OSU Physiology and Cell Biology Monthly Newsletter February, 2012 This edition is covering the news of January, 2012, and announcing seminars and calendar events for February, 2012. Please email your news to treon.4@osu.edu by the end of each month. Research Awards Rafael-Fortney JA, Janssen PM. Investigation of a new treatment target for heart failure in muscular dystrophy. Muscular Dystrophy Assn Inc, $19,038.00, 01-01-10/12-31-12. Ziolo MT. Nitric oxide signaling in healthy and diseased cardiac myocytes. NIH-NHLBI, $104,166.00, 01-01-10/12-31-13. Research Submissions - - Janssen PM. A new regulator of muscle fibrosis and repair. Nationwide Children’s, $200,554.00, 12-01-12/11-30-17. Radwanski P, Gyorke S. Mechanism of arrhythmia prevention by tetrodotoxin-selective Na+ channel blockade in a genetic model of catecholaminergic polymorphic ventricular tachycardia (CPVT). Heart Rhythm Society, $42,128.00, 07-01-12/06-30-13. Brunello L, Gyorke S. Synchronization of extrasystolic Ca2+ release and contraction in cardiac muscle harboring the arrhythmogenic CASQ2 mutation R33Q. AHA Great Rivers, $89,000, 07-01-12/06-30-14. Janssen PM. A new role for dystrophin in cardiac beta-adrenergic response. TRINCH, $25,768.00, 07-01-12/06-3014. Tang L, Ziolo MT. A novel regulation of CAMKII function by neuronal nitric oxide synthase. AHA, $50,000.00, 07-0112/06-30-14. Roof S, Ziolo MT. Neuronal nitric oxide synthases’s role in the beneficial effects of exercise. AHA, $50,000.00, 07-0112/06-30-14. Janssen PM, Davis JP, Ziolo MT, Biesiadecki BJ, Beattie CE, Rafael-Fortney JA, Gyorke S. Reprogramming cellular function by rewiring calcium/calmodulin signaling pathways. NIH, $6,829,922.00, 09-01-12/08-31-17. Janssen PM. New anti-fibrotic drug treatment for DMD. TRINCH, $23,252.00, 08-01-12/07-31-13. Nixon B, Biesiadecki BJ. Troponin Phosphorylation Crosstalk. AHA, $50,000.00, 07-01-12/06-30-14. Rowland LA, Periasamy M. SLN-mediated heat generation is the primary mechanism in UCP1-independent thermogenesis. AHA, $50,000.00, 07-01-12/06-30-14. Milani Nejad N, Janssen PM. Regulation of cardiac cross-bridge cycling rate via length-dependent Post-translational modifications in health and disease. AHA, $50,000.00, 07-01-12/06-30-14. Radwanski P, Gyorke S. The role of tetrodotoxin-sensitive NA+ channels in catecholaminergic polymorphic ventricular tachycardia (CPVT). AHA Great Rivers, $89,000.00, 07-01-12/06-30-14. Kalyanasundaram A, Periasamy M. Role of RyR2 mediated calcium leak in diabetic cardiomyopathy. AHA, $46,000.00, 07-01-12/06-30-13. Sopariwala DH, Periasamy M. The molecular basis for skeletal muscle based non shivering thermogenesis. AHA Great Rivers Affiliate, $50,000.00, 07-01-12/06-30-14. Shaikh SA, Periasamy M. How does the SERCA-SLN interaction lead to uncoupling and heat production? AHA, $50,000.00, 07-01-12/06-30-14. 1 - Maurya SK, Periasamy M. Increased ubiquitination as a mechanism for cardiac and skeletal muscle dysfunction in Type 2 diabetes. AHA Great Rivers, $91,000.00, 07-01-12/06-30-14. Publications Wheeler DG, Joseph ME, Mahamud SD, Aurand WL, Mohler PJ, Pompili VJ, Dwyer KM, Nottle MB, Harrison SJ, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic swine: Expression of human CD39 protects against myocardial injury Wheeler, CD39 reduces myocardial injury in swine. J Mol Cell Cardiol. 2012 Jan 12. [Epub ahead of print]. Lou Q, Fedorov VV. Shock-Induced Focal Arrhythmias: Not Driven by Calcium? Heart Rhythm. 