YANG, Xuexian
Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Xuexian O.YANG
Assistant Professor in Immunology & Inflammation
Member, UNM Cancer Center
eRA COMMONS USER NAME
XOYANG
EDUCATION/TRAINING
DEGREE
(if applicable)
INSTITUTION AND LOCATION
Peking Union Medical College, Beijing
University of Washington, Seattle
U of Texas M D Anderson Cancer Center, Houston
PhD
Postdoc
Postdoc
YEAR(s)
FIELD OF STUDY
1999
Mol. Biology & Biochem.
2000-2003 Immunobiology
2005-2006 Immunology
A. Personal Statement
My work focuses on lymphocyte and cytokine biology, and their roles in immune and inflammatory
responses. My previous work has contributed to understanding the development of T helper
lymphocytes and their function in inflammatory diseases including cancer. Currently, we are working on
the roles of T cell cytokines and their cytokine products in modulation of cancer microenvironment. My
experiences make me suitable for the proposed role.
B. Positions, Honors and Professional Activities.
Positions
201120112010-2011
2007-2010
2005-2006
2003-2004
2000-2003
Assistant Professor, Departments of Molecular Genetics & Microbiology (primary),
Neurology and Pathology, University of New Mexico Shool of Medicine, Albuquerque
Member, University of New Mexico Cancer Center, Albuquerque
Research Assistant Professor, Department of Immunology, University of Texas M D
Anderson Cancer Center, Houston
Instructor, Department of Immunology, U of Texas M D Anderson Cancer Center, Houston
Postdoctoral Fellow, U of Texas M D Anderson Cancer Center, Houston
T helper cell (TH17 & TH2) development and function (Advisor: Dr. Chen Dong)
Research Associate, Fred Hutchinson Cancer Research Center, Seattle
Senior Fellow, University of Washington Shool of Medicine, Seattle
Germline transcription and TCR rearrangement (Advisor: Dr. Dennis Willerford)
Honors and Recognition
Junior Faculty Travel Award, American Association of Immunologists, 2010
Beginning Grant-in-Aid Award, American Heart Association, 2009-2011
Graduate Excellence Award, Peking Union Medical College, 1998
Undergraduate Scholarship, Peking University, 1990-1991
Professional Activities
Ad hoc journal reviewer, Cell Research, 2010-; Clinical Science, 2011-; Autoimmunity, 2012Editorial board member, Journal of Medical Microbiology & Diagnosis, 2012Member, American Association of Immunologists, 2011Member, Institutional Animal Care and Use Committee, University of New Mexico, 2012Member, Scholarship Committee, University of New Mexico, 2011Coordinator, Neuroinflammation seminar series, University of New Mexico, 2011-2012
C. Selected Peer-reviewed Publications (of 26).
Most relevant to the current application
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YANG, Xuexian
Tong Z*, Yang XO*, Yan H, Liu W, Niu X, Shi Y, Fang W, Xiong B, Wan Y, Dong C. A Protective Role
by Interleukin-17F in Colon Tumorigenesis. PLoS ONE 7(4): e34959 (2012). PMCID: PMC3324558
(*co-first author)
Principal Investigator/Program Director (Last, First, Middle):
1.
2.
Peng J*, Yang XO*,**, Chang SH, Yang J, and Dong C**. IL-23 signaling enhances Th2 polarization
and regulates allergic airway inflammation. Cell Res. 20(1): 62-71 (2010). PMCID: PMC2801763 (*cofirst & **joint senior author)
Asthma
3.
Yang XO**, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B**,
and Dong C**. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage
commitment. Nat. Immunol. 10(12): 1260-1266 (2009). PMCID: PMC2784129 (**joint senior author)
Asthma
4.
Nurieva R*, Yang XO*, Chung Y*, and Dong C. Cutting edge: in vitro generated Th17 cells maintain
their cytokine expression program in normal but not lymphopenic hosts. J. Immunol. 182(5): 2565-2568
(2009). PMCID: PMC2755098 (*co-first author)
5.
Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW,
Dong C. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5):787-98
(2009). PMCID: PMC2787786
6.
Yang XO*, Pappu BP*, Nurieva R*, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD,
Schluns KS, Watowich SS, Tian Q, Jetten AM and Dong C. T helper 17 lineage differentiation is
programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1): 29-39 (2008).
PMCID: PMC2587175 (*co-first author)
7.
Yang XO*, Chang SH*, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu
Z and Dong C. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205(5): 1063-1075 (2008).
PMCID: PMC2373839 (*co-first author)
Asthma
8.
Yang XO*, Nurieva R*, Martinez GJ*, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS,
Watowich SS, Feng XH, Jetten AM and Dong C. Molecular antagonism and plasticity of regulatory and
inflammatory T cell programs. Immunity 29(1): 44-56 (2008). PMCID: PMC2630532 (*co-first author)
9.
Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, and Dong C. STAT3
regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282(13): 93589363 (2007). PMID: 17277312
10. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS,
Jetten AM, and Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T
cells. Nature 448(7152): 480-483 (2007). PMID: 17581589
11. Park H*, Li Z*, Yang XO*, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, and Dong
C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat.
Immunol. 6(11): 1133-1141 (2005). PMCID: PMC1618871 (*co-first author)
Additional recent publications important to the field
12. Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten
AM, Dong C. Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2.
Immunity 36(1): 23-31 (2012). PMID: 22244845
13. Reynolds JM, Pappu BP, Peng J, Martinez GJ, Zhang Y, Chung Y, Ma L, Yang XO, Nurieva RI, Tian Q,
Dong C. Toll-like Receptor 2 Signaling in CD4(+) T Lymphocytes Promotes T Helper 17 Responses and
Regulates the Pathogenesis of Autoimmune Disease. Immunity 32(5):692-702 (2010). PMCID:
PMC2878917
14. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L,
Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, and Dong C. CCR6 regulates the migration
of inflammatory and regulatory T cells. J. Immunol. 181(12): 8391-8401 (2008). PMCID: PMC2752441
15. Akimzhanov AM, Yang XO, and Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine
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YANG, Xuexian
gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282(9): 5969-5972 (2007).
PMID: 17218320
Principal Investigator/Program Director (Last, First, Middle):
D. Research Support.
Ongoing
None.
Completed
Institutional Research Grant (PD: Ozbun M)
10/01/11-09/31/12
American Cancer Society
Differential regulation of inflammation-associated colon cancer by IL-17 and IL-17F
The goal was to determine the signaling of pro-inflammatory cytokines IL-17 and IL-17F in
inflammation-associated colon cancer.
Role: Sub-award PI
09BGIA2060420 (PI: Yang X)
07/01/09-06/30/11 (ext. thru 06/30/12)
American Heart Association
Roles of IL-17 and IL-17F in asthmatic inflammation
The goal was to determine the distinct impacts of IL-17 and IL-17F in allergic airway responses.
Role: PI
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