Tuesday, 10 May 2011
2.00 - 6.00 pm Arrival and Registration
6.00 pm Opening of Conference
6.15 pm Keynote Lecture
Hans R. Schöler – Induction of pluripotency in adult stem cells
7.00 pm Buffett
Evening Session – Model Organisms
8.00 pm – 9.30 pm
Chair: Philip W. Ingham
8.00 pm Helen Blau - Of Newts and Niches: Regenerating tissues by mimicking natural processes
8.30 pm Frank Schnorrer - The making of flight muscles
9.00 pm Alejandro Sánchez Alvarado – Regeneration, Stem Cells and the Planaria Schmidtea
mediterranea
Wednesday, 11 May 2011
Somite Patterning and Muscle Development I
9.00 am – 12.10 pm
Chair: Thomas Braun
9.00 am Christophe Marcelle – The molecular and cellular mechanisms regulating skeletal muscle
development and regeneration
9.30 am Eldad Tzahor – Lhx2 plays a role in pharyngeal muscle development and in the genetic
pathway that leads to the DiGeorge syndrome
10.00 am Delphine Duprez - Intrinsic regulators of muscle progenitors during embryonic myogenesis
10.15 am Coffee break
11.00 am Simon Hughes - Muscle formation and growth in the zebrafish
11.30 am Krzysztof Jagla – Genetic control of muscle-type specific differentiation programs: insights
from Drosophila
11.55 am Laurence Dubois - A genetic screen to identify new genes involved in specification of
muscle identity in Drosophila: interaction between tailup (tup) and collier (col) specify
DA2 and DA3 muscle identity.
12.10 pm Lunch
Somite Patterning and Muscle Development II
1.15 pm – 4.30 pm
Chair: Frank Stockdale
1.15 pm Chaya Kalcheim - Molecular insights into lineage segregation of dermomyotome
progenitors
1.45 pm Philip Ingham – Cell type specification in the zebrafish myotome: signals, transcription
factors and miRNAs
2.15 pm Robert Kelly - Myogenic derivatives of pharyngeal mesoderm
2.45 pm Chrissa Kioussi Motility of Myogenic Cells in Filling Limb Muscle Anlagen
3.00 pm Coffee break
3.30 pm Pete Currie – Development and Growth of the Zebrafish myotome
4.00 pm Huai-Jen Tsai – Novel microRNA-In300 and its target gene dickkopf-3-related
gene regulate the promoter activity of Muscle Regulatory Factor myf5 gene
Genetic Control of Muscle Cell Differentiation
4.30 pm – 7.30 pm
Chair: Pura Munoz-Canoves
4.30 pm Frederic Relaix – Molecular mechanisms coordinating myogenesis and cell cycle
regulation during development
5.00 pm Robert S. Krauss – Regulation of promyogenic signal transduction by cell-cell contact and
adhesion
5.30 pm
6.00 pm
6.30 pm
7.00 pm
Coffee break
Hans-Henning Arnold - Canonical Wnt signaling in early and late mouse myogenesis
Jaime Carvajal - Regulation of MRF expression in facial muscle precursors
George Muscat - Regulation of skeletal muscle insulin signaling by the nuclear receptor,
RORalpha.
7.30 pm Stephen D. Hauschka - Basic regulatory controls of muscle gene expression
8.00 pm Dinner
Poster Session
9.00 pm- 10.30 pm
Thursday, 12 May 2011
Posttranscriptional Control of Myogenesis (miRNAs) and Epigenetics I
8.30 am – 1.15 pm
8.30 am
9.00 am
9.30 am
10.00 am
Chair: Stephen D. Hauschka
Eric Olson – New Insights into the Genetic Networks of Skeletal Muscle Disease
Carola Ponzetto - MicroRNAs in myogenesis: from physiology to pathology
Andrea Münsterberg – Muscle specific microRNAs control developmental timing of
myogenesis
Irene Bozzoni - Epigenetic control of miRNA expression through the dystrophin-nNOS
signalling cascade
10.25 am
Coffee break
11.00 am
Keynote Lecture
Howard Cedar - Reprograming
11.45 am
12.15 am
12.45 pm
1.00 pm
Posttranscriptional Control of Myogenesis (miRNAs) and Epigenetics II
Margaret Buckingham – The modulation of myogenic behaviour in progenitor cells
Pier Lorenzo Puri – Epigenetic regulation of muscle regeneration by HDAC-regulated
miRNA-SWI/SNF circuitry
Davide Gabellini - A chromatin-associated RNA regulates a Polycomb/Trithorax epigenetic
switch at the basis of facioscapulohumeral muscular dystrophy (FSHD)
Bruce Paterson – Drosophila nautilus (MyoD) activates a miRNA circuit that fine-tunes
dMef2, tinman and output from the Notch and Jak-Stat pathways to regulate somatic
muscle formation
1.15 pm Lunch
Epigenetic Regulation and Reprograming
02.15 pm – 4.15 pm
Chair: Michael Rudnicki
02.15 pm Vittorio Satorelli – Epigenetics of Skeletal Myogenesis.