2012;9(1):105-106. Conferences and Presentations Dr. Mark Ziolo presented “Don’t Just Say NO: NOS1 Signaling in Cardiac Myocytes” during Cardiology Grand Rounds at Johns Hopkins University on January 11, 2012. Zhaobin Xu, a Postdoctoral Research in Dr. Gumina’s DHLRI lab, will present his poster entitled “CD39 Expression Modulates Ischemia Induced Diastolic Dysfunction” in a moderated poster session at the American College of Cardiology 61st Annual Scientific Session, Sunday, March 25, 2012. U February 12, 13, 14: Department Seminars and Meetings Academic Review Self Study Site Visit Tentative Agenda for Monday, February 13 Feb. 13: 9:00-9:15 304 Hamilton Hall 9:15-9:45 304 Hamilton Hall 9:45-10:15 304 Hamilton Hall 10:15-10:30 304 Hamilton Hall 10:30-11:00 304 Hamilton Hall 11:00-11:30 304 Hamilton Hall 11:30-12:00 304 Hamilton Hall 12:00-1:00 304 Hamilton Hall 1:00-1:30 304 Hamilton Hall 1:30-2:00 304 Hamilton Hall All Faculty and Staff – Overview and Introductions Cardiovascular Research Faculty Cellular Research Faculty Break Neuroscience Research Teaching Faculty Untenured Faculty Lunch w/ Graduate Students Research Scientists & Postdoctoral Researchers PCB Staff: Mary and Carolyn February 21, 2011, 12:00 p.m., 302 Hamilton Hall: Faculty Meeting w/ Dean Lockwood 2 UReminders to Faculty OSU:pro is being used now for all University and College Faculty reporting. Please keep your profile updated - https://pro.osu.edu/. All Promotion and Tenure, Annual, Teaching, Research, and other reports are now developed from the system for College and University uses. Faculty appointments and the semester conversion Do you have questions about how faculty pay schedules, leave policies, or service credit will operate under semesters? These issues and more are addressed in a series of frequently asked questions about faculty appointments and the semester switch. Center for Education and Scholarship February Training Courses The College of Medicine’s Center for Education and Scholarship will host Lead.Serve.Inspire curriculum training courses for faculty in teaching skills and technology resources as the new curriculum is implemented this year. Training courses for February include: Feb. 1 – Competency Based Learning and Assessment, 7 a.m., 1059 Graves Feb. 10 – Using the Meiling Auditoriums, 7:30 a.m., 1024 Graves Feb. 14 – Simulation in Med Ed, noon, 1069 Graves Feb. 15 – Facilitating Small Group Learning, noon, 518A James Feb. 16 – Articulate Overview, 4 p.m., 1024 Graves Feb. 22 – Articulate Overview, 5 p.m., B120 Graves Feb. 27 – Carmen Quizzes, noon, 1059 Graves Feb. 27 – Team Based Learning, 5 p.m., 1059 Graves Register online. Contact Karla Vick at 292-0018 with questions. University Senate elections underway The University Senate has launched a new round of elections for faculty senators. The nomination phase is currently open and will continue until Friday (2/3); the ensuing election period will run Monday (2/6)-Wednesday (2/29). Results will be announced on Thursday (3/1). When elected, senators accept a three-year term of service. They join administrators and student representatives at the meetings of the University Senate, presided over by President Gordon Gee, and attend the meetings of Faculty Council (the faculty caucus of the Senate), which raises issues specific to faculty life on the campus. Senators are also asked to serve on at least one of the 20 Senate committees. (See the University Senate website for a complete listing of committees, their current membership, as well as a directory of current senators.) Contact: Jim Rathman or Tim Gerber Read the onCampus article about the Senate elections: http://oncampus.osu.edu/2012/01/senate-elections/ Physiology and Cell Biology Faculty Committee Reports U Merit – Dr. Janssen Teaching – Dr. Lucas Appointment, Promotion & Tenure – Dr. Strauch Faculty Council – Dr. Lucas/Dr. Janssen Graduate Recruitment – Dr. Davis/Dr. Biesiadecki