicate active inflammation

Circulating alkaline phosphatase; condition

Hematopathology

159. Hodgkin’s disease; lymph node excision

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Plasma cell leukemia; peripheral blood smear

Sickle cell disease; hemoglobin electrophoresis patterns

Small megakaryocytes; chronic myelogenous leukemia

Abetalipoproteinemia; peripheral blood smear

Chronic myelomonocytic leukemia; peripheral blood smear

Anemia of chronic disease; lymphadenopathy

Plasma cell myeloma; WHO

Severe neutropenia in the neonatal age; bacterial sepsis chronic myelogenous leukemia; absolute basophilia

Chloroacetate esterase; myeloid sarcoma

Beta-thalassemia trait; hemoglobin A2

Hyperdiploid karyotype; peripheral blood slide

Toxoplasmosis; lymph node

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Mantle cell lymphoma; CD5-expression

CD15 positive neoplastic cells; slide

Monoclonal chronic large granular lymphocyte proliferations; neutropenia

Acute lymphoytic leukemia; cytochemical reactions

Hairy cell leukemia; tartrate-resistant acid phosphatase

Thrombotic thrombocytopenic purpura; platelet count

Refractory anemia; peripheral blood smear and laboratory studies

S-beta thalassemia; hemoglobin electrophoresis

Platelet function; inhibition

Bernard-Soulier disease; platelet aggregation study

Essential thrombocythemia; platelet count

B-cell lymphoma; immunoglobulin

Post-transfusion purpura; P1A1 antigen

B-cells; Hairy cell leukemia

Cold agglutinin disease; red cell finding

Alder-Reilly anomaly; mucopolysaccharidoses

Thrombotic thrombocytopenic purpura; pathogenesis

Factor XII deficiency; bleeding risk

Liver disease; coagulation results

Viral infection; blood smear shown

Osteoblasts; bone marrow smear

Chediak-Higashi syndrome; peripheral blood smear

Thrombotic thrombocytopenic purpura; blood smear

Specimen requirement for CBC; Quality Control

Spleen; PAS/diastase stains

Mean cell volume (MCV); hyperglycemia nemias Hemolytic

Megaloblastic anemia; bone marrow aspirate smear

Prothrombin G20210A mutation; predispositions

Hereditary bleeding disorder; von Willebrand disease

Platelet glycoprotein Ib; von Willebrand factor

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Microbiology

204. Coxsackieviruses; persistent viral infection

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Susceptibility testing; disk selection

Listeria; gram positive bacillus

Staphylococcus aureus; coagulase test

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Staphylococcus aureus; colony characterizations

Prevotella intermedi; pleural fluid

Granulomatous dermatitis; microscopic appearance

Anaplasma phagocytophilia; human granulocytic ehrilichiosis (HE)

Rickettsia rickettssii; camping trip

Staphylococcus aureus; mec A gene

FTA-ABS test; Treponema pallidum

Streptococcus pyogenes; blood culture slide

Enterococcus faecalis; blood culture slide

Stool assay; post-antibiotic diarrhea

Ascaris lumbricoides; cysticercosis

Highly pathogenic; non immunocompromised human hosts

Bartonella henselae; cat scratch disease

Pneumocococus; erythromycin resistance

Mycobacterium tuberculosis; nitrate positive

Trichophyton species; infections of hair follicles

Penicillin resistant S. pneumoniae; oxacillin disk

Parvovirus B19; "fifth's" disease

Clostridium difficile toxin assays; hospitalized adult patient

Neonate sepsis; blood culture

Bovine spongioform encephalopathy; Creutzfeldt-Jacob disease

Epstein-Barr virus infection; post-transplant lymphoproliferative disorders

Malarial infection; red blood cell morphologic alterations

Colonic spirochetosis; identified histologically

Toxoplasma encephalitis; multifocal necrotizing lesions

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Cryptococcal meningitis; CSF titers of cryptococcal antigen