02.45 pm Anthony Imbalzano - Regulation of higher order chromatin structure and gene positioning
during myogenesis
03.15 pm Coffee break
03.30 pm Thomas Rando - Molecular regulation of muscle stem cell quiescence
04.00 pm Atsushi Asakura - MyoD gene suppression by Oct4 is required for reprogramming in
myoblasts to produce induced pluripotent stem (iPS) cells
04.30 pm Excursion to “Rheingau” incl. Dinner
Bustransfer to world famous Rüdesheim
Boarding on Cruiseship Loreley-Elegance
4 h Diner Rhine-River-Shuffle
Friday, 13 May 2011
Satellite Cells and Stem Cell Properties
8.30 am – 12.15 pm
Chair: Margaret Buckingham
Chen-Ming Fang - Pax7-positive muscle stem cell lineage
Michael Rudnicki - Molecular Regulation of Muscle Stem Cell Function
Peter Zammit - The regulation of muscle satellite cell fate choice
Athanassia Sotiropoulos - Srf-dependent paracrine signals produced by myofibers control
satellite cell-mediated skeletal muscle hypertrophy
10.15 am Coffee break
8.30 am
9.00 am
9.30 am
10.00 am
11.00 am Johnny Kim - Identification of epigenetic modifiers involved in muscle stem cell
differentiation
11.15 am David Sassoon - p53 effectors, muscle stem cells, and aging: towards a common nodal
point in adult stem cell regulation
11.45 am Bradley Olwin – The Role of the Satellite Cell Niche in Cell Homeostasis and Aging.
12.15 pm Lunch
Cell Signaling and the Stem Cell Niche
1.15 pm – 4.10 pm
1.45 pm
2.15 pm
2.40 pm
Chair: Helen Blau
Carmen Birchmeier – Function of Notch and its target gene Hes1 in development of
myogenic progenitor cells and Satellite cells
Shahragim Tajbakhsh – Satellite cell properties and function
Ketan Patel – Regulation of Satellite Cell Migration
Coffee break
2.55 pm
3.25 pm
3.55 pm
4.10 pm
Fabio Rossi - Regulation of the balance between repair and regeneration in skeletal muscle
Andrew Brack - Regulation of satellite cell quiescence during muscle growth
Sören Alsheimer - Muscle Stem Cells Secrete Tenascin W, a Key Component of Their Niche
Coffe break
1.15 pm
Systems Biology
4.40 pm – 5.40 pm
Chair: Carmen Birchmeier
4.40 pm Eileen Furlong – cis-regulatory networks during development: Is there a code?
5.10 pm Abraham Fong – Comparison of the Myogenic and Neurogenic Regulatory Programs.
Therapeutic Approaches to Muscle Diseases
5.40 pm – 7.10 pm
Chair: Christophe Marcelle
5.40 pm Giulio Cossu - A phase I/II trial of cell transplantation for Duchenne Muscular Dystrophy
6.10 pm Gert-Jan van Ommen – Antisense-based exon skipping as a therapy for Duchenne
Muscular Dystrophy, status and prospects
7.00 pm Dinner
Poster Session
9.00 pm- 10.30 pm
Saturday, 14 May 2011
Organ Development I (ECM, Nerve-Muscle Interactions, Migration, Myoblast Fusion)
8.30 am – 10.45 pm
Chair: Krystzof Jagla
8.30 am Steve Burden - Muscle-derived Signals For Regulating Motor Innervation
9.00 am Benny Shilo – The roles of N-WASp in myoblast fusion and sarcomere organization
9.30 am Renate Renkawitz-Pohl - FuRMAS, topology and signaling during myoblast fusion in
Drosophila
10.00 am Mary Baylies - MAP and Kinesin dependent nuclear positioning is required for skeletal
muscle function
10.30 am Jeffrey Dilworth - Comparative gene expression profiling identifies the tetraspanin CD53 as
a p38alpha-dependent protein that modulates cell fusion
10.45 am Coffee break
Organ Development II
11.30pm – 1.15 pm
Chair: Renate Renkawitz-Pohl
11.30 am Olivier Pourquie – Early patterning and differentiation of vertebrate muscles
12.00 pm Laurent Schaeffer – Neural control of muscle gene expression: CtBP mediates repression
12.30 pm Ilona Skerjanc - Skeletal myosin light chain kinase regulates skeletal myogenesis by
phosphorylation of MEF2C
12.45 pm Malcom Logan - Regulation of limb muscle morphogenesis
01.15 pm Lunch
Regenerative Biology
2.15 pm – 4.00 pm
2.15 pm
2.45 pm
3.15 pm
3.45 pm
4.00 pm
Chair: Peter Rigby
Andras Simon - Dynamics of skeletal muscle cells during newt limb regeneration
Elly Tanaka - Muscle dedifferentiation during salamander limb regeneration
Nadia Rosenthal - Immune modulation of muscle regeneration
Rachel Sarig - p53 plays a pivotal role in preventing malignant transformation of induced
pluripotent stem cells
Coffee break
4.45 pm Stefano Schiaffino - Novel players in the regulation of muscle growth
5.15 pm David J. Glass - Signaling pathways that mediate skeletal muscle atrophy and hypertrophy
5.45 pm Alfred Goldberg - New Insights into the Molecular Mechanisms of Muscle Atrophy
6.15 pm Excursion to the Cistercian Eberbach Monastery incl. Wine-Tasting and Farewell Dinner
Known from the famous movie “The Name of the rose”
Sunday, 15
May 2011
Breakfast and Departure
8.30 am – 12.00 pm