Seminar – Dr. Davis Space – Dr. Rall U U U U U 3 Department News and Announcements On January 26, 2012, Dr. Gee invited Dr. Fedorov, Dr. Biesiadecki and Dr. Laura Schmitt, an Assistant Professor of Physical Therapy, for lunch in his office. They are all relatively new Assistant Professors at The Ohio State University. They had an informal discussion regarding their work, life at Ohio State and life in general. News Notification Emails Being Sent to OSU Email Addresses Only Beginning Thursday (Jan. 19), all email notifications (e.g. approvals) from the PeopleSoft Financial system, eRequest, and eTravel will be sent to a user’s OSU email account (name.#@osu.edu). This change affects only users who currently receive emails from these systems to their OSUMC email account (firstname.lastname@osumc.edu). This change has no impact on the HR/SIS PeopleSoft System at this time. It is highly recommended that Medical Center employees forward their OSU emails to their Medical Center email address to ensure delivery of important and time sensitive emails. Go to my.osu.edu, enter your information and select Change Email Delivery to set up email forwarding. Call the OSUMC Help Desk at 293-3861 with questions. News 25 0 U N IV E R S IT Y H A L L | 23 0 N . O V A L MA L L | C O LU MB U S , O H 43 2 10 - 1 36 6 | P H : ( 61 4 ) 2 47 - 74 1 3 | WWW .GRADSCH.OSU.EDU Candidacy paperwork MUST be submitted by Graduate School deadlines There have been several instances recently where the Graduate School has not been notified two weeks in advance of an upcoming candidacy exam. The Notification of Candidacy Exam forms MUST be submitted to the Graduate School at least two weeks before the proposed oral examination date. This time frame is essential so that graduation services staff can validate the exam committee and resolve any potential problems. Forms will not be accepted outside of the two-week notice, and any exam that takes place without prior clearance from the Graduate School will be invalidated. Contact: Tim Watson, 247-7292 4 Hayes Graduate Research Forum — Friday, February 24 The 26th annual Edward F. Hayes Graduate Research Forum is set for Friday, Feb. 24, in the Ohio Union. This event showcases the high quality research conducted by graduate students across Ohio State, and it is co-sponsored by the Council of Graduate Students, Office of Research, and the Graduate School. The abstract submission deadline has passed, and graduate faculty are judging the abstracts for possible participation. Faculty are encouraged to volunteer to serve as presentation judges on the day of the forum. To apply and volunteer Contact: Allen Cochran, vice president, Council of Graduate Students. Important Graduate School Deadlines Applications to graduate for winter quarter 2012, doctoral and master’s: Friday, Jan. 13 Submission of master’s and doctoral examination report forms: Wednesday, Feb. 29 Submission of final approved theses and dissertations: Wednesday, March 7 OSU Environmental Health & Safety News Institutional Animal Care and Use Committee newsletter The latest edition of the Animal Care and Use Newsletter is now available at http://orrp.osu.edu/iacuc/. This issue reminds researchers of the upcoming IACUC semi-annual inspections, provides FAQs regarding the online process of animal ordering, and has additional news and updates regarding animal research and hazardous agents. News Events Thursday and Friday Kick Off Heart Month - Interactive Lecture on Heart Disease Prevention Join Martha Gulati, MD, director of Ohio State’s Women’s Cardiovascular Health Program, Thursday (Feb. 2) from 3-4 p.m. in the Ross Heart Hospital Auditorium for an interactive lecture on heart disease