HISTOLOGY SSN PRACTICE KODACHROME QUIZ Wednesday, April 9, 2003 Page 1 1) Which of the following is (are) secreted by the cell located at the pointer? a. Intrinsic factor b. Hydrochloric acid c. Pepsinogen d. Both a & b e. All of the above 2) The cells at the pointer empty their ________ secretions into the base of the ________. a. Mucous; circumvallate papillae b. Mucous; filiform papillae c. Serous; circumvallate papillae d. Serous; filiform papillae 3) In what organ is the structure at the pointer found? a. Small intestine b. Large intestine c. Esophagus d. Tongue 4) Which organ is this? a. Esophagus b. Stomach c. Small intestine d. Large intestine 5) This is ________ epithelium and its location is the ________. a. Stratified squamous non-keratinized; esophagus b. Stratified squamous keratinized; stomach c. Stratified squamous keratinized; esophagus d. Stratified squamous non-keratinized; stomach 6) Which of the following is NOT true about the cell at the pointer? a. The cell secretes an enzyme that increases activity of the gallbladder. b. The cell functions in immune surveillance of the contents of the lumen. c. The cell can be found in the stomach. d. The cell possesses secretory granules that stain with silver. e. The cell secretes an enzyme that inhibits gastric motility. 7) Which of the following is an INCORRECT statement about the structure at the pointer? a. The structure is lined by endothelial cells. b. The structure is located in the lamina propria. c. The structure participates in lipid absorption. d. The structure marks the boundary between the mucosa and the submucosa. HISTOLOGY SSN PRACTICE KODACHROME QUIZ Wednesday, April 9, 2003 Page 2 8) This slide demonstrates which of the following structures: a. Brunner’s glands b. Villi c. Intestinal crypts d. Plicae circularis 9) The structure at the pointer: a. distributes arterial blood to the hepatocytes b. distributes portal venous blood to the hepatocytes c. carries bile toward the common bile duct d. carries bile to the hepatocytes 10) Which is true of the bright pink structure at the pointer? a. It is composed of type IV collagen b. The hepatocytes secrete bile directly into it. c. It is a basement membrane d. Sinusoids drain directly into it. 11) Which of the following is most correct regarding the structure at the pointer? a. Blood flows centrally toward the structure in order to supply the hepatocytes. b. Blood drains radially away from it and is drained via the portal veins. c. This is the space of Disse. d. It contains blood that drains into the hepatic vein. 12) The duct shown at the arrow is specialized to: a. absorb sodium b. secrete bicarbonate c. secrete the hormone secretin d. contract 13) The morphological and staining characteristics of the acinar cells reveal that this is: a. a mixed gland (serous and mucous) b. a purely serous gland c. a purely mucous gland d. an endocrine gland 14) What is true about the duct at the pointer? a. It is striated due to elongated mitochondria in the infoldings of the basal plasma membrane. b. It is found in the parotid gland c. It is found in the pancreas d. Both a and b are true e. All of the above 15) The cell at the pointer secretes: a. amylase b. carbohydrates c. both a and b d. neither a nor b HISTOLOGY SSN PRACTICE KODACHROME QUIZ Wednesday, April 9, 2003 16) The organ shown is: a. an exocrine organ b. an endocrine organ c. both a and b d. neither a nor b 17) Most likely, the structures shown have recently been stimulated by: a. CCK b. Secretin c. both a and b Page 3 d. neither a nor b Questions 18 and 19: 18) This section is through which part of the kidney? a. Deep cortex b. Medulla c. Juxtamedullary cortex d. Papilla 19) The cells at the pointer do which of the following? a. Secrete rennin b. Secrete hydrogen ions c. Secrete excess glucose d. Secrete aldosterone e. B and C 20) The epithelial cells of this organ are specialized for their specific function(s) in which of the following ways? a. apical plaques of plasma membrane for distension b. contractile actin and myosin for luminal content expulsion c. apical Na+/H+ ATPases which respond to aldosterone d. all of the above 21) The structure indicated is also expected to stain more strongly than other tubules in the section with which of the following? a. Alkaline phosphatase b. Iron hematoxylin c. PAS d. All of the above e. None of the above HISTOLOGY SSN PRACTICE KODACHROME QUIZ Wednesday, April 9, 2003 Page 4 ANSWERS Gastrointestinal Tract I – Part I (Tongue, Esophagus, Stomach) - (Oliver) 1) 2) 3) 4) 5) D. Slide #34, stomach. Pointer on parietal cell. Parietal cells secrete HCl & IF. The HCl made by the parietal cell serves to cleave the pepsinogen (produced by the chief cells) to pepsin. Remember: Chiefs drink Pepsi. C. Slide #87, tongue. Pointer on von Ebner’s gland. These glands secrete their serous secretions into the moat circumscribing the circumvallate papillae. This serves to wash away food bits in order to make way for more food and possibly new flavors. D. Slide #87, tongue. Pointer on taste bud. Though the taste bud may partially resemble the goblet cell of the small intestine, note the stratified squamous epithelium of the tongue, which is different from the simple columnar epithelium of the small intestine. B. Slide #34, stomach. Note the relatively even epithelial surface with invaginations (gastric pits). This is unlike what you would see in the small intestine. A. Slide #73, esophagus. The pointer is on the stratified squamous non-keratinized epithelium. The epithelium of the stomach is simple columnar. Small & Large Intestine - (Erika) 6) 7) 8) B. Slide 102, pointer on enteroendocrine cell. This cell can be found in the stomach and the small intestine. Its secretory granules, which stain with silver, contain hormones such as CCK, Secretin, and GIP. These hormones function to increase activity of the gallbladder and pancreas and inhibit gastric motility respectively. D. Slide 102, pointer on lacteal. This structure can be found within the lamina propria core of intestinal villi. It is an endothelial-lined lymphatic channel that uptakes lipid droplets that have been absorbed by the villus. C. Slide 39, colon. The slide depicts a segment of the colon, which can be distinguished from the small intestine by its absence of both plicae circularis and villi and the presence of more numerous goblet cells. Brunner’s glands are characteristic of the duodenum. The mucosa of the large intestine contains straight, tubular intestinal glands (crypts) consisting of simple columnar epithelium and goblet cells. Liver – (Jenny) 9) 10) 11) C. This slide shows a portal tract in the liver, and the pointer is on a branch of the bile duct. The portal tract shown also includes a hepatic artery which delivers arterial blood to the hepatocytes (answer choice A), and a portal vein, carrying blood from the portal circulation to the hepatocytes (answer choice B). There is no structure that carries bile to the hepatocytes, only away (answer choice D.) B. The pointer is on a bile canaliculus, into which the bile produced by hepatocytes is secreted. This structure is not basement membrane (answer choices A and C). The sinusoids do not drain into the canaliculi. Instead, they bathe the hepatocytes with blood. The blood from the sinusoids then drains toward the central veins; the central veins merge to form the hepatic vein, which dumps into the inferior vena cava. D. The pointer is on a central vein, which contains blood that came from the sinusoids and bathed the hepatocytes. The central veins merge to form the hepatic vein, which dumps into the inferior vena cava. Answer choice A is wrong because the blood HISTOLOGY SSN PRACTICE KODACHROME QUIZ Wednesday, April 9, 2003 Page 5 in the central vein does not supply the hepatocytes, but rather came from them. Choice B is wrong because the portal veins supply the liver with blood from the portal circulation. This blood eventually ends up draining back into the central vein. The space of Disse (choice C) is found between the fenestrated endothelium of the sinusoid and the hepatocytes. This is where the exchange of materials between blood and hepatocytes occurs. Salivary Gland - (Sue) 12) 13) 14) B. This is an intercalated duct in the parotid gland (aka intralobular duct). The intercalated duct secretes HCO3A. This is a mixed, sublingual gland. The mixed gland is found in the sublingual gland and is composed of mucous acinus with a serous demilume. D. This is a striated duct of the parotid gland (aka intralobular duct). The striated appearance is caused by mitochondria stuck between the basal plasma membrane. The pancreas has intralobular ducts but they are NOT striated. NOTE: the answers to questions 12-14 spell “BAD.” Coincidence? You decide… Pancreas – (Stephanie) 15) 16) 17) D. The cell in question is a centroacinar cell of the pancreas. It represents the beginning of the intercalated duct. The serous acinar cells secrete amylase (as well as proenzymes). There are no mucous acini in the pancreas, and therefore there is no secretion of carbohydrates. C. The pancreas can be recognized by both its exocrine and endocrine structures. D. The pancreatic acini are shown full of zymogens (acidophilic granules). Most likely, the acini are still awaiting the signal from CCK to initiate exocytosis. Duct cells are stimulated by secretin. Renal - (Nickie) 18) 19) 20) 21) B. This section is through the medulla. This can be discerned by the presence of loops of Henle (which appear almost capillary like in their thin epithelium) and collecting ducts (with their dome shaped apical surfaces and distinct cell margins). B. Pointer on proximal tubule. The proximal tubule is specialized for absorption of many of the filtrated substances. Glucose is absorbed here and not secreted; an excess of glucose in the serum will overwhelm the reabsorption capacity but will not lead to active secretion. Hydrogen ions are secreted here (and therefore bicarbonate is reabsorbed). Renin is secreted at the JGA, and aldosterone in the adrenal cortex. A. Slide of transitional epithelium of bladder. The transitional epithelium has apical membrane plaques which aid in its distension to accommodate urine. It does not have any of the other characteristics listed (contraction/expulsion provided by smooth muscle and aldosterone sensitive Na+/H+ ATPases are in the proximal tubule). E. Pointer on distal tubule in cortex on H&E stain. The proximal tubule—not the distal—has all of the characteristics listed above in greater amounts than any other cortical tubule. The proximal is specialized for absorption with mitochondria (Iron hematoxylin), lysosomes (AlkPhos), and apical brush border (PAS).