Genetics Unit 4 UNIT TITLE: Genes Enduring Understanding: Students will be able to explain the mechanics of both cellular division/reproduction and the central dogma of biology and how mutations to these cycles effect the variation in a population. SC.912.L.16.3: Describe the basic process of DNA replication and how it relates to the transmission and conservation of the genetic information. 1. What are the subunits that make up a single strand of DNA and how are they arranged? 2. Required Topic: DNA Model 3. Summarize the steps of DNA replication. 4. What are some reasons that DNA will undergo replication? Students will describe the structure of DNA or double helix structure. Students will understand the use of complementary base pairing to construct DNA. Required Topic: DNA Model – Suggested activity: DNA Building Also address SC.912.N.1.2: Describe and explain what characterizes science and its methods and SC.912.N.3.5: Describe the function of models in science, and identify the wide range of models used in science. Students will be able to summarize how DNA replicates. Students will understand that DNA serves as a template in replication. Students will be able to explain semiconservational in terms of DNA replication. Student will be able explain the central dogma of biology Pacing (1/2 day) SC.912.L.16.4: Explain how mutations in the DNA sequence may or may not result in phenotypic change. Explain how mutations in gametes may result in phenotypic 1. Explain why a silent mutation is less changes in offspring. harmful than a deletion or insertion. Students will be able to recall the four key mutations. Explain what the phrase “one gene one- polypeptide,” means. 2. Name the three types of RNA and their role in creation of a protein. 1. Students will be able to explain the effects of a mutation upon the phenotype. SC.912.L.16.5: Explain the basic processes of transcription and translation, and how they result in the expression of genes. Students will be able to define transcription and translation Students will be able explain what codons are and how they are created. Students will be able to identify the different types of RNA and explain their role. Students will be able to explain how proteins are created. Students will be able to discuss how proteins are a result of gene expression. Students will be able to discuss the pathway from gene to protein. Also address SC.912.N.3.5: Describe the function of models in science, and identify the wide range of models used in science. Students will be able to distinguish introns from exons. Students will be able to relate the process of RNA splicing to gene expression. 1. Explain how gene expression is regulated. 2. Compare and contrast gene expression in prokaryotes and eukaryotes. 3. Explain why the RNA transcripts must be edited in a eukaryotic cell. 4. List the different methods of genetic recombination in bacteria. 1. SC.912.L.16.6: Discuss the mechanisms for regulation of gene expression in prokaryotes and eukaryotes at transcription and translation level. Students will be able to identify regulatory mechanisms used for prokaryotes Students will be able to discuss the role of operons, promoters, and operators in gene regulation. Students will be able identify the repressor as a key regulator in transcription Students will be able to identifying regulation mechanics, used for eukaryotes. Students will be able to discuss the various transcription factors that regulate genes in eukaryotes. Explain the usefulness of the Human SC.912.L.16.9: Explain how and why the genetic code is universal and is common to Genome Project. almost all organisms. Students will be able to define the term genome. Student will understand the significance of the Human Genome Project. Students will be discuss how the genetic code connects all organisms