發文單位：醫學系
業務承辦：許秀惠
Email: med0053@mail.fju.edu.tw
輔仁大學醫學系邀請傑出學者專題演講
時
地
間：九十六年十月二十四日（星期三）13:30~15:00
點：醫學綜合大樓 2 樓會議室
主辦單位：輔仁大學醫學系
應邀學者：Dr. Wang
Prof. Paul C. Wang
Department of Radiology, Howard University Hospital
學術活動行程：
Time
13:30 ~ 14:30
14:30 ~ 15:00
Topic
Seminar Topic:
Molecular Imaging of Solid Tumor
Xenografts Using a Dual
Fluorescent and MRI Probe
Place
醫學綜合大樓
2 樓會議室
醫學綜合大樓
MD531
座談會
回
條
姓名：
服務單位及職稱：
聯絡電話：
時間
13:30 ~ 14:30
14:30 ~ 15:00
主 題
Seminar Topic:
Molecular Imaging of Solid
Tumor Xenografts Using a Dual
Fluorescent and MRI Probe
座談會
聯絡人：醫學系 許秀惠 技士
Email: med0053@mail.fju.edu.tw
地點
請勾選
醫學綜合大樓
2 樓會議室
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醫學綜合大樓
MD531
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Tel: 02-29053493、02-29053490
Fax: 02-29052096
Molecular Imaging of Solid Tumor Xenografts Using a Dual Fluorescent and MRI Probe
Paul C. Wang, Ph.D.
Department of Radiology
Howard University
Washington DC
Abstract
Conventional imaging modalities such as CT and MRI exploit the differences of the physical properties of the
normal and malignant tumor tissues. These differences are often insufficient for obtaining good image contrast.
In order to improve the image contrast and low sensitivity of MRI, a large amount of contrast agent is often
needed. In recent years, several targeted MRI contrast agent delivery systems have been developed to improve
the signal-to-noise ratio of image based on exploiting the differences of the molecular properties between
cancerous and normal tissues. Another imaging modality, optical imaging, offers several advantages over CT or
MRI. It is simple to use, highly sensitive, and no ionizing radiation. Optical imaging has been used for in vivo
evaluation of gene expression, monitoring of gene delivery and real-time intraoperative visualization of tumor
margins and metastatic lesions. Limited depth of light penetration and lack of tomographic information prevent
in vivo efficiency of optical imaging. We have developed a dual molecular probe with fluorescent and magnetic
reporter groups for MRI and optical imaging of tumors. This probe contains a near-infrared fluorescent
transferrin conjugate on the surface of a cationic fluorescent liposome, which encapsulates MRI contrast agent.
The efficiency of the probe was evaluated by MDA-MB-231-luc breast cancer cells grown as monolayers in
vitro study and as solid tumor xenografts in nude mice. The results from these studies demonstrate that this
newly developed dual nano probe enhances the tumor MRI image contrast and it is superior than using MRI
contrast agent alone for identifying the tumor pathological features. This probe also provides high sensitivity for
near infrared (NIR)-based optical imaging. Due to the superior sensitivity and specificity of targeting transferrin
receptors on the cancer cells, this newly developed nano probe has a great potential to be used for early
detection of cancers and evaluating drug delivery in general.