prevention. There will be a “build your own” parfait bar with various toppings for a healthy afternoon snack. Each parfait is $5, and all of the proceeds will go to the American Heart Association. Contact Emily Kaeding with questions. - Wear Red Day Is Friday Friday (Feb. 3) is National Wear Red Day in support of preventing heart disease. Ohio State staff and faculty are encouraged to wear red all day. The “Go Red” Prize Patrol will be on the lookout for those wearing red and will hand out gifts to those who are “caught.” Contact Emily Kaeding for more information. ID Processing and Security Office to Move On Feb. 17, ID Processing, along with the administrative offices within in the Department of Security, will move temporarily to the fifth floor of Cramblett Medical Clinic. ID Processing will be in room 5013. This temporary move will allow for construction on the concourse that will connect the new James Cancer Hospital and Critical Care Tower to Rhodes Hall. ID Processing will maintain normal hours at this temporary location. The Control Center for Security will remain in its current location on the first floor of Rhodes Hall. ID Processing and the Security administrative offices will remain in their new space until July. Wednesday Lunch and Learn Session for Pelotonia Fellowship Program The Pelotonia Fellowship Program is accepting applications for undergraduate, graduate, medical and postdoctoral fellowships. A lunch and learn session about the program and application process will be held Wednesday (Feb. 1) at 11:30 a.m. in 105 Biomedical Research Tower. Register online. These fellowships are for cancer-related projects and can go to students in any field of study. All students, who would like to conduct cancer research, are encouraged to apply. To date, 116 fellowships have been awarded to students in various fields of study, including Arts and Sciences, Business, Engineering, Humanities, Medicine and Pharmacy. This year, the program expects to fund an additional 49 fellowships. Applications are due March 1. More information, including eligibility guidelines and an application, are online. Email Jeff Mason with questions. 5 Receive Buckeye Alerts by Providing Cell Phone Number The Buckeye Alert System is used to alert students and staff of any significant issue requiring action or of immediate concern affecting the OSU and/or OSUMC campus. To sign up, staff must enter their cell telephone number at Employee Self Service. There is not a special call out for Buckeye Alert but if a staff member has entered a cell phone number, they are automatically signed up to receive Buckeye Alerts. The cell phone does not need to be listed as the preferred number, it just needs to be entered. Contact Michael Gregory, director of Safety, for more information at 293-6738. Making Posters in PowerPoint Class Offered Wednesday Medical Visuals, a service of the Health Sciences Library, is offering free instruction on laying out posters using PowerPoint. Email Meg Birmingham with questions and to preregister. Space is limited and walk-ins will not be accepted. All classes will be held in 200 Prior Hall. Classes are: Wednesday (Jan. 18), 10-11:30 a.m.; Jan. 23, 2-3:30 p.m.; and Feb. 9, 9:30-11 a.m. Save the Date for 2012 OSUMC Research Day Mark your calendars for the 11th Annual OSUMC Trainee Research Day, scheduled for April 18-19 at the Biomedical Research Tower. Trainee Research Day provides faculty, staff and students an opportunity to learn about the biomedical research conducted by trainees in the College of Medicine. This group spans the educational continuum of research training from postdoctoral fellows and researchers, to medical and undergraduate