Cytomegalovirus; Latent infection

SARS; Coronavirus

West Nile Virus; meningoencephalitis

Food-borne infections; screening

Anaerobe specimens; synovial fluid

Enterobius vermicularis; Cellulose tape preparations

Actinomyces israelii; oral surgery

Transfusion Medicine

241. Irradiation of Blood; CMV

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Red blood cell preservative or; approved shelf life

Plasmapheresis for TTP; replacement solution

Cord red blood cells; Le a

Transfusion records; FDA

Dosage; Kidd

Gamma irradiation; GVHD

Cold-reactive agglutinin; anti-I

TRALI; pulmonary edema

Autologous donor; Requirements

Plasmodium vivax; Fy(a-b-)

Transfusion reaction; additional transfusions

Platelet pheresis donors; Requirement

HLA-identical match; siblings

Enzyme treatment; S antigen

Donor reaction; treatment is

Blood preservation; pH

Massively transfused patient; bleeding

HIV infections; EIA-detectable antibodies

Critical titer of anti-D; amniocentesis

TRALI; anti-leukocyte antibodies

Leukocyte-reduced Red Blood Cells; cytomegalovirus

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Infectious mononucleosis; anti-I

Massive transfusion; platelet transfusion

Donor Collection; additional blood

Chronic Transfusion; chelators

Anti-K and anti-Fya; Enzyme techniques

Malaria; Haiti

Antithetical platelet antigens; GPIIIa

Rh null phenotype; stomatocytes

Plasma products; expiration

Bleeding complications; central line placement

Anti-M; glycophorin A

Apheresis catheter placement; patient management

Cryoprecipitate; minimum factor

Mislabeled Specimen; RBC unit issue

Lewis antibody; first pregnancy

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Granulocyte transfusion; graft versus host disease

T cell depletion; engraftment failure

Blood component preparation; order of steps

Special Topics

Immunopathology

281. Paroxysmal nocturnal hemoglobinuria; Ham's test

282. Immunofluorescence Lupus Band Test; skin

IgA molecules; placenta

IgA deficiency; Caucasians

Severe renal pathology; autoantibody

Silicone breast implants; autoimmune disease

Bence Jones protein; chemical structure

Anti-mitochondrial antibody; symptoms

Acute-phase reaction; indicator

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290. C-reactive protein; pneumoccocal C-polysaccharide

291. Acute-phase reaction; electrophoresis

292. Systemic vasculitis; abnormal serologic test

293. CREST variant of scleroderma; anti-centromere antibody

294. HIV disease Monitoring; CD34 enumeration

295. Acute leukemias; immunophenotypic analysis

296. Hemoglobin F; replacement assay

297. Linear deposition of IgG and C3; Bullous pemphigoid

298. Amyotrophic lateral sclerosis; superoxide dismutase-1 (SOD-1) gene

299. Huntington's chorea; trinucleotide repeat disorder

Laboratory Administration

300. Maslow; highest level

301. Motivation technique; empowerment

302. Accrediting organization; JCAHO

303. CLIA waived tests; FDA review

304. Internet connection; T1

305. Archive hypertext documents; CD-RW

306. Retention of laboratory reports; time requirements

307. Current Procedural Terminology; code for a medical procedure or service

308. Flow chart; symbol

309. Medicare Part B reimbursement; pathologist services

310. Specimen referral; illegal

311. Laboratory employees; Hepatitis B vaccine

312. majority of tests; type of laboratory

313. Medicare; billing notification

Special Techniques

314. Flow cytometry; lymphocyte scatter

315. HLA type; disease association

316. Angioimmunoblastic lymphadenopathy; gene rearrangements

317. Mantle cell lymphoma; phenotypic marker

318. Acute myelogenous leukemia; retinoic acid therapy

319. Anaplastic large cell lymphoma; CD30 positivity and t(2;5) translocation

320. Synovial sarcoma; t(X;18)(p11;q11)

321. Fragile X syndrome; trinucleotide expansion disease

322. Hairy cell leukemia; CD11c, CD22, CD25, and CD103

323. Myelodysplastic syndromes; chromosome changes

324. Multiple Endocrine Neoplasia type 2; RET gene

325. Inherited thrombophilia; factor V Leiden mutation

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