Version: 7.2014
Section D 04
Agent Administration
Chemical Agents
Compliance with pharmaceutical grade agents. Investigators are expected to use pharmaceutical-grade agents
whenever possible. Note that per federal guidelines the use of non-pharmaceutical grade agents requires justification,
even for acute procedures. Please consult the IACUC Policy on the use of Non-Pharmaceutical grade
Chemicals/Compounds to be aware of recent clarifications to this policy.
If any non-pharmaceutical grade agent is used, will the criteria outlined in the IACUC policy on non-pharmaceutical
grade agents be applied (i.e., justification from “always acceptable” list)?
Yes. The criteria outlined in the IACUC policy will be used
No. Please provide justification for a deviation from IACUC policy
NonPharmaceutical
grade
(yes or no)
Pharmaceutical, Non-pharmaceutical grade and Non-hazardous compounds
Agent Name
Route of administration
Max Dose (mg/kg, gm,
& volume
mL, etc.)
Frequency
Please provide justification for using any Non-Pharmaceutial grade compounds listed in the above table.
Agent Name
Hazardous Compounds (including, carcinogens, toxins, teratogens, etc.)
Type of
Route of
Max Dose (mg/kg,
Frequency
Route of
agent
administration
gm, mL, etc.)
excretion
& volume
Will LARC or lab
workers be
exposed?
Biohazard agents
(biological toxins, blood, body fluids, normal/neoplastic tissues or cells, recombinant DNA, etc.)
Protocols using biohazard agents will not receive IACUC approval until the Investigator provides evidence of approval
from the Institutional Biosafety Committee (IBC). If you are unsure, please contact the IBC office.
Do you have an IBC approved protocol for the work described in this study?
Yes. Please provide the IBC protocol #
No. Please contact the IBC http://researchadmin.iu.edu/Biosafety/IUPUI/bio_contacts.html
Agent Name
ABS Level;
Route of
Is the agent
Is the agent
Is the agent shed in feces,
1, 2, 2+3
administration
infectious to
infectious to
urine, or body secretions?
Precautions, or 3
& volume
humans?
animals?
Note: It is required that the LARC BSL-2 veterinarian be notified prior to any work with biohazard or hazardous agents.
See notice in the assurance section.
Safety Procedures for Animal Handlers - (LARC Personnel and Laboratory Staff)
Who has the potential to be exposed to this material?
LARC staff
Personal Protection (indicate personal protective apparel/procedures to be used):
Hair cover
Gown
Lab coat
Waterproof boots
Safety glasses
Goggles
Film Badges
Respiratory mask (type)
Gloves (type):
Laboratory
staff
Booties
Face shield
1
Version: 7.2014
Materials Handling:
In cabinet (indicate type):
Chemical Fume Hood
Biosafety cabinet
Decontamination of area after use:
Surveys performed required?
Yes, if “yes,” all areas less than 200 cpm/100 cm 2 (must be to be released)
Procedures:
Location of each hood used:
Waste Disposal:
Bedding/excreta radioactive:
Indicate disposal method:
Incinerate
Bedding/excreta disposed as normal
Decontaminate cage before washing:
No
Duration: (days)
Autoclave
Bedding/excreta disposed through RSO
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