students. Read more. Note to trainees: Abstracts are due by Feb. 10. Office of Research Office of Sponsored Programs (Formerly the Research Foundation) News Research Development and Grant Writing Newsletter The January 2012 issue of Research Development & Grant Writing News is now available. Some of the topics for this month include: - NSF Math/Science Partnership Webinar Report - Writing a Successful Project Management Plan - Writing Shared Use Infrastructure Grants - NIH Changes: NCRR Dissolved, NCATS Created - New Funding Opportunities - etc. Next ARC Meeting - Register Today! Join us on Tuesday (2/21/12), 9:30 a.m. - 11:00 a.m. in 1080 Physics Research Building and be sure to arrive early (between 9:10 am - 9:30 a.m.) to enjoy refreshments and time for networking courtesy of the ARC Steering Committee. Our agenda includes presentations from: - Bernadette Melnyk, Associate Vice President for Health Promotion, Chief Wellness Officer, and Dean, College of Nursing: Building Successful Programs of Funded Research in Health and Wellness - Vedavyas (Vedu) Hariths, Research In View (formerly OSU:pro), Office of the CIO: Research In View goes live on February 24th - Vedu will provide a system demo and overview - Anne Moffat, Executive Director, Office of Sponsored Programs: Updates on semester conversion, salary caps, and other research administration topics - Other announcements. UPCOMING RESEARCH TRAINING AND EVENTS - HTTP://OSP.OSU.EDU/TRAINING/ Pelotonia Fellowship Program - Lunch & Learn 02/01/2012 Register NCURA TV – International Collaborations: Negotiations and Compliance 02/08/2012 Register Exempt Forms Help 02/15/2012 Register Administrative Research Council (ARC) Meeting 02/21/2012 Register ARC Discussions – Access the Power of the PI Portal 02/23/2012 Register Cost Sharing on Sponsored Programs 02/24/2012 Register Grant Writing: An Introduction 02/29/2012 Register 6 OSP Job Aids/Training Guides Being a PI at OSU – Roles and Responsibilities Cayuse424 Effort Certification: What is it and why is it important? Entrepreneurial Faculty: Advancing Innovation in a University Setting Facilities and Administrative (Indirect) Costs at The Ohio State University PI Portal Required Research Personnel Training: http://researchonline.osu.edu/training/ INFO to KNOW for GRANT SUBMISSIONS OSURF Benefit Rates Appointment Faculty 9 and 12 mo Faculty (QOD) A&P, including Post-Doctoral Researchers CCS Non-OSU Students, Visiting Scholars GRAs, Pre & Post Fellows/Trainees, Students FY12 28% 14.6% 36.7% 46.5% 14.6% 4.4% F & A Rate 52.5% 2010 NIH Salary Cap $179,700 "Thirty days hath September, April, June, and November, February has twenty-eight alone, All the rest have thirty-one; Excepting leap year, that 's the time When February's days are twenty-nine." - traditional English mnemonic rhyme Happy Valentine’s Day! 7 Conference Room Calendar – 304 Hamilton Hall – subject to frequent changes - contact Carolyn or Mary for updates U U FEBRUARY 2012 Sun Monday Tuesday Wednesday Thursday Friday Sat 2 3 9:30-11:30Jhiang 12:00-2:00Cell Biol Group 2:00-3:00Jakeman 1 2 9:00-11:00Robinson 12:00-1:30Big 6 Lab Mtg 3:30-5:30602 Tutorial 3 4 5 6 9:00-10:00CV Jrnl Club 7 9:30-11:30Jhiang 12:00-2:00Cell Biology 8 9:00-10:00Janssen 9 12:00-1:30Jakeman 10 2:00-4:00Periasamy 11 12 13 7:00-5:00 – Academic Review Site Visit 14 7:00-5:00 – Academic Review Site Visit 15 16 9:00-11:00Robinson 12:00-1:30Big 6 Lab Mtg 17 3:30-5:30602 Tutorial 18 19 20 9:00-10:00CV Jrnl Club 10:00-1:00 – Haizlip Practice 21 9:30-11:30Jhiang 12:00-1:30Faculty Mtg 22 9:00-10:00Janssen 10:00-12:00Haizlip Defense 23 12:00-1:30Jakeman 24 2:00-4:00Periasamy 25 26 27 28 9:30-11:30Jhiang 29 8:00-2:00Roman Defense 8