Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
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NAME
POSITION TITLE
Cheryl L. Fattman, Ph.D.
Assistant Professor
eRA COMMONS USER NAME
CFATTMAN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Slippery Rock University, Slippery Rock, PA
University of Pittsburgh, Pittsburgh, PA
University of Pittsburgh, Pittsburgh, PA
DEGREE
(if applicable)
B.S.
Ph.D.
(honors)
PostDoctoral
Fellowship
YEAR(s)
FIELD OF STUDY
1991
Biology
1999
Molecular Pharmacology
2003
Pathology
Please refer to the application instructions in order to complete sections A, B, and C of the Biographical
Sketch.
Positions:
2005 – Present
2003 – 2005
1999-2003
Honors:
1991
1997
1999
2002
2007
Assistant Professor, Department of Environmental and Occupational Health, University of
Pittsburgh
Research Associate, Department of Pathology, University of Pittsburgh
Post-doctoral Fellow, Department of Pathology, University of Pittsburgh
Richard Tillack Memorial Scholarship in Biology, Slippery Rock University
Best Abstract, 2nd World Congress on Advances in Oncology
Ph.D. with honors, University of Pittsburgh
Travel Award Recipient, Pittsburgh International Lung Conference
Giles F . Filley Memorial Award in Respiratory Physiology and Medicine
Selected publications:
1.
Ritke, M.K., Allan, W.P., Fattman, C.L., Gunduz, N.N., and Yalowich, J.C. (1994) Reduced
phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells. Mol.
Pharmacol. 46: 58-66.
2.
Hoyt, K.R., Rajdev, S., Fattman, C.L., and Reynolds, I.J. (1995) Cyclothiazide modulates
AMPA receptor-mediated increases in intracellular free calcium an magnesium in cultured
neurons from rat brain. J. Neurochem. 64: 2049-2056.
3.
Fattman, C.L., Allan, W.P., Hasinoff , B.B., and Yalowich, J.C. (1996) Collateral sensitivity to
the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia
K562 cells. Biochem. Pharmacol. 52: 635-642.
4.
Hasinoff, B.B., Kuschak, T.I., Fattman, C.L., Allan, W.P., and Yalowich, J.C. (1997)
Characterization of a bisdioxopiperazine (ICRF-187, dexrazoxane) resistant CHO cell line.
Biochem. Pharmacol. 53: 1834-1853.
5.
Fattman, C.L., An, B., and Dou, Q.P. (1997) Characterization of interior cleavage of
retinoblastoma protein in apoptosis. J. Cell. Biochem. 67: 399-408.
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10.
Hasinoff, B.B., Kuschak, T.I., Fattman, C.L., and Yalowich, J.C. (1998) The one-ring open
hydrolysis of the cardioprotective agent dexrazoxane (ICRF-187) do not inhibit the growth of
Chinese hamster ovary cells or the catalytic activity of DNA topoisomerase II. Anticancer
Drugs 9: 465-471.
Fattman, C.L., An, B., Sussman, L., and Dou, Q.P. (1998) p53-independent dephosphorylation
and cleavage of retinoblastoma protein during tamoxifen-induced apoptosis in human breast
cancer cells. Cancer Let. 130: 103-113.
Fattman, C.L., Enghlid, J.J., Crapo, J.D., Schaefer, L.M., Valnickova, Z., and Oury, T.D.
(2000) Purification and characterization of extracellular superoxide dismutase in mouse lung.
Biochem. Biophys. Res. Comm. 275: 542-548.
Fattman, C.L., Delach, S., Dou, Q.P., and Johnson, D.E. (2001) Caspase-mediated interior
cleavage of the retinoblastoma protein during apoptosis. Oncogene. 20: 2918-2926.
Fattman, C.L., Chu, C.T., Kulich, S. M., Enghild, J.J. and Oury, T.D. (2001) Altered
expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment
Free Rad. Biol. Med. 31: 1198-1207.
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Oury, T.D., Schaefer, L.M., Fattman, C.L. Weck, K.E., Choi, A., and Watkins, S.C. (2002)
Depletion of pulmonary EC-SOD following exposure to hyperoxia. Am. J. Resp. Cell Mol. Biol.
283: L777-L784.
Hanford, L.E., Fattman, C.L., Schaefer, L.M., Enghild, J.J., Valnickova, Z., and Oury, T.D.
(2003) Regulation of receptor for advanced glycation end products during bleomycin-induced
lung injury. Am. J. of Resp. Cell Mol. Biol. 29 (suppl): S77-S81.
Fattman, C.L., Chang, L.-Y., Termin, T.A. Petersen, L. Enghlid, J.J. and Oury, T.D. (2003)
Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide
dismutase. Free Rad. Biol. Med. 35: 763-771.
