Drug Delivery to the Lungs 23 5th – 7th December 2012 Wednesday 5th December 2012 11.00 Coffee & Registration 12.00 – 13.30 Networking Buffet Lunch in Exhibition Hall 13.30 Welcome and Opening Remarks: Gary Pitcairn, Chair, DDL Committee 13.45 - 14.30 The DDL Lecture Phil Haywood DDL Committee Bronchodilators – the past, present and future Malcolm Johnson, Respiratory Science Consultant, GlaxoSmithKline Research & Development, UK Session 1: Drug Discovery and Development Chairs: Janet Maas / Darragh Murnane DDL Committee 14.30 - 15.00 Writers, Readers and Erasers’ – The Chemical Biology of Epigenetics Professor Ian M Adcock FSB, National Heart & Lung Institute, Imperial College, London 15.00 - 15.30 Circadian Rhythms and Drug Discovery Professor Stuart Farrow, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, UK and Faculty of Academic Health Sciences, University of Manchester, UK 15.30 – 17.00 Posters, Exhibition & Coffee GROUP A - MANNED POSTER SESSION 17.00- 17.25 Combining Long acting β2 agonists and M3 antagonists for the treatment of COPD: An evaluation of the potential mechanisms for achieving maximal bronchodilation Dr Mark R. Dowling, Investigator III, Novartis Centre for Respiratory Research 17.25 – 17.45 Understanding the Particle/Lung Cell Interaction, One Particle at a Time A.E. Haddrell, School of Chemistry, University of Bristol, Bristol, UK 17.45 – 18.05 Cerivastatin Effectively Reduced Pulmonary Artery Hyperplasia, Pulmonary Artery Pressure and Right Ventricular Thickening upon Local Delivery to the Lung in a Model of Pulmonary Arterial Hypertension Jaipal Singh, Georgia Institute of Technology and St. Joseph’s Translational Research Institute, USA 18.05 - 18.25 Targeted delivery of antimicrobials to the lung: sheep as a clinically relevant model to assess the pharmacokinetics of colistin and colistin methanesulfonate after pulmonary and intravenous administration TH Nguyen, Monash Institute of Pharmaceutical Sciences, Australia 18.25 Close 18.30 – 20.00 Exhibitor Drinks Reception with Entertainment sponsored by Vectura Group plc Thursday 6th December 2012 - AM 08.15 Registration and Coffee and Poster Viewing 08.45 Opening of Conference 08. 45 – 09.15 The Ups and Downs of 2012 - a Year in Review Dr Steven C. Nichols, OINDP Consultancy Session 2: New Approaches to Pulmonary and Nasal Drug Delivery Chairs: Omar Usmani / Gary Pitcairn DDL Committee 09.15 - 09.45 Technical challenges faced when developing an inhaled product targeting delivery to the small airways Francesca Schiaretti PhD, R&D-CMC-DP Development Department, Chiesi Farmaceutici S.p.A., Italy 09.45 - 10.15 Novel imaging in assessing small airway disease and therapy Dr. Jan De Backer, CEO FluidDA nv, Belgium 10.15 - 10.45 Clinical relevance of small airways directed therapy Assoc. Professor, M.D., FCCP Arschang Valipour, Ludwig-Boltzmann Institute for COPD and Respiratory Epidemiology, Austria 10.45 - 11.45 Coffee/Tea Break GROUP B - MANNED POSTER SESSION 11.45 - 12.05 Does aerosol particle size affect total and peripheral lung deposition in children with cystic fibrosis? S G Devadason, School of Paediatrics and Child Health, University of Western Australia, Australia 12.05 - 12.25 In Vivo/In Vitro Comparison of Aerosol Nasal Deposition L Vecellio, DTF-Aerodrug, Faculty of medicine, France 12.25 - 12.55 Development of a Nasal Virus-Like-Particle Vaccine Formulation Using a Spray Dry Process Dr David T Vodak, Bend Research, Inc., USA 12.55 – 14.30 Lunch Thursday 6th December – PM Session 3: Pat Burnell New Investigator Award Chairs: Omar Usmani, Ben Forbes, Phil Haywood, DDL Committee Eva Littringer, Research Center Pharmaceutical Engineering GmbH, Austria 14.30 – 14.45 Analysis of pMDI aerosol plume dynamics via laser diffraction using the Sympatec Helos F Freestone, Chiesi Ltd, UK 14.45 - 15.00 The Bipolar Next Generation Impactor (bp-NGI) as a Tool for the Simultaneous Measurement of the Bipolar Charge Distribution and Mass Quantification of Aerosols for Inhalation Martin Rowland, Department of Pharmacy and Pharmacology, University of Bath, UK 15.00 - 15.15 Aerodynamic size-fractionated sub-populations of salmeterol xinafoate and fluticasone propionate powders possess distinct properties and aerosolisability S Jaffari, King’s College London, Institute of Pharmaceutical Sciences, UK 15.15 - 15.30 Absorption Profiling of Inhaled Liposomal Ciprofloxacin Nanoparticles using Isolated Perfused Lung Hui Xin Ong, Woolcock Institute of Medical Research, The University of Sydney, Australia 15.30 - 15.45 Challenges in bronchial challenge testing A J Lexmond, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands 15.45 - 16.50 Coffee/Tea Break Session 4: Advances In Analytical Science For Respiratory Products Chairs: Matt Pollard / Mark Hammond, DDL Committee 16.50 - 17.20 Opportunities for Clinically Relevant Methods in the Laboratory Evaluation of Spacers and Valved Holding Chambers (VHCs) Jolyon Mitchell, Trudell Medical International, Canada 17.20 - 17.45 Development of the Hydraulic Lung Dr David Prime, Inhaled Product and Device Technology, GlaxoSmithKline R&D, Ware, Hertfordshire, UK 17.45 - 18.05 Comparison of 3D Imaging and 1D Deposition Models: At Which Dimension? I Katz, Medical Gases Group, Air Liquide Santé International, France, Department of Mechanical Engineering, Lafayette College, USA 18.05 - 18.25 Characterization and Feasibility of the Single Particle Mass Spectrometer (SPAMS) for the Determination of Aerodynamic Particle Size Distributions and Chemical Composition of Inhalation Products B. Morrical, Novartis AG Pharma Development, Switzerland 18.30 - 20.30 DDL23 Cocktail Reception and Award Night Sponsored by Aptar Pharma & Presspart Manufacturing Limited Friday 7th December 2012 08.15 Coffee and Poster Viewing 09.00 - 09.30 Evaluating the effects of formulation and device design on in vitro comparability of dry powder inhalers Professor Robert Price, University of Bath, UK Session 5: The inhaled market - where is it going? Chairs: Phil Haywood/Alan Ferrie, DDL Committee 09.30 - 10.00 An Innovative Route to Inhaled Product Industrialisation: The Monash-GSK Australia Partnership Ass. Prof. David A V Morton, Monash Institute of Pharmaceutical Sciences, Monash University, Australia 10.00 – 10.30 Inhalation Technology – What might the future hold? Mr Phil Seeney, Drug Delivery – PA Consulting Group, Technology and Innovation, UK 10.30 – 11.30 Coffee/Tea Break 11.30 – 12.00 Real life’ studies – the way ahead in assessing current and new inhaler therapies Professor David Price, Professor of Primary Care Respiratory Medicine, University of Aberdeen, UK 12.00 – 12.30 Inhalation drug delivery products and emerging markets, a “S.W.O.T” analysis Mr David Howlett, PharmaDelivery Solutions Ltd, UK 12.30 – 13.00 57 Varieties: Challenging the Barriers to Consumer Choice P Greenhalgh, Team Consulting Ltd, UK 13.00 Concluding Remarks and Conference Close Gary Pitcairn, Chair, DDL Committee 13.15 Close