MP Behavior terms
abnormal response to novel conspecific
syn - abnormal social discrimination
def - deviation of the normal behavior of animals towards an unfamiliar animal
child of abnormal social investigation (MP:0001360) and abnormal response to novelty (MP:0003107)
(some annotations for this term are under abnormal social/conspecific interaction)
abnormal social memory retention
def - deviation in the ability of animals to recall familiar animals
child of both abnormal response to novel conspecific and abnormal learning/ memory (MP:0001449)
with child: social amnesia (inability to recall familiar animals)
with child: annotations for enhanced social memory retention
def - increased ability to recall familiar animals after periods of separation
increased and decreased children for abnormal social investigation (MP:0001360) with social withdrawal
(MP:0001361) as a child of decreased social investigation
abnormal socio-sexual investigation
def - altered behavior of animals to approach and examine potential mates
child of abnormal social investigation (MP:0001360) and abnormal sexual interaction (MP:0002566)
Some possible issues here, for example there is a note of "females prefer same sex scent markings in an
odor preference test" that is currently under abnormal social investigation that maybe should be moved
to this term? (J:125716)
abnormal latency to social interaction
def- deviation in the length of time before an initial interaction between two individuals
decreased and increased children
We may need to clarify the difference between interaction and investigation. The use of abnormal
social/conspecific interaction vs abnormal social investigation seems muddled.
obsolete increased/decreased aggression towards mice and replace with increased/decreased
aggression towards conspecific
abnormal heterospecific interaction
def - deviation of the normal behavior of animals towards a member of another species
There are some annotations to abnormal behavior that could be moved here see:
J:89708, J:127877; J:139886
obsolete increased aggression toward humans (MP:0001357) add new term of increased aggression
towards heterospecific
def - when compared to controls, subjects exhibit greater than the normal level of domineering, assault
posture and/or hostile physical action towards members of another species
abnormal social/conspecific interaction modify definition to: deviation of the normal behavior of
animals towards a member of the same or a closely related species
I'm thinking we may need closely related species for some mouse inter species studies
abnormal social dominance behavior
deviation in the expected tendency to exert a priority of access in an approach situation or to leave an
avoidance situation involving conspecific(s)
(modified definition from
http://notes.utk.edu/bio/unistudy.nsf/854ba168246c6472852563ee006f31ee/457f4c865776ef6385256
459004e1ff3?OpenDocument)
This may be difficult to distinguish from abnormal aggression but at least one annotation indicates that
dominance may be abnormal while aggression is normal (J:138589)
abnormal conspecific play behavior
syn - abnormal social play behavior
def - Behavior performed with a conspecific in the absence of normal stimuli or behavior elicited by
normal stimuli but not followed to the completion of the ritualized behavior pattern. (modified from
NBO:0000075. The NBO definition of social play (NBO:0000049) is " Play behavior that is associated with
the socialization of an individual into the group." That seemed both overly narrow and lacking the
definition of "play" so I went with a modified version of the parent term). Although it may be that "social
play" is a narrower synonym of conspecific play, as some of the other children of play behavior
(imitative play) would typically involve a conspecific.
child of abnormal social/conspecific interaction (MP:0002557)
I've included conspecific in the term to distinguish this from general play behavior. I could not find any
annotations discussing play with anything other than another mouse so I don't think we need to add
abnormal play behavior at this time.
abnormal paternal behavior
def - alteration in any response from the father or attending male related to the ability of young to
thrive
We have a few annotations that could be moved to this term and it would be a nice balance to the
existing term abnormal maternal behavior
Modify the definition of abnormal maternal behavior to alteration in any response from the mother or
attending female related to the ability of young to thrive (bold text added)
Many of the annotations to abnormal sexual interaction (MP:0002566) refer to "failure to breed" or
"males/females breed poorly". We may want to add the terms
impaired mating behavior
def - decrease in the ability of animals to successfully complete mating behaviors
I was also thinking about how to handle "failure to breed" but I don't think the term "absent mating
behavior" would work so I think we might be better off putting failures under impaired mating behavior.
abnormal rooting behavior
syn - abnormal rooting reflex
def - any abnormality in the reflex that causes a newborn or infant animal to turn its head toward
anything that strokes the cheek or mouth, searching for the object by moving its head in steadily
decreasing arcs until the object is found. (NBO:0000400
child of abnormal reflex
existing annotations under abnormal behavior
Abnormal learning/memory/conditioning has only the child abnormal learning/memory. This seems
odd, why have this child at all if all the other terms are under it including terms that refer to
conditioning. I would obsolete abnormal learning/memory and move all the child terms up a level.
There are annotations to abnormal behavior for mice lacking all behaviors dependent on a particular
sense (mostly hearing or sight) and a few with impaired olfactory related behaviors so we may
eventually want to add these terms:
abnormal auditory related behavior - any anomaly in a behavior related to the actions or
reactions of an organism in response to a sound (NBO:0000316)
abnormal visual related behavior - any anomaly in a behavior related to the actions or reactions
of an organism in response to a visual stimulus (NBO:0000314)
abnormal olfactory related behavior - any anomaly in a behavior related to the sensation of
odors. This is a child of chemosensation in NBO.
Some points from the NBO
The MP has some multi-slash grouping terms that could be made obsolete if we adopted some of the
terms from the NBO. For example:
abnormal kinesthetic behavior could replace abnormal motor capabilities/coordination/movement
In the NBO kinesthetic behavior is defined as "Behavior related to the movement of the body's muscles,
tendons, and joints." and has the children involuntary movement behavior and voluntary movement
behavior.
Coordination would need to be moved. In the NBO this is under vestibular behavior (def - Behavior
related to the awareness of body balance and movement.) which is under:
cognitive behavior (Behavior related to cognitive processes.)
sensation behavior (Cognitive perception of a sensation by any of the five senses -vision, touch, smell, taste, and hearing. I'm not really satisfied with this definition)
perception behavior by means (undefined)
Cognitive behavior also includes learning/memory behavior
There are some existing annotations to abnormal behavior that could be moved to abnormal cognitive
behavior:
J:170670 - impaired attention (attention behavior, NBO:0000455, is a child of sensation behavior, I
don't think we have the need to add attention behavior or sensation behavior terms)
J:183467 - impaired cognitive performance
J:96229 - attention
J:13320 - "less alert" currently annotated to abnormal sensory capabilities/reflexes/nociception
so consider adding
abnormal cognitive behavior
def - any anomaly in a behavior related to cognitive processes (NBO:0000607)
If we adopt abnormal sensation behavior. This would break up the slash term "abnormal sensory
capabilities/reflexes/nociception." Nociception and sensory capabilities would be under abnormal
sensation while reflexes would now only be under abnormal involuntary movement. I don't see any
annotations to abnormal sensory capabilities/reflexes/nociception that couldn't be moved, so I'd
recommend abnormal sensory capabilities/reflexes/nociception be made obsolete and we add the term:
abnormal sensation behavior
def - any anomaly in behaviors related to cognitive perception of a stimulus by any of the senses
(modified from NBO:0000308)
Consider changing abnormal eating/drinking behavior to abnormal consumption behavior
(NBO:0001845)
The term abnormal circadian rhythm (MP:0001502) should be made obsolete and replaced with the
term abnormal circadian behavior to differentiate this from physiological processes that occur on a 24 h
cycle. NBO has the term circadian behavior (Behavior related to any biological process in an organism
that recurs with a regularity of approximately 24 hours. NBO:0000084)
The term abnormal rhythmic behavior (def - deviation in any specific action or reaction of an organism
that recur with measured regularity. GO:0007622) could be added and used to group abnormal circadian
behavior and abnormal sleep behavior (MP:0011396)
abnormal coping response (MP:0003062) vs coping behavior (NBO:0000103)
We have coping response under depression related behavior but the NBO has it under stress related
behavior (not in the MP). I'm thinking we should consider adding abnormal stress related behavior to
the MP (child of abnormal behavior to mimic NBO) and move abnormal coping response to be a child of
this term.
abnormal stress related behavior
def - any abnormality in a behavior related to how the body reacts to a stressor (a stimulus that causes
stress), real or imagined. (NBO:0000469)
There are some annotations under abnormal behavior that could be moved to this term
J:117778, J:101849, J:7690?, J:115270 (freezing while swimming); J:15554 (movement on cold concrete);
J:106812 and others (response to tail suspension)
also possibly some of the open field studies that are not associated with anxiety for some reason
abnormal fear/anxiety-related behavior would be a child of this term in addition to its current
placement
Summary of proposed high level term changes
abnormal behavior
abnormal cognitive behavior (new term)
abnormal learning/memory/conditioning
abnormal sensation behavior (new term)
abnormal auditory related behavior (potential term)
abnormal thermosensation
abnormal touch/ nociception
hyperresponsive
abnormal motor coordination/ balance (assuming we don't add NBO parents)
abnormal visual related behavior
abnormal olfactory related behavior
abnormal consumption behavior (name change)
abnormal heterospecific interaction (new term)
abnormal kinesthetic behavior (new term)
abnormal involuntary movement
abnormal physical strength
abnormal voluntary movement
stereotypic behavior (this is under voluntary movement in NBO but I would stick with
MP placement)
abnormal rhythmic behavior (new term)
abnormal circadian behavior (name change)
abnormal sleep behavior
abnormal stress related behavior (new term)
abnormal coping response