Petersen, S.V., Oury, T.D., Ostergaard, L., Valnickova, Z., Wegrzyn, J., Thogersen, I.B.,
Jacobsen, C., Bowler, R.P., Fattman, C.L., Crapo, J.D., and Enghild, J.J. (2004) Extracellular
superoxide dismutase (EC-SOD) binds to type I collagen and protects against oxidative
fragmentation. J. Biol. Chem. 279: 13705-13710.
Tan, R.J.*, Fattman, C.L.*, Watkins, S.C. and Oury, T.D. (2004) Redistribution of pulmonary
EC-SOD after exposure to asbestos. Am. J. Appl. Phys. 97: 2006-2013. *Authors contributed
equally.
Zhou, Z., Song, R., Fattman, C.L., Feghali-Bostwick, C., Oury, T.D., Benezra, R., Choi,
A.M.K., Morse, D. (2005) Carbon monoxide suppresses bleomycin-induced lung fibrosis via
anti-proliferative and anti-fibrotic effects. Am. J. Pathol. 166: 27-37.
Fattman, C.L., Tan, R.J., Tobolewski, J.M., and Oury, T.D. (2006) Increased Sensitivity to Asbestosinduced Lung Injury in Mice Lacking Extracellular Superoxide Dismutase. Free Rad. Biol. Med.
40:601-607.
Tan, R.J., Lee, J.S., Manni, M.L., Fattman, C.L., Tobolewski, J.M., Kolls, J., Martin, T.R., and Oury,
T.D. (2006) Inflammatory cells as a source of airspace extracellular superoxide dismutase after
pulmonary injury. Am. J. Resp. Cell Mol. Biol. 34:226-232.
Tan, R.J., Fattman, C.L., Niehouse, L.M., Tobolewski, J.M., Hanford, L.E., Li, Q., Monzo, F.A., Parks,
W.C., and Oury, T.D. (2006) Matrix metalloproteinases promote inflammation and fibrosis in asbestosinduced lung injury in mice. Am. J. Respir. Cell Mol. Biol. 35: 289-97
Reviews, invited published papers, proceedings of conference and symposia, monographs, books, and
book chapters
1.
Fattman, C.L., Chu, C.T., and Oury, T. (2002) Experimental models of asbestos-related diseases, In
Pathology of Asbestos-Associated Diseases, 2nd ed. Roggli V.L, Sporn, T., and Oury, T.D. eds. Little
Brown and Co., Boston.
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Fattman, C.L. Schaefer, L.M. and Oury, T.D. (2003) Extracellular superoxide dismutase in biology and
medicine. (Review) Free Rad. Biol. Med. 35: 236-256.
Kinnula, V.L., Fattman, C.L., Tan, R.J. and Oury, T.D. (2005) Oxidative stress in pulmonary fibrosis:
A possible role for redox-modulatory therapy. Am. J. Resp. Crit. Care Med. In press.
RESEARCH
Current:
“ECSOD in Asbestos-related pulmonary fibrosis”
Source/Project # or type (P.I.)
Transition to Independent Position (TIP-K22) NIH (RFA-ES-04-002)
Project Period
9/1/06 – 6/30/09
This grant proposes to investigate the role of ECSOD in the pathogenesis of asbestosis with an emphasis on
apoptotic/cell death pathways.
“The effects of the hydrogen peroxide-mediated TNF production on the survival of asbestos-exposed
macrophages
Source/Project# or type (P.I.)
Giles F. Filley Memorial Award
Project Period
7/1/07 – 6/30/08
This grant investigates the role of hydrogen peroxide-mediated TNF production on macrophage apoptosis.
Pending:
ECSOD in Silica-induced Lung Injury
Source / Project # or type (P.I.)
Outstanding New Environmental Scientist Award (ONES – RO1)
Project Period
7/1/07 – 6/30/12
This grant investigates the ability of ECSOD to enhance the engraftment and efficacy of transplanted adult
mesenchymal stem cell to ameliorate silica-induced lung injury in mice.
Completed:
“Etoposide-induced apoptosis in human breast cancer”
Source/Project # or type (P.I.)
U.S. Army Department of Defense Predoctoral Fellowship
in Pharmacology (DAMD-17-94-J-4039)
Project Period
10/1/1996 – 9/30/1998
This grant investigated the mechanism of etoposide-induced apoptosis on human breast cancer cells.
“EC-SOD in Pulmonary Fibrosis”
Source/Project# or type (P.I.)
Individual National Research Service Award, NIH
(1F32HL10439-01)
Project Period
7/1/00 – 6/30/02
This grant investigated the role of extracellular superoxide dismutase in the pathogenesis of pulmonary
fibrosis.
“The role of EC-SOD in the pathogenesis of pulmonary fibrosis”
Source/Project# or type (P.I.)
Pathology Postdoctoral Research Training Grant
Project Period
7/1/01 – 6/30/02
This grant investigated the regulation of extracellular superoxide dismutase in an in vitro model of
bleomycin-treated lung epithelial